The Olfactomedin family is a group of extracellular glycoproteins that contain an OLF domain in its C-terminal region []. Olfactomedin-like (OLFML) glycoproteins are members of Olfactomedin family. There are at least four OLFMLs: OLFML1, OLFML2A, OLFML2B and OLFML3.OLFML1 regulates cell proliferation by increasing the percentage of cells in the S phase [].