Type |
Details |
Score |
Genotype |
Symbol: |
Slu7/Slu7 |
Background: |
C57BL/6N-Slu7/Wtsi |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Slu7/Slu7<+> |
Background: |
C57BL/6N-Slu7/Wtsi |
Zygosity: |
ht |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Montaville P |
Year: |
2006 |
Journal: |
Biochim Biophys Acta |
Title: |
Nuclear translocation of the calcium-binding protein ALG-2 induced by the RNA-binding protein RBM22. |
Volume: |
1763 |
Issue: |
11 |
Pages: |
1335-43 |
|
•
•
•
•
•
|
Publication |
First Author: |
Xu D |
Year: |
1998 |
Journal: |
Mol Cell Biol |
Title: |
Synthetic lethality of yeast slt mutations with U2 small nuclear RNA mutations suggests functional interactions between U2 and U5 snRNPs that are important for both steps of pre-mRNA splicing. |
Volume: |
18 |
Issue: |
4 |
Pages: |
2055-66 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
This entry contains proteins involved in the first step of pre-mRNA splicing to remove introns. Splicing is performed by the spliceosome, which is a complex of snRNAs U1, U2, U4, U5, and U6 and proteins such as pre-mRNA-processing factor 19 (Prp19). The yeast protein Cwc2 contains motifs known to bind RNA, a zinc finger and an RNA recognition motif. Because mutations in the gene are lethal and lead to accumulation of pre-mRNA, and reduced levels of U1, U4, U5 and U6 snRNAs and U4/U6 snRNA complex levels, Cwc2 has been proposed to link the Prp19 complex to the spliceosome during pre-mRNA splicing []. Because Cwc2 is at the spliceosome catalytic centre, it induces an active conformation of the spliceosome's catalytic RNA elements []. Cwc2 is a component of the CWC complex []. The human homologue, known as RBM22 [], also translocates the protein SLU7 from the nucleus to the cytoplasm or vice versa in the case of the calcium-binding protein PDCD6 [].Also included in this entry is the pre-mRNA-splicing factor Slt11 (also known as Ecm2) []. |
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•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1139
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1150
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1139
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Rasche N |
Year: |
2012 |
Journal: |
EMBO J |
Title: |
Cwc2 and its human homologue RBM22 promote an active conformation of the spliceosome catalytic centre. |
Volume: |
31 |
Issue: |
6 |
Pages: |
1591-604 |
|
•
•
•
•
•
|
Publication |
First Author: |
McGrail JC |
Year: |
2009 |
Journal: |
Nucleic Acids Res |
Title: |
The RNA binding protein Cwc2 interacts directly with the U6 snRNA to link the nineteen complex to the spliceosome during pre-mRNA splicing. |
Volume: |
37 |
Issue: |
13 |
Pages: |
4205-17 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
420
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Ohi MD |
Year: |
2002 |
Journal: |
Mol Cell Biol |
Title: |
Proteomics analysis reveals stable multiprotein complexes in both fission and budding yeasts containing Myb-related Cdc5p/Cef1p, novel pre-mRNA splicing factors, and snRNAs. |
Volume: |
22 |
Issue: |
7 |
Pages: |
2011-24 |
|
•
•
•
•
•
|
Publication |
First Author: |
Trost M |
Year: |
2009 |
Journal: |
Immunity |
Title: |
The phagosomal proteome in interferon-gamma-activated macrophages. |
Volume: |
30 |
Issue: |
1 |
Pages: |
143-54 |
|
•
•
•
•
•
|
Publication |
First Author: |
Carninci P |
Year: |
2005 |
Journal: |
Science |
Title: |
The transcriptional landscape of the mammalian genome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
1559-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gerhard DS |
Year: |
2004 |
Journal: |
Genome Res |
Title: |
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
Volume: |
14 |
Issue: |
10B |
Pages: |
2121-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Huttlin EL |
Year: |
2010 |
Journal: |
Cell |
Title: |
A tissue-specific atlas of mouse protein phosphorylation and expression. |
Volume: |
143 |
Issue: |
7 |
Pages: |
1174-89 |
|
•
•
•
•
•
|
Publication |
First Author: |
Church DM |
Year: |
2009 |
Journal: |
PLoS Biol |
Title: |
Lineage-specific biology revealed by a finished genome assembly of the mouse. |
Volume: |
7 |
Issue: |
5 |
Pages: |
e1000112 |
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•
•
•
•
•
|