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Search results 701 to 800 out of 855 for Atr

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Type Details Score
Publication
20305300 | J:162958
First Author: Greer Card DA
Year: 2010
Journal: J Biol Chem
Title: Rad9A is required for G2 decatenation checkpoint and to prevent endoreduplication in response to topoisomerase II inhibition.
Volume: 285
Issue: 20
Pages: 15653-61
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Publication
18054789 | J:166501
First Author: Shimura T
Year: 2008
Journal: J Mol Biol
Title: Bloom's syndrome helicase and Mus81 are required to induce transient double-strand DNA breaks in response to DNA replication stress.
Volume: 375
Issue: 4
Pages: 1152-64
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Publication
19071136 | J:168938
First Author: Yajima H
Year: 2009
Journal: J Mol Biol
Title: DNA double-strand break formation upon UV-induced replication stress activates ATM and DNA-PKcs kinases.
Volume: 385
Issue: 3
Pages: 800-10
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Publication
22797300 | J:190073
First Author: Xie L
Year: 2012
Journal: J Clin Invest
Title: PHD3-dependent hydroxylation of HCLK2 promotes the DNA damage response.
Volume: 122
Issue: 8
Pages: 2827-36
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Publication
25873625 | J:232664
First Author: Panigrahi SK
Year: 2015
Journal: Nucleic Acids Res
Title: Regulation of NEIL1 protein abundance by RAD9 is important for efficient base excision repair.
Volume: 43
Issue: 9
Pages: 4531-46
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Publication
27920088 | J:237491
First Author: Eid A
Year: 2016
Journal: Genes Dev
Title: SUV4-20 activity in the preimplantation mouse embryo controls timely replication.
Volume: 30
Issue: 22
Pages: 2513-2526
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Publication
28439015 | J:242221
First Author: Liu K
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Mutant p53 perturbs DNA replication checkpoint control through TopBP1 and Treslin.
Volume: 114
Issue: 19
Pages: E3766-E3775
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Publication
28483909 | J:244331
 
First Author: Wheaton K
Year: 2017
Journal: Mol Cell Biol
Title: Progerin-Induced Replication Stress Facilitates Premature Senescence in Hutchinson-Gilford Progeria Syndrome.
Volume: 37
Issue: 14
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Publication
28381412 | J:242347
First Author: Timashev LA
Year: 2017
Journal: Genes Dev
Title: The DDR at telomeres lacking intact shelterin does not require substantial chromatin decompaction.
Volume: 31
Issue: 6
Pages: 578-589
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Publication
27538817 | J:258385
 
First Author: Fujikane R
Year: 2016
Journal: Sci Rep
Title: Function of high-mobility group A proteins in the DNA damage signaling for the induction of apoptosis.
Volume: 6
Pages: 31714
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Publication
31405847 | J:279987
First Author: Erber J
Year: 2019
Journal: Cancer Res
Title: Dual Inhibition of GLUT1 and the ATR/CHK1 Kinase Axis Displays Synergistic Cytotoxicity in KRAS-Mutant Cancer Cells.
Volume: 79
Issue: 19
Pages: 4855-4868
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Publication
33619545 | J:313251
First Author: Dereli I
Year: 2021
Journal: Nucleic Acids Res
Title: Four-pronged negative feedback of DSB machinery in meiotic DNA-break control in mice.
Volume: 49
Issue: 5
Pages: 2609-2628
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Publication
29107825 | J:318504
 
First Author: Xia J
Year: 2018
Journal: J Nutr Biochem
Title: Atrazine-induced environmental nephrosis was mitigated by lycopene via modulating nuclear xenobiotic receptors-mediated response.
Volume: 51
Pages: 80-90
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Publication
35051531 | J:319625
 
First Author: Ma S
Year: 2022
Journal: Cancer Lett
Title: Disrupting PHF8-TOPBP1 connection elicits a breast tumor-specific vulnerability to chemotherapeutics.
Volume: 530
Pages: 29-44
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Publication
24084170 | J:320206
First Author: Melis JP
Year: 2013
Journal: DNA Repair (Amst)
Title: Slow accumulation of mutations in Xpc-/- mice upon induction of oxidative stress.
Volume: 12
Issue: 12
Pages: 1081-6
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Publication
36563124 | J:344817
First Author: Liu W
Year: 2023
Journal: Adv Sci (Weinh)
Title: RNF126-Mediated MRE11 Ubiquitination Activates the DNA Damage Response and Confers Resistance of Triple-Negative Breast Cancer to Radiotherapy.
Volume: 10
Issue: 5
Pages: e2203884
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Publication
16908670 | J:112621
First Author: Jehle AW
Year: 2006
Journal: J Cell Biol
Title: ATP-binding cassette transporter A7 enhances phagocytosis of apoptotic cells and associated ERK signaling in macrophages.
Volume: 174
Issue: 4
Pages: 547-56
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Protein
Q24JP3
Organism: Mus musculus/domesticus
Length: 464  
Fragment?: false
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Protein
Q6P9P0
Organism: Mus musculus/domesticus
Length: 1278  
Fragment?: false
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Protein
Q80WC1
Organism: Mus musculus/domesticus
Length: 1314  
Fragment?: false
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Protein
Q8JZS6
Organism: Mus musculus/domesticus
Length: 575  
Fragment?: false
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Protein
Q8BZ50
Organism: Mus musculus/domesticus
Length: 323  
Fragment?: true
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Protein
Q8CDR1
Organism: Mus musculus/domesticus
Length: 503  
Fragment?: false
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Protein
F6VRS2
Organism: Mus musculus/domesticus
Length: 92  
Fragment?: true
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Protein
Q3TST9
Organism: Mus musculus/domesticus
Length: 681  
Fragment?: true
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Protein
A2AAW4
Organism: Mus musculus/domesticus
Length: 137  
Fragment?: true
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Protein
Q9D4Y4
Organism: Mus musculus/domesticus
Length: 159  
Fragment?: false
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Protein
Q06RJ2
Organism: Mus musculus/domesticus
Length: 144  
Fragment?: true
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Protein
E9Q839
Organism: Mus musculus/domesticus
Length: 1163  
Fragment?: false
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Protein
A0A494BAY5
Organism: Mus musculus/domesticus
Length: 144  
Fragment?: true
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Protein
F6WBP1
Organism: Mus musculus/domesticus
Length: 138  
Fragment?: true
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Protein
A0A494BAL0
Organism: Mus musculus/domesticus
Length: 73  
Fragment?: false
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Protein
F6TB64
Organism: Mus musculus/domesticus
Length: 1043  
Fragment?: true
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Protein
E9PXB2
Organism: Mus musculus/domesticus
Length: 523  
Fragment?: false
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Protein
A0A494BB77
Organism: Mus musculus/domesticus
Length: 546  
Fragment?: false
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Protein
A0A3Q4ECA2
Organism: Mus musculus/domesticus
Length: 214  
Fragment?: false
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Protein
B7ZWK5
Organism: Mus musculus/domesticus
Length: 1140  
Fragment?: false
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Protein
D3Z515
Organism: Mus musculus/domesticus
Length: 64  
Fragment?: true
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Protein
A0A0A6YWQ3
Organism: Mus musculus/domesticus
Length: 140  
Fragment?: true
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Protein
A0A494BB73
Organism: Mus musculus/domesticus
Length: 518  
Fragment?: false
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Protein
A0A0A6YWE8
Organism: Mus musculus/domesticus
Length: 98  
Fragment?: true
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Protein
E9PUL8
Organism: Mus musculus/domesticus
Length: 379  
Fragment?: false
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Protein
A0A494B9R8
Organism: Mus musculus/domesticus
Length: 80  
Fragment?: true
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Protein
Q8CEN1
Organism: Mus musculus/domesticus
Length: 130  
Fragment?: false
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Protein
Q8QZZ4
Organism: Mus musculus/domesticus
Length: 122  
Fragment?: true
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Protein
Q78XZ3
Organism: Mus musculus/domesticus
Length: 200  
Fragment?: false
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Protein
B2RXQ3
Organism: Mus musculus/domesticus
Length: 1163  
Fragment?: false
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Protein
Q8C623
Organism: Mus musculus/domesticus
Length: 109  
Fragment?: false
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Publication
10075733 | -
First Author: Sun H
Year: 1999
Journal: J Biol Chem
Title: Retinal stimulates ATP hydrolysis by purified and reconstituted ABCR, the photoreceptor-specific ATP-binding cassette transporter responsible for Stargardt disease.
Volume: 274
Issue: 12
Pages: 8269-81
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Publication
16540294 | -
First Author: Kaminski WE
Year: 2006
Journal: Biochim Biophys Acta
Title: ABC A-subfamily transporters: structure, function and disease.
Volume: 1762
Issue: 5
Pages: 510-24
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Publication
17081983 | -
First Author: Olsen JV
Year: 2006
Journal: Cell
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
Volume: 127
Issue: 3
Pages: 635-48
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Publication
32389690 | -
First Author: Adamus M
Year: 2020
Journal: J Mol Biol
Title: Molecular Insights into the Architecture of the Human SMC5/6 Complex.
Volume: 432
Issue: 13
Pages: 3820-3837
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Publication
19029251 | -
First Author: Banumathy G
Year: 2009
Journal: Mol Cell Biol
Title: Human UBN1 is an ortholog of yeast Hpc2p and has an essential role in the HIRA/ASF1a chromatin-remodeling pathway in senescent cells.
Volume: 29
Issue: 3
Pages: 758-70
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Protein Domain
IPR026082 | ABCA
Type: Family
Description: ATP-binding cassette transporters (ABC) are multipass transmembrane proteins that use the energy of ATP hydrolysis to transport substrates across membrane bilayers. Members of ABC transporter subfamily A are full-length transporters [], which consist of a single long polypeptide chain organised into two tandemly arranged halves. Each half contains a membrane-spanning domain (MSD) followed by a cytoplasmic nucleotide binding domain (NBD) []. Several members of this group have been shown to mediate the transport of a variety of physiologic lipid compounds, such as sterols, phospholipids and bile acids [, ].ABCA7 plays a role in clearance of apoptotic cells by affecting their phagocytosis []. In the human visual cycle, ABCA4 acts as an inward-directed retinoid flipase, retinoid substrates imported by ABCA4 from the extracellular or intradiscal (rod) membrane surfaces to the cytoplasmic membrane surface are all-trans-retinaldehyde (ATR) and N-retinyl-phosphatidyl-ethanolamine (NR-PE). Once transported to the cytoplasmic surface, ATR is reduced to vitamin A by trans-retinol dehydrogenase (tRDH) and then transferred to the retinal pigment epithelium (RPE) where it is converted to 11-cis-retinal. ABCA4 may also play a role in photoresponse, removing ATR/NR-PE from the extracellular photoreceptor surfaces during bleach recovery []. It has been suggested that ABCA9 plays a role in monocyte differentiation and lipid homeostasis [].
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Protein Domain
IPR007268 | Rad9/Ddc1
Type: Family
Description: This entry represents the DNA damage checkpoint protein Rad9 and its homologue in budding yeast, Ddc1. Rad9 forms a complex with Hus1 and Rad1 (called 9-1-1 complex). Ddc1 forms a similar complex with Mec1 and Rad17. Structurally, the 9-1-1 / Ddc1-Mec3-Rad17 complex is similar to the PCNA complex, which forms trimeric ring-shaped clamps. The 9-1-1 / Ddc1-Mec3-Rad17 complex plays a role in checkpoint activation that permits DNA-repair pathways to prevent cell cycle progression in response to DNA damage and replication stress [, ].In humans, 9-1-1 binds to TopBP1 and activates the ATR-Chk1 checkpoint pathway []. Besides its function in the 9-1-1 complex, Rad9 can also act as a transcriptional factor and participate in immunoglobulin class switch recombination []. It also shows 3'-5' exonuclease activity []. Aberrant Rad9 expression has been associated with prostate, breast, lung, skin, thyroid, and gastric cancers [].In budding yeast, Ddc1 can activate Mec1 (the principal checkpoint protein kinase, human ATR homologue) in G1 phase. In G2 phase, Ddc1 can either activate Mec1 directly or recruit Dpb11 (the orthologue of human TopBP1) and subsequently activate Mec1 []. Ddc1 does not have DNA exonuclease function [].It is worth noting that the Rad9 proteins referred to in this entry are the mammalian and fission yeast homologues of budding yeast Ddc1. Members of this family do not share the sequence homology another DNA damage-dependent checkpoint protein from budding yeast, confusingly also called Rad9.
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Publication
15449545 | J:92574
First Author: Okazaki N
Year: 2004
Journal: DNA Res
Title: Prediction of the coding sequences of mouse homologues of FLJ genes: the complete nucleotide sequences of 110 mouse FLJ-homologous cDnas identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.
Volume: 11
Issue: 2
Pages: 127-35
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Publication
19851446 | J:161829
First Author: Wojtasz L
Year: 2009
Journal: PLoS Genet
Title: Mouse HORMAD1 and HORMAD2, two conserved meiotic chromosomal proteins, are depleted from synapsed chromosome axes with the help of TRIP13 AAA-ATPase.
Volume: 5
Issue: 10
Pages: e1000702
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Publication
9382850 | J:46333
First Author: Flaggs G
Year: 1997
Journal: Curr Biol
Title: Atm-dependent interactions of a mammalian chk1 homolog with meiotic chromosomes.
Volume: 7
Issue: 12
Pages: 977-86
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Publication
12514191 | J:82409
First Author: Leal NA
Year: 2003
Journal: J Biol Chem
Title: Identification of the human and bovine ATP:Cob(I)alamin adenosyltransferase cDNAs based on complementation of a bacterial mutant.
Volume: 278
Issue: 11
Pages: 9227-34
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Publication
31038736 | J:281168
First Author: Sakita JY
Year: 2019
Journal: J Pathol
Title: Serotonin synthesis protects the mouse colonic crypt from DNA damage and colorectal tumorigenesis.
Volume: 249
Issue: 1
Pages: 102-113
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Publication
23468651 | J:195191
First Author: Lyndaker AM
Year: 2013
Journal: PLoS Genet
Title: Conditional inactivation of the DNA damage response gene Hus1 in mouse testis reveals separable roles for components of the RAD9-RAD1-HUS1 complex in meiotic chromosome maintenance.
Volume: 9
Issue: 2
Pages: e1003320
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Publication
23436801 | J:197061
First Author: Liu Q
Year: 2013
Journal: Cancer Res
Title: Characterization of Torin2, an ATP-competitive inhibitor of mTOR, ATM, and ATR.
Volume: 73
Issue: 8
Pages: 2574-86
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Publication
20212154 | J:158685
First Author: Cannell IG
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: p38 MAPK/MK2-mediated induction of miR-34c following DNA damage prevents Myc-dependent DNA replication.
Volume: 107
Issue: 12
Pages: 5375-80
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Publication
22006019 | J:178305
First Author: Pines A
Year: 2011
Journal: Mol Cell Biol
Title: Global phosphoproteome profiling reveals unanticipated networks responsive to cisplatin treatment of embryonic stem cells.
Volume: 31
Issue: 24
Pages: 4964-77
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Publication
30693543 | J:339256
First Author: Ge C
Year: 2019
Journal: Hepatology
Title: The BRUCE-ATR Signaling Axis Is Required for Accurate DNA Replication and Suppression of Liver Cancer Development.
Volume: 69
Issue: 6
Pages: 2608-2622
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Protein
Q8BVV7
Organism: Mus musculus/domesticus
Length: 827  
Fragment?: false
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Protein
Q14B65
Organism: Mus musculus/domesticus
Length: 784  
Fragment?: false
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Protein
Q8BWE9
Organism: Mus musculus/domesticus
Length: 458  
Fragment?: true
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Publication
9311982 | -
First Author: Longhese MP
Year: 1997
Journal: EMBO J
Title: The novel DNA damage checkpoint protein ddc1p is phosphorylated periodically during the cell cycle and in response to DNA damage in budding yeast.
Volume: 16
Issue: 17
Pages: 5216-26
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Publication
28882873 | J:269226
First Author: Trigueros-Motos L
Year: 2017
Journal: Arterioscler Thromb Vasc Biol
Title: ABCA8 Regulates Cholesterol Efflux and High-Density Lipoprotein Cholesterol Levels.
Volume: 37
Issue: 11
Pages: 2147-2155
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Protein
Q3TZM0
Organism: Mus musculus/domesticus
Length: 176  
Fragment?: true
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Protein
Q8BZ38
Organism: Mus musculus/domesticus
Length: 719  
Fragment?: true
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Protein
A2A6R7
Organism: Mus musculus/domesticus
Length: 134  
Fragment?: true
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Protein
Q8BIS4
Organism: Mus musculus/domesticus
Length: 212  
Fragment?: false
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Protein
Q8R1I3
Organism: Mus musculus/domesticus
Length: 308  
Fragment?: true
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Protein
A2AEP6
Organism: Mus musculus/domesticus
Length: 181  
Fragment?: true
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Protein
Q8CJA1
Organism: Mus musculus/domesticus
Length: 148  
Fragment?: true
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Protein
Q8C137
Organism: Mus musculus/domesticus
Length: 839  
Fragment?: false
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Protein
Q3UF86
Organism: Mus musculus/domesticus
Length: 111  
Fragment?: true
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Protein
Q3TMR1
Organism: Mus musculus/domesticus
Length: 142  
Fragment?: true
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Publication
12150964 | -
First Author: Piehler A
Year: 2002
Journal: Biochem Biophys Res Commun
Title: Molecular structure of a novel cholesterol-responsive A subclass ABC transporter, ABCA9.
Volume: 295
Issue: 2
Pages: 408-16
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Publication
37965327 | J:342591
 
First Author: Sarad K
Year: 2023
Journal: Front Immunol
Title: Single-cell transcriptomics reveals subtype-specific molecular profiles in Nrf2-deficient macrophages from murine atherosclerotic aortas.
Volume: 14
Pages: 1249379
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Protein
Q8VC54
Organism: Mus musculus/domesticus
Length: 403  
Fragment?: false
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Protein
D3Z3W7
Organism: Mus musculus/domesticus
Length: 366  
Fragment?: false
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Publication
9891048 | -
First Author: Kondo T
Year: 1999
Journal: Mol Cell Biol
Title: Role of a complex containing Rad17, Mec3, and Ddc1 in the yeast DNA damage checkpoint pathway.
Volume: 19
Issue: 2
Pages: 1136-43
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Publication
22034047 | -
First Author: Broustas CG
Year: 2012
Journal: J Cell Biochem
Title: Contributions of Rad9 to tumorigenesis.
Volume: 113
Issue: 3
Pages: 742-51
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Publication
22925454 | -
First Author: Ueda S
Year: 2012
Journal: Genes Cells
Title: Two serine phosphorylation sites in the C-terminus of Rad9 are critical for 9-1-1 binding to TopBP1 and activation of the DNA damage checkpoint response in HeLa cells.
Volume: 17
Issue: 10
Pages: 807-16
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Publication
10713044 | -
First Author: Bessho T
Year: 2000
Journal: J Biol Chem
Title: Human DNA damage checkpoint protein hRAD9 is a 3' to 5' exonuclease.
Volume: 275
Issue: 11
Pages: 7451-4
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Publication
20729201 | J:166880
First Author: An L
Year: 2010
Journal: J Biol Chem
Title: Rad9 is required for B cell proliferation and immunoglobulin class switch recombination.
Volume: 285
Issue: 46
Pages: 35267-73
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Protein
Q6A065
Organism: Mus musculus/domesticus
Length: 1588  
Fragment?: false
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Protein
Q6PHB8
Organism: Mus musculus/domesticus
Length: 200  
Fragment?: true
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Protein
H7BX26
Organism: Mus musculus/domesticus
Length: 1578  
Fragment?: false
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Protein
Q9CVK4
Organism: Mus musculus/domesticus
Length: 189  
Fragment?: true
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Protein
A0A0A6YWV9
Organism: Mus musculus/domesticus
Length: 91  
Fragment?: true
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Protein
A0A0A6YXR9
Organism: Mus musculus/domesticus
Length: 96  
Fragment?: false
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Publication
21978893 | -
First Author: Eichinger CS
Year: 2011
Journal: Trends Biochem Sci
Title: 9-1-1: PCNA's specialized cousin.
Volume: 36
Issue: 11
Pages: 563-8
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Publication
11320094 | -
First Author: Bungert S
Year: 2001
Journal: J Biol Chem
Title: Membrane topology of the ATP binding cassette transporter ABCR and its relationship to ABC1 and related ABCA transporters: identification of N-linked glycosylation sites.
Volume: 276
Issue: 26
Pages: 23539-46
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Publication
12604797 | -
First Author: Majka J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Yeast Rad17/Mec3/Ddc1: a sliding clamp for the DNA damage checkpoint.
Volume: 100
Issue: 5
Pages: 2249-54
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Protein
Q3TTQ3
Organism: Mus musculus/domesticus
Length: 162  
Fragment?: false
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Protein
Q80VS6
Organism: Mus musculus/domesticus
Length: 305  
Fragment?: true
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom