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Search results 1 to 1 out of 1 for Kmt2e

Category restricted to ProteinDomain (x)

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Category: ProteinDomain
Type Details Score
Protein Domain
Type: Family
Description: The protein known as histone-lysine N-methyltransferase 2E (KMT2E, mixed-lineage leukemia 5 or MLL5) has been shown to lack key residues and an essential loop in the the SET-I subdomain required for binding substrate and cofactors []. MLL5 had been thought to be specific for mono- and dimethylation of 'Lys-4' of histone H3 (H3K4me1 and H3K4me2; which are specific tags for epigenetic transcriptional activation), and a component of an MLL5 complex, but the paper describing this alleged complex has been retracted by the authors []. MLL5 mediates hematopoietic cell homeostasis, spermatogenesis, cell cycle progression, and survival [, ]. It is recruited to gene-rich euchromatic regions via the interaction of its plant homeodomain finger with the histone mark H3K4me3 []. Overexpression of the MLL5 gene induced cell cycle arrest in G(1) phase [].