Centrosomal protein of 170kDa (Cep170) plays a role in microtubule organisation []. Human Cep170 is constantly expressed throughout the cell cycle but phosphorylated during mitosis. Cep170 is a substrate of Polo-like kinase 1 (Plk1) []. It is associated with the mature mother centriole. Upon DNA damage, it is phosphorylated probably by ATM or ATR [, , ].
This entry represents the C terminus of centrosomal protein of 170kDa (CEP170) [].Centrosomal protein of 170kDa (Cep170) plays a role in microtubule organisation []. Human Cep170 is constantly expressed throughout the cell cycle, but phosphorylated during mitosis. Cep170 is a substrate of Polo-like kinase 1 (Plk1) []. It is associated with the mature mother centriole. Cep170 is also required for Kif2b-induced microtubule depolymerisation [].
