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Search results 3201 to 3300 out of 4590 for Bcl2

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Type Details Score
Genotype
Genotype
Symbol: Rab8a/Rab8a
Background: Not Specified
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Bax/Bax Ntf3/Ntf3
Background: involves: 129S4/SvJae * 129X1/SvJ * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Bax/Bax Lama2/Lama2
Background: B6.129-Bax Lama2
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Lama2/Lama2 Tg(Myod1-BCL2)1Jbm/?
Background: B6.Cg-Lama2 Tg(Myod1-BCL2)1Jbm
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gpr68/Gpr68
Background: B6.129-Gpr68
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Bax/Bax<+>
Background: involves: 129X1/SvJ
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Bax/Bax<+> Grid2/Grid2<+>
Background: involves: 129X1/SvJ * BALB/cByJ * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Bax/Bax Grid2/Grid2<+>
Background: involves: 129X1/SvJ * BALB/cByJ * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Bax/Bax
Background: involves: 129X1/SvJ * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Sox5/Sox5
Background: involves: C3H * C57BL/6 * DBA/2 * ICR
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Atp11c/? Tg(BCL2)22Wehi/?
Background: involves: C57BL/6J * C57BL/6JWehi * SJL/Wehi
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Atp11c/? Tg(Vav-BCL2)69Jad/?
Background: involves: C57BL/6 * C57BL/6J * C57BL/6JApb
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gpr68/Gpr68
Background: B6.129(C)-Gpr68
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Fnip1/Fnip1 Tg(BCL2)22Wehi/?
Background: involves: C57BL/6 * FVB/N * SJL
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Cd68-BCL2)535Medz/?
Background: involves: 129 * C57BL/6
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Becn1/Becn1
Background: B6.129-Becn1
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rragc/Rragc<+> Tg(Vav-BCL2)69Jad/?
Background: Not Specified
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Bax/Bax Cyp26b1/Cyp26b1
Background: involves: 129S4/SvJae * 129X1/SvJ * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Publication
11784036 | J:72582
First Author: Ross AJ
Year: 2001
Journal: Dev Biol
Title: BCLW mediates survival of postmitotic Sertoli cells by regulating BAX activity.
Volume: 239
Issue: 2
Pages: 295-308
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Publication
15800576 | J:97662
First Author: Honda K
Year: 2005
Journal: Nature
Title: IRF-7 is the master regulator of type-I interferon-dependent immune responses.
Volume: 434
Issue: 7034
Pages: 772-7
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Publication
11381032 | J:69974
First Author: Footz TK
Year: 2001
Journal: Genome Res
Title: Analysis of the cat eye syndrome critical region in humans and the region of conserved synteny in mice: a search for candidate genes at or near the human chromosome 22 pericentromere.
Volume: 11
Issue: 6
Pages: 1053-70
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Publication
26966181 | J:233705
First Author: Zhao H
Year: 2016
Journal: J Biol Chem
Title: Deletions of Retinoblastoma 1 (Rb1) and Its Repressing Target S Phase Kinase-associated protein 2 (Skp2) Are Synthetic Lethal in Mouse Embryogenesis.
Volume: 291
Issue: 19
Pages: 10201-9
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Publication
25049377 | J:212237
First Author: McComb S
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Type-I interferon signaling through ISGF3 complex is required for sustained Rip3 activation and necroptosis in macrophages.
Volume: 111
Issue: 31
Pages: E3206-13
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Publication
27001308 | J:236189
First Author: Chinnam M
Year: 2016
Journal: Mol Cell Biol
Title: Evaluating Effects of Hypomorphic Thoc1 Alleles on Embryonic Development in Rb1 Null Mice.
Volume: 36
Issue: 11
Pages: 1621-7
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Publication
17452523 | J:125737
First Author: Henry T
Year: 2007
Journal: J Exp Med
Title: Type I interferon signaling is required for activation of the inflammasome during Francisella infection.
Volume: 204
Issue: 5
Pages: 987-94
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Publication
21820332 | J:175845
First Author: Sharma S
Year: 2011
Journal: Immunity
Title: Innate immune recognition of an AT-rich stem-loop DNA motif in the Plasmodium falciparum genome.
Volume: 35
Issue: 2
Pages: 194-207
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Publication
19652017 | J:152182
First Author: McWhirter SM
Year: 2009
Journal: J Exp Med
Title: A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP.
Volume: 206
Issue: 9
Pages: 1899-911
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Publication
24362933 | J:226672
First Author: Liehl P
Year: 2014
Journal: Nat Med
Title: Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection.
Volume: 20
Issue: 1
Pages: 47-53
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Publication
21765404 | J:174513
First Author: Marichal T
Year: 2011
Journal: Nat Med
Title: DNA released from dying host cells mediates aluminum adjuvant activity.
Volume: 17
Issue: 8
Pages: 996-1002
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Publication
23903655 | J:205017
First Author: Dorner M
Year: 2013
Journal: Nature
Title: Completion of the entire hepatitis C virus life cycle in genetically humanized mice.
Volume: 501
Issue: 7466
Pages: 237-41
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Publication
25694434 | J:278701
First Author: Shi X
Year: 2015
Journal: J Biol Chem
Title: The transcription factor Mesp1 interacts with cAMP-responsive element binding protein 1 (Creb1) and coactivates Ets variant 2 (Etv2) gene expression.
Volume: 290
Issue: 15
Pages: 9614-25
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Publication
21480215 | J:177313
First Author: Biondo C
Year: 2011
Journal: Eur J Immunol
Title: Recognition of yeast nucleic acids triggers a host-protective type I interferon response.
Volume: 41
Issue: 7
Pages: 1969-79
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Publication
22896628 | J:189947
First Author: Weiss G
Year: 2012
Journal: J Immunol
Title: MyD88 drives the IFN-β response to Lactobacillus acidophilus in dendritic cells through a mechanism involving IRF1, IRF3, and IRF7.
Volume: 189
Issue: 6
Pages: 2860-8
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Publication
22777843 | J:188005
First Author: Biondo C
Year: 2012
Journal: Eur J Immunol
Title: Recognition of fungal RNA by TLR7 has a nonredundant role in host defense against experimental candidiasis.
Volume: 42
Issue: 10
Pages: 2632-43
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Publication
19915568 | J:157877
First Author: Poeck H
Year: 2010
Journal: Nat Immunol
Title: Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1 beta production.
Volume: 11
Issue: 1
Pages: 63-9
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Publication
27130031 | J:315123
 
First Author: Zhong J
Year: 2016
Journal: Free Radic Biol Med
Title: Superoxide dismutase 2 overexpression alleviates maternal diabetes-induced neural tube defects, restores mitochondrial function and suppresses cellular stress in diabetic embryopathy.
Volume: 96
Pages: 234-44
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Publication
22036947 | J:180238
First Author: Schwandt T
Year: 2012
Journal: EMBO J
Title: Expression of type I interferon by splenic macrophages suppresses adaptive immunity during sepsis.
Volume: 31
Issue: 1
Pages: 201-13
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Publication
20975040 | J:176879
First Author: Lauterbach H
Year: 2010
Journal: J Exp Med
Title: Mouse CD8alpha+ DCs and human BDCA3+ DCs are major producers of IFN-lambda in response to poly IC.
Volume: 207
Issue: 12
Pages: 2703-17
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Publication
20637660 | J:162548
First Author: Farlik M
Year: 2010
Journal: Immunity
Title: Nonconventional initiation complex assembly by STAT and NF-kappaB transcription factors regulates nitric oxide synthase expression.
Volume: 33
Issue: 1
Pages: 25-34
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Publication
24042114 | J:202330
First Author: Baccarella A
Year: 2013
Journal: Infect Immun
Title: Toll-like receptor 7 mediates early innate immune responses to malaria.
Volume: 81
Issue: 12
Pages: 4431-42
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Publication
21622562 | J:175389
First Author: Carow B
Year: 2011
Journal: J Biol Chem
Title: Silencing suppressor of cytokine signaling-1 (SOCS1) in macrophages improves Mycobacterium tuberculosis control in an interferon-gamma (IFN-gamma)-dependent manner.
Volume: 286
Issue: 30
Pages: 26873-87
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Publication
22474394 | J:183609
First Author: Ge J
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Preventing bacterial DNA release and absent in melanoma 2 inflammasome activation by a Legionella effector functioning in membrane trafficking.
Volume: 109
Issue: 16
Pages: 6193-8
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Publication
18368052 | J:133772
First Author: Kleinman ME
Year: 2008
Journal: Nature
Title: Sequence- and target-independent angiogenesis suppression by siRNA via TLR3.
Volume: 452
Issue: 7187
Pages: 591-7
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Publication
23422957 | J:195312
First Author: Mancino A
Year: 2013
Journal: EMBO J
Title: I kappa B kinase alpha (IKKα) activity is required for functional maturation of dendritic cells and acquired immunity to infection.
Volume: 32
Issue: 6
Pages: 816-28
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Publication
20107183 | J:159659
First Author: Prantner D
Year: 2010
Journal: J Immunol
Title: Stimulator of IFN gene is critical for induction of IFN-beta during Chlamydia muridarum infection.
Volume: 184
Issue: 5
Pages: 2551-60
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Publication
24637670 | J:210311
 
First Author: Takemura N
Year: 2014
Journal: Nat Commun
Title: Blockade of TLR3 protects mice from lethal radiation-induced gastrointestinal syndrome.
Volume: 5
Pages: 3492
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Publication
23982205 | J:260330
First Author: Yang P
Year: 2013
Journal: Sci Signal
Title: Maternal hyperglycemia activates an ASK1-FoxO3a-caspase 8 pathway that leads to embryonic neural tube defects.
Volume: 6
Issue: 290
Pages: ra74
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Publication
19798431 | J:162908
First Author: Daffis S
Year: 2009
Journal: PLoS Pathog
Title: Induction of IFN-beta and the innate antiviral response in myeloid cells occurs through an IPS-1-dependent signal that does not require IRF-3 and IRF-7.
Volume: 5
Issue: 10
Pages: e1000607
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Publication
36206490 | J:333323
First Author: Chen H
Year: 2023
Journal: Blood
Title: PRL2 phosphatase enhances oncogenic FLT3 signaling via dephosphorylation of the E3 ubiquitin ligase CBL at tyrosine 371.
Volume: 141
Issue: 3
Pages: 244-259
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Publication
28007900 | J:239305
First Author: Tan Q
Year: 2016
Journal: Hum Mol Genet
Title: Extensive cryptic splicing upon loss of RBM17 and TDP43 in neurodegeneration models.
Volume: 25
Issue: 23
Pages: 5083-5093
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Publication
31749402 | J:283328
First Author: Klimovich B
Year: 2020
Journal: Cell Cycle
Title: Inactivation of Mdm2 restores apoptosis proficiency of cooperativity mutant p53 in vivo.
Volume: 19
Issue: 1
Pages: 109-123
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Publication
22402282 | J:182585
First Author: Oh S
Year: 2012
Journal: Biochem Biophys Res Commun
Title: Histone demethylase JMJD5 is essential for embryonic development.
Volume: 420
Issue: 1
Pages: 61-5
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Publication
25799988 | J:220466
First Author: Jiang L
Year: 2015
Journal: Nature
Title: Ferroptosis as a p53-mediated activity during tumour suppression.
Volume: 520
Issue: 7545
Pages: 57-62
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Publication
17893884 | J:145221
First Author: Liu G
Year: 2007
Journal: J Pathol
Title: The p53-Mdm2 network in progenitor cell expansion during mouse postnatal development.
Volume: 213
Issue: 4
Pages: 360-8
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Publication
18786355 | J:149874
First Author: Wetzel MK
Year: 2008
Journal: Neuron
Title: p73 regulates neurodegeneration and phospho-tau accumulation during aging and Alzheimer's disease.
Volume: 59
Issue: 5
Pages: 708-21
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Publication
24013501 | J:201153
First Author: Hamard PJ
Year: 2013
Journal: Genes Dev
Title: The C terminus of p53 regulates gene expression by multiple mechanisms in a target- and tissue-specific manner in vivo.
Volume: 27
Issue: 17
Pages: 1868-85
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Publication
36856110 | J:333827
 
First Author: Huang C
Year: 2023
Journal: J Clin Invest
Title: TP63 gain-of-function mutations cause premature ovarian insufficiency by inducing oocyte apoptosis.
Volume: 133
Issue: 5
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Publication
21368833 | J:170813
First Author: Inuzuka H
Year: 2011
Journal: Nature
Title: SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction.
Volume: 471
Issue: 7336
Pages: 104-9
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Protein
Q9ESF4
Organism: Mus musculus/domesticus
Length: 345  
Fragment?: false
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Protein
Q8K097
Organism: Mus musculus/domesticus
Length: 317  
Fragment?: false
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Protein
Q8BJZ3
Organism: Mus musculus/domesticus
Length: 309  
Fragment?: false
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Protein
Q9DA39
Organism: Mus musculus/domesticus
Length: 238  
Fragment?: false
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Protein
Q8K191
Organism: Mus musculus/domesticus
Length: 120  
Fragment?: false
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Protein
Q3U717
Organism: Mus musculus/domesticus
Length: 309  
Fragment?: false
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Protein
A0A0G2JFN2
Organism: Mus musculus/domesticus
Length: 125  
Fragment?: true
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Protein
F7AB47
Organism: Mus musculus/domesticus
Length: 206  
Fragment?: true
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Protein
Q3TJV3
Organism: Mus musculus/domesticus
Length: 160  
Fragment?: true
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Protein
F6YG30
Organism: Mus musculus/domesticus
Length: 156  
Fragment?: true
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Protein
Q9CWB0
Organism: Mus musculus/domesticus
Length: 109  
Fragment?: false
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Protein
A0A286YDK2
Organism: Mus musculus/domesticus
Length: 198  
Fragment?: true
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Protein
Q9D561
Organism: Mus musculus/domesticus
Length: 224  
Fragment?: false
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Protein
Q3TCN7
Organism: Mus musculus/domesticus
Length: 309  
Fragment?: false
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Protein
Q570Z3
Organism: Mus musculus/domesticus
Length: 140  
Fragment?: true
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Protein
Q9D592
Organism: Mus musculus/domesticus
Length: 302  
Fragment?: false
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Publication
19704470 | -
First Author: Watanabe N
Year: 2008
Journal: Plant Signal Behav
Title: Arabidopsis Bax inhibitor-1: A rheostat for ER stress-induced programmed cell death.
Volume: 3
Issue: 8
Pages: 564-6
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Publication
19742129 | -
First Author: Watanabe N
Year: 2009
Journal: Int J Mol Sci
Title: Bax Inhibitor-1, a conserved cell death suppressor, is a key molecular switch downstream from a variety of biotic and abiotic stress signals in plants.
Volume: 10
Issue: 7
Pages: 3149-67
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Publication
24904158 | -
First Author: Chang Y
Year: 2014
Journal: Science
Title: Structural basis for a pH-sensitive calcium leak across membranes.
Volume: 344
Issue: 6188
Pages: 1131-5
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Publication
23888068 | -
First Author: Weis C
Year: 2013
Journal: J Exp Bot
Title: LIFEGUARD proteins support plant colonization by biotrophic powdery mildew fungi.
Volume: 64
Issue: 12
Pages: 3855-67
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Publication
22128171 | -
First Author: Bultynck G
Year: 2012
Journal: J Biol Chem
Title: The C terminus of Bax inhibitor-1 forms a Ca2+-permeable channel pore.
Volume: 287
Issue: 4
Pages: 2544-57
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Protein Domain
IPR006214 | Bax_inhibitor_1-related
Type: Family
Description: Bax inhibitor-1 (BI-1) []is a suppressor of apoptosis that interacts with BCL2 and BCL-X. Human Bax BI-1 is an evolutionarily conserved integral membrane protein containing multiple membrane-spanning segments localised to the ER membrane. It has 6-7 membrane-spanning domains. The C termini of the mammalian BI-1 proteins are comprised of basic amino acids resembling some nuclear targeting sequences, but otherwise the predicted proteins lack motifs that suggest this function. BI-1 also regulates cell death triggered by ER stress [, , ]. BI-1 appears to exert its effect through an interaction with calmodulin []. Crystal structure of a bacterial member reveals that these proteins mediate a calcium leak across the membrane in a pH-dependent manner. Calcium homoeostasis balances passive calcium leak with active calcium uptake. The structure exists in a pore-closed and pore-open conformation, at pHs of 8 and 6 respectively [, ].This entry represents BI-1 and related sequences, including lifeguard proteins, which resemble BI-1 and also act as apoptotic regulators [].
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Publication
10428027 | J:56509
First Author: Carmeliet P
Year: 1999
Journal: Cell
Title: Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis.
Volume: 98
Issue: 2
Pages: 147-57
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Publication
9727492 | J:49460
First Author: Li H
Year: 1998
Journal: Cell
Title: Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis.
Volume: 94
Issue: 4
Pages: 491-501
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Publication
18402774 | J:134669
First Author: Fueller J
Year: 2008
Journal: Biochem Biophys Res Commun
Title: C-RAF activation promotes BAD poly-ubiquitylation and turn-over by the proteasome.
Volume: 370
Issue: 4
Pages: 552-6
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Publication
22709692 | J:189078
First Author: Baba M
Year: 2012
Journal: Blood
Title: The folliculin-FNIP1 pathway deleted in human Birt-Hogg-Dubé syndrome is required for murine B-cell development.
Volume: 120
Issue: 6
Pages: 1254-61
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Publication
24415779 | J:209385
First Author: Horowitz JE
Year: 2014
Journal: J Immunol
Title: Noncore RAG1 regions promote Vβ rearrangements and αβ T cell development by overcoming inherent inefficiency of Vβ recombination signal sequences.
Volume: 192
Issue: 4
Pages: 1609-19
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Publication
33959612 | J:306253
 
First Author: Flemmer RT
Year: 2021
Journal: Front Cell Dev Biol
Title: The Role of Mcl-1 in Embryonic Neural Precursor Cell Apoptosis.
Volume: 9
Pages: 659531
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Publication
25775525 | J:220677
First Author: Carrington EM
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Prosurvival Bcl-2 family members reveal a distinct apoptotic identity between conventional and plasmacytoid dendritic cells.
Volume: 112
Issue: 13
Pages: 4044-9
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Publication
17823980 | J:125265
First Author: Peng S
Year: 2007
Journal: Eur J Immunol
Title: c-Maf interacts with c-Myb to down-regulate Bcl-2 expression and increase apoptosis in peripheral CD4 cells.
Volume: 37
Issue: 10
Pages: 2868-80
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Publication
21194678 | J:169180
First Author: Okada I
Year: 2011
Journal: Am J Hum Genet
Title: SMOC1 is essential for ocular and limb development in humans and mice.
Volume: 88
Issue: 1
Pages: 30-41
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Publication
11672537 | J:93128
First Author: Hu CJ
Year: 2001
Journal: Immunity
Title: PU.1/Spi-B regulation of c-rel is essential for mature B cell survival.
Volume: 15
Issue: 4
Pages: 545-55
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Publication
9310832 | J:93122
First Author: O'Reilly LA
Year: 1997
Journal: Int Immunol
Title: bcl-2 transgene expression promotes survival and reduces proliferation of CD3-CD4-CD8- T cell progenitors.
Volume: 9
Issue: 9
Pages: 1291-301
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Publication
9278319 | J:93123
First Author: O'Reilly LA
Year: 1997
Journal: J Immunol
Title: Expression of a bcl-2 transgene reduces proliferation and slows turnover of developing B lymphocytes in vivo.
Volume: 159
Issue: 5
Pages: 2301-11
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Publication
15259021 | J:91772
First Author: Bell SE
Year: 2004
Journal: Eur J Immunol
Title: PLCgamma2 regulates Bcl-2 levels and is required for survival rather than differentiation of marginal zone and follicular B cells.
Volume: 34
Issue: 8
Pages: 2237-47
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Publication
15048721 | J:131486
First Author: Meade J
Year: 2004
Journal: Eur J Immunol
Title: The tyrosine kinase Syk is required for light chain isotype exclusion but dispensable for the negative selection of B cells.
Volume: 34
Issue: 4
Pages: 1102-10
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Publication
36097618 | J:328900
First Author: Webb ER
Year: 2022
Journal: iScience
Title: Cyclophosphamide depletes tumor infiltrating T regulatory cells and combined with anti-PD-1 therapy improves survival in murine neuroblastoma.
Volume: 25
Issue: 9
Pages: 104995
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Strain
MGI:6145903 | B6.Cg-Smoc1<Tn(sb-lacZ,GFP)IR3.PV384Jtak>/JtakHisaRbrc
Attribute String: mutant strain, congenic
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Strain
MGI:6144713 | B6.Cg-Smoc1<Tn(sb-lacZ,GFP)IR3.PV384Jtak>/JtakRbrc
Attribute String: mutant strain, congenic
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Strain
MGI:6144806 | B6.Cg-Bmpr1b<Tn(sb-lacZ,GFP)IR3.PV50Jtak>/JtakRbrc
Attribute String: mutant strain, congenic
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Publication
26224005 | J:226269
First Author: Bustamante-Marin XM
Year: 2015
Journal: Biol Reprod
Title: Left-Biased Spermatogenic Failure in 129/SvJ Dnd1Ter/+ Mice Correlates with Differences in Vascular Architecture, Oxygen Availability, and Metabolites.
Volume: 93
Issue: 3
Pages: 78
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Publication
21115610 | J:167041
First Author: Cook MS
Year: 2011
Journal: Development
Title: Regulation of male germ cell cycle arrest and differentiation by DND1 is modulated by genetic background.
Volume: 138
Issue: 1
Pages: 23-32
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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