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Search results 1 to 100 out of 476 for Bnip3

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Hits by Strain

Type Details Score
Protein Domain
IPR010548 | BNIP3
Type: Family
Description: This family consists of several mammalian specific BCL2/adenovirus E1B 19kDa protein-interacting protein 3 or BNIP3 sequences. BNIP3 belongs to the Bcl-2 homology 3 (BH3)-only family, a Bcl-2-related family possessing an atypical Bcl-2 homology 3 (BH3) domain, which regulates PCD from mitochondrial sites by selective Bcl-2/Bcl-XL interactions. BNIP3 family members contain a C-terminal transmembrane domain that is required for their mitochondrial localisation, homodimerisation, as well as regulation of their pro-apoptotic activities. BNIP3-mediated apoptosis has been reported to be independent of caspase activation and cytochrome c release and is characterised by early plasma membrane and mitochondrial damage, prior to the appearance of chromatin condensation or DNA fragmentation [].
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Gene
664 | BNIP3
Type: gene
Organism: human
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Gene
548576 | bnip3
Type: gene
Organism: frog, western clawed
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Gene
84480 | Bnip3
Type: gene
Organism: rat
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Gene
607408 | BNIP3
Type: gene
Organism: dog, domestic
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Gene
450831 | BNIP3
Type: gene
Organism: chimpanzee
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Gene
615342 | BNIP3
Type: gene
Organism: cattle
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Gene
423971 | BNIP3
Type: gene
Organism: chicken
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Gene
336116 | bnip3
Type: gene
Organism: zebrafish
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Gene
100426120 | BNIP3
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:109326 | Bnip3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
O55003
Organism: Mus musculus/domesticus
Length: 187  
Fragment?: false
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Protein
Q9Z2F7
Organism: Mus musculus/domesticus
Length: 218  
Fragment?: false
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Protein
Q3TEW0
Organism: Mus musculus/domesticus
Length: 218  
Fragment?: false
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Protein
A0A2S1CVQ7
Organism: Mus musculus/domesticus
Length: 75  
Fragment?: false
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Protein
A0A1B0GT26
Organism: Mus musculus/domesticus
Length: 173  
Fragment?: false
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Protein
Q91Z78
Organism: Mus musculus/domesticus
Length: 204  
Fragment?: false
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Publication
12690108 | -
First Author: Lamy L
Year: 2003
Journal: J Biol Chem
Title: CD47 and the 19 kDa interacting protein-3 (BNIP3) in T cell apoptosis.
Volume: 278
Issue: 26
Pages: 23915-21
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Gene
127379681 | BNIP3P47
Type: gene
Organism: human
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Gene
127379721 | BNIP3P43
Type: gene
Organism: human
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Gene
127379725 | BNIP3P45
Type: gene
Organism: human
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Gene
127379734 | BNIP3P46
Type: gene
Organism: human
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Gene
127379755 | BNIP3P44
Type: gene
Organism: human
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Publication
19321129 | J:148706
First Author: Ghavami S
Year: 2009
Journal: Biochim Biophys Acta
Title: Role of BNIP3 in TNF-induced cell death--TNF upregulates BNIP3 expression.
Volume: 1793
Issue: 3
Pages: 546-60
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Publication
16645637 | J:132235
First Author: Hamacher-Brady A
Year: 2007
Journal: Cell Death Differ
Title: Response to myocardial ischemia/reperfusion injury involves Bnip3 and autophagy.
Volume: 14
Issue: 1
Pages: 146-57
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Publication
25753537 | J:250805
First Author: Ney PA
Year: 2015
Journal: Biochim Biophys Acta
Title: Mitochondrial autophagy: Origins, significance, and role of BNIP3 and NIX.
Volume: 1853
Issue: 10 Pt B
Pages: 2775-83
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Publication
23692407 | J:202632
First Author: Li C
Year: 2013
Journal: J Neurochem
Title: BNIP3 mediates pre-myelinating oligodendrocyte cell death in hypoxia and ischemia.
Volume: 127
Issue: 3
Pages: 426-33
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Publication
22547685 | J:186671
First Author: Glick D
Year: 2012
Journal: Mol Cell Biol
Title: BNip3 regulates mitochondrial function and lipid metabolism in the liver.
Volume: 32
Issue: 13
Pages: 2570-84
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Publication
30307949 | J:269313
First Author: Singh A
Year: 2018
Journal: PLoS One
Title: The BH3 only Bcl-2 family member BNIP3 regulates cellular proliferation.
Volume: 13
Issue: 10
Pages: e0204792
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Publication
21278801 | J:186962
First Author: Rikka S
Year: 2011
Journal: Cell Death Differ
Title: Bnip3 impairs mitochondrial bioenergetics and stimulates mitochondrial turnover.
Volume: 18
Issue: 4
Pages: 721-31
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Publication
26232272 | J:224832
First Author: Chourasia AH
Year: 2015
Journal: EMBO Rep
Title: Mitophagy defects arising from BNip3 loss promote mammary tumor progression to metastasis.
Volume: 16
Issue: 9
Pages: 1145-63
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Publication
17576813 | J:125010
First Author: Tracy K
Year: 2007
Journal: Mol Cell Biol
Title: BNIP3 is an RB/E2F target gene required for hypoxia-induced autophagy.
Volume: 27
Issue: 17
Pages: 6229-42
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Publication
25489073 | J:216943
First Author: Dhingra R
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Bnip3 mediates doxorubicin-induced cardiac myocyte necrosis and mortality through changes in mitochondrial signaling.
Volume: 111
Issue: 51
Pages: E5537-44
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Publication
17909626 | J:127533
First Author: Diwan A
Year: 2007
Journal: J Clin Invest
Title: Inhibition of ischemic cardiomyocyte apoptosis through targeted ablation of Bnip3 restrains postinfarction remodeling in mice.
Volume: 117
Issue: 10
Pages: 2825-33
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Publication
10891486 | J:113908
First Author: Vande Velde C
Year: 2000
Journal: Mol Cell Biol
Title: BNIP3 and genetic control of necrosis-like cell death through the mitochondrial permeability transition pore.
Volume: 20
Issue: 15
Pages: 5454-68
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Publication
26317696 | J:243018
First Author: Thompson JW
Year: 2015
Journal: PLoS One
Title: Bnip3 Binds and Activates p300: Possible Role in Cardiac Transcription and Myocyte Morphology.
Volume: 10
Issue: 8
Pages: e0136847
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Publication
33290258 | J:307443
First Author: Liu J
Year: 2020
Journal: Aging (Albany NY)
Title: Bnip3 interacts with vimentin, an intermediate filament protein, and regulates autophagy of hepatic stellate cells.
Volume: 13
Issue: 1
Pages: 957-972
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Publication
25230377 | J:318259
First Author: Shi RY
Year: 2014
Journal: CNS Neurosci Ther
Title: BNIP3 interacting with LC3 triggers excessive mitophagy in delayed neuronal death in stroke.
Volume: 20
Issue: 12
Pages: 1045-55
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Publication
21415393 | J:183586
First Author: Gang H
Year: 2011
Journal: Circ Res
Title: A novel hypoxia-inducible spliced variant of mitochondrial death gene Bnip3 promotes survival of ventricular myocytes.
Volume: 108
Issue: 9
Pages: 1084-92
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Publication
16954213 | J:117391
First Author: An HJ
Year: 2006
Journal: J Biol Chem
Title: Activation of Ras up-regulates pro-apoptotic BNIP3 in nitric oxide-induced cell death.
Volume: 281
Issue: 45
Pages: 33939-48
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Publication
35410319 | J:346871
First Author: Liu K
Year: 2022
Journal: Cell Death Dis
Title: BNIP3 (BCL2 interacting protein 3) regulates pluripotency by modulating mitochondrial homeostasis via mitophagy.
Volume: 13
Issue: 4
Pages: 334
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Publication
27472901 | J:235435
   
First Author: Pedanou VE
Year: 2016
Journal: Elife
Title: The histone H3K9 demethylase KDM3A promotes anoikis by transcriptionally activating pro-apoptotic genes BNIP3 and BNIP3L.
Volume: 5
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Publication
15358175 | J:91305
First Author: Yook YH
Year: 2004
Journal: Biochem Biophys Res Commun
Title: Nitric oxide induces BNIP3 expression that causes cell death in macrophages.
Volume: 321
Issue: 2
Pages: 298-305
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Publication
19147804 | J:146532
First Author: Metukuri MR
Year: 2009
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Expression and subcellular localization of BNIP3 in hypoxic hepatocytes and liver stress.
Volume: 296
Issue: 3
Pages: G499-509
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Publication
38043200 | J:344735
 
First Author: Lee SI
Year: 2024
Journal: Biochem Biophys Res Commun
Title: HDAC6 preserves BNIP3 expression and mitochondrial integrity by deacetylating p53 at lysine 320.
Volume: 691
Pages: 149320
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Publication
17623653 | J:124647
First Author: Ha SD
Year: 2007
Journal: J Biol Chem
Title: Mitochondrial proteins Bnip3 and Bnip3L are involved in anthrax lethal toxin-induced macrophage cell death.
Volume: 282
Issue: 36
Pages: 26275-83
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Publication
32240015 | J:344423
First Author: Fuller KNZ
Year: 2020
Journal: J Appl Physiol (1985)
Title: Sex and BNIP3 genotype, rather than acute lipid injection, modulate hepatic mitochondrial function and steatosis risk in mice.
Volume: 128
Issue: 5
Pages: 1251-1261
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Publication
22753893 | J:190758
First Author: Qi Y
Year: 2012
Journal: J Cell Biol
Title: Bnip3 and AIF cooperate to induce apoptosis and cavitation during epithelial morphogenesis.
Volume: 198
Issue: 1
Pages: 103-14
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Publication
24402046 | J:210855
First Author: Moriyama M
Year: 2014
Journal: J Invest Dermatol
Title: BNIP3 plays crucial roles in the differentiation and maintenance of epidermal keratinocytes.
Volume: 134
Issue: 6
Pages: 1627-1635
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Publication
19273585 | J:148996
First Author: Bellot G
Year: 2009
Journal: Mol Cell Biol
Title: Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains.
Volume: 29
Issue: 10
Pages: 2570-81
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Publication
21890690 | J:178330
First Author: Lee Y
Year: 2011
Journal: Am J Physiol Heart Circ Physiol
Title: Mitochondrial autophagy by Bnip3 involves Drp1-mediated mitochondrial fission and recruitment of Parkin in cardiac myocytes.
Volume: 301
Issue: 5
Pages: H1924-31
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Publication
36896912 | J:360272
First Author: Cao Y
Year: 2023
Journal: EMBO J
Title: A mitochondrial SCF-FBXL4 ubiquitin E3 ligase complex degrades BNIP3 and NIX to restrain mitophagy and prevent mitochondrial disease.
Volume: 42
Issue: 13
Pages: e113033
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Publication
32277346 | J:329671
First Author: Li E
Year: 2020
Journal: Protein Cell
Title: BMAL1 regulates mitochondrial fission and mitophagy through mitochondrial protein BNIP3 and is critical in the development of dilated cardiomyopathy.
Volume: 11
Issue: 9
Pages: 661-679
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Publication
33345685 | J:351042
First Author: Lin Q
Year: 2021
Journal: Autophagy
Title: Inhibiting NLRP3 inflammasome attenuates apoptosis in contrast-induced acute kidney injury through the upregulation of HIF1A and BNIP3-mediated mitophagy.
Volume: 17
Issue: 10
Pages: 2975-2990
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Publication
36923942 | J:351041
First Author: Lin Q
Year: 2023
Journal: Int J Biol Sci
Title: Mitophagy alleviates cisplatin-induced renal tubular epithelial cell ferroptosis through ROS/HO-1/GPX4 axis.
Volume: 19
Issue: 4
Pages: 1192-1210
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Publication
36223464 | J:330586
First Author: Berardi DE
Year: 2022
Journal: Sci Adv
Title: Lipid droplet turnover at the lysosome inhibits growth of hepatocellular carcinoma in a BNIP3-dependent manner.
Volume: 8
Issue: 41
Pages: eabo2510
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Publication
31515472 | J:295309
First Author: Tang C
Year: 2019
Journal: Cell Death Dis
Title: Activation of BNIP3-mediated mitophagy protects against renal ischemia-reperfusion injury.
Volume: 10
Issue: 9
Pages: 677
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Publication
36928344 | J:341463
First Author: Li J
Year: 2023
Journal: Cell Death Dis
Title: HIF1α-BNIP3-mediated mitophagy protects against renal fibrosis by decreasing ROS and inhibiting activation of the NLRP3 inflammasome.
Volume: 14
Issue: 3
Pages: 200
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Publication
34314069 | J:321382
First Author: Kunimi H
Year: 2021
Journal: FASEB J
Title: Inhibition of the HIF-1α/BNIP3 pathway has a retinal neuroprotective effect.
Volume: 35
Issue: 8
Pages: e21829
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Publication
27325287 | J:246243
First Author: Tol MJ
Year: 2016
Journal: Diabetes
Title: A PPARγ-Bnip3 Axis Couples Adipose Mitochondrial Fusion-Fission Balance to Systemic Insulin Sensitivity.
Volume: 65
Issue: 9
Pages: 2591-605
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Publication
25429139 | J:218187
First Author: Lu P
Year: 2014
Journal: J Neurosci
Title: Poly(ADP-ribose) polymerase-1 causes mitochondrial damage and neuron death mediated by Bnip3.
Volume: 34
Issue: 48
Pages: 15975-87
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Publication
33459136 | J:345481
First Author: Springer MZ
Year: 2021
Journal: Autophagy
Title: BNIP3-dependent mitophagy promotes cytosolic localization of LC3B and metabolic homeostasis in the liver.
Volume: 17
Issue: 11
Pages: 3530-3546
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Publication
27861891 | J:239178
First Author: Moulis MF
Year: 2017
Journal: J Neurochem
Title: OPA1 haploinsufficiency induces a BNIP3-dependent decrease in mitophagy in neurons: relevance to Dominant Optic Atrophy.
Volume: 140
Issue: 3
Pages: 485-494
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Publication
18632667 | J:142327
First Author: Oshima Y
Year: 2008
Journal: J Biol Chem
Title: Pivotal role of Bcl-2 family proteins in the regulation of chondrocyte apoptosis.
Volume: 283
Issue: 39
Pages: 26499-508
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Publication
29149759 | J:331738
 
First Author: Jin Q
Year: 2018
Journal: Redox Biol
Title: DUSP1 alleviates cardiac ischemia/reperfusion injury by suppressing the Mff-required mitochondrial fission and Bnip3-related mitophagy via the JNK pathways.
Volume: 14
Pages: 576-587
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Publication
22241963 | J:315496
First Author: Wu SY
Year: 2011
Journal: Neoplasia
Title: Ras-related tumorigenesis is suppressed by BNIP3-mediated autophagy through inhibition of cell proliferation.
Volume: 13
Issue: 12
Pages: 1171-82
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Publication
31039007 | J:281090
First Author: McCoin CS
Year: 2019
Journal: Am J Physiol Endocrinol Metab
Title: Sex modulates hepatic mitochondrial adaptations to high-fat diet and physical activity.
Volume: 317
Issue: 2
Pages: E298-E311
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Publication
22044588 | J:183674
First Author: Hoshino A
Year: 2012
Journal: J Mol Cell Cardiol
Title: p53-TIGAR axis attenuates mitophagy to exacerbate cardiac damage after ischemia.
Volume: 52
Issue: 1
Pages: 175-84
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Publication
23568341 | J:196679
First Author: Cao DJ
Year: 2013
Journal: J Am Heart Assoc
Title: Mechanical unloading activates FoxO3 to trigger Bnip3-dependent cardiomyocyte atrophy.
Volume: 2
Issue: 2
Pages: e000016
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Publication
30062822 | J:325847
First Author: Von Schulze A
Year: 2018
Journal: J Physiol
Title: Hepatic mitochondrial adaptations to physical activity: impact of sexual dimorphism, PGC1α and BNIP3-mediated mitophagy.
Volume: 596
Issue: 24
Pages: 6157-6171
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Protein Coding Gene
MGP_CAROLIEiJ_G0030611 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0033144 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0033126 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0033058 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0033127 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0032841 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_109326 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0033638 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0032171 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0032814 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0032966 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0032919 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0033060 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0032951 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0033658 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0031877 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0032282 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0013816 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0031722 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
     
Probe: MGI:4836255
Assay Type: RT-PCR
Annotation Date: 2010-10-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:4836491
Age: postnatal
Specimen Label: WT
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:4836255
Assay Type: RT-PCR
Annotation Date: 2010-10-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:4836491
Age: postnatal
Specimen Label: FIH KO
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
       
Probe: MGI:5825515
Assay Type: RT-PCR
Annotation Date: 2017-03-03
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1603917
Stage: TS17
Assay Id: MGI:5827533
Age: embryonic day 10.5
Specimen Label: +/+
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:5825515
Assay Type: RT-PCR
Annotation Date: 2017-03-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603917
Stage: TS17
Assay Id: MGI:5827533
Age: embryonic day 10.5
Specimen Label: -/-
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:5817976
Assay Type: RT-PCR
Annotation Date: 2017-01-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598827
Stage: TS27
Assay Id: MGI:5818009
Age: postnatal day 1
Image: 7
Specimen Label: Kbtbd5+/+
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:5817976
Assay Type: RT-PCR
Annotation Date: 2017-01-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598827
Stage: TS27
Assay Id: MGI:5818009
Age: postnatal day 1
Image: 7
Specimen Label: Kbtbd5-/-
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:5817976
Assay Type: RT-PCR
Annotation Date: 2017-01-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598827
Stage: TS27
Assay Id: MGI:5818018
Age: postnatal day 1
Image: 8
Specimen Label: Kbtbd5+/+;E2F1-/-
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:5817976
Assay Type: RT-PCR
Annotation Date: 2017-01-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598827
Stage: TS27
Assay Id: MGI:5818018
Age: postnatal day 1
Image: 8
Specimen Label: Kbtbd5-/-;E2F1-/-
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:6192461
Assay Type: RT-PCR
Annotation Date: 2018-08-01
Strength: Present
Sex: Female
Emaps: EMAPS:3568928
Stage: TS28
Assay Id: MGI:6192473
Age: postnatal adult
Specimen Label: placenta normoxia
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:6192461
Assay Type: RT-PCR
Annotation Date: 2018-08-01
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689426
Stage: TS26
Assay Id: MGI:6192473
Age: embryonic day 20.0
Specimen Label: brain normoxia
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:6468541
Assay Type: RT-PCR
Annotation Date: 2020-10-23
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:360422
Stage: TS02
Assay Id: MGI:6468542
Age: embryonic day 1.0
Specimen Label: 2-cell
Detected: false
Specimen Num: 1
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