SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS4 (Suppressor of cytokine signalling 4) is the substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins []. SOCS4 and SOCS5 regulate epidermal growth factor receptor signaling [].
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS4 (Suppressor of cytokine signalling 4) is the substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins []. SOCS4 and SOCS5 regulate epidermal growth factor receptor signaling [].This entry represents the SH3 domain of SOCS4.
Suppressor of cytokine signalling (SOCS) proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS5 inhibits the IL4 signaling pathway, which promotes the Th (helper T) 2 cell development []. SOCS5 and SOCS4 regulate epidermal growth factor receptor signaling [].
This entry represents the SOCS box domain of SOCS4.SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS4 (Suppressor of cytokine signalling 4) is the substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins []. SOCS4 and SOCS5 regulate epidermal growth factor receptor signaling [].The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions [, ].
Suppressors of cytokine signaling (SOCS) proteins play important roles in regulating a variety of signal transduction pathways that are involved in immunity, growth and development of organisms. They share a similar domain organisation, with a central SH2 domain and a conserved C-terminal SOCS box. In contrast, the N-terminal domains vary in length and amino acid sequence. In the case of SOCS4-7, the N-terminal domain accounts for a large proportion of the protein [].This entry represents a conserved region in the N-terminal domains of SOCS4 and 5. This domain is approximately 60 amino acids in length. It is found in association with , .
This entry represents the SOCS box domain of SOCS5.Suppressor of cytokine signalling (SOCS) proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS5 inhibits the IL4 signaling pathway, which promotes the Th (helper T) 2 cell development []. SOCS5 and SOCS4 regulate epidermal growth factor receptor signaling [].The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions [, ].
