|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 1101 to 1182 out of 1182 for Frzb

<< First    < Previous  |  Next >    Last >>
0.026s

Categories

Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Protein Domain
IPR020067 | Frizzled_dom
Type: Domain
Description: The frizzled (fz) domain is an extracellular domain of about 120 amino acids.It was first identified in the alpha-1 chain of type XVIII collagen and in members of the Frizzled family of seven transmembrane (7TM) proteins which act as receptors for secreted Wingless (Wg)/Wnt glycoproteins []. In addition to these proteins, one or two copies of the fz domain are also found [, , , , ]in:The Frzb family; secreted frizzled-like proteins.Smoothened; another 7TM receptor involved in hedgehog signaling.Carboxpeptidase Z (CPZ).Transmembrane serine protease corin (atrial natriuretic peptide-converting enzyme).Two receptor tyrosine kinases (RTKs) subfamilies, the Ror family and the muscle-specific kinase (MuSK) family.As the fz domain contains 10 cysteines which are largely conserved, it has also been called cysteine-rich domain (CRD) []. The fz domain also contains several other highly conserved residues, for example, a basic amino acid follows C6, and a conserved proline residues lies four residues C-terminal to C9 []. The crystal structure of a fz domain shows that it is predominantly α-helical with all cysteines forming disulphide bonds. In addition to helical regions, two short β-strands at the N terminus form a minimal β-sheet with the second beta sheet passing through a knot created by disulphide bonds [].Several fz domains have been shown to be both necessary and sufficient for Wg/Wnt ligand binding, strongly suggesting that the fz domain is a Wg/Wnt interacting domain [, ].
•
•
•
•
•
Protein Domain
IPR036790 | Frizzled_dom_sf
Type: Homologous_superfamily
Description: This entry represents the frizzled domain superfamily.The frizzled (fz) domain is an extracellular domain of about 120 amino acids.It was first identified in the alpha-1 chain of type XVIII collagen and in members of the Frizzled family of seven transmembrane (7TM) proteins which act as receptors for secreted Wingless (Wg)/Wnt glycoproteins []. In addition to these proteins, one or two copies of the fz domain are also found [, , , , ]in:The Frzb family; secreted frizzled-like proteins.Smoothened; another 7TM receptor involved in hedgehog signaling.Carboxpeptidase Z (CPZ).Transmembrane serine protease corin (atrial natriuretic peptide-converting enzyme).Two receptor tyrosine kinases (RTKs) subfamilies, the Ror family and the muscle-specific kinase (MuSK) family.As the fz domain contains 10 cysteines which are largely conserved, it has also been called cysteine-rich domain (CRD) []. The fz domain also contains several other highly conserved residues, for example, a basic amino acid follows C6, and a conserved proline residues lies four residues C-terminal to C9 []. The crystal structure of a fz domain shows that it is predominantly α-helical with all cysteines forming disulphide bonds. In addition to helical regions, two short β-strands at the N terminus form a minimal β-sheet with the second beta sheet passing through a knot created by disulphide bonds [].Several fz domains have been shown to be both necessary and sufficient for Wg/Wnt ligand binding, strongly suggesting that the fz domain is a Wg/Wnt interacting domain [, ].
•
•
•
•
•
Publication
18767925 | J:168528
First Author: Zhu M
Year: 2009
Journal: J Bone Miner Res
Title: Activation of beta-catenin signaling in articular chondrocytes leads to osteoarthritis-like phenotype in adult beta-catenin conditional activation mice.
Volume: 24
Issue: 1
Pages: 12-21
•
•
•
•
•
Publication
7876242 | J:23590
First Author: Rehn M
Year: 1995
Journal: J Biol Chem
Title: Identification of three N-terminal ends of type XVIII collagen chains and tissue-specific differences in the expression of the corresponding transcripts. The longest form contains a novel motif homologous to rat and Drosophila frizzled proteins.
Volume: 270
Issue: 9
Pages: 4705-11
•
•
•
•
•
Protein
D3YYF7
Organism: Mus musculus/domesticus
Length: 102  
Fragment?: true
•
•
•
•
•
Protein
A0A0U1RPV4
Organism: Mus musculus/domesticus
Length: 187  
Fragment?: true
•
•
•
•
•
Publication
8717036 | -
First Author: Bhanot P
Year: 1996
Journal: Nature
Title: A new member of the frizzled family from Drosophila functions as a Wingless receptor.
Volume: 382
Issue: 6588
Pages: 225-30
•
•
•
•
•
Publication
9637908 | -
First Author: Xu YK
Year: 1998
Journal: Curr Biol
Title: The Frizzled CRD domain is conserved in diverse proteins including several receptor tyrosine kinases.
Volume: 8
Issue: 12
Pages: R405-6
•
•
•
•
•
Publication
9852758 | -
First Author: Rehn M
Year: 1998
Journal: Trends Biochem Sci
Title: The frizzled motif: in how many different protein families does it occur?
Volume: 23
Issue: 11
Pages: 415-7
•
•
•
•
•
Publication
9637909 | -
First Author: Masiakowski P
Year: 1998
Journal: Curr Biol
Title: The Wnt receptor CRD domain is also found in MuSK and related orphan receptor tyrosine kinases.
Volume: 8
Issue: 12
Pages: R407
•
•
•
•
•
Publication
10082384 | -
First Author: Saldanha J
Year: 1998
Journal: Protein Sci
Title: Identification of a Frizzled-like cysteine rich domain in the extracellular region of developmental receptor tyrosine kinases.
Volume: 7
Issue: 8
Pages: 1632-5
•
•
•
•
•
Publication
10329693 | J:55021
First Author: Yan W
Year: 1999
Journal: J Biol Chem
Title: Corin, a mosaic transmembrane serine protease encoded by a novel cDNA from human heart.
Volume: 274
Issue: 21
Pages: 14926-35
•
•
•
•
•
Publication
9326585 | -
First Author: Lin K
Year: 1997
Journal: Proc Natl Acad Sci U S A
Title: The cysteine-rich frizzled domain of Frzb-1 is required and sufficient for modulation of Wnt signaling.
Volume: 94
Issue: 21
Pages: 11196-200
•
•
•
•
•
Protein
Q3TUV1
Organism: Mus musculus/domesticus
Length: 224  
Fragment?: true
•
•
•
•
•
Protein
A0A172Q396
Organism: Mus musculus/domesticus
Length: 203  
Fragment?: true
•
•
•
•
•
Protein
P39061
Organism: Mus musculus/domesticus
Length: 1774  
Fragment?: false
•
•
•
•
•
Protein
Q61086
Organism: Mus musculus/domesticus
Length: 666  
Fragment?: false
•
•
•
•
•
Protein
Q9JIP6
Organism: Mus musculus/domesticus
Length: 570  
Fragment?: false
•
•
•
•
•
Protein
Q8BKG4
Organism: Mus musculus/domesticus
Length: 582  
Fragment?: false
•
•
•
•
•
Protein
O70421
Organism: Mus musculus/domesticus
Length: 642  
Fragment?: false
•
•
•
•
•
Protein
Q61088
Organism: Mus musculus/domesticus
Length: 537  
Fragment?: false
•
•
•
•
•
Protein
Q9EQD0
Organism: Mus musculus/domesticus
Length: 585  
Fragment?: false
•
•
•
•
•
Protein
Q61089
Organism: Mus musculus/domesticus
Length: 709  
Fragment?: false
•
•
•
•
•
Protein
Q61090
Organism: Mus musculus/domesticus
Length: 572  
Fragment?: false
•
•
•
•
•
Protein
Q61091
Organism: Mus musculus/domesticus
Length: 685  
Fragment?: false
•
•
•
•
•
Protein
Q9R216
Organism: Mus musculus/domesticus
Length: 592  
Fragment?: false
•
•
•
•
•
Protein
Q8R4V4
Organism: Mus musculus/domesticus
Length: 654  
Fragment?: false
•
•
•
•
•
Protein
P56726
Organism: Mus musculus/domesticus
Length: 793  
Fragment?: false
•
•
•
•
•
Protein
Q9Z1N6
Organism: Mus musculus/domesticus
Length: 351  
Fragment?: false
•
•
•
•
•
Protein
P97401
Organism: Mus musculus/domesticus
Length: 323  
Fragment?: false
•
•
•
•
•
Protein
Q8C4U3
Organism: Mus musculus/domesticus
Length: 314  
Fragment?: false
•
•
•
•
•
Protein
Q9WU66
Organism: Mus musculus/domesticus
Length: 314  
Fragment?: false
•
•
•
•
•
Protein
P97299
Organism: Mus musculus/domesticus
Length: 295  
Fragment?: false
•
•
•
•
•
Protein
Q3V1B2
Organism: Mus musculus/domesticus
Length: 537  
Fragment?: false
•
•
•
•
•
Protein
Q4VBD5
Organism: Mus musculus/domesticus
Length: 793  
Fragment?: false
•
•
•
•
•
Protein
Q8CAH7
Organism: Mus musculus/domesticus
Length: 365  
Fragment?: false
•
•
•
•
•
Protein
Q6P551
Organism: Mus musculus/domesticus
Length: 572  
Fragment?: false
•
•
•
•
•
Protein
Q149J3
Organism: Mus musculus/domesticus
Length: 582  
Fragment?: false
•
•
•
•
•
Protein
Q3UUM9
Organism: Mus musculus/domesticus
Length: 295  
Fragment?: false
•
•
•
•
•
Protein
Q3UI35
Organism: Mus musculus/domesticus
Length: 295  
Fragment?: false
•
•
•
•
•
Protein
A0A0R4J001
Organism: Mus musculus/domesticus
Length: 314  
Fragment?: false
•
•
•
•
•
Protein
Q542J1
Organism: Mus musculus/domesticus
Length: 709  
Fragment?: false
•
•
•
•
•
Protein
Q149L3
Organism: Mus musculus/domesticus
Length: 585  
Fragment?: false
•
•
•
•
•
Protein
Q80VD0
Organism: Mus musculus/domesticus
Length: 439  
Fragment?: false
•
•
•
•
•
Protein
Q71S95
Organism: Mus musculus/domesticus
Length: 618  
Fragment?: false
•
•
•
•
•
Protein
E9QPX1
Organism: Mus musculus/domesticus
Length: 1774  
Fragment?: false
•
•
•
•
•
Protein
Q8BKS3
Organism: Mus musculus/domesticus
Length: 537  
Fragment?: false
•
•
•
•
•
Protein
Q3UYZ0
Organism: Mus musculus/domesticus
Length: 357  
Fragment?: true
•
•
•
•
•
Protein
Q810L8
Organism: Mus musculus/domesticus
Length: 750  
Fragment?: true
•
•
•
•
•
Protein
Q8R382
Organism: Mus musculus/domesticus
Length: 709  
Fragment?: false
•
•
•
•
•
Protein
Q8BLL2
Organism: Mus musculus/domesticus
Length: 537  
Fragment?: false
•
•
•
•
•
Protein
A0A2I3BR53
Organism: Mus musculus/domesticus
Length: 80  
Fragment?: false
•
•
•
•
•
Protein
A0A2I3BQF8
Organism: Mus musculus/domesticus
Length: 68  
Fragment?: false
•
•
•
•
•
Protein
Q8K480
Organism: Mus musculus/domesticus
Length: 584  
Fragment?: false
•
•
•
•
•
Protein
Q8K0Q8
Organism: Mus musculus/domesticus
Length: 801  
Fragment?: true
•
•
•
•
•
Protein
Q1XD56
Organism: Mus musculus/domesticus
Length: 464  
Fragment?: false
•
•
•
•
•
Protein
A0A0U1RNR7
Organism: Mus musculus/domesticus
Length: 584  
Fragment?: false
•
•
•
•
•
Protein
Q9Z319
Organism: Mus musculus/domesticus
Length: 1113  
Fragment?: false
•
•
•
•
•
Protein
Q9Z139
Organism: Mus musculus/domesticus
Length: 937  
Fragment?: false
•
•
•
•
•
Protein
Q9Z138
Organism: Mus musculus/domesticus
Length: 944  
Fragment?: false
•
•
•
•
•
Protein
Q61006
Organism: Mus musculus/domesticus
Length: 868  
Fragment?: false
•
•
•
•
•
Protein
Q497X0
Organism: Mus musculus/domesticus
Length: 870  
Fragment?: false
•
•
•
•
•
Protein
Q8C3W2
Organism: Mus musculus/domesticus
Length: 944  
Fragment?: false
•
•
•
•
•
Protein
K3W4P7
Organism: Mus musculus/domesticus
Length: 868  
Fragment?: false
•
•
•
•
•
Protein
J3QPS3
Organism: Mus musculus/domesticus
Length: 878  
Fragment?: false
•
•
•
•
•
Protein
H3BLR7
Organism: Mus musculus/domesticus
Length: 972  
Fragment?: true
•
•
•
•
•
Protein
Q32SD4
Organism: Mus musculus/domesticus
Length: 893  
Fragment?: false
•
•
•
•
•
Protein
F6WVU1
Organism: Mus musculus/domesticus
Length: 870  
Fragment?: false
•
•
•
•
•
Protein
Q8BSP6
Organism: Mus musculus/domesticus
Length: 944  
Fragment?: false
•
•
•
•
•
Protein
Q3TZP9
Organism: Mus musculus/domesticus
Length: 944  
Fragment?: false
•
•
•
•
•
Protein
H3BKS9
Organism: Mus musculus/domesticus
Length: 980  
Fragment?: false
•
•
•
•
•
Protein
E9PUN5
Organism: Mus musculus/domesticus
Length: 932  
Fragment?: false
•
•
•
•
•
Protein
Q32S49
Organism: Mus musculus/domesticus
Length: 860  
Fragment?: false
•
•
•
•
•
Protein
Q32SD3
Organism: Mus musculus/domesticus
Length: 878  
Fragment?: false
•
•
•
•
•
Protein
Q8BNP9
Organism: Mus musculus/domesticus
Length: 937  
Fragment?: false
•
•
•
•
•
Protein
E9PVV8
Organism: Mus musculus/domesticus
Length: 893  
Fragment?: false
•
•
•
•
•
Protein
Q32S50
Organism: Mus musculus/domesticus
Length: 868  
Fragment?: false
•
•
•
•
•
Protein
I7GSQ5
Organism: Mus musculus/domesticus
Length: 860  
Fragment?: false
•
•
•
•
•
Protein
B7ZNH6
Organism: Mus musculus/domesticus
Length: 1000  
Fragment?: false
•
•
•
•
•
Protein
H3BLB2
Organism: Mus musculus/domesticus
Length: 1007  
Fragment?: true
•
•
•
•
•
Publication
11452312 | -
First Author: Dann CE
Year: 2001
Journal: Nature
Title: Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains.
Volume: 412
Issue: 6842
Pages: 86-90
•
•
•
•
•
Publication
- | J:100256
     
First Author: The Gene Expression Nervous System Atlas (GENSAT) Project, The Rockefeller University (New York, NY)
Year: 2005
Journal: Database Download
Title: MGI download of GENSAT transgene data
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom