This entry include Nav1/2/3 from mammals, unc-53 from C. elegans. They contain a calponin homology (CH) domain in the N terminus, several coiled-coil regions, polyproline rich SH3 binding motifs, and an ATPases associated with diverse cellular activities domain (AAA domain) []. They are required for the migration of cells and neuronal processes. Nav2 has been shown to rescue the mechanosensory neuron outgrowth defects of unc-53 mutants []. Unc-53 has been found to bind to ABI-1, a regulator of Arp2/3 mediated actin filament nucleation []. The Drosophila Nav2 homologue Sickie, also included in this family, regulates F-actin-mediated axonal growth [].
