This entry represents a group of vacuolar-sorting proteins, including Bro1 from yeasts, PTPN23/PDCD6IP (or ALIX) from humans and Rim20 from Yarrowia lipolytica. Bro1 is an endosome-associated protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles []. It acts as an adapter that recruits the DOA4 deubiquitinase to the endosomes, leading to deubiquitination of cargo proteins prior to the lumenal sequestration []. PTPN23 has been shown to direct the molecular sorting of several transmembrane receptors, such as epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor (PDGFR) in non-neuronal cells and neurotrophin receptor in neuronal cells []. ALIX, together with syndecan and syntenin, regulates the biogenesis of exosomes [].
