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Search results 201 to 273 out of 273 for Igfbp4

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Type Details Score
Publication
24006456 | J:221550
First Author: Abonnenc M
Year: 2013
Journal: Circ Res
Title: Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c.
Volume: 113
Issue: 10
Pages: 1138-47
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Publication
24154525 | J:205051
First Author: Miller JA
Year: 2013
Journal: Development
Title: Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates.
Volume: 140
Issue: 22
Pages: 4633-44
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Publication
- | J:165964
     
First Author: Mammalian Functional Genomics Centre
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the NorCOMM project by the Mammalian Functional Genomics Centre (Mfgc), University of Manitoba
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Publication
24952961 | J:215487
First Author: Thompson CL
Year: 2014
Journal: Neuron
Title: A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Volume: 83
Issue: 2
Pages: 309-323
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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Publication
- | J:136110
     
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Allele
Pappa<tm1Cac> | MGI:3037868
Name: pregnancy-associated plasma protein A; targeted mutation 1, Cheryl Conover
Allele Type: Targeted
Attribute String: Null/knockout
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Publication
20130263 | J:161983
First Author: Nyegaard M
Year: 2010
Journal: Biol Reprod
Title: Lack of functional pregnancy-associated plasma protein-A (PAPPA) compromises mouse ovarian steroidogenesis and female fertility.
Volume: 82
Issue: 6
Pages: 1129-38
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Publication
31990681 | J:287011
 
First Author: Kashyap S
Year: 2020
Journal: JCI Insight
Title: Metalloproteinase PAPP-A regulation of IGF-1 contributes to polycystic kidney disease pathogenesis.
Volume: 5
Issue: 4
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Publication
27086066 | J:312163
 
First Author: Conover CA
Year: 2016
Journal: Exp Gerontol
Title: Comparative gene expression and phenotype analyses of skeletal muscle from aged wild-type and PAPP-A-deficient mice.
Volume: 80
Pages: 36-42
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Publication
18566100 | J:138275
First Author: Conover CA
Year: 2008
Journal: J Endocrinol
Title: Metabolic consequences of pregnancy-associated plasma protein-A deficiency in mice: exploring possible relationship to the longevity phenotype.
Volume: 198
Issue: 3
Pages: 599-605
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Publication
18086007 | J:150178
First Author: Tanner SJ
Year: 2008
Journal: J Bone Miner Res
Title: Impact of pregnancy-associated plasma protein-a deletion on the adult murine skeleton.
Volume: 23
Issue: 5
Pages: 655-62
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Publication
33239385 | J:299263
 
First Author: Rojas-Rodriguez R
Year: 2020
Journal: Sci Transl Med
Title: PAPPA-mediated adipose tissue remodeling mitigates insulin resistance and protects against gestational diabetes in mice and humans.
Volume: 12
Issue: 571
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Publication
16959843 | J:129567
First Author: Resch ZT
Year: 2006
Journal: Endocrinology
Title: Targeted disruption of the pregnancy-associated plasma protein-A gene is associated with diminished smooth muscle cell response to insulin-like growth factor-I and resistance to neointimal hyperplasia after vascular injury.
Volume: 147
Issue: 12
Pages: 5634-40
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Publication
26297833 | J:228437
 
First Author: Clifton KB
Year: 2015
Journal: Bone
Title: Pregnancy-associated plasma protein-A modulates the anabolic effects of parathyroid hormone in mouse bone.
Volume: 81
Pages: 413-6
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Publication
20351075 | J:236957
First Author: Conover CA
Year: 2010
Journal: J Gerontol A Biol Sci Med Sci
Title: Longevity and age-related pathology of mice deficient in pregnancy-associated plasma protein-A.
Volume: 65
Issue: 6
Pages: 590-9
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Publication
17332520 | J:119790
First Author: Miller BS
Year: 2007
Journal: J Endocrinol
Title: Pregnancy associated plasma protein-A is necessary for expeditious fracture healing in mice.
Volume: 192
Issue: 3
Pages: 505-13
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Publication
24045868 | J:204903
First Author: Conover CA
Year: 2013
Journal: Am J Physiol Endocrinol Metab
Title: Preferential impact of pregnancy-associated plasma protein-A deficiency on visceral fat in mice on high-fat diet.
Volume: 305
Issue: 9
Pages: E1145-53
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Publication
19549878 | J:150820
First Author: Vallejo AN
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Resistance to age-dependent thymic atrophy in long-lived mice that are deficient in pregnancy-associated plasma protein A.
Volume: 106
Issue: 27
Pages: 11252-7
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Allele
Tg(Igfbp4-EGFP)IS47Gsat | MGI:4847156
Name: transgene insertion IS47, GENSAT Project at Rockefeller University
Allele Type: Transgenic
Attribute String: Reporter
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Genotype
Genotype
Symbol: Pappa/Pappa
Background: involves: 129 * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Publication
24691093 | J:328967
First Author: Li W
Year: 2015
Journal: J Gerontol A Biol Sci Med Sci
Title: Elevated ATF4 function in fibroblasts and liver of slow-aging mutant mice.
Volume: 70
Issue: 3
Pages: 263-72
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Publication
16079258 | J:99975
First Author: Bale LK
Year: 2005
Journal: J Endocrinol
Title: Disruption of insulin-like growth factor-II imprinting during embryonic development rescues the dwarf phenotype of mice null for pregnancy-associated plasma protein-A.
Volume: 186
Issue: 2
Pages: 325-31
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Strain
MGI:5003998 | STOCK Tg(Igfbp4-EGFP)IS47Gsat/Mmucd
Attribute String: mutant stock, transgenic
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Publication
17510462 | J:137790
First Author: Harrington SC
Year: 2007
Journal: Circ Res
Title: Genetic deletion of pregnancy-associated plasma protein-A is associated with resistance to atherosclerotic lesion development in apolipoprotein E-deficient mice challenged with a high-fat diet.
Volume: 100
Issue: 12
Pages: 1696-702
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Publication
1375185 | J:1097
First Author: Bajalica S
Year: 1992
Journal: Hum Genet
Title: Localization of the human insulin-like growth-factor-binding protein 4 gene to chromosomal region 17q12-21.1.
Volume: 89
Issue: 2
Pages: 234-6
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Publication
7683522 | J:16364
First Author: Allander SV
Year: 1993
Journal: Growth Regul
Title: Structure and chromosomal localization of human insulin-like growth factor-binding protein genes.
Volume: 3
Issue: 1
Pages: 3-5
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Publication
27618784 | J:238760
First Author: Dominick G
Year: 2017
Journal: Aging Cell
Title: mTOR regulates the expression of DNA damage response enzymes in long-lived Snell dwarf, GHRKO, and PAPPA-KO mice.
Volume: 16
Issue: 1
Pages: 52-60
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Publication
32452758 | J:290555
   
First Author: Pai EL
Year: 2020
Journal: Elife
Title: Maf and Mafb control mouse pallial interneuron fate and maturation through neuropsychiatric disease gene regulation.
Volume: 9
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Publication
21822286 | J:175840
First Author: Korpal M
Year: 2011
Journal: Nat Med
Title: Direct targeting of Sec23a by miR-200s influences cancer cell secretome and promotes metastatic colonization.
Volume: 17
Issue: 9
Pages: 1101-8
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Publication
20197085 | J:164141
First Author: Swindell WR
Year: 2010
Journal: Exp Gerontol
Title: In vivo analysis of gene expression in long-lived mice lacking the pregnancy-associated plasma protein A (PappA) gene.
Volume: 45
Issue: 5
Pages: 366-74
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Protein Domain
IPR022327 | IGFBP-4
Type: Family
Description: Insulin-like growth factors (IGFs)-I and -II are small secreted peptides that stimulate the survival, and promote the proliferation and differentiation, of many cell types []. In biological fluids, these growth factors are usually bound to IGF binding proteins (IGFBPs), which regulate their availability and activity by prolonging their half-life and modulating their receptor interactions. To date, six IGFBP family members have been identified (termed IGFBP1-6) []. They share a conserved gene (intron-exon) organisation and high IGF binding affinity. Structurally, the proteins also share a common domain architecture, possessing a conserved N-terminal IGFBP domain, a highly variable mid-section, and a thyroglobulin type-1 (Tg1) domain in their C-terminal regions. In addition to their role in the regulation of IGF activity, there is evidence for the direct association of IGFBPs with a variety of extracellular and cell surface molecules [, ], with consequent effects upon important biological processes. These include modulation of bone cell proliferation [], and growth arrest of breast and prostate cancer cells [, ]. IGFBP4 is abundant in serum, and is expressed in many different tissues. The protein functions as a cardiogenic growth factor in mice -an effect that is IGF-independent, and mediated by inhibition on the canonical Wnt signalling pathway [].
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Publication
17611229 | J:124114
First Author: Lee J
Year: 2007
Journal: Development
Title: Bi-compartmental communication contributes to the opposite proliferative behavior of Notch1-deficient hair follicle and epidermal keratinocytes.
Volume: 134
Issue: 15
Pages: 2795-806
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Publication
34143773 | J:342570
First Author: Hanson MK
Year: 2021
Journal: PLoS One
Title: Phlpp1 is induced by estrogen in osteoclasts and its loss in Ctsk-expressing cells does not protect against ovariectomy-induced bone loss.
Volume: 16
Issue: 6
Pages: e0251732
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Publication
39349117 | J:355029
 
First Author: Bale LK
Year: 2024
Journal: Exp Neurol
Title: Gene deletion of Pregnancy-associated Plasma Protein-A (PAPP-A) improves pathology and cognition in an Alzheimer's disease mouse model.
Volume: 382
Pages: 114976
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Publication
19007875 | J:146582
First Author: Swindell WR
Year: 2009
Journal: Exp Gerontol
Title: Accelerated failure time models provide a useful statistical framework for aging research.
Volume: 44
Issue: 3
Pages: 190-200
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Protein
H3BJT2
Organism: Mus musculus/domesticus
Length: 122  
Fragment?: true
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Protein
H3BLB7
Organism: Mus musculus/domesticus
Length: 161  
Fragment?: false
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Publication
8874492 | -
First Author: Stewart CE
Year: 1996
Journal: Physiol Rev
Title: Growth, differentiation, and survival: multiple physiological functions for insulin-like growth factors.
Volume: 76
Issue: 4
Pages: 1005-26
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Publication
10605625 | -
First Author: Hwa V
Year: 1999
Journal: Endocr Rev
Title: The insulin-like growth factor-binding protein (IGFBP) superfamily.
Volume: 20
Issue: 6
Pages: 761-87
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Publication
7504671 | -
First Author: Oh Y
Year: 1993
Journal: J Biol Chem
Title: Demonstration of receptors for insulin-like growth factor binding protein-3 on Hs578T human breast cancer cells.
Volume: 268
Issue: 35
Pages: 26045-8
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Publication
7499327 | -
First Author: Andress DL
Year: 1995
Journal: J Biol Chem
Title: Heparin modulates the binding of insulin-like growth factor (IGF) binding protein-5 to a membrane protein in osteoblastic cells.
Volume: 270
Issue: 47
Pages: 28289-96
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Publication
7544787 | -
First Author: Mohan S
Year: 1995
Journal: J Biol Chem
Title: Studies on the mechanisms by which insulin-like growth factor (IGF) binding protein-4 (IGFBP-4) and IGFBP-5 modulate IGF actions in bone cells.
Volume: 270
Issue: 35
Pages: 20424-31
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Publication
9115291 | -
First Author: Rajah R
Year: 1997
Journal: J Biol Chem
Title: Insulin-like growth factor (IGF)-binding protein-3 induces apoptosis and mediates the effects of transforming growth factor-beta1 on programmed cell death through a p53- and IGF-independent mechanism.
Volume: 272
Issue: 18
Pages: 12181-8
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Protein
P47879
Organism: Mus musculus/domesticus
Length: 254  
Fragment?: false
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Protein
Q8BSM9
Organism: Mus musculus/domesticus
Length: 254  
Fragment?: false
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Publication
- | J:100256
     
First Author: The Gene Expression Nervous System Atlas (GENSAT) Project, The Rockefeller University (New York, NY)
Year: 2005
Journal: Database Download
Title: MGI download of GENSAT transgene data
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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