Type |
Details |
Score |
Publication |
First Author: |
Velocigene |
Year: |
2008 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals) |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
International Mouse Strain Resource |
Year: |
2014 |
Journal: |
Database Download |
Title: |
MGI download of germline transmission data for alleles from IMSR strain data |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Wellcome Trust Sanger Institute |
Year: |
2009 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Cyagen Biosciences Inc. |
Year: |
2022 |
|
Title: |
Cyagen Biosciences Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
GOA curators |
Year: |
2016 |
|
Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Magdaleno S |
Year: |
2006 |
Journal: |
PLoS Biol |
Title: |
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. |
Volume: |
4 |
Issue: |
4 |
Pages: |
e86 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2003 |
|
Title: |
MGI Sequence Curation Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Carninci P |
Year: |
2005 |
Journal: |
Science |
Title: |
The transcriptional landscape of the mammalian genome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
1559-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kawai J |
Year: |
2001 |
Journal: |
Nature |
Title: |
Functional annotation of a full-length mouse cDNA collection. |
Volume: |
409 |
Issue: |
6821 |
Pages: |
685-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
Skarnes WC |
Year: |
2011 |
Journal: |
Nature |
Title: |
A conditional knockout resource for the genome-wide study of mouse gene function. |
Volume: |
474 |
Issue: |
7351 |
Pages: |
337-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
|
Title: |
GemPharmatech Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
Year: |
2004 |
Journal: |
Database Release |
Title: |
Mouse T31 Radiation Hybrid Data Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
Allele |
Name: |
pregnancy-associated plasma protein A; targeted mutation 1, Cheryl Conover |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Publication |
First Author: |
Nyegaard M |
Year: |
2010 |
Journal: |
Biol Reprod |
Title: |
Lack of functional pregnancy-associated plasma protein-A (PAPPA) compromises mouse ovarian steroidogenesis and female fertility. |
Volume: |
82 |
Issue: |
6 |
Pages: |
1129-38 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kashyap S |
Year: |
2020 |
Journal: |
JCI Insight |
Title: |
Metalloproteinase PAPP-A regulation of IGF-1 contributes to polycystic kidney disease pathogenesis. |
Volume: |
5 |
Issue: |
4 |
|
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion IS47, GENSAT Project at Rockefeller University |
Allele Type: |
Transgenic |
Attribute String: |
Reporter |
|
•
•
•
•
•
|
Publication |
First Author: |
Resch ZT |
Year: |
2006 |
Journal: |
Endocrinology |
Title: |
Targeted disruption of the pregnancy-associated plasma protein-A gene is associated with diminished smooth muscle cell response to insulin-like growth factor-I and resistance to neointimal hyperplasia after vascular injury. |
Volume: |
147 |
Issue: |
12 |
Pages: |
5634-40 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rojas-Rodriguez R |
Year: |
2020 |
Journal: |
Sci Transl Med |
Title: |
PAPPA-mediated adipose tissue remodeling mitigates insulin resistance and protects against gestational diabetes in mice and humans. |
Volume: |
12 |
Issue: |
571 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Clifton KB |
Year: |
2015 |
Journal: |
Bone |
Title: |
Pregnancy-associated plasma protein-A modulates the anabolic effects of parathyroid hormone in mouse bone. |
Volume: |
81 |
|
Pages: |
413-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Conover CA |
Year: |
2008 |
Journal: |
J Endocrinol |
Title: |
Metabolic consequences of pregnancy-associated plasma protein-A deficiency in mice: exploring possible relationship to the longevity phenotype. |
Volume: |
198 |
Issue: |
3 |
Pages: |
599-605 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vallejo AN |
Year: |
2009 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Resistance to age-dependent thymic atrophy in long-lived mice that are deficient in pregnancy-associated plasma protein A. |
Volume: |
106 |
Issue: |
27 |
Pages: |
11252-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Conover CA |
Year: |
2016 |
Journal: |
Exp Gerontol |
Title: |
Comparative gene expression and phenotype analyses of skeletal muscle from aged wild-type and PAPP-A-deficient mice. |
Volume: |
80 |
|
Pages: |
36-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
Conover CA |
Year: |
2010 |
Journal: |
J Gerontol A Biol Sci Med Sci |
Title: |
Longevity and age-related pathology of mice deficient in pregnancy-associated plasma protein-A. |
Volume: |
65 |
Issue: |
6 |
Pages: |
590-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Miller BS |
Year: |
2007 |
Journal: |
J Endocrinol |
Title: |
Pregnancy associated plasma protein-A is necessary for expeditious fracture healing in mice. |
Volume: |
192 |
Issue: |
3 |
Pages: |
505-13 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tanner SJ |
Year: |
2008 |
Journal: |
J Bone Miner Res |
Title: |
Impact of pregnancy-associated plasma protein-a deletion on the adult murine skeleton. |
Volume: |
23 |
Issue: |
5 |
Pages: |
655-62 |
|
•
•
•
•
•
|
Publication |
First Author: |
Conover CA |
Year: |
2013 |
Journal: |
Am J Physiol Endocrinol Metab |
Title: |
Preferential impact of pregnancy-associated plasma protein-A deficiency on visceral fat in mice on high-fat diet. |
Volume: |
305 |
Issue: |
9 |
Pages: |
E1145-53 |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Pappa/Pappa |
Background: |
involves: 129 * C57BL/6 |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Strain |
Attribute String: |
mutant stock, transgenic |
|
•
•
•
•
•
|
Publication |
First Author: |
Bale LK |
Year: |
2005 |
Journal: |
J Endocrinol |
Title: |
Disruption of insulin-like growth factor-II imprinting during embryonic development rescues the dwarf phenotype of mice null for pregnancy-associated plasma protein-A. |
Volume: |
186 |
Issue: |
2 |
Pages: |
325-31 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li W |
Year: |
2015 |
Journal: |
J Gerontol A Biol Sci Med Sci |
Title: |
Elevated ATF4 function in fibroblasts and liver of slow-aging mutant mice. |
Volume: |
70 |
Issue: |
3 |
Pages: |
263-72 |
|
•
•
•
•
•
|
Publication |
First Author: |
Harrington SC |
Year: |
2007 |
Journal: |
Circ Res |
Title: |
Genetic deletion of pregnancy-associated plasma protein-A is associated with resistance to atherosclerotic lesion development in apolipoprotein E-deficient mice challenged with a high-fat diet. |
Volume: |
100 |
Issue: |
12 |
Pages: |
1696-702 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bajalica S |
Year: |
1992 |
Journal: |
Hum Genet |
Title: |
Localization of the human insulin-like growth-factor-binding protein 4 gene to chromosomal region 17q12-21.1. |
Volume: |
89 |
Issue: |
2 |
Pages: |
234-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Allander SV |
Year: |
1993 |
Journal: |
Growth Regul |
Title: |
Structure and chromosomal localization of human insulin-like growth factor-binding protein genes. |
Volume: |
3 |
Issue: |
1 |
Pages: |
3-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dominick G |
Year: |
2017 |
Journal: |
Aging Cell |
Title: |
mTOR regulates the expression of DNA damage response enzymes in long-lived Snell dwarf, GHRKO, and PAPPA-KO mice. |
Volume: |
16 |
Issue: |
1 |
Pages: |
52-60 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pai EL |
Year: |
2020 |
Journal: |
Elife |
Title: |
Maf and Mafb control mouse pallial interneuron fate and maturation through neuropsychiatric disease gene regulation. |
Volume: |
9 |
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Korpal M |
Year: |
2011 |
Journal: |
Nat Med |
Title: |
Direct targeting of Sec23a by miR-200s influences cancer cell secretome and promotes metastatic colonization. |
Volume: |
17 |
Issue: |
9 |
Pages: |
1101-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Swindell WR |
Year: |
2010 |
Journal: |
Exp Gerontol |
Title: |
In vivo analysis of gene expression in long-lived mice lacking the pregnancy-associated plasma protein A (PappA) gene. |
Volume: |
45 |
Issue: |
5 |
Pages: |
366-74 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Insulin-like growth factors (IGFs)-I and -II are small secreted peptides that stimulate the survival, and promote the proliferation and differentiation, of many cell types []. In biological fluids, these growth factors are usually bound to IGF binding proteins (IGFBPs), which regulate their availability and activity by prolonging their half-life and modulating their receptor interactions. To date, six IGFBP family members have been identified (termed IGFBP1-6) []. They share a conserved gene (intron-exon) organisation and high IGF binding affinity. Structurally, the proteins also share a common domain architecture, possessing a conserved N-terminal IGFBP domain, a highly variable mid-section, and a thyroglobulin type-1 (Tg1) domain in their C-terminal regions. In addition to their role in the regulation of IGF activity, there is evidence for the direct association of IGFBPs with a variety of extracellular and cell surface molecules [, ], with consequent effects upon important biological processes. These include modulation of bone cell proliferation [], and growth arrest of breast and prostate cancer cells [, ]. IGFBP4 is abundant in serum, and is expressed in many different tissues. The protein functions as a cardiogenic growth factor in mice -an effect that is IGF-independent, and mediated by inhibition on the canonical Wnt signalling pathway []. |
|
•
•
•
•
•
|
Publication |
First Author: |
Lee J |
Year: |
2007 |
Journal: |
Development |
Title: |
Bi-compartmental communication contributes to the opposite proliferative behavior of Notch1-deficient hair follicle and epidermal keratinocytes. |
Volume: |
134 |
Issue: |
15 |
Pages: |
2795-806 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hanson MK |
Year: |
2021 |
Journal: |
PLoS One |
Title: |
Phlpp1 is induced by estrogen in osteoclasts and its loss in Ctsk-expressing cells does not protect against ovariectomy-induced bone loss. |
Volume: |
16 |
Issue: |
6 |
Pages: |
e0251732 |
|
•
•
•
•
•
|
Publication |
First Author: |
Swindell WR |
Year: |
2009 |
Journal: |
Exp Gerontol |
Title: |
Accelerated failure time models provide a useful statistical framework for aging research. |
Volume: |
44 |
Issue: |
3 |
Pages: |
190-200 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
122
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
161
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Stewart CE |
Year: |
1996 |
Journal: |
Physiol Rev |
Title: |
Growth, differentiation, and survival: multiple physiological functions for insulin-like growth factors. |
Volume: |
76 |
Issue: |
4 |
Pages: |
1005-26 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hwa V |
Year: |
1999 |
Journal: |
Endocr Rev |
Title: |
The insulin-like growth factor-binding protein (IGFBP) superfamily. |
Volume: |
20 |
Issue: |
6 |
Pages: |
761-87 |
|
•
•
•
•
•
|
Publication |
First Author: |
Oh Y |
Year: |
1993 |
Journal: |
J Biol Chem |
Title: |
Demonstration of receptors for insulin-like growth factor binding protein-3 on Hs578T human breast cancer cells. |
Volume: |
268 |
Issue: |
35 |
Pages: |
26045-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Andress DL |
Year: |
1995 |
Journal: |
J Biol Chem |
Title: |
Heparin modulates the binding of insulin-like growth factor (IGF) binding protein-5 to a membrane protein in osteoblastic cells. |
Volume: |
270 |
Issue: |
47 |
Pages: |
28289-96 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mohan S |
Year: |
1995 |
Journal: |
J Biol Chem |
Title: |
Studies on the mechanisms by which insulin-like growth factor (IGF) binding protein-4 (IGFBP-4) and IGFBP-5 modulate IGF actions in bone cells. |
Volume: |
270 |
Issue: |
35 |
Pages: |
20424-31 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rajah R |
Year: |
1997 |
Journal: |
J Biol Chem |
Title: |
Insulin-like growth factor (IGF)-binding protein-3 induces apoptosis and mediates the effects of transforming growth factor-beta1 on programmed cell death through a p53- and IGF-independent mechanism. |
Volume: |
272 |
Issue: |
18 |
Pages: |
12181-8 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
254
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
254
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Expression Nervous System Atlas (GENSAT) Project, The Rockefeller University (New York, NY) |
Year: |
2005 |
Journal: |
Database Download |
Title: |
MGI download of GENSAT transgene data |
|
|
|
|
•
•
•
•
•
|