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Search results 101 to 193 out of 193 for Grm2

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Type Details Score
Publication
31665922 | J:292850
First Author: Imbriglio T
Year: 2019
Journal: FASEB J
Title: Developmental abnormalities in cortical GABAergic system in mice lacking mGlu3 metabotropic glutamate receptors.
Volume: 33
Issue: 12
Pages: 14204-14220
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Publication
35746896 | J:335422
First Author: Špirková A
Year: 2022
Journal: Biol Reprod
Title: Glutamate can act as a signaling molecule in mouse preimplantation embryos†.
Volume: 107
Issue: 4
Pages: 916-927
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Publication
34170322 | J:308818
 
First Author: Moreau MX
Year: 2021
Journal: Development
Title: Single-cell transcriptomics of the early developing mouse cerebral cortex disentangle the spatial and temporal components of neuronal fate acquisition.
Volume: 148
Issue: 14
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Publication
25979088 | J:242531
First Author: Bedogni F
Year: 2016
Journal: Cereb Cortex
Title: Defects During Mecp2 Null Embryonic Cortex Development Precede the Onset of Overt Neurological Symptoms.
Volume: 26
Issue: 6
Pages: 2517-2529
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Publication
22723691 | J:185665
First Author: Guo Z
Year: 2012
Journal: J Neurosci
Title: Tlx1/3 and Ptf1a control the expression of distinct sets of transmitter and peptide receptor genes in the developing dorsal spinal cord.
Volume: 32
Issue: 25
Pages: 8509-20
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Publication
19554387 | J:156036
First Author: Schilling K
Year: 2009
Journal: Cerebellum
Title: The treasury of the commons: making use of public gene expression resources to better characterize the molecular diversity of inhibitory interneurons in the cerebellar cortex.
Volume: 8
Issue: 4
Pages: 477-89
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Publication
- | J:346132
       
First Author: The Gene Ontology Consortium
Year: 2016
Title: Automatic assignment of GO terms using logical inference, based on on inter-ontology links
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Publication
24952961 | J:215487
First Author: Thompson CL
Year: 2014
Journal: Neuron
Title: A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Volume: 83
Issue: 2
Pages: 309-323
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Allele
Grm2<em1Geh> | MGI:7530802
Name: glutamate receptor, metabotropic 2; endonuclease-mediated mutation 1, Gregg Homanics
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready
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Allele
Tg(Grm2-IL2RA/EGFP)1Nak | MGI:6116470
Name: transgene insertion 1, Shigetada Nakanishi
Allele Type: Transgenic
Attribute String: Inserted expressed sequence, Reporter
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Allele
Tg(Grm2-IL2RA)2Nak | MGI:7495750
Name: transgene insertion 2, Shigetada Nakanishi
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(Grm2-IL2RA/EGFP)16Nak | MGI:7495761
Name: transgene insertion 16, Shigetada Nakanishi
Allele Type: Transgenic
Attribute String: Inserted expressed sequence, Reporter
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Allele
Tg(Grm2-IL2RA)1Nak | MGI:6116469
Name: transgene insertion 1, Shigetada Nakanishi
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Strain
MGI:6144591 | B6;D2-Tg(Grm2-IL2RA/GFP)1Nak/NakRbrc
Attribute String: transgenic, mutant stock
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Strain
MGI:6144622 | B6;D2-Tg(Grm2-IL2RA/EGFP)2Nak/NakRbrc
Attribute String: transgenic, mutant stock
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Publication
15452350 | J:256661
First Author: Yamazaki H
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: Distinct ontogenic and regional expressions of newly identified Cajal-Retzius cell-specific genes during neocorticogenesis.
Volume: 101
Issue: 40
Pages: 14509-14
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Publication
12802017 | J:256660
First Author: Kitabatake Y
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Impairment of reward-related learning by cholinergic cell ablation in the striatum.
Volume: 100
Issue: 13
Pages: 7965-70
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Publication
11606786 | J:72575
First Author: Hikida T
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: Increased sensitivity to cocaine by cholinergic cell ablation in nucleus accumbens.
Volume: 98
Issue: 23
Pages: 13351-4
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Publication
33616036 | J:314490
   
First Author: Balmer TS
Year: 2021
Journal: Elife
Title: Incomplete removal of extracellular glutamate controls synaptic transmission and integration at a cerebellar synapse.
Volume: 10
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Publication
12721372 | J:256659
First Author: Hikida T
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Acetylcholine enhancement in the nucleus accumbens prevents addictive behaviors of cocaine and morphine.
Volume: 100
Issue: 10
Pages: 6169-73
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Strain
MGI:6144627 | B6;D2-Tg(Grm2-IL2RA)2Nak/NakRbrc
Attribute String: transgenic, mutant stock
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Strain
MGI:6144628 | B6;D2-Tg(Grm2-IL2RA/EGFP)16Nak/NakRbrc
Attribute String: transgenic, mutant stock
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Allele
Tg(Grm2-cre)MR90Gsat | MGI:4940613
Name: transgene insertion MR90, GENSAT Project at Rockefeller University
Allele Type: Transgenic
Attribute String: Recombinase
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Allele
Tg(Grm2-cre)MR89Gsat | MGI:5311758
Name: transgene insertion MR89, GENSAT Project at Rockefeller University
Allele Type: Transgenic
Attribute String: Recombinase
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Strain
MGI:6144626 | B6;D2-Tg(Grm2-IL2RA)1Nak/NakRbrc
Attribute String: transgenic, mutant stock
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Strain
MGI:7530803 | C57BL/6J-Grm2<em1Geh>/J
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Strain
MGI:5004361 | STOCK Tg(Grm2-cre)MR90Gsat/Mmucd
Attribute String: mutant stock, transgenic
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Publication
23223300 | J:253602
First Author: Cruikshank SJ
Year: 2012
Journal: J Neurosci
Title: Thalamic control of layer 1 circuits in prefrontal cortex.
Volume: 32
Issue: 49
Pages: 17813-23
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Publication
29398217 | J:263275
First Author: Gelegen C
Year: 2018
Journal: Curr Biol
Title: Excitatory Pathways from the Lateral Habenula Enable Propofol-Induced Sedation.
Volume: 28
Issue: 4
Pages: 580-587.e5
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Strain
MGI:5313027 | STOCK Tg(Grm2-cre)MR89Gsat/Mmucd
Attribute String: transgenic, mutant stock
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Publication
34079054 | J:314356
First Author: van der Veen B
Year: 2021
Journal: Commun Biol
Title: Control of impulsivity by Gi-protein signalling in layer-5 pyramidal neurons of the anterior cingulate cortex.
Volume: 4
Issue: 1
Pages: 662
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Publication
21131947 | J:264966
First Author: Wei W
Year: 2011
Journal: Nature
Title: Development of asymmetric inhibition underlying direction selectivity in the retina.
Volume: 469
Issue: 7330
Pages: 402-6
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Publication
28919175 | J:256112
First Author: Lu HW
Year: 2017
Journal: Neuron
Title: Slow AMPAR Synaptic Transmission Is Determined by Stargazin and Glutamate Transporters.
Volume: 96
Issue: 1
Pages: 73-80.e4
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Grm2-cre)MR90Gsat/?
Background: involves: 129S4/SvJaeSor * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Publication
9778244 | J:131116
First Author: Watanabe D
Year: 1998
Journal: Cell
Title: Ablation of cerebellar Golgi cells disrupts synaptic integration involving GABA inhibition and NMDA receptor activation in motor coordination.
Volume: 95
Issue: 1
Pages: 17-27
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Publication
31784287 | J:330682
First Author: Acosta-Ruiz A
Year: 2020
Journal: Neuron
Title: Branched Photoswitchable Tethered Ligands Enable Ultra-efficient Optical Control and Detection of G Protein-Coupled Receptors In Vivo.
Volume: 105
Issue: 3
Pages: 446-463.e13
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Publication
25099741 | J:244074
First Author: Quina LA
Year: 2015
Journal: J Comp Neurol
Title: Efferent pathways of the mouse lateral habenula.
Volume: 523
Issue: 1
Pages: 32-60
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Publication
9330603 | J:43038
First Author: Fukuda S
Year: 1997
Journal: Jpn J Cancer Res
Title: Isolation of a novel gene showing reduced expression in metastatic colorectal carcinoma cell lines and carcinomas.
Volume: 88
Issue: 8
Pages: 725-31
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Publication
22300836 | -
First Author: Delille HK
Year: 2012
Journal: Neuropharmacology
Title: Heterocomplex formation of 5-HT2A-mGlu2 and its relevance for cellular signaling cascades.
Volume: 62
Issue: 7
Pages: 2184-91
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Protein Domain
IPR001458 | GPCR_3_mGluR2
Type: Family
Description: G protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions, including various autocrine, paracrine and endocrine processes. They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups []. The term clan can be used to describe the GPCRs, as they embrace a group of families for which there are indications of evolutionary relationship, but between which there is no statistically significant similarity in sequence []. The currently known clan members include rhodopsin-like GPCRs (Class A, GPCRA), secretin-like GPCRs (Class B, GPCRB), metabotropic glutamate receptor family (Class C, GPCRC), fungal mating pheromone receptors (Class D, GPCRD), cAMP receptors (Class E, GPCRE) and frizzled/smoothened (Class F, GPCRF) [, , , , ]. GPCRs are major drug targets, and are consequently the subject of considerable research interest. It has been reported that the repertoire of GPCRs for endogenous ligands consists of approximately 400 receptors in humans and mice []. Most GPCRs are identified on the basis of their DNA sequences, rather than the ligand they bind, those that are unmatched to known natural ligands are designated by as orphan GPCRs, or unclassified GPCRs [].GPCR family 3 receptors (also known as family C) are structurally similar to other GPCRs, but do not show any significant sequence similarity and thus represent a distinct group. Structurally they are composed of four elements; an N-terminal signal sequence; a large hydrophilic extracellular agonist-binding region containing several conserved cysteine residues which could be involved in disulphide bonds; a shorter region containing seven transmembrane domains; and a C-terminal cytoplasmic domain of variable length []. Family 3 members include the metabotropic glutamate receptors, the extracellular calcium-sensing receptors, the gamma-amino-butyric acid (GABA) type B receptors, and the vomeronasal type-2 receptors [, , , ]. As these receptors regulate many important physiological processes they are potentially promising targets for drug development.The metabotropic glutamate receptors are functionally and pharmacologically distinct from the ionotropic glutamate receptors. They are coupled to G-proteins and stimulate the inositol phosphate/Ca2+intracellular signalling pathway [, , , ]. At least eight sub-types of metabotropic receptor (GRM1-8) have been identified in cloning studies. The sub-types differ in their agonist pharmacology and signal transduction pathways.mRNA for GRM2 is widespread in the brain, with a unique distribution; it is found in highlevels in neurons in olfactory bulb, cerebral cortex, cerebellum Golgicells, and dendate gyrus granule cells. GRM2 inhibits adenylyl cyclasethrough a pertussis-toxin-sensitive G-protein, probably of the Gi/Go class;the receptor has also been reported to cause a weak stimulation ofphosphoinositide metabolism. It may mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization [, , ].
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Publication
23390312 | J:223205
First Author: Ford KJ
Year: 2013
Journal: J Neurophysiol
Title: A role for TREK1 in generating the slow afterhyperpolarization in developing starburst amacrine cells.
Volume: 109
Issue: 9
Pages: 2250-9
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Publication
30994458 | J:275845
   
First Author: Balmer TS
Year: 2019
Journal: Elife
Title: Selective targeting of unipolar brush cell subtypes by cerebellar mossy fibers.
Volume: 8
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Protein
A0A0J9YVF0
Organism: Mus musculus/domesticus
Length: 594  
Fragment?: false
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Protein
A0A0J9YU95
Organism: Mus musculus/domesticus
Length: 381  
Fragment?: true
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Protein
Q14BI2
Organism: Mus musculus/domesticus
Length: 872  
Fragment?: false
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Publication
1320017 | -
First Author: Abe T
Year: 1992
Journal: J Biol Chem
Title: Molecular characterization of a novel metabotropic glutamate receptor mGluR5 coupled to inositol phosphate/Ca2+ signal transduction.
Volume: 267
Issue: 19
Pages: 13361-8
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Publication
1847995 | -
First Author: Masu M
Year: 1991
Journal: Nature
Title: Sequence and expression of a metabotropic glutamate receptor.
Volume: 349
Issue: 6312
Pages: 760-5
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Publication
1656524 | -
First Author: Houamed KM
Year: 1991
Journal: Science
Title: Cloning, expression, and gene structure of a G protein-coupled glutamate receptor from rat brain.
Volume: 252
Issue: 5010
Pages: 1318-21
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Publication
32433957 | J:314719
First Author: Ding SL
Year: 2020
Journal: Cell Rep
Title: Distinct Transcriptomic Cell Types and Neural Circuits of the Subiculum and Prosubiculum along the Dorsal-Ventral Axis.
Volume: 31
Issue: 7
Pages: 107648
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Publication
10773016 | -
First Author: Sullivan R
Year: 2000
Journal: J Pharmacol Exp Ther
Title: Coexpression of full-length gamma-aminobutyric acid(B) (GABA(B)) receptors with truncated receptors and metabotropic glutamate receptor 4 supports the GABA(B) heterodimer as the functional receptor.
Volume: 293
Issue: 2
Pages: 460-7
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Publication
9292726 | J:42626
First Author: Ryba NJ
Year: 1997
Journal: Neuron
Title: A new multigene family of putative pheromone receptors.
Volume: 19
Issue: 2
Pages: 371-9
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Publication
17266540 | -
First Author: Bräuner-Osborne H
Year: 2007
Journal: Curr Drug Targets
Title: Structure, pharmacology and therapeutic prospects of family C G-protein coupled receptors.
Volume: 8
Issue: 1
Pages: 169-84
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Publication
8255296 | -
First Author: Brown EM
Year: 1993
Journal: Nature
Title: Cloning and characterization of an extracellular Ca(2+)-sensing receptor from bovine parathyroid.
Volume: 366
Issue: 6455
Pages: 575-80
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Publication
1309649 | -
First Author: Tanabe Y
Year: 1992
Journal: Neuron
Title: A family of metabotropic glutamate receptors.
Volume: 8
Issue: 1
Pages: 169-79
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Publication
31666704 | J:287379
First Author: Harris JA
Year: 2019
Journal: Nature
Title: Hierarchical organization of cortical and thalamic connectivity.
Volume: 575
Issue: 7781
Pages: 195-202
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Publication
24360541 | J:203555
First Author: Gerfen CR
Year: 2013
Journal: Neuron
Title: GENSAT BAC cre-recombinase driver lines to study the functional organization of cerebral cortical and basal ganglia circuits.
Volume: 80
Issue: 6
Pages: 1368-83
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Publication
28228269 | J:247473
First Author: Martersteck EM
Year: 2017
Journal: Cell Rep
Title: Diverse Central Projection Patterns of Retinal Ganglion Cells.
Volume: 18
Issue: 8
Pages: 2058-2072
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Publication
36774552 | J:337820
First Author: Wang Q
Year: 2023
Journal: Cell Rep
Title: Regional and cell-type-specific afferent and efferent projections of the mouse claustrum.
Volume: 42
Issue: 2
Pages: 112118
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Publication
29043563 | J:284637
First Author: Cuoco JA
Year: 2018
Journal: Cerebellum
Title: Malformation of the Posterior Cerebellar Vermis Is a Common Neuroanatomical Phenotype of Genetically Engineered Mice on the C57BL/6 Background.
Volume: 17
Issue: 2
Pages: 173-190
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Publication
25071457 | J:220523
 
First Author: Harris JA
Year: 2014
Journal: Front Neural Circuits
Title: Anatomical characterization of Cre driver mice for neural circuit mapping and manipulation.
Volume: 8
Pages: 76
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Publication
12679517 | J:83410
First Author: Vassilatis DK
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: The G protein-coupled receptor repertoires of human and mouse.
Volume: 100
Issue: 8
Pages: 4903-8
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Publication
8170923 | -
First Author: Attwood TK
Year: 1994
Journal: Protein Eng
Title: Fingerprinting G-protein-coupled receptors.
Volume: 7
Issue: 2
Pages: 195-203
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Publication
8081729 | -
First Author: Kolakowski LF Jr
Year: 1994
Journal: Receptors Channels
Title: GCRDb: a G-protein-coupled receptor database.
Volume: 2
Issue: 1
Pages: 1-7
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Publication
15914470 | -
First Author: Foord SM
Year: 2005
Journal: Pharmacol Rev
Title: International Union of Pharmacology. XLVI. G protein-coupled receptor list.
Volume: 57
Issue: 2
Pages: 279-88
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Publication
18948278 | -
First Author: Harmar AJ
Year: 2009
Journal: Nucleic Acids Res
Title: IUPHAR-DB: the IUPHAR database of G protein-coupled receptors and ion channels.
Volume: 37
Issue: Database issue
Pages: D680-5
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Publication
16753280 | J:115055
First Author: Bjarnadóttir TK
Year: 2006
Journal: Genomics
Title: Comprehensive repertoire and phylogenetic analysis of the G protein-coupled receptors in human and mouse.
Volume: 88
Issue: 3
Pages: 263-73
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Publication
23020293 | -
 
First Author: Civelli O
Year: 2013
Journal: Annu Rev Pharmacol Toxicol
Title: G protein-coupled receptor deorphanizations.
Volume: 53
Pages: 127-46
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Publication
- | J:100256
     
First Author: The Gene Expression Nervous System Atlas (GENSAT) Project, The Rockefeller University (New York, NY)
Year: 2005
Journal: Database Download
Title: MGI download of GENSAT transgene data
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