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Search results 701 to 753 out of 753 for Itgb2

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Type Details Score
Genotype
Genotype
Symbol: Itgb2/? Psrs4/Psrs4 Psrs6/Psrs6
Background: involves: C57BL/6J * PL/J
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Itgb2/? Psrs7/?
Background: involves: 129S7/SvEvBrd * C57BL/6J * PL/J
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Itgb2/Itgb2 Psrs1/Psrs1
Background: B6.Cg-(D10Mit126-D10Mit38) Itgb2
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Itgb2/Itgb2 Psrs1/Psrs1
Background: B6.Cg-(D10Mit75-D10Mit271) Itgb2
Zygosity: cx
Has Mutant Allele: true
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Publication
29891680 | J:263963
First Author: Wu J
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Critical role of integrin CD11c in splenic dendritic cell capture of missing-self CD47 cells to induce adaptive immunity.
Volume: 115
Issue: 26
Pages: 6786-6791
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Publication
29084770 | J:255694
First Author: Xu Q
Year: 2017
Journal: Dis Model Mech
Title: Renal carcinoma/kidney progenitor cell chimera organoid as a novel tumorigenesis gene discovery model.
Volume: 10
Issue: 12
Pages: 1503-1515
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Publication
10766246 | -
First Author: Bianchi E
Year: 2000
Journal: Nature
Title: Integrin LFA-1 interacts with the transcriptional co-activator JAB1 to modulate AP-1 activity.
Volume: 404
Issue: 6778
Pages: 617-21
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Publication
11812992 | -
First Author: Ostermann G
Year: 2002
Journal: Nat Immunol
Title: JAM-1 is a ligand of the beta(2) integrin LFA-1 involved in transendothelial migration of leukocytes.
Volume: 3
Issue: 2
Pages: 151-8
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Publication
12130787 | -
First Author: Lu TT
Year: 2002
Journal: Science
Title: Integrin-mediated long-term B cell retention in the splenic marginal zone.
Volume: 297
Issue: 5580
Pages: 409-12
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Protein Domain
IPR015439 | Integrin_bsu-2
Type: Family
Description: Integrins are the major metazoan receptors for cell adhesion to extracellular matrix proteins and, in vertebrates, also play important roles in certain cell-cell adhesions, make transmembrane connections to the cytoskeleton and activate many intracellular signalling pathways [, ]. An integrin receptor is a heterodimer composed of alpha and beta subunits. Each subunit crosses the membrane once, with most of the polypeptide residing in the extracellular space, and has two short cytoplasmic domains. Some members of this family have EGF repeats at the C terminus and also have a vWA domain inserted within the integrin domain at the N terminus.Most integrins recognise relatively short peptide motifs, and in general require an acidic amino acid to be present. Ligand specificity depends upon both the alpha and beta subunits []. There are at least 18 types of alpha and 8 types of beta subunits recognised in humans []. Each alpha subunit tends to associate only with one type of beta subunit, but there are exceptions to this rule []. Each association of alpha and beta subunits has its own binding specificity and signalling properties. Many integrins require activation on the cell surface before they can bind ligands. Integrins frequently intercommunicate, and binding at one integrin receptor activate or inhibit another.Integrin Beta-2 is also referred to as ITGB2 and is known to interact with three different alpha integrin chains: ITGAL, ITGAM and ITGAX. These three integrin heterodimers are associated with leukocyte adhesion deficiency (LAD), which is characterised by recurrent bacterial infections. LFA-1 (ITGB2/ITGAL) is one of the most well studied of these integrins. Engagement of LFA-1 results in increased AP-1 dependent gene expression, which is mediated by the nuclear translocation of JAB1 []. The ligand for LFA-1 is JAM-1, a member of the endothelial immunoglobulin superfamily. JAM-1 contributes to LFA-1 dependent transendothelial migration of leukocytes and LFA-1 mediated arrest of T cells []. Studies of marginal zone (MZ) B cells also showed that LFA-1, together with alpha4beta1, is required for localisation of those cells in the splenic MZ and that these integrins are necessary for lymphoid tissue compartmentalization [].
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Protein Coding Gene
MGI:1277979 | Itgb2l
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CAROLIEiJ_G0021005 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0023086 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0023054 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0023024 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0023056 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0022817 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1277979 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0023503 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0022337 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0022786 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0022920 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0022894 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0022990 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0022915 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0023521 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0022081 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0022387 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0016710 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0021911 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
9535848 | J:46963
First Author: Chen Y
Year: 1998
Journal: J Biol Chem
Title: Identification of pactolus, an integrin beta subunit-like cell-surface protein preferentially expressed by cells of the bone marrow.
Volume: 273
Issue: 15
Pages: 8711-8
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Publication
10556426 | J:58217
First Author: Margraf RL
Year: 1999
Journal: Mamm Genome
Title: Genomic organization, chromosomal localization, and transcriptional variants of the murine Pactolus gene.
Volume: 10
Issue: 11
Pages: 1075-81
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Publication
11461913 | J:71665
First Author: Garrison S
Year: 2001
Journal: J Biol Chem
Title: Functional characterization of Pactolus, a beta-integrin-like protein preferentially expressed by neutrophils.
Volume: 276
Issue: 38
Pages: 35500-11
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Publication
14662885 | J:118477
First Author: Garrison S
Year: 2003
Journal: J Immunol
Title: Surface translocation of pactolus is induced by cell activation and death, but is not required for neutrophil migration and function.
Volume: 171
Issue: 12
Pages: 6795-806
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Publication
16836649 | J:118539
First Author: Hojgaard A
Year: 2006
Journal: Immunology
Title: Altered localization of CXCL13 expressing cells in mice deficient in Pactolus following an inflammatory stimulus.
Volume: 119
Issue: 2
Pages: 212-23
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Protein
D3Z1S4
Organism: Mus musculus/domesticus
Length: 54  
Fragment?: true
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Protein
M0QWJ6
Organism: Mus musculus/domesticus
Length: 56  
Fragment?: false
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Protein
M0QWA7
Organism: Mus musculus/domesticus
Length: 480  
Fragment?: false
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Protein
D3YYP8
Organism: Mus musculus/domesticus
Length: 130  
Fragment?: true
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Publication
16735694 | J:111308
First Author: Hale JS
Year: 2006
Journal: J Leukoc Biol
Title: Transcriptional control of Pactolus: evidence of a negative control region and comparison with its evolutionary paralogue, CD18 (beta2 integrin).
Volume: 80
Issue: 2
Pages: 383-98
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Protein
P11835
Organism: Mus musculus/domesticus
Length: 771  
Fragment?: false
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Protein
Q3UV74
Organism: Mus musculus/domesticus
Length: 738  
Fragment?: false
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Protein
D3YXH8
Organism: Mus musculus/domesticus
Length: 795  
Fragment?: false
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Protein
Q542I8
Organism: Mus musculus/domesticus
Length: 770  
Fragment?: false
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Publication
14689578 | -
First Author: Demetriou MC
Year: 2004
Journal: J Cell Biochem
Title: Integrin clipping: a novel adhesion switch?
Volume: 91
Issue: 1
Pages: 26-35
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Publication
2467745 | -
First Author: Cheresh DA
Year: 1989
Journal: Cell
Title: A novel vitronectin receptor integrin (alpha v beta x) is responsible for distinct adhesive properties of carcinoma cells.
Volume: 57
Issue: 1
Pages: 59-69
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Publication
12234368 | -
 
First Author: Arnaout MA
Year: 2002
Journal: Immunol Rev
Title: Integrin structure: new twists and turns in dynamic cell adhesion.
Volume: 186
Pages: 125-40
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Publication
12297042 | -
First Author: Hynes RO
Year: 2002
Journal: Cell
Title: Integrins: bidirectional, allosteric signaling machines.
Volume: 110
Issue: 6
Pages: 673-87
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Publication
12361595 | -
First Author: Bökel C
Year: 2002
Journal: Dev Cell
Title: Integrins in development: moving on, responding to, and sticking to the extracellular matrix.
Volume: 3
Issue: 3
Pages: 311-21
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Publication
11374901 | J:69920
First Author: Pletcher MT
Year: 2001
Journal: Genomics
Title: Use of comparative physical and sequence mapping to annotate mouse chromosome 16 and human chromosome 21.
Volume: 74
Issue: 1
Pages: 45-54
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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