Ribosome-binding protein 1 (RRBP1), also called ES/130 or p180, is an endoplasmic reticulum membrane protein that is critical for ribosome binding and for the the transportation and secretion of nascent proteins []. RRBP1 plays a critical role in terminal differentiation of secretory cells and tissues []. RRBP1 is highly expressed in several cancers [, , ].