Glutamate delta-1 (GluD1) and delta-2 (GluD2) constitute the delta subfamily of ionotropic glutamate receptors. They have a crucial role in synapse formation by interacting with presynaptic proteins such as Neurexin-1. GluD1 is expressed diffusively throughout the forebrain and cerebellum during early development and adulthood, with high levels in the hippocampus [, ], whereas GluD2 is predominantly expressed in the Purkinje cells of the cerebellum [].It has been shown that delta receptors (GluD1, GluD2) might play a role in the underlying pathophysiology of autism and schizophrenia [].This entry represents the ionotropic glutamate receptors delta 1 and delta 2.
