Rab-like protein 6 (RABL6 or RBEL1) is one of several proteins identified as binding partners of the ARF tumour suppressor, which protects against cancer through protein-protein interactions, interacting with CDKN2A []. RABL6 binds GTP and is found either in the cytoplasm or the nucleus depending in the isoform; isoform 1 is O-glycosylated and cytoplasmic [].
This entry represents to the second PHD finger found in MTF2.MTF2 (also known as PCL2), complexes with the polycomb repressive complex-2 (PRC2) in embryonic stem cells and regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation []. It recruits the PRC2 complex to the inactive X chromosome and target loci in embryonic stem cells []. Moreover, MTF2 is required for PRC2-mediated Hox cluster repression []. It activates the Cdkn2a gene and promotes cellular senescence, thus suppressing the catalytic activity of PRC2 locally. MTF2 consists of an N-terminal Tudor domain followed by two PHD fingers, and a C-terminal MTF2 domain.
This entry represents the first PHD finger found in MTF2.MTF2 (also known as PCL2), complexes with the polycomb repressive complex-2 (PRC2) in embryonic stem cells and regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation []. It recruits the PRC2 complex to the inactive X chromosome and target loci in embryonic stem cells []. Moreover, MTF2 is required for PRC2-mediated Hox cluster repression []. It activates the Cdkn2a gene and promotes cellular senescence, thus suppressing the catalytic activity of PRC2 locally. MTF2 consists of an N-terminal Tudor domain followed by two PHD fingers, and a C-terminal MTF2 domain.
