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Search results 101 to 190 out of 190 for Rrm2b

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Type Details Score
GXD Expression
GXD Expression
 
Probe: MGI:5309929
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1750322
Pattern: Ubiquitous
Stage: TS22
Assay Id: MGI:5423255
Age: embryonic day 14.5
Image: EH4252; Specimen C3717
Specimen Label: EH4252; Specimen C3717
Detected: true
Specimen Num: 1
•
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•
•
GXD Expression
GXD Expression
 
Probe: MGI:5309929
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1775122
Pattern: Ubiquitous
Stage: TS22
Assay Id: MGI:5423255
Age: embryonic day 14.5
Image: EH4252; Specimen C3717
Specimen Label: EH4252; Specimen C3717
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:5309929
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3274122
Stage: TS22
Assay Id: MGI:5423255
Age: embryonic day 14.5
Specimen Label: EH4252; Specimen C3717
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5309929
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3287422
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5423255
Age: embryonic day 14.5
Image: EH4252; Specimen C3717
Specimen Label: EH4252; Specimen C3717
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:5309929
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3266022
Stage: TS22
Assay Id: MGI:5423255
Age: embryonic day 14.5
Specimen Label: EH4252; Specimen C3717
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:5309929
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1624622
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5423255
Age: embryonic day 14.5
Image: EH4252; Specimen C3717
Note: Expression was detected in the digestive system.
Specimen Label: EH4252; Specimen C3717
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:5309929
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1721422
Stage: TS22
Assay Id: MGI:5423255
Age: embryonic day 14.5
Specimen Label: EH4252; Specimen C3717
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5309929
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1646922
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5423255
Age: embryonic day 14.5
Image: EH4252; Specimen C3717
Specimen Label: EH4252; Specimen C3717
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:5309929
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1736222
Stage: TS22
Assay Id: MGI:5423255
Age: embryonic day 14.5
Specimen Label: EH4252; Specimen C3717
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5309929
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1683322
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5423255
Age: embryonic day 14.5
Image: EH4252; Specimen C3717
Specimen Label: EH4252; Specimen C3717
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5309929
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1700022
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5423255
Age: embryonic day 14.5
Image: EH4252; Specimen C3717
Specimen Label: EH4252; Specimen C3717
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:5309929
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1832122
Stage: TS22
Assay Id: MGI:5423255
Age: embryonic day 14.5
Specimen Label: EH4252; Specimen C3717
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:5309929
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1876522
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5423255
Age: embryonic day 14.5
Image: EH4252; Specimen C3717
Note: Expression was detected in the immune system.
Specimen Label: EH4252; Specimen C3717
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:5309929
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1741222
Stage: TS22
Assay Id: MGI:5423255
Age: embryonic day 14.5
Specimen Label: EH4252; Specimen C3717
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:5309929
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1754022
Stage: TS22
Assay Id: MGI:5423255
Age: embryonic day 14.5
Specimen Label: EH4252; Specimen C3717
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5309929
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3599822
Pattern: Ubiquitous
Stage: TS22
Assay Id: MGI:5423255
Age: embryonic day 14.5
Image: EH4252; Specimen C3717
Specimen Label: EH4252; Specimen C3717
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5309929
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:3280922
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5423255
Age: embryonic day 14.5
Image: EH4252; Specimen C3717
Specimen Label: EH4252; Specimen C3717
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5309929
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1833322
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5423255
Age: embryonic day 14.5
Image: EH4252; Specimen C3717
Specimen Label: EH4252; Specimen C3717
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5309929
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3287022
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5423255
Age: embryonic day 14.5
Image: EH4252; Specimen C3717
Specimen Label: EH4252; Specimen C3717
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:5309929
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1752522
Stage: TS22
Assay Id: MGI:5423255
Age: embryonic day 14.5
Specimen Label: EH4252; Specimen C3717
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5309929
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1821522
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5423255
Age: embryonic day 14.5
Image: EH4252; Specimen C3717
Specimen Label: EH4252; Specimen C3717
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:5309929
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3557722
Stage: TS22
Assay Id: MGI:5423255
Age: embryonic day 14.5
Specimen Label: EH4252; Specimen C3717
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5309929
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1702122
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5423255
Age: embryonic day 14.5
Image: EH4252; Specimen C3717
Specimen Label: EH4252; Specimen C3717
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5309929
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1756322
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5423255
Age: embryonic day 14.5
Image: EH4252; Specimen C3717
Specimen Label: EH4252; Specimen C3717
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:5309929
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1668822
Stage: TS22
Assay Id: MGI:5423255
Age: embryonic day 14.5
Specimen Label: EH4252; Specimen C3717
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5309929
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1757722
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5423255
Age: embryonic day 14.5
Image: EH4252; Specimen C3717
Specimen Label: EH4252; Specimen C3717
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:5309929
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1757522
Stage: TS22
Assay Id: MGI:5423255
Age: embryonic day 14.5
Specimen Label: EH4252; Specimen C3717
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5309929
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1738322
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5423255
Age: embryonic day 14.5
Image: EH4252; Specimen C3717
Specimen Label: EH4252; Specimen C3717
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:5309929
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1802422
Stage: TS22
Assay Id: MGI:5423255
Age: embryonic day 14.5
Specimen Label: EH4252; Specimen C3717
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5309929
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1768022
Stage: TS22
Assay Id: MGI:5423255
Age: embryonic day 14.5
Note: Expression was not detected in the skull (base and vault).
Specimen Label: EH4252; Specimen C3717
Detected: false
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:5309929
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:2672022
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5423255
Age: embryonic day 14.5
Image: EH4252; Specimen C3717
Note: Expression was strong in whisker follicle.
Specimen Label: EH4252; Specimen C3717
Detected: true
Specimen Num: 1
•
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•
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Publication
32750454 | J:302684
First Author: Molina-Jijon E
Year: 2020
Journal: Kidney Int
Title: Secretion of the epithelial sodium channel chaperone PCSK9 from the cortical collecting duct links sodium retention with hypercholesterolemia in nephrotic syndrome.
Volume: 98
Issue: 6
Pages: 1449-1460
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•
•
Publication
10716435 | J:320121
First Author: Tanaka H
Year: 2000
Journal: Nature
Title: A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage.
Volume: 404
Issue: 6773
Pages: 42-9
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Publication
15322079 | J:94486
First Author: Strand KR
Year: 2004
Journal: J Biol Chem
Title: Crystal structural studies of changes in the native dinuclear iron center of ribonucleotide reductase protein R2 from mouse.
Volume: 279
Issue: 45
Pages: 46794-801
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Publication
11517226 | J:72397
First Author: Guittet O
Year: 2001
Journal: J Biol Chem
Title: Mammalian p53R2 protein forms an active ribonucleotide reductase in vitro with the R1 protein, which is expressed both in resting cells in response to DNA damage and in proliferating cells.
Volume: 276
Issue: 44
Pages: 40647-51
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Publication
21146511 | J:278909
First Author: Weng SY
Year: 2011
Journal: J Hepatol
Title: Synergism between p53 and Mcl-1 in protecting from hepatic injury, fibrosis and cancer.
Volume: 54
Issue: 4
Pages: 685-94
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:82809
     
First Author: European Mouse Mutant Archive
Year: 2003
Journal: Unpublished
Title: Information obtained from the European Mouse Mutant Archive (EMMA)
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•
•
•
Publication
- | J:94338
     
First Author: NIH Mouse Knockout Inventory
Year: 2004
Journal: MGI Direct Data Submission
Title: Information obtained from the NIH Mouse Knockout Inventory
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•
•
•
Publication
- | J:342607
       
First Author: Birgit Meldal and Sandra Orchard (1). (1) European Bioinformatics Institute (EBI), Hinxton, Cambridgeshire, United Kingdom
Year: 2023
Title: Manual transfer of experimentally-verified manual GO annotation data to homologous complexes by curator judgment of sequence, composition and function similarity
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Publication
- | J:81858
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: Data Curation Using Mouse Genome Assembly
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Publication
14681479 | J:122989
First Author: Visel A
Year: 2004
Journal: Nucleic Acids Res
Title: GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
Volume: 32
Issue: Database issue
Pages: D552-6
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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•
•
•
Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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•
•
•
Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Allele
Rrm2b<em1Smoc> | MGI:7292126
Name: ribonucleotide reductase M2 B (TP53 inducible); endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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DO Term
DOID:0111518 | autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 5
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Strain
MGI:6476202 | C57BL/6-Rrm2b<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Allele
Tg(CAG-Rrm2b)#Rsw | MGI:5488607
Name: transgene insertion, Robert S Weiss
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Publication
8331655 | -
First Author: Nordlund P
Year: 1993
Journal: J Mol Biol
Title: Structure and function of the Escherichia coli ribonucleotide reductase protein R2.
Volume: 232
Issue: 1
Pages: 123-64
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Publication
9558317 | -
First Author: Tong W
Year: 1998
Journal: Biochemistry
Title: Characterization of Y122F R2 of Escherichia coli ribonucleotide reductase by time-resolved physical biochemical methods and X-ray crystallography.
Volume: 37
Issue: 17
Pages: 5840-8
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Publication
11526233 | -
First Author: Voegtli WC
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: Structure of the yeast ribonucleotide reductase Y2Y4 heterodimer.
Volume: 98
Issue: 18
Pages: 10073-8
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Publication
11802741 | -
First Author: Högbom M
Year: 2002
Journal: Biochemistry
Title: Crystal structure of the di-iron/radical protein of ribonucleotide reductase from Corynebacterium ammoniagenes.
Volume: 41
Issue: 4
Pages: 1381-9
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Publication
9748343 | -
First Author: Eriksson M
Year: 1998
Journal: Biochemistry
Title: Structure of Salmonella typhimurium nrdF ribonucleotide reductase in its oxidized and reduced forms.
Volume: 37
Issue: 38
Pages: 13359-69
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Publication
10980602 | -
First Author: Nakano K
Year: 2000
Journal: Oncogene
Title: A ribonucleotide reductase gene is a transcriptional target of p53 and p73.
Volume: 19
Issue: 37
Pages: 4283-9
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Publication
26089597 | -
 
First Author: Cho EC
Year: 2015
Journal: Mediators Inflamm
Title: RRM2B-Mediated Regulation of Mitochondrial Activity and Inflammation under Oxidative Stress.
Volume: 2015
Pages: 287345
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Publication
18990579 | -
First Author: Lembo D
Year: 2009
Journal: Trends Biochem Sci
Title: Tinkering with a viral ribonucleotide reductase.
Volume: 34
Issue: 1
Pages: 25-32
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Protein Domain
IPR033909 | RNR_small
Type: Family
Description: The beta (small) subunit of ribonucleotide reductase (RNR) is a member of a broad superfamily of ferritin-like diiron-carboxylate proteins. The RNR protein catalyzes the conversion of ribonucleotides to deoxyribonucleotides and is found in all eukaryotes, many prokaryotes, several viruses, and few archaea. The catalytically active form of RNR is a proposed alpha2-beta2 tetramer. The homodimeric alpha subunit (R1) contains the active site and redox active cysteines as well as the allosteric binding sites. The beta subunit (R2) contains a di-iron cluster that, in its reduced state, reacts with dioxygen to form a stable tyrosyl radical and a di-iron(III) cluster. This essential tyrosyl radical is proposed to generate a thiyl radical, located on a cysteine residue in the R1 active site that initiates ribonucleotide reduction. The beta subunit is composed of 10-13 helices, the eight longest helices form an α-helical bundle; some have two addition beta strands [, , , ].The beta-herpesvirus RNR R1 subunit homologues are catalytically inactive; the enzyme seem to function by inhibiting cellular adaptor protein RIP1 to block cellular signaling pathways involved in innate immunity and inflammation [].Yeast is unique in that it assembles both homodimers and heterodimers of RNR. The yeast heterodimer, Y2Y4, contains R2 (Y2) and a R2 homologue (Y4) that lacks the diiron centre and is proposed to only assist in cofactor assembly, and perhaps stabilize R1 (Y1) in its active conformation [, ]. In mammals, the active form of the enzyme is composed of two identical large subunits (RRM1) and two identical small subunits (RRM2 or its homologue RRM2B). RRM1 is the catalytic subunit, and RRM2 and RRM2B the regulatory subunits. RRM2B (also called p53R2) can be induced by p53 [, ].
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Protein Domain
IPR034715 | HSV_RIR2
Type: Family
Description: The beta (small) subunit of ribonucleotide reductase (RNR) is a member of a broad superfamily of ferritin-like diiron-carboxylate proteins. The RNR protein catalyzes the conversion of ribonucleotides to deoxyribonucleotides and is found in all eukaryotes, many prokaryotes, several viruses, and few archaea. The catalytically active form of RNR is a proposed alpha2-beta2 tetramer. The homodimeric alpha subunit (R1) contains the active site and redox active cysteines as well as the allosteric binding sites. The beta subunit (R2) contains a di-iron cluster that, in its reduced state, reacts with dioxygen to form a stable tyrosyl radical and a di-iron(III) cluster. This essential tyrosyl radical is proposed to generate a thiyl radical, located on a cysteine residue in the R1 active site that initiates ribonucleotide reduction. The beta subunit is composed of 10-13 helices, the eight longest helices form an α-helical bundle; some have two addition beta strands [, , , ].The beta-herpesvirus RNR R1 subunit homologues are catalytically inactive; the enzyme seem to function by inhibiting cellular adaptor protein RIP1 to block cellular signaling pathways involved in innate immunity and inflammation [].Yeast is unique in that it assembles both homodimers and heterodimers of RNR. The yeast heterodimer, Y2Y4, contains R2 (Y2) and a R2 homologue (Y4) that lacks the diiron centre and is proposed to only assist in cofactor assembly, and perhaps stabilize R1 (Y1) in its active conformation [, ]. In mammals, the active form of the enzyme is composed of two identical large subunits (RRM1) and two identical small subunits (RRM2 or its homologue RRM2B). RRM1 is the catalytic subunit, and RRM2 and RRM2B the regulatory subunits. RRM2B (also called p53R2) can be induced by p53 [, ].This entry includes the ribonucleoside-diphosphate reductase small subunit from Herpesviruses.
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Publication
20724444 | J:173820
First Author: Ylikallio E
Year: 2010
Journal: Nucleic Acids Res
Title: Ribonucleotide reductase is not limiting for mitochondrial DNA copy number in mice.
Volume: 38
Issue: 22
Pages: 8208-18
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Publication
18413732 | J:133963
First Author: Xu X
Year: 2008
Journal: Cancer Res
Title: Broad overexpression of ribonucleotide reductase genes in mice specifically induces lung neoplasms.
Volume: 68
Issue: 8
Pages: 2652-60
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Publication
8876648 | J:240311
First Author: Kauppi B
Year: 1996
Journal: J Mol Biol
Title: The three-dimensional structure of mammalian ribonucleotide reductase protein R2 reveals a more-accessible iron-radical site than Escherichia coli R2.
Volume: 262
Issue: 5
Pages: 706-20
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Protein
Q6PEE3
Organism: Mus musculus/domesticus
Length: 351  
Fragment?: false
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Protein
P11157
Organism: Mus musculus/domesticus
Length: 390  
Fragment?: false
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Protein
D3Z2A4
Organism: Mus musculus/domesticus
Length: 299  
Fragment?: false
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Protein
F6RUC3
Organism: Mus musculus/domesticus
Length: 243  
Fragment?: true
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Protein
Q3THV8
Organism: Mus musculus/domesticus
Length: 390  
Fragment?: false
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Protein
D3Z0D8
Organism: Mus musculus/domesticus
Length: 225  
Fragment?: true
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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