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Search results 401 to 424 out of 424 for Aspa

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Type Details Score
Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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DO Term
DOID:3613 | Canavan disease
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Allele
Aspa<tm1Mata> | MGI:3038539
Name: aspartoacylase; targeted mutation 1, Reuben Matalon
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Aspa<em1Smoc> | MGI:7288366
Name: aspartoacylase; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Genotype
Genotype
Symbol: Aspa/Aspa
Background: involves: 129S5/SvEvBrd
Zygosity: hm
Has Mutant Allele: true
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Strain
MGI:6428197 | C57BL/6J-Aspa<em1Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Allele
Aspa<tm1a(EUCOMM)Wtsi> | MGI:4434258
Name: aspartoacylase; targeted mutation 1a, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Conditional ready, Null/knockout, Reporter
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Allele
Aspa<deaf14> | MGI:5787576
Name: aspartoacylase; deaf 14
Allele Type: Chemically induced (ENU)
Attribute String: Null/knockout
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Allele
Aspa<nur7> | MGI:2671733
 
Name: aspartoacylase; neurological 7
Allele Type: Chemically induced (ENU)
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Genotype
Genotype
Symbol: Aspa/Aspa
Background: involves: C57BL/6J
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Aspa/Aspa
Background: involves: C57BL/6J * C57BL/6N
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Aspa/Aspa
Background: BALB/c-Aspa
Zygosity: hm
Has Mutant Allele: true
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Allele
Sod2<tm1Cje> | MGI:1857344
Name: superoxide dismutase 2, mitochondrial; targeted mutation 1, Charles J Epstein
Allele Type: Targeted
Attribute String: Null/knockout
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Publication
18478328 | -
First Author: Wang J
Year: 2009
Journal: Neurochem Res
Title: Myelin lipid abnormalities in the aspartoacylase-deficient tremor rat.
Volume: 34
Issue: 1
Pages: 138-48
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Protein Domain
IPR016708 | Aspartoacylase
Type: Family
Description: Aspartoacylase (ASPA) is the N-acetylaspartate- (NAA)-hydrolysing enzyme. It catalyses the deacetylation of N-acetyl-L-aspartate to produce L-aspartate and acetate. N-phosphonomethyl-L-aspartate is a potent inhibitor of this enzyme []. There is a high concentration of (NAA) in neurons of the central nervous system, which is used as an indicator of neuronal viability. The myelin-associated pathology; Canavan disease (also known as spongy degeneration of the brain), is an inherited childhood disorder that results from a mutation of ASPA. The dysmyelination that results from the inactivation of ASPA is characterised by selective decreases as well as some increases in specific lipids [].
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Genotype
Genotype
Symbol: Sod2/Sod2
Background: involves: C57BL/6J
Zygosity: hm
Has Mutant Allele: true
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Protein
Q8R3P0
Organism: Mus musculus/domesticus
Length: 312  
Fragment?: false
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Protein
Q91XE4
Organism: Mus musculus/domesticus
Length: 318  
Fragment?: false
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Publication
18293939 | -
First Author: Le Coq J
Year: 2008
Journal: Biochemistry
Title: Examination of the mechanism of human brain aspartoacylase through the binding of an intermediate analogue.
Volume: 47
Issue: 11
Pages: 3484-92
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Protein Coding Gene
MGI:98352 | Sod2
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
25766789 | J:231794
 
First Author: Zaroff S
Year: 2015
Journal: Mol Cell Neurosci
Title: Transcriptional regulation of N-acetylaspartate metabolism in the 5xFAD model of Alzheimer's disease: evidence for neuron-glia communication during energetic crisis.
Volume: 65
Pages: 143-52
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Publication
36568275 | J:334359
 
First Author: Fröhlich D
Year: 2022
Journal: Front Mol Neurosci
Title: Dual-function AAV gene therapy reverses late-stage Canavan disease pathology in mice.
Volume: 15
Pages: 1061257
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