This entry represents the N-terminal domain of the BAMBI proteins. This domain might contain putative extracellular domains [].This entry consists of several eukaryotic BMP and activin membrane-bound inhibitor (BAMBI) proteins. Members of the transforming growth factor-beta (TGF-beta) superfamily, including TGF-beta, bone morphogenetic proteins (BMPs), activins and nodals, are vital for regulating growth and differentiation. BAMBI is related to TGF-beta-family type I receptors but lacks an intracellular kinase domain [].BAMBI is an essential regulator of cell proliferation and differentiation that represses TGF-beta and enhances Wnt/beta-catenin signalling in various cell types [, ]. Thus, it is involved in a high number of physiological and pathological processes [, , ]. It stably associates with TGF-beta-family receptors and inhibits BMP and activin as well as TGF-beta signalling [].
Identification of BMP and activin membrane-bound inhibitor (BAMBI) as a potent negative regulator of adipogenesis and modulator of autocrine/paracrine adipogenic factors.
