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Search results 801 to 868 out of 868 for Vdr

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Type Details Score
Genotype
Genotype
Symbol: Tg(VDR*L233S,luc)T807Pike/? Vdr/Vdr
Background: involves: 129S4/SvJae * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Protein Domain
IPR000324 | VitD_rcpt
Type: Family
Description: Steroid or nuclear hormone receptors (NRs) constitute an important super-family of transcription regulators that are involved in widely diverse physiological functions, including control of embryonic development, celldifferentiation and homeostasis. Members of the superfamily include thesteroid hormone receptors and receptors for thyroid hormone, retinoids, 1,25-dihydroxy-vitamin D3 and a variety of other ligands. The proteins function as dimeric molecules in nuclei to regulate the transcription of target genes in a ligand-responsive manner [, ]. In addition to C-terminalligand-binding domains, these nuclear receptors contain a highly-conserved,N-terminal zinc-finger that mediates specific binding to target DNA sequences, termed ligand-responsive elements. In the absence of ligand,steroid hormone receptors are thought to be weakly associated with nuclearcomponents; hormone binding greatly increases receptor affinity.NRs are extremely important in medical research, a large number of thembeing implicated in diseases such as cancer, diabetes, hormone resistancesyndromes, etc. While several NRs act as ligand-inducible transcriptionfactors, many do not yet have a defined ligand and are accordingly termed "orphan"receptors. During the last decade, more than 300 NRs have beendescribed, many of which are orphans, which cannot easily be named due to current nomenclature confusions in the literature. However, a new system has recently been introduced in an attempt to rationalise the increasingly complex set of names used to describe superfamily members.The vitamin D receptor (VDR) mediates the signal of 1-a,25-dihydroxyvitamin D3 by binding to vitamin D responsive elements - it functions either as a homodimer, or as a heterodimer of vitamin D and retinoid X receptorsubunits. Deficiency of VDR causes type IIA rickets [].
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Protein
Q3U0J7
Organism: Mus musculus/domesticus
Length: 422  
Fragment?: false
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Protein
Q4FJV8
Organism: Mus musculus/domesticus
Length: 422  
Fragment?: false
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Publication
21362569 | J:171125
First Author: Zhang L
Year: 2011
Journal: Cell Stem Cell
Title: Specific microRNAs are preferentially expressed by skin stem cells to balance self-renewal and early lineage commitment.
Volume: 8
Issue: 3
Pages: 294-308
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Publication
19133230 | J:145151
First Author: Kim JY
Year: 2009
Journal: Biochem Biophys Res Commun
Title: A role of helix 12 of the vitamin D receptor in SMRT corepressor interaction.
Volume: 379
Issue: 3
Pages: 780-4
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Publication
32086292 | J:288629
First Author: Morró M
Year: 2020
Journal: Diabetes
Title: Vitamin D Receptor Overexpression in β-Cells Ameliorates Diabetes in Mice.
Volume: 69
Issue: 5
Pages: 927-939
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Publication
24849345 | J:223180
First Author: Durk MR
Year: 2014
Journal: J Neurosci
Title: 1α,25-Dihydroxyvitamin D3 reduces cerebral amyloid-β accumulation and improves cognition in mouse models of Alzheimer's disease.
Volume: 34
Issue: 21
Pages: 7091-101
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Publication
8967346 | J:32699
First Author: Liu L
Year: 1996
Journal: Am J Physiol
Title: RT-PCR microlocalization of mRNAs for calbindin D28k and vitamin D receptor in the murine nephron.
Volume: 270
Issue: 4 Pt 2
Pages: F677-81
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Publication
10049761 | J:53270
First Author: Fujita A
Year: 1999
Journal: Biochem Biophys Res Commun
Title: Differential regulation of ligand-dependent and ligand-independent functions of the mouse retinoid X receptor beta by alternative splicing.
Volume: 255
Issue: 3
Pages: 625-30
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Publication
21664253 | J:184113
First Author: St-Arnaud R
Year: 2011
Journal: Mol Cell Endocrinol
Title: Vitamin D metabolism, cartilage and bone fracture repair.
Volume: 347
Issue: 1-2
Pages: 48-54
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Publication
32958661 | J:296456
First Author: Fernandez Lahore G
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: Vitamin D3 receptor polymorphisms regulate T cells and T cell-dependent inflammatory diseases.
Volume: 117
Issue: 40
Pages: 24986-24997
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Publication
37664593 | J:340589
First Author: Li X
Year: 2023
Journal: iScience
Title: MYCT1 attenuates renal fibrosis and tubular injury in diabetic kidney disease.
Volume: 26
Issue: 9
Pages: 107609
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Publication
8598193 | J:30618
First Author: vom Baur E
Year: 1996
Journal: EMBO J
Title: Differential ligand-dependent interactions between the AF-2 activating domain of nuclear receptors and the putative transcriptional intermediary factors mSUG1 and TIF1.
Volume: 15
Issue: 1
Pages: 110-24
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Publication
18287084 | J:132781
First Author: Ignat M
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: Arterial calcifications and increased expression of vitamin D receptor targets in mice lacking TIF1alpha.
Volume: 105
Issue: 7
Pages: 2598-603
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Publication
9247308 | J:42245
First Author: Prasad R
Year: 1997
Journal: Oncogene
Title: Structure and expression pattern of human ALR, a novel gene with strong homology to ALL-1 involved in acute leukemia and to Drosophila trithorax.
Volume: 15
Issue: 5
Pages: 549-60
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Publication
16324150 | J:111900
First Author: Urahama N
Year: 2005
Journal: Genes Cells
Title: The role of transcriptional coactivator TRAP220 in myelomonocytic differentiation.
Volume: 10
Issue: 12
Pages: 1127-37
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Publication
34088983 | J:314953
First Author: Kosinsky RL
Year: 2021
Journal: Cell Death Differ
Title: RNF20 and RNF40 regulate vitamin D receptor-dependent signaling in inflammatory bowel disease.
Volume: 28
Issue: 11
Pages: 3161-3175
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Publication
28817668 | J:248424
First Author: Hassan N
Year: 2017
Journal: PLoS One
Title: Titanium biomaterials with complex surfaces induced aberrant peripheral circadian rhythms in bone marrow mesenchymal stromal cells.
Volume: 12
Issue: 8
Pages: e0183359
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Publication
21436386 | J:194585
First Author: Tang JY
Year: 2011
Journal: Cancer Prev Res (Phila)
Title: Vitamin D3 inhibits hedgehog signaling and proliferation in murine Basal cell carcinomas.
Volume: 4
Issue: 5
Pages: 744-51
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Publication
15498883 | J:105499
First Author: Masuda S
Year: 2005
Journal: Endocrinology
Title: Altered pharmacokinetics of 1alpha,25-dihydroxyvitamin D3 and 25-hydroxyvitamin D3 in the blood and tissues of the 25-hydroxyvitamin D-24-hydroxylase (Cyp24a1) null mouse.
Volume: 146
Issue: 2
Pages: 825-34
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Publication
11796525 | J:74973
First Author: Yoshida T
Year: 2002
Journal: Endocrinology
Title: Mediation of unusually high concentrations of 1,25-dihydroxyvitamin D in homozygous klotho mutant mice by increased expression of renal 1alpha-hydroxylase gene.
Volume: 143
Issue: 2
Pages: 683-9
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Publication
15769857 | J:97370
First Author: Healy KD
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: Parathyroid hormone decreases renal vitamin D receptor expression in vivo.
Volume: 102
Issue: 13
Pages: 4724-8
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Publication
16455232 | J:108173
First Author: Nam Y
Year: 2006
Journal: Genomics
Title: A novel missense mutation in the mouse hairless gene causes irreversible hair loss: genetic and molecular analyses of Hr m1Enu.
Volume: 87
Issue: 4
Pages: 520-6
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Publication
16424941 | J:105417
First Author: Takasu H
Year: 2006
Journal: J Clin Invest
Title: c-Fos protein as a target of anti-osteoclastogenic action of vitamin D, and synthesis of new analogs.
Volume: 116
Issue: 2
Pages: 528-35
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Publication
30730853 | J:283450
 
First Author: Kawai M
Year: 2019
Journal: JCI Insight
Title: Intestinal clock system regulates skeletal homeostasis.
Volume: 4
Issue: 5
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Publication
32432928 | J:302054
First Author: Zhang Y
Year: 2020
Journal: Am J Physiol Cell Physiol
Title: RNA-binding protein HuR regulates translation of vitamin D receptor modulating rapid epithelial restitution after wounding.
Volume: 319
Issue: 1
Pages: C208-C217
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Publication
28602864 | J:254307
 
First Author: Yang H
Year: 2017
Journal: Mol Cell Endocrinol
Title: NCKX3 was compensated by calcium transporting genes and bone resorption in a NCKX3 KO mouse model.
Volume: 454
Pages: 93-102
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Publication
33149110 | J:306979
First Author: Kim E
Year: 2020
Journal: Transl Psychiatry
Title: Coexistence of perseveration and apathy in the TDP-43Q331K knock-in mouse model of ALS-FTD.
Volume: 10
Issue: 1
Pages: 377
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Publication
24777663 | J:271546
First Author: Bach FC
Year: 2014
Journal: J Cell Physiol
Title: The paracrine feedback loop between vitamin D₃ (1,25(OH)₂D₃) and PTHrP in prehypertrophic chondrocytes.
Volume: 229
Issue: 12
Pages: 1999-2014
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Publication
28390947 | J:336823
First Author: Gonzalez-Sanchez E
Year: 2017
Journal: Biochim Biophys Acta Mol Basis Dis
Title: Expression patterns of nuclear receptors in parenchymal and non-parenchymal mouse liver cells and their modulation in cholestasis.
Volume: 1863
Issue: 7
Pages: 1699-1708
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Publication
8603573 | J:31874
First Author: McCary LC
Year: 1996
Journal: Endocrinology
Title: Osteopetrotic (op/op) mice are unable to maintain serum calcium levels despite hyperabsorption of calcium.
Volume: 137
Issue: 3
Pages: 1049-56
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Publication
31405972 | J:278904
First Author: Alam C
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: Upregulation of reduced folate carrier by vitamin D enhances brain folate uptake in mice lacking folate receptor alpha.
Volume: 116
Issue: 35
Pages: 17531-17540
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Publication
1362507 | J:11861
First Author: Slavkin HC
Year: 1992
Journal: Crit Rev Eukaryot Gene Expr
Title: Gene expression, signal transduction and tissue-specific biomineralization during mammalian tooth development.
Volume: 2
Issue: 4
Pages: 315-29
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Publication
7626501 | J:28250
First Author: Pereira FA
Year: 1995
Journal: J Steroid Biochem Mol Biol
Title: Chicken ovalbumin upstream promoter transcription factor (COUP-TF): expression during mouse embryogenesis.
Volume: 53
Issue: 1-6
Pages: 503-8
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Publication
9389537 | J:44461
First Author: Nguyen TM
Year: 1997
Journal: Endocrinology
Title: Changes in 1,25-(OH)2D3 synthesis and its receptor expression in spleen cell subpopulations of mice infected with LPBM5 retrovirus.
Volume: 138
Issue: 12
Pages: 5505-10
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Publication
10224044 | J:54891
First Author: Yanagi Y
Year: 1999
Journal: J Biol Chem
Title: Positive and negative modulation of vitamin D receptor function by transforming growth factor-beta signaling through smad proteins.
Volume: 274
Issue: 19
Pages: 12971-4
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Publication
15585794 | J:95468
First Author: Welsh J
Year: 2004
Journal: Am J Clin Nutr
Title: Vitamin D and breast cancer: insights from animal models.
Volume: 80
Issue: 6 Suppl
Pages: 1721S-4S
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Publication
17339334 | J:122227
First Author: Eckey M
Year: 2007
Journal: Mol Cell Biol
Title: The nucleosome assembly activity of NAP1 is enhanced by Alien.
Volume: 27
Issue: 10
Pages: 3557-68
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Publication
18424254 | J:136257
First Author: St-Arnaud R
Year: 2008
Journal: Arch Biochem Biophys
Title: The direct role of vitamin D on bone homeostasis.
Volume: 473
Issue: 2
Pages: 225-30
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Publication
20371703 | J:162260
First Author: Han S
Year: 2010
Journal: Mol Endocrinol
Title: A novel bile acid-activated vitamin D receptor signaling in human hepatocytes.
Volume: 24
Issue: 6
Pages: 1151-64
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Publication
21458526 | J:179537
First Author: Cui J
Year: 2011
Journal: Mol Cell Endocrinol
Title: A novel interaction between insulin-like growth factor binding protein-6 and the vitamin D receptor inhibits the role of vitamin D3 in osteoblast differentiation.
Volume: 338
Issue: 1-2
Pages: 84-92
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Publication
22561756 | J:188077
First Author: Lundqvist J
Year: 2012
Journal: Biochim Biophys Acta
Title: Vitamin D-mediated regulation of CYP21A2 transcription - a novel mechanism for vitamin D action.
Volume: 1820
Issue: 10
Pages: 1553-9
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Publication
22085499 | J:191383
First Author: Welsh J
Year: 2012
Journal: Arch Biochem Biophys
Title: Cellular and molecular effects of vitamin D on carcinogenesis.
Volume: 523
Issue: 1
Pages: 107-14
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Publication
23142286 | J:198254
First Author: Mehta RG
Year: 2013
Journal: Cancer Lett
Title: Vitamin D and breast cancer: emerging concepts.
Volume: 334
Issue: 1
Pages: 95-100
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Publication
25191969 | J:221526
First Author: Hill NT
Year: 2014
Journal: PLoS One
Title: Role of vitamin D3 in modulation of ΔNp63α expression during UVB induced tumor formation in SKH-1 mice.
Volume: 9
Issue: 9
Pages: e107052
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Publication
28493883 | J:245209
First Author: Pols TWH
Year: 2017
Journal: PLoS One
Title: Lithocholic acid controls adaptive immune responses by inhibition of Th1 activation through the Vitamin D receptor.
Volume: 12
Issue: 5
Pages: e0176715
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Publication
31092845 | J:281996
First Author: Hasan N
Year: 2019
Journal: Sci Rep
Title: Vitamin D3 constrains estrogen's effects and influences mammary epithelial organization in 3D cultures.
Volume: 9
Issue: 1
Pages: 7423
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Publication
31940245 | J:285317
First Author: Ashcroft SP
Year: 2020
Journal: Am J Physiol Cell Physiol
Title: The vitamin D receptor regulates mitochondrial function in C2C12 myoblasts.
Volume: 318
Issue: 3
Pages: C536-C541
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Publication
33713706 | J:304957
   
First Author: Yu M
Year: 2021
Journal: J Biol Chem
Title: Vitamin D receptor inhibits EMT via regulation of epithelial mitochondrial function in intestinal fibrosis.
Pages: 100531
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Publication
33139494 | J:307040
 
First Author: Li S
Year: 2020
Journal: Mol Cell Biol
Title: Analysis of 1,25-Dihydroxyvitamin D3 Genomic Action Reveals Calcium-Regulating and Calcium-Independent Effects in Mouse Intestine and Human Enteroids.
Volume: 41
Issue: 1
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Publication
22899855 | J:318092
First Author: Griffin AC 3rd
Year: 2012
Journal: Mol Endocrinol
Title: MKP-1 is essential for canonical vitamin D-induced signaling through nuclear import and regulates RANKL expression and function.
Volume: 26
Issue: 10
Pages: 1682-93
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Publication
35620386 | J:324997
 
First Author: Beck J
Year: 2022
Journal: Front Endocrinol (Lausanne)
Title: Paraventricular Vitamin D Receptors Are Required for Glucose Tolerance in Males but Not Females.
Volume: 13
Pages: 869678
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Publication
36845152 | J:343365
 
First Author: Gao H
Year: 2023
Journal: Front Immunol
Title: Vitamin D3 alleviates inflammation in ulcerative colitis by activating the VDR-NLRP6 signaling pathway.
Volume: 14
Pages: 1135930
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Publication
36909229 | J:345210
 
First Author: Dai Q
Year: 2023
Journal: Front Physiol
Title: Vitamin D-VDR (vitamin D receptor) alleviates glucose metabolism reprogramming in lipopolysaccharide-induced acute kidney injury.
Volume: 14
Pages: 1083643
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Publication
9933478 | J:304703
First Author: Yamamoto H
Year: 1999
Journal: J Bone Miner Res
Title: The caudal-related homeodomain protein Cdx-2 regulates vitamin D receptor gene expression in the small intestine.
Volume: 14
Issue: 2
Pages: 240-7
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Publication
16995819 | J:128103
First Author: Boyan BD
Year: 2006
Journal: J Bone Miner Res
Title: Regulation of growth plate chondrocytes by 1,25-dihydroxyvitamin D3 requires caveolae and caveolin-1.
Volume: 21
Issue: 10
Pages: 1637-47
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Publication
21159735 | J:169320
First Author: Becker LE
Year: 2011
Journal: Am J Physiol Renal Physiol
Title: Effect of paricalcitol and calcitriol on aortic wall remodeling in uninephrectomized ApoE knockout mice.
Volume: 300
Issue: 3
Pages: F772-82
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Publication
11455592 | J:70665
First Author: Rotkiewicz P
Year: 2001
Journal: Proteins
Title: Model of three-dimensional structure of vitamin D receptor and its binding mechanism with 1alpha,25-dihydroxyvitamin D(3).
Volume: 44
Issue: 3
Pages: 188-99
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Publication
16995817 | J:128104
First Author: Baldock PA
Year: 2006
Journal: J Bone Miner Res
Title: Vitamin D action and regulation of bone remodeling: suppression of osteoclastogenesis by the mature osteoblast.
Volume: 21
Issue: 10
Pages: 1618-26
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Publication
26820600 | J:235813
 
First Author: Guo YX
Year: 2016
Journal: Neuroscience
Title: 1,25-Dihydroxyvitamin D3 regulates expression of LRP1 and RAGE in vitro and in vivo, enhancing Aβ1-40 brain-to-blood efflux and peripheral uptake transport.
Volume: 322
Pages: 28-38
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Publication
28526240 | J:254305
 
First Author: Reichrath J
Year: 2017
Journal: Mol Cell Endocrinol
Title: Endocrine actions of vitamin D in skin: Relevance for photocarcinogenesis of non-melanoma skin cancer, and beyond.
Volume: 453
Pages: 96-102
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Publication
36726200 | J:338183
First Author: Hariri H
Year: 2023
Journal: J Bone Miner Res
Title: USP53 Regulates Bone Homeostasis by Controlling Rankl Expression in Osteoblasts and Bone Marrow Adipocytes.
Volume: 38
Issue: 4
Pages: 578-596
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Protein
D3Z3H9
Organism: Mus musculus/domesticus
Length: 75  
Fragment?: true
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Publication
37200907 | J:343400
 
First Author: Wang P
Year: 2023
Journal: J Orthop Translat
Title: Sirt1 protects against intervertebral disc degeneration induced by 1,25-dihydroxyvitamin D insufficiency in mice by inhibiting the NF-κB inflammatory pathway.
Volume: 40
Pages: 13-26
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Publication
9379138 | J:42789
 
First Author: Haussler MR
Year: 1997
Journal: J Endocrinol
Title: The vitamin D hormone and its nuclear receptor: molecular actions and disease states.
Volume: 154 Suppl
Pages: S57-73
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Publication
7899080 | -
First Author: Nishikawa J
Year: 1995
Journal: Nucleic Acids Res
Title: Vitamin D receptor contains multiple dimerization interfaces that are functionally different.
Volume: 23
Issue: 4
Pages: 606-11
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Publication
8165128 | -
First Author: De Vos P
Year: 1994
Journal: Nucleic Acids Res
Title: Human androgen receptor expressed in HeLa cells activates transcription in vitro.
Volume: 22
Issue: 7
Pages: 1161-6
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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