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Search results 1 to 4 out of 4 for Cep120

Category restricted to ProteinDomain (x)

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Categories

Category: ProteinDomain
Type Details Score
Protein Domain
Type: Domain
Description: This domain is found in a number of proteins, including the Cep120 protein which is associated with centriole structure and function [].
Protein Domain
Type: Family
Description: CEP120 is a centrosomal protein required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner []. It has been shown to interact with SPICE1 and CPAP []. This entry also includes CEP120-like proteins from plants and fungi, which do not have centrosomes.Mutations of the CEP120 gene cause short-rib thoracic dysplasia 13 with or without polydactyly (SRTD13) []and Joubert syndrome 31 (JBTS31) [].
Protein Domain
Type: Family
Description: SPICE1 localises to spindle microtubules in mitosis and to centrioles throughout the cell cycle. Deletion of SPICE1 compromises the architecture of spindles, the integrity of the spindle pole and the process of aligning chromosomes on the spindle (chromosome congression) []. SPICE1 interacts with CEP120 in centriole duplication and elongation [].
Protein Domain
Type: Family
Description: Centromere protein J (CENP-J, also known as CPAP) is a cell-cycle regulation protein that controls centriole length. Its intrinsic tubulin-dimer binding activity is required for procentriole elongation []. CPAP has been shown to work with CEP120 to regulate centriole elongation [].