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Search results 201 to 300 out of 329 for Nalcn

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Type Details Score
Protein Coding Gene
MGP_PWKPhJ_G0034600 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0032477 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0035040 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0021269 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_PahariEiJ_G0031802 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0031916 | -
Type: protein_coding_gene
Organism: Mus spretus
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Protein Coding Gene
MGP_SPRETEiJ_G0034428 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
 
Probe: MGI:3585125
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3586034
Age: postnatal day 6-7
Image: P6/7
Specimen Label: P6/7
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
 
Probe: MGI:3585125
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3586034
Age: postnatal day 8-10
Image: P8/10
Specimen Label: P8/10
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:3585125
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1778728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3586034
Age: postnatal day 6
Specimen Label: CNS
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
   
Probe: MGI:3585125
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3586034
Age: postnatal day 6
Specimen Label: CNS
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
 
Probe: MGI:3585125
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1603924
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:3586034
Age: embryonic day 16.0
Note: Expression was widespread.
Specimen Label: Embryo
Detected: true
Specimen Num: 9
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GXD Expression
GXD Expression
Probe: MGI:3585125
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1915726
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:3586034
Age: embryonic day 18.0
Image: E18
Note: Expression was detected in the outer neuroblastic layer.
Specimen Label: E18
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:3585125
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915727
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3586034
Age: postnatal day 0-1
Image: P0/1
Note: Expression was detected in the outer neuroblastic layer.
Specimen Label: P0/1
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:3585125
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915727
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3586034
Age: postnatal day 2-3
Image: P2/3
Note: Expression was detected in the outer neuroblastic layer.
Specimen Label: P2/3
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:3585125
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3586034
Age: postnatal day 4-5
Note: Expression was detected in the outer neuroblastic layer.
Specimen Label: P4/5
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:3585125
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3586034
Age: postnatal day 6-7
Image: P6/7
Specimen Label: P6/7
Detected: true
Specimen Num: 5
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•
GXD Expression
GXD Expression
 
Probe: MGI:3585125
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3586034
Age: postnatal day 8-10
Image: P8/10
Specimen Label: P8/10
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
 
Probe: MGI:3585125
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Male
Emaps: EMAPS:1915728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3586034
Age: postnatal adult
Image: Adult
Specimen Label: Adult
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
 
Probe: MGI:4424493
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1757723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824714
Age: embryonic day 14.5
Image: euxassay_010352_08
Specimen Label: euxassay_010352_08
Detected: true
Specimen Num: 6
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•
•
GXD Expression
GXD Expression
 
Probe: MGI:4424493
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1757723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824714
Age: embryonic day 14.5
Image: euxassay_010352_09
Specimen Label: euxassay_010352_09
Detected: true
Specimen Num: 7
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•
•
GXD Expression
GXD Expression
 
Probe: MGI:4424493
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1757723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824714
Age: embryonic day 14.5
Image: euxassay_010352_10
Specimen Label: euxassay_010352_10
Detected: true
Specimen Num: 8
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•
•
GXD Expression
GXD Expression
 
Probe: MGI:4424493
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1757723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824714
Age: embryonic day 14.5
Image: euxassay_010352_11
Specimen Label: euxassay_010352_11
Detected: true
Specimen Num: 9
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GXD Expression
GXD Expression
 
Probe: MGI:4424493
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1757723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824714
Age: embryonic day 14.5
Image: euxassay_010352_12
Specimen Label: euxassay_010352_12
Detected: true
Specimen Num: 10
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GXD Expression
GXD Expression
 
Probe: MGI:4424493
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1757723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824714
Age: embryonic day 14.5
Image: euxassay_010352_13
Specimen Label: euxassay_010352_13
Detected: true
Specimen Num: 11
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•
•
GXD Expression
GXD Expression
 
Probe: MGI:4424493
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1757723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824714
Age: embryonic day 14.5
Image: euxassay_010352_14
Specimen Label: euxassay_010352_14
Detected: true
Specimen Num: 12
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•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4424493
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1757723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824714
Age: embryonic day 14.5
Image: euxassay_010352_15
Specimen Label: euxassay_010352_15
Detected: true
Specimen Num: 13
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4424493
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824714
Age: embryonic day 14.5
Image: euxassay_010352_03
Specimen Label: euxassay_010352_03
Detected: true
Specimen Num: 1
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•
•
GXD Expression
GXD Expression
 
Probe: MGI:4424493
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824714
Age: embryonic day 14.5
Image: euxassay_010352_04
Specimen Label: euxassay_010352_04
Detected: true
Specimen Num: 2
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•
•
GXD Expression
GXD Expression
 
Probe: MGI:4424493
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824714
Age: embryonic day 14.5
Image: euxassay_010352_05
Specimen Label: euxassay_010352_05
Detected: true
Specimen Num: 3
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•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4424493
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824714
Age: embryonic day 14.5
Image: euxassay_010352_06
Specimen Label: euxassay_010352_06
Detected: true
Specimen Num: 4
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•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4424493
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824714
Age: embryonic day 14.5
Image: euxassay_010352_07
Specimen Label: euxassay_010352_07
Detected: true
Specimen Num: 5
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•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4424493
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824714
Age: embryonic day 14.5
Image: euxassay_010352_08
Specimen Label: euxassay_010352_08
Detected: true
Specimen Num: 6
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4424493
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824714
Age: embryonic day 14.5
Image: euxassay_010352_09
Specimen Label: euxassay_010352_09
Detected: true
Specimen Num: 7
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4424493
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824714
Age: embryonic day 14.5
Image: euxassay_010352_10
Specimen Label: euxassay_010352_10
Detected: true
Specimen Num: 8
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4424493
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824714
Age: embryonic day 14.5
Image: euxassay_010352_11
Specimen Label: euxassay_010352_11
Detected: true
Specimen Num: 9
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4424493
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824714
Age: embryonic day 14.5
Image: euxassay_010352_12
Specimen Label: euxassay_010352_12
Detected: true
Specimen Num: 10
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4424493
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824714
Age: embryonic day 14.5
Image: euxassay_010352_13
Specimen Label: euxassay_010352_13
Detected: true
Specimen Num: 11
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•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4424493
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824714
Age: embryonic day 14.5
Image: euxassay_010352_14
Specimen Label: euxassay_010352_14
Detected: true
Specimen Num: 12
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•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4424493
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824714
Age: embryonic day 14.5
Image: euxassay_010352_15
Specimen Label: euxassay_010352_15
Detected: true
Specimen Num: 13
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•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4424493
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824714
Age: embryonic day 14.5
Image: euxassay_010352_16
Specimen Label: euxassay_010352_16
Detected: true
Specimen Num: 14
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•
•
GXD Expression
GXD Expression
 
Probe: MGI:4424493
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824714
Age: embryonic day 14.5
Image: euxassay_010352_17
Specimen Label: euxassay_010352_17
Detected: true
Specimen Num: 15
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•
•
GXD Expression
GXD Expression
 
Probe: MGI:4424493
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824714
Age: embryonic day 14.5
Image: euxassay_010352_18
Specimen Label: euxassay_010352_18
Detected: true
Specimen Num: 16
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•
•
GXD Expression
GXD Expression
 
Probe: MGI:4424493
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824714
Age: embryonic day 14.5
Image: euxassay_010352_19
Specimen Label: euxassay_010352_19
Detected: true
Specimen Num: 17
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•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4424493
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824714
Age: embryonic day 14.5
Image: euxassay_010352_20
Specimen Label: euxassay_010352_20
Detected: true
Specimen Num: 18
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•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4424493
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824714
Age: embryonic day 14.5
Image: euxassay_010352_21
Specimen Label: euxassay_010352_21
Detected: true
Specimen Num: 19
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•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4424493
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824714
Age: embryonic day 14.5
Image: euxassay_010352_22
Specimen Label: euxassay_010352_22
Detected: true
Specimen Num: 20
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4424493
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824714
Age: embryonic day 14.5
Image: euxassay_010352_23
Specimen Label: euxassay_010352_23
Detected: true
Specimen Num: 21
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4424493
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4824714
Age: embryonic day 14.5
Image: euxassay_010352_24
Specimen Label: euxassay_010352_24
Detected: true
Specimen Num: 22
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Publication
22508057 | -
First Author: Kim BJ
Year: 2012
Journal: Cell Physiol Biochem
Title: Involvement of Na(+)-leak channel in substance P-induced depolarization of pacemaking activity in interstitial cells of Cajal.
Volume: 29
Issue: 3-4
Pages: 501-10
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Publication
33273469 | -
First Author: Kang Y
Year: 2020
Journal: Nat Commun
Title: Structure of voltage-modulated sodium-selective NALCN-FAM155A channel complex.
Volume: 11
Issue: 1
Pages: 6199
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Strain
MGI:6334960 | C57BL/6N-Unc80<em1(IMPC)Tcp>
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Strain
MGI:6407855 | C57BL/6N-Unc80<em1(IMPC)Tcp>/Tcp
Attribute String: coisogenic, targeted mutation
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Strain
MGI:6866648 | C57BL/6NCrl-Unc80<em1(IMPC)Tcp>/TcpMmucd
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Allele
Nalf1<em1Gpt> | MGI:7302789
Name: NALCN channel auxiliary factor 1; endonuclease-mediated mutation 1, GemPharmatech Co., Ltd
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Allele
Nalf1<em4Gpt> | MGI:7302790
Name: NALCN channel auxiliary factor 1; endonuclease-mediated mutation 4, GemPharmatech Co., Ltd
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Strain
MGI:6866785 | C57BL/6NTac-Nalf1<em1(IMPC)H>/Mmnc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Strain
MGI:6408112 | C57BL/6N-Nalf1<em1(IMPC)H>/H
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Strain
MGI:6451186 | C57BL/6J-Unc80<em1Dren>
Attribute String: mutant strain, endonuclease-mediated mutation, coisogenic
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Allele
Nalf2<em7Gpt> | MGI:7302792
Name: NALCN channel auxiliary factor 2; endonuclease-mediated mutation 7, GemPharmatech Co., Ltd
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Allele
Nalf2<tm1a(KOMP)Wtsi> | MGI:4451526
Name: NALCN channel auxiliary factor 2; targeted mutation 1a, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Conditional ready, Null/knockout, Reporter
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Allele
Nalf2<em1Gpt> | MGI:7302791
Name: NALCN channel auxiliary factor 2; endonuclease-mediated mutation 1, GemPharmatech Co., Ltd
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Allele
Nalf2<tm1e(KOMP)Wtsi> | MGI:4451340
Name: NALCN channel auxiliary factor 2; targeted mutation 1e, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Genotype
Genotype
Symbol: Unc80/Unc80
Background: C57BL/6J-Unc80
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Unc80/Unc80
Background: involves: C57BL/6J * SJL/J
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Nalf1/Nalf1
Background: C57BL/6N-Nalf1/H
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Unc80/Unc80
Background: C57BL/6N-Unc80/Tcp
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Nalf1/Nalf1<+>
Background: C57BL/6N-Nalf1/H
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Unc80/Unc80<+>
Background: C57BL/6N-Unc80/Tcp
Zygosity: ht
Has Mutant Allele: true
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Protein
E5CYJ9
Organism: Mus musculus/domesticus
Length: 2654  
Fragment?: false
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Protein
J3QP77
Organism: Mus musculus/domesticus
Length: 188  
Fragment?: true
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Protein
G8JL63
Organism: Mus musculus/domesticus
Length: 2458  
Fragment?: false
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Protein
Q3UN20
Organism: Mus musculus/domesticus
Length: 127  
Fragment?: false
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Protein
J3QMH8
Organism: Mus musculus/domesticus
Length: 85  
Fragment?: true
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Protein
J3QPJ0
Organism: Mus musculus/domesticus
Length: 231  
Fragment?: true
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Protein Domain
IPR024855 | UNC79
Type: Family
Description: The NALCN cation channel, which controls neuronal excitability, can be activated by a reduction in extracellular calcium ions. Its activation in neurons requires the proteins UNC79 and UNC80, where UNC79 indirectly associates with NALCN through its interaction with UNC80 [].
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DO Term
DOID:0081048 | congenital limbs-face contractures-hypotonia-developmental delay syndrome
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Protein Domain
IPR045852 | UNC80_central
Type: Domain
Description: This entry represents the central region of protein UNC80 from eukaryotes, a component of the NALCN sodium channel complex. NALCN is a cation voltage-independent channel activated by substance P, neurotensin, acetylcholine and noradrenaline that controls neuronal excitability. UNC80 forms a complex with UNC79 and both are key regulators of the channel and required for the proper expression and axonal localisation of NALCN. UNC80 is required for NALCN control by GPCRs and essential for its sensitivity to extracellular calcium. This protein acts as a scaffold for Src family of tyrosine kinases (SFK) and UNC-79 to mediate interaction with NALCN [, , ]. Proteins containing this domain also include some uncharacterised proteins from fungi.
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Protein
Q8BLN6
Organism: Mus musculus/domesticus
Length: 3326  
Fragment?: false
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Protein
A0A1D5RLV3
Organism: Mus musculus/domesticus
Length: 3258  
Fragment?: false
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Publication
24904279 | -
 
First Author: Cochet-Bissuel M
Year: 2014
Journal: Front Cell Neurosci
Title: The sodium leak channel, NALCN, in health and disease.
Volume: 8
Pages: 132
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Protein
I6L9J4
Organism: Mus musculus/domesticus
Length: 298  
Fragment?: false
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Publication
17825559 | -
First Author: Jospin M
Year: 2007
Journal: Curr Biol
Title: UNC-80 and the NCA ion channels contribute to endocytosis defects in synaptojanin mutants.
Volume: 17
Issue: 18
Pages: 1595-600
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Publication
18336069 | -
First Author: Yeh E
Year: 2008
Journal: PLoS Biol
Title: A putative cation channel, NCA-1, and a novel protein, UNC-80, transmit neuronal activity in C. elegans.
Volume: 6
Issue: 3
Pages: e55
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Protein Domain
IPR031542 | UNC80_N
Type: Domain
Description: UNC80 is a protein associated with the NALCN sodium channel complex, and is required for the activation of this channel by the neuropeptide substance P. NALCN activation is G-protein-independent, but requires Src kinases. NUNC80 binds Src kinases and recruits Src into the channel complex []. UNC80 is required for the proper localisation of C. elegans NCA-1 and NCA-2, the homologues of the vertebrate cation leak channel NALCN []. NCA-1 and UNC-80 regulate neuronal activity in C. elegans [].This entry represents the N-terminal domain of UNC80.
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Protein Domain
IPR046460 | UNC80_C
Type: Domain
Description: This entry represents the C-terminal domain of protein UNC80 from eukaryotes, a component of the NALCN sodium channel complex. NALC is a cation voltage-independent channel activated by substance P, neurotensin, acetylcholine and noradrenaline that controls neuronal excitability. UNC80 forms a complex with UNC79 and both are key regulators of the channel and required for the proper expression and axonal localisation of NALCN. UNC80 is required for NALCN control by GPCRs and essential for its sensitivity to extracellular calcium. This protein acts as a scaffold for Src family of tyrosine kinases (SFK) and UNC-79 to mediate interaction with NALCN [, , ].
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HT Experiment
GSE78521 | Transcriptomes of individual substantia nigra pars reticulata neurons
Series Id: E-GEOD-78521
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
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Protein
Q0KK59
Organism: Mus musculus/domesticus
Length: 2596  
Fragment?: false
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Protein
J3QNP0
Organism: Mus musculus/domesticus
Length: 2461  
Fragment?: true
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Protein Coding Gene
MGI:2684729 | Unc79
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CAROLIEiJ_G0018047 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0020043 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0019999 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0019975 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0019985 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0019787 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_2684729 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0020434 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0019333 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0019759 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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