Ice2 is a fungal ER protein which has been shown to play an important role in forming/maintaining the cortical ER []. It has also been identified as a protein which is necessary for nuclear inner membrane targeting [].
This entry represents the C-terminal of little elongation complex subunit 2 (ICE2, also known as NARG2). ICE2 is a component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III [, ]. This C-terminal domain belongs to the PD-(D/E)XK nuclease superfamily [].
