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Search results 501 to 600 out of 634 for Vav3

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Type Details Score
GXD Expression
GXD Expression
Probe: MGI:7275213
Assay Type: RNA in situ
Annotation Date: 2022-05-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1715019
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:7275223
Age: embryonic day 11.5
Image: 1H
Note: Expression is in the lateral and medial subpopulations of the lateral motor column at the lumbar level.
Specimen Label: 1H
Detected: true
Specimen Num: 1
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Publication
30703063 | J:302664
First Author: Lorenzo-Martín LF
Year: 2019
Journal: J Endocrinol
Title: Vagal afferents contribute to sympathoexcitation-driven metabolic dysfunctions.
Volume: 240
Issue: 3
Pages: 483-496
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Publication
23931752 | J:200991
First Author: Menacho-Márquez M
Year: 2013
Journal: Cell Metab
Title: Chronic sympathoexcitation through loss of Vav3, a Rac1 activator, results in divergent effects on metabolic syndrome and obesity depending on diet.
Volume: 18
Issue: 2
Pages: 199-211
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Publication
21880903 | J:176225
First Author: Hale CF
Year: 2011
Journal: J Neurosci
Title: Essential role for vav Guanine nucleotide exchange factors in brain-derived neurotrophic factor-induced dendritic spine growth and synapse plasticity.
Volume: 31
Issue: 35
Pages: 12426-36
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Publication
20038798 | J:156698
First Author: Sauzeau V
Year: 2010
Journal: J Clin Invest
Title: The Rho/Rac exchange factor Vav2 controls nitric oxide-dependent responses in mouse vascular smooth muscle cells.
Volume: 120
Issue: 1
Pages: 315-30
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Publication
26147533 | J:224528
First Author: Zhu S
Year: 2015
Journal: Nat Neurosci
Title: Identification of a Vav2-dependent mechanism for GDNF/Ret control of mesolimbic DAT trafficking.
Volume: 18
Issue: 8
Pages: 1084-93
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Publication
20011522 | J:155962
First Author: Ruiz S
Year: 2009
Journal: PLoS One
Title: The use of knockout mice reveals a synergistic role of the Vav1 and Rasgrf2 gene deficiencies in lymphomagenesis and metastasis.
Volume: 4
Issue: 12
Pages: e8229
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Publication
29136506 | J:248841
First Author: Robles-Valero J
Year: 2017
Journal: Cancer Cell
Title: A Paradoxical Tumor-Suppressor Role for the Rac1 Exchange Factor Vav1 in T Cell Acute Lymphoblastic Leukemia.
Volume: 32
Issue: 5
Pages: 608-623.e9
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Publication
26240279 | J:228223
First Author: Fabbiano S
Year: 2015
Journal: Mol Cell Biol
Title: Immunosuppression-Independent Role of Regulatory T Cells against Hypertension-Driven Renal Dysfunctions.
Volume: 35
Issue: 20
Pages: 3528-46
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Publication
32963234 | J:298629
First Author: Lorenzo-Martín LF
Year: 2020
Journal: Nat Commun
Title: VAV2 signaling promotes regenerative proliferation in both cutaneous and head and neck squamous cell carcinoma.
Volume: 11
Issue: 1
Pages: 4788
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Publication
32528129 | J:290809
First Author: Lorenzo-Martín LF
Year: 2020
Journal: Oncogene
Title: Vav2 pharmaco-mimetic mice reveal the therapeutic value and caveats of the catalytic inactivation of a Rho exchange factor.
Volume: 39
Issue: 28
Pages: 5098-5111
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Publication
22718904 | J:198877
First Author: Park YM
Year: 2012
Journal: Mol Biol Cell
Title: Oxidized LDL/CD36 interaction induces loss of cell polarity and inhibits macrophage locomotion.
Volume: 23
Issue: 16
Pages: 3057-68
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Protein Domain
IPR035734 | VAV3_SH3_2
Type: Domain
Description: VAV3 is ubiquitously expressed and functions as a phosphorylation-dependent guanine nucleotide exchange factor (GEF) for RhoA, RhoG, and Rac1 []. It has been implicated to function in the hematopoietic, bone, cerebellar, and cardiovascular systems. VAV3 is essential in axon guidance in neurons that control blood pressure and respiration []. It is overexpressed in prostate cancer cells and it plays a role in regulating androgen receptor transcriptional activity [, ]. VAV proteins contain several domains that enable their function: N-terminal calponin homology (CH), acidic, RhoGEF (also called Dbl-homologous or DH), Pleckstrin Homology (PH), C1 (zinc finger), SH2, and two SH3 domains. This entry represents the SH3 domain of VAV3. The SH3 domain of VAV3 is involved in the localization of proteins to specific sites within the cell, by interacting with proline-rich sequences within target proteins [].
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Publication
20634378 | J:165865
First Author: Graham DB
Year: 2010
Journal: Blood
Title: ITAM signaling in dendritic cells controls T helper cell priming by regulating MHC class II recycling.
Volume: 116
Issue: 17
Pages: 3208-18
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Publication
17158234 | J:145345
First Author: Miletic AV
Year: 2007
Journal: Blood
Title: Vav proteins control MyD88-dependent oxidative burst.
Volume: 109
Issue: 8
Pages: 3360-8
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Publication
19139088 | J:146174
First Author: Liu JY
Year: 2009
Journal: J Cell Sci
Title: Vav proteins are necessary for correct differentiation of mouse cecal and colonic enterocytes.
Volume: 122
Issue: Pt 3
Pages: 324-34
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Publication
22884313 | J:187375
First Author: Acton SE
Year: 2012
Journal: Immunity
Title: Podoplanin-rich stromal networks induce dendritic cell motility via activation of the C-type lectin receptor CLEC-2.
Volume: 37
Issue: 2
Pages: 276-89
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Publication
25288640 | J:224320
First Author: Fabbiano S
Year: 2014
Journal: Mol Cell Biol
Title: Genetic dissection of the vav2-rac1 signaling axis in vascular smooth muscle cells.
Volume: 34
Issue: 24
Pages: 4404-19
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Publication
19715691 | J:154472
First Author: Bhavsar PJ
Year: 2009
Journal: Exp Cell Res
Title: Vav GEFs regulate macrophage morphology and adhesion-induced Rac and Rho activation.
Volume: 315
Issue: 19
Pages: 3345-58
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Publication
17142761 | J:140668
First Author: Stephenson LM
Year: 2006
Journal: J Immunol
Title: Vav proteins regulate the plasma cell program and secretory Ig production.
Volume: 177
Issue: 12
Pages: 8620-5
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Publication
17932569 | J:127399
First Author: Graham DB
Year: 2007
Journal: J Clin Invest
Title: Neutrophil-mediated oxidative burst and host defense are controlled by a Vav-PLCgamma2 signaling axis in mice.
Volume: 117
Issue: 11
Pages: 3445-52
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Publication
17015685 | J:139456
First Author: Charvet C
Year: 2006
Journal: J Immunol
Title: Vav1 promotes T cell cycle progression by linking TCR/CD28 costimulation to FOXO1 and p27kip1 expression.
Volume: 177
Issue: 8
Pages: 5024-31
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Publication
15848800 | J:98310
First Author: Cowan CW
Year: 2005
Journal: Neuron
Title: Vav family GEFs link activated Ephs to endocytosis and axon guidance.
Volume: 46
Issue: 2
Pages: 205-17
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Publication
16015370 | J:101473
First Author: Johannesson M
Year: 2005
Journal: Genes Immun
Title: Gene expression profiling of arthritis using a QTL chip reveals a complex gene regulation of the Cia5 region in mice.
Volume: 6
Issue: 7
Pages: 575-83
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Publication
19592646 | J:151601
First Author: Reeve JL
Year: 2009
Journal: J Immunol
Title: SLP-76 couples Syk to the osteoclast cytoskeleton.
Volume: 183
Issue: 3
Pages: 1804-12
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Publication
21979919 | J:177426
First Author: Kant S
Year: 2011
Journal: Genes Dev
Title: TNF-stimulated MAP kinase activation mediated by a Rho family GTPase signaling pathway.
Volume: 25
Issue: 19
Pages: 2069-78
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Publication
19088377 | J:148437
First Author: Dumont C
Year: 2009
Journal: Blood
Title: Rac GTPases play critical roles in early T-cell development.
Volume: 113
Issue: 17
Pages: 3990-8
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Publication
24155889 | J:209098
First Author: Gmyrek GB
Year: 2013
Journal: PLoS One
Title: Loss of DAP12 and FcRγ drives exaggerated IL-12 production and CD8(+) T cell response by CCR2(+) Mo-DCs.
Volume: 8
Issue: 10
Pages: e76145
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Publication
17984307 | J:128521
First Author: Graham DB
Year: 2007
Journal: J Exp Med
Title: An ITAM-signaling pathway controls cross-presentation of particulate but not soluble antigens in dendritic cells.
Volume: 204
Issue: 12
Pages: 2889-97
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Publication
18424751 | J:134524
First Author: Utomo A
Year: 2008
Journal: J Immunol
Title: Requirement for Vav proteins in post-recruitment neutrophil cytotoxicity in IgG but not complement C3-dependent injury.
Volume: 180
Issue: 9
Pages: 6279-87
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Publication
21930962 | J:179460
First Author: Janas ML
Year: 2011
Journal: J Immunol
Title: Interaction of Ras with p110γ is required for thymic β-selection in the mouse.
Volume: 187
Issue: 9
Pages: 4667-75
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Publication
15941910 | J:119378
First Author: Vigorito E
Year: 2005
Journal: Blood
Title: Vav proteins regulate peripheral B-cell survival.
Volume: 106
Issue: 7
Pages: 2391-8
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Publication
24659802 | J:214692
First Author: Damoulakis G
Year: 2014
Journal: J Cell Sci
Title: P-Rex1 directly activates RhoG to regulate GPCR-driven Rac signalling and actin polarity in neutrophils.
Volume: 127
Issue: Pt 11
Pages: 2589-600
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Publication
20308364 | J:159176
First Author: Henderson RB
Year: 2010
Journal: J Exp Med
Title: A novel Rac-dependent checkpoint in B cell development controls entry into the splenic white pulp and cell survival.
Volume: 207
Issue: 4
Pages: 837-53
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Publication
24091327 | J:203981
First Author: Martin H
Year: 2013
Journal: J Clin Invest
Title: Pak and Rac GTPases promote oncogenic KIT-induced neoplasms.
Volume: 123
Issue: 10
Pages: 4449-63
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Publication
21209086 | J:170538
First Author: Rahaman SO
Year: 2011
Journal: J Biol Chem
Title: Vav family Rho guanine nucleotide exchange factors regulate CD36-mediated macrophage foam cell formation.
Volume: 286
Issue: 9
Pages: 7010-7
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Publication
21178006 | J:168922
First Author: Lawson CD
Year: 2011
Journal: J Immunol
Title: P-Rex1 and Vav1 cooperate in the regulation of formyl-methionyl-leucyl-phenylalanine-dependent neutrophil responses.
Volume: 186
Issue: 3
Pages: 1467-76
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Publication
25538043 | J:221504
First Author: Pan D
Year: 2015
Journal: Blood
Title: P-Rex and Vav Rac-GEFs in platelets control leukocyte recruitment to sites of inflammation.
Volume: 125
Issue: 7
Pages: 1146-58
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Publication
28930674 | J:261382
First Author: Kant S
Year: 2017
Journal: Cell Rep
Title: A Protein Scaffold Coordinates SRC-Mediated JNK Activation in Response to Metabolic Stress.
Volume: 20
Issue: 12
Pages: 2775-2783
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Publication
15249579 | J:91862
First Author: Gakidis MA
Year: 2004
Journal: J Cell Biol
Title: Vav GEFs are required for beta2 integrin-dependent functions of neutrophils.
Volume: 166
Issue: 2
Pages: 273-82
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Publication
22683124 | J:187430
First Author: Dong Z
Year: 2012
Journal: Immunity
Title: The adaptor SAP controls NK cell activation by regulating the enzymes Vav-1 and SHIP-1 and by enhancing conjugates with target cells.
Volume: 36
Issue: 6
Pages: 974-85
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Publication
19141316 | J:148967
First Author: Glassmann A
Year: 2009
Journal: Neuroscience
Title: Basic molecular fingerprinting of immature cerebellar cortical inhibitory interneurons and their precursors.
Volume: 159
Issue: 1
Pages: 69-82
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Publication
- | J:25000
       
First Author: MGI Nomenclature Committee/Homology Group
Year: 1998
Title: MGI/HUGO Nomenclature Homology Determination
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Publication
21257963 | J:169412
First Author: Boyle KB
Year: 2011
Journal: J Immunol
Title: Class IA phosphoinositide 3-kinase β and δ regulate neutrophil oxidase activation in response to Aspergillus fumigatus hyphae.
Volume: 186
Issue: 5
Pages: 2978-89
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
19906978 | J:154739
First Author: Quina LA
Year: 2009
Journal: J Neurosci
Title: Brn3a and Nurr1 mediate a gene regulatory pathway for habenula development.
Volume: 29
Issue: 45
Pages: 14309-22
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UniProt Feature
UniProt Feature
Begin: 1
Description: Guanine nucleotide exchange factor VAV3
Type: chain
End: 847
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Publication
- | J:80001
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: FANTOM2 Data Curation in Mouse Genome Informatics
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:171409
     
First Author: GUDMAP Consortium
Year: 2004
Journal: www.gudmap.org
Title: GUDMAP: the GenitoUrinary Development Molecular Anatomy Project
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Protein
Q9R0C8-4
Organism: Mus musculus/domesticus
Length: 574  
Fragment?: false
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Protein
Q9R0C8-3
Organism: Mus musculus/domesticus
Length: 287  
Fragment?: false
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Publication
28214347 | -
First Author: Ulc A
Year: 2017
Journal: Biol Chem
Title: Involvement of the guanine nucleotide exchange factor Vav3 in central nervous system development and plasticity.
Volume: 398
Issue: 5-6
Pages: 663-675
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Publication
10713454 | -
First Author: Trenkle T
Year: 2000
Journal: Gene
Title: Major transcript variants of VAV3, a new member of the VAV family of guanine nucleotide exchange factors.
Volume: 245
Issue: 1
Pages: 139-49
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Publication
9115846 | -
First Author: Romero F
Year: 1996
Journal: Cell Signal
Title: Structure and function of vav.
Volume: 8
Issue: 8
Pages: 545-53
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Publication
15886116 | -
First Author: Tybulewicz VL
Year: 2005
Journal: Curr Opin Immunol
Title: Vav-family proteins in T-cell signalling.
Volume: 17
Issue: 3
Pages: 267-74
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Interaction Experiment
Yu J (2016)
Description: Interaction of Tumor Necrosis Factor Receptor-associated Factor 6 (TRAF6) and Vav3 in the Receptor Activator of Nuclear Factor B (RANK) Signaling Complex Enhances Osteoclastogenesis.
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Publication
19008376 | -
First Author: Salhia B
Year: 2008
Journal: Am J Pathol
Title: The guanine nucleotide exchange factors trio, Ect2, and Vav3 mediate the invasive behavior of glioblastoma.
Volume: 173
Issue: 6
Pages: 1828-38
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Publication
12400014 | -
First Author: Yabana N
Year: 2002
Journal: Oncogene
Title: Adaptor protein APS binds the NH2-terminal autoinhibitory domain of guanine nucleotide exchange factor Vav3 and augments its activity.
Volume: 21
Issue: 50
Pages: 7720-9
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Publication
27507811 | -
First Author: Yu J
Year: 2016
Journal: J Biol Chem
Title: Interaction of Tumor Necrosis Factor Receptor-associated Factor 6 (TRAF6) and Vav3 in the Receptor Activator of Nuclear Factor κB (RANK) Signaling Complex Enhances Osteoclastogenesis.
Volume: 291
Issue: 39
Pages: 20643-60
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Protein Domain
IPR035881 | VAV3_SH2
Type: Domain
Description: This entry represents the SH2 domain of VAV3, which belongs to the VAV family. VAV3 is involved in the regulation of osteoclast function []and in central nervous system development and plasticity [].The VAV protein family members are multiple domain proteins, including Vav from flies and VAV1/2/3 from mammals. VAV1 predominates in hematopoietic cells, whereas VAV2 and VAV3 are more broadly expressed. They have a calponin homology (CH) domain, an acidic domain (AC), a Dbl homology (DH) domain, a pleckstrin homology (PH) domain, a cysteine-rich (CR) domain containing a zinc finger, and a complex region with SH2 and SH3 domains. Therefore they may participate in the activity of several pathways [, ]. They are signal transducer proteins that couple tyrosine kinase signals with the activation of the Rho/Rac GTPases, [, , ].
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Publication
17909013 | J:125506
First Author: Banach-Petrosky W
Year: 2007
Journal: Cancer Res
Title: Prolonged exposure to reduced levels of androgen accelerates prostate cancer progression in Nkx3.1; Pten mutant mice.
Volume: 67
Issue: 19
Pages: 9089-96
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Publication
27681594 | J:314289
First Author: Maruyama K
Year: 2016
Journal: J Biol Chem
Title: Bone-protective Functions of Netrin 1 Protein.
Volume: 291
Issue: 46
Pages: 23854-23868
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Publication
33397922 | J:300957
First Author: Pickering KA
Year: 2021
Journal: Nat Commun
Title: A RAC-GEF network critical for early intestinal tumourigenesis.
Volume: 12
Issue: 1
Pages: 56
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Publication
26919541 | -
First Author: Liu S
Year: 2016
Journal: FEBS Lett
Title: Structural basis for a novel interaction between TXNIP and Vav2.
Volume: 590
Issue: 6
Pages: 857-65
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Protein Domain
IPR035880 | VAV2_SH2
Type: Domain
Description: This entry represents the SH2 domain of VAV2, which is a member of the VAV family. The SH2 domain of VAV2 has been shown to interact with PPxY motifs of TXNIP (thioredoxin-interacting protein) []. The VAV protein family members are multiple domain proteins, including Vav from flies and VAV1/2/3 from mammals. VAV1 predominates in hematopoietic cells, whereas VAV2 and VAV3 are more broadly expressed. They have a calponin homology (CH) domain, an acidic domain (AC), a Dbl homology (DH) domain, a pleckstrin homology (PH) domain, a cysteine-rich (CR) domain containing a zinc finger, and a complex region with SH2 and SH3 domains. Therefore they may participate in the activity of several pathways [, ]. They are signal transducer proteins that couple tyrosine kinase signals with the activation of the Rho/Rac GTPases, [, , ].
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Publication
10781813 | -
First Author: Dekel I
Year: 2000
Journal: FEBS Lett
Title: Identification of the Drosophila melanogaster homologue of the mammalian signal transducer protein, Vav.
Volume: 472
Issue: 1
Pages: 99-104
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Publication
23525006 | -
First Author: Fernández-Espartero CH
Year: 2013
Journal: J Cell Sci
Title: GTP exchange factor Vav regulates guided cell migration by coupling guidance receptor signalling to local Rac activation.
Volume: 126
Issue: Pt 10
Pages: 2285-93
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Publication
16106078 | -
First Author: Swat W
Year: 2005
Journal: Immunol Res
Title: The Vav family: at the crossroads of signaling pathways.
Volume: 32
Issue: 1-3
Pages: 259-65
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Publication
16950670 | J:116971
First Author: Sakai H
Year: 2006
Journal: Bone
Title: Activated c-Fms recruits Vav and Rac during CSF-1-induced cytoskeletal remodeling and spreading in osteoclasts.
Volume: 39
Issue: 6
Pages: 1290-301
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Publication
18387945 | J:137566
First Author: Fang WB
Year: 2008
Journal: J Biol Chem
Title: Identification and functional analysis of phosphorylated tyrosine residues within EphA2 receptor tyrosine kinase.
Volume: 283
Issue: 23
Pages: 16017-26
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Publication
31570505 | J:302817
First Author: Huang R
Year: 2019
Journal: J Lipid Res
Title: The three members of the Vav family proteins form complexes that concur to foam cell formation and atherosclerosis.
Volume: 60
Issue: 12
Pages: 2006-2019
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Publication
17855053 | -
First Author: Lazer G
Year: 2007
Journal: Cell Signal
Title: The association of Sam68 with Vav1 contributes to tumorigenesis.
Volume: 19
Issue: 12
Pages: 2479-86
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Protein Domain
IPR035879 | VAV1_SH2
Type: Domain
Description: This entry represents the SH2 domain of VAV1 from vertebrates.VAV1 (also known as proto-oncogene vav) is expressed predominantly in the hematopoietic system and it plays an important role in the development and activation of B and T cells [, , ]. It is activated by tyrosine phosphorylation to function as a guanine nucleotide exchange factor (GEF) for Rho GTPases following cell surface receptor activation, triggering various effects such as cytoskeletal reorganization, transcription regulation, cell cycle progression, and calcium mobilization [, ]. It also serves as a scaffold protein and has been shown to interact with Ku70, Socs1, Janus kinase 2, SIAH2, S100B, Abl gene, ZAP-70, SLP76, and Syk, among others []. The VAV protein family members are multiple domain proteins, including Vav from flies and VAV1/2/3 from mammals. VAV1 predominates in hematopoietic cells, whereas VAV2 and VAV3 are more broadly expressed. They have a calponin homology (CH) domain, an acidic domain (AC), a Dbl homology (DH) domain, a pleckstrin homology (PH) domain, a cysteine-rich (CR) domain containing a zinc finger, and a complex region with SH2 and SH3 domains. Therefore they may participate in the activity of several pathways [, ]. They are signal transducer proteins that couple tyrosine kinase signals with the activation of the Rho/Rac GTPases, [, , ].
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Protein Domain
IPR035729 | VAV1_SH3_2
Type: Domain
Description: VAV1 (also known as proto-oncogene vav) is expressed predominantly in the hematopoietic system and it plays an important role in the development and activation of B and T cells [, , ]. It is activated by tyrosine phosphorylation to function as a guanine nucleotide exchange factor (GEF) for Rho GTPases following cell surface receptor activation, triggering various effects such as cytoskeletal reorganization, transcription regulation, cell cycle progression, and calcium mobilization [, ]. It also serves as a scaffold protein and has been shown to interact with Ku70, Socs1, Janus kinase 2, SIAH2, S100B, Abl gene, ZAP-70, SLP76, and Syk, among others []. The VAV protein family members are multiple domain proteins, including Vav from flies and VAV1/2/3 from mammals. VAV1 predominates in hematopoietic cells, whereas VAV2 and VAV3 are more broadly expressed. They have a calponin homology (CH) domain, an acidic domain (AC), a Dbl homology (DH) domain, a pleckstrin homology (PH) domain, a cysteine-rich (CR) domain containing a zinc finger, and a complex region with SH2 and SH3 domains. Therefore they may participate in the activity of several pathways [, ]. They are signal transducer proteins that couple tyrosine kinase signals with the activation of the Rho/Rac GTPases, [, , ]. This entry represents the second SH3 domain of VAV1. This domain interacts with a wide variety of proteins including cytoskeletal regulators (zyxin), RNA-binding proteins (Sam68), transcriptional regulators, viral proteins, and dynamin 2 [].
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