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Search results 1 to 100 out of 230 for Hdac4

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Category: Publication
Type Details Score
Publication
First Author: Penrod RD
Year: 2018
Journal: Addict Biol
Title: Novel role and regulation of HDAC4 in cocaine-related behaviors.
Volume: 23
Issue: 2
Pages: 653-664
Publication  
First Author: Renzini A
Year: 2018
Journal: Front Physiol
Title: HDAC4 Regulates Skeletal Muscle Regeneration via Soluble Factors.
Volume: 9
Pages: 1387
Publication
First Author: Crow M
Year: 2015
Journal: FASEB J
Title: HDAC4 is required for inflammation-associated thermal hypersensitivity.
Volume: 29
Issue: 8
Pages: 3370-8
Publication
First Author: Hohl M
Year: 2013
Journal: J Clin Invest
Title: HDAC4 controls histone methylation in response to elevated cardiac load.
Volume: 123
Issue: 3
Pages: 1359-70
Publication
First Author: Choi MC
Year: 2014
Journal: EMBO Rep
Title: HDAC4 promotes Pax7-dependent satellite cell activation and muscle regeneration.
Volume: 15
Issue: 11
Pages: 1175-83
Publication
First Author: Pigna E
Year: 2018
Journal: Skelet Muscle
Title: HDAC4 preserves skeletal muscle structure following long-term denervation by mediating distinct cellular responses.
Volume: 8
Issue: 1
Pages: 6
Publication      
First Author: Funato, H
Year: 2022
Journal: MGI Direct Data Submission
Title: Direct Data Submission of Hdac4 allele.
Publication
First Author: Obri A
Year: 2014
Journal: J Cell Biol
Title: HDAC4 integrates PTH and sympathetic signaling in osteoblasts.
Volume: 205
Issue: 6
Pages: 771-80
Publication
First Author: Yang D
Year: 2018
Journal: Cardiovasc Res
Title: HDAC4 regulates vascular inflammation via activation of autophagy.
Volume: 114
Issue: 7
Pages: 1016-1028
Publication
First Author: Chen B
Year: 2009
Journal: Science
Title: HDAC4 regulates neuronal survival in normal and diseased retinas.
Volume: 323
Issue: 5911
Pages: 256-9
Publication
First Author: Nakatani T
Year: 2018
Journal: J Bone Miner Res
Title: The Deletion of Hdac4 in Mouse Osteoblasts Influences Both Catabolic and Anabolic Effects in Bone.
Volume: 33
Issue: 7
Pages: 1362-1375
Publication  
First Author: Nishimori S
Year: 2019
Journal: JCI Insight
Title: PTHrP targets HDAC4 and HDAC5 to repress chondrocyte hypertrophy.
Volume: 4
Issue: 5
Publication
First Author: Liu Q
Year: 2017
Journal: Oncotarget
Title: HDAC4 is expressed on multiple T cell lineages but dispensable for their development and function.
Volume: 8
Issue: 11
Pages: 17562-17572
Publication
First Author: Zhou J
Year: 2015
Journal: Biochim Biophys Acta
Title: Mitogen-activated protein kinase p38 induces HDAC4 degradation in hypertrophic chondrocytes.
Volume: 1853
Issue: 2
Pages: 370-376
Publication
First Author: Cui H
Year: 2013
Journal: J Clin Invest
Title: Eating disorder predisposition is associated with ESRRA and HDAC4 mutations.
Volume: 123
Issue: 11
Pages: 4706-13
Publication
First Author: Lu W
Year: 2015
Journal: Nat Immunol
Title: The microRNA miR-22 inhibits the histone deacetylase HDAC4 to promote T(H)17 cell-dependent emphysema.
Volume: 16
Issue: 11
Pages: 1185-94
Publication
First Author: Marroncelli N
Year: 2018
Journal: Sci Rep
Title: HDAC4 regulates satellite cell proliferation and differentiation by targeting P21 and Sharp1 genes.
Volume: 8
Issue: 1
Pages: 3448
Publication
First Author: Sando R 3rd
Year: 2012
Journal: Cell
Title: HDAC4 governs a transcriptional program essential for synaptic plasticity and memory.
Volume: 151
Issue: 4
Pages: 821-34
Publication
First Author: Wang H
Year: 2019
Journal: J Cell Physiol
Title: Chondrocyte mTORC1 activation stimulates miR-483-5p via HDAC4 in osteoarthritis progression.
Volume: 234
Issue: 3
Pages: 2730-2740
Publication
First Author: Luo L
Year: 2019
Journal: Cell Rep
Title: HDAC4 Controls Muscle Homeostasis through Deacetylation of Myosin Heavy Chain, PGC-1α, and Hsc70.
Volume: 29
Issue: 3
Pages: 749-763.e12
Publication
First Author: Cohen TJ
Year: 2009
Journal: FASEB J
Title: The deacetylase HDAC4 controls myocyte enhancing factor-2-dependent structural gene expression in response to neural activity.
Volume: 23
Issue: 1
Pages: 99-106
Publication
First Author: Li J
Year: 2012
Journal: Nat Med
Title: Nuclear accumulation of HDAC4 in ATM deficiency promotes neurodegeneration in ataxia telangiectasia.
Volume: 18
Issue: 5
Pages: 783-90
Publication
First Author: Cohen TJ
Year: 2007
Journal: J Biol Chem
Title: The histone deacetylase HDAC4 connects neural activity to muscle transcriptional reprogramming.
Volume: 282
Issue: 46
Pages: 33752-9
Publication
First Author: Mielcarek M
Year: 2013
Journal: PLoS Biol
Title: HDAC4 reduction: a novel therapeutic strategy to target cytoplasmic huntingtin and ameliorate neurodegeneration.
Volume: 11
Issue: 11
Pages: e1001717
Publication
First Author: Zhang LX
Year: 2014
Journal: Am J Physiol Cell Physiol
Title: Specific inhibition of HDAC4 in cardiac progenitor cells enhances myocardial repairs.
Volume: 307
Issue: 4
Pages: C358-72
Publication
First Author: Mielcarek M
Year: 2013
Journal: PLoS One
Title: HDAC4 does not act as a protein deacetylase in the postnatal murine brain in vivo.
Volume: 8
Issue: 11
Pages: e80849
Publication
First Author: Matsushima S
Year: 2013
Journal: Circ Res
Title: Increased oxidative stress in the nucleus caused by Nox4 mediates oxidation of HDAC4 and cardiac hypertrophy.
Volume: 112
Issue: 4
Pages: 651-63
Publication
First Author: Gupta MP
Year: 2008
Journal: J Biol Chem
Title: HDAC4 and PCAF bind to cardiac sarcomeres and play a role in regulating myofilament contractile activity.
Volume: 283
Issue: 15
Pages: 10135-46
Publication
First Author: Ozcan L
Year: 2016
Journal: Cell Rep
Title: Hepatocyte DACH1 Is Increased in Obesity via Nuclear Exclusion of HDAC4 and Promotes Hepatic Insulin Resistance.
Volume: 15
Issue: 10
Pages: 2214-2225
Publication
First Author: Shimizu E
Year: 2010
Journal: J Biol Chem
Title: HDAC4 represses matrix metalloproteinase-13 transcription in osteoblastic cells, and parathyroid hormone controls this repression.
Volume: 285
Issue: 13
Pages: 9616-26
Publication  
First Author: Nakatani T
Year: 2016
Journal: Bone
Title: MMP-13 is one of the critical mediators of the effect of HDAC4 deletion on the skeleton.
Volume: 90
Pages: 142-51
Publication
First Author: Rajan I
Year: 2009
Journal: PLoS One
Title: Loss of the putative catalytic domain of HDAC4 leads to reduced thermal nociception and seizures while allowing normal bone development.
Volume: 4
Issue: 8
Pages: e6612
Publication
First Author: Zhang LX
Year: 2018
Journal: J Appl Physiol (1985)
Title: Transgenic overexpression of active HDAC4 in the heart attenuates cardiac function and exacerbates remodeling in infarcted myocardium.
Volume: 125
Issue: 6
Pages: 1968-1978
Publication
First Author: Liu Y
Year: 2013
Journal: J Physiol
Title: Opposing HDAC4 nuclear fluxes due to phosphorylation by β-adrenergic activated protein kinase A or by activity or Epac activated CaMKII in skeletal muscle fibres.
Volume: 591
Issue: 14
Pages: 3605-23
Publication
First Author: Liu Y
Year: 2012
Journal: Am J Physiol Cell Physiol
Title: NOX2-dependent ROS is required for HDAC5 nuclear efflux and contributes to HDAC4 nuclear efflux during intense repetitive activity of fast skeletal muscle fibers.
Volume: 303
Issue: 3
Pages: C334-47
Publication  
First Author: Ha N
Year: 2022
Journal: Front Physiol
Title: Hdac4 Regulates the Proliferation of Neural Crest-Derived Osteoblasts During Murine Craniofacial Development.
Volume: 13
Pages: 819619
Publication  
First Author: Davis KC
Year: 2020
Journal: Front Neurosci
Title: Behavioral Alterations in Mice Carrying Homozygous HDAC4 A778T Missense Mutation Associated With Eating Disorder.
Volume: 14
Pages: 139
Publication
First Author: Backs J
Year: 2006
Journal: Circ Res
Title: Control of cardiac growth by histone acetylation/deacetylation.
Volume: 98
Issue: 1
Pages: 15-24
Publication
First Author: Kim MS
Year: 2012
Journal: J Neurosci
Title: An essential role for histone deacetylase 4 in synaptic plasticity and memory formation.
Volume: 32
Issue: 32
Pages: 10879-86
Publication  
First Author: Finke D
Year: 2021
Journal: J Mol Cell Cardiol
Title: Histone deacetylase 4 deletion broadly affects cardiac epigenetic repression and regulates transcriptional susceptibility via H3K9 methylation.
Volume: 162
Pages: 119-129
Publication  
First Author: Pigna E
Year: 2019
Journal: EBioMedicine
Title: Histone deacetylase 4 protects from denervation and skeletal muscle atrophy in a murine model of amyotrophic lateral sclerosis.
Volume: 40
Pages: 717-732
Publication
First Author: Gomis-Coloma C
Year: 2018
Journal: J Cell Biol
Title: Class IIa histone deacetylases link cAMP signaling to the myelin transcriptional program of Schwann cells.
Volume: 217
Issue: 4
Pages: 1249-1268
Publication
First Author: Vega RB
Year: 2004
Journal: Cell
Title: Histone deacetylase 4 controls chondrocyte hypertrophy during skeletogenesis.
Volume: 119
Issue: 4
Pages: 555-66
Publication
First Author: Price V
Year: 2013
Journal: J Neurosci Res
Title: Conditional deletion of histone deacetylase-4 in the central nervous system has no major effect on brain architecture or neuronal viability.
Volume: 91
Issue: 3
Pages: 407-15
Publication  
First Author: Wein MN
Year: 2016
Journal: Nat Commun
Title: SIKs control osteocyte responses to parathyroid hormone.
Volume: 7
Pages: 13176
Publication  
First Author: Meyers CMG
Year: 2022
Journal: Bone
Title: Histone deacetylase 5 is a phosphorylation substrate of protein kinase D in osteoclasts.
Volume: 159
Pages: 116393
Publication    
First Author: Velasco-Aviles S
Year: 2022
Journal: Elife
Title: A genetic compensatory mechanism regulated by Jun and Mef2d modulates the expression of distinct class IIa Hdacs to ensure peripheral nerve myelination and repair.
Volume: 11
Publication
First Author: Lehmann LH
Year: 2018
Journal: Nat Med
Title: A proteolytic fragment of histone deacetylase 4 protects the heart from failure by regulating the hexosamine biosynthetic pathway.
Volume: 24
Issue: 1
Pages: 62-72
Publication
First Author: Williams AH
Year: 2009
Journal: Science
Title: MicroRNA-206 delays ALS progression and promotes regeneration of neuromuscular synapses in mice.
Volume: 326
Issue: 5959
Pages: 1549-54
Publication
First Author: Sato T
Year: 2020
Journal: Nat Commun
Title: A FAK/HDAC5 signaling axis controls osteocyte mechanotransduction.
Volume: 11
Issue: 1
Pages: 3282
Publication
First Author: Choi MC
Year: 2012
Journal: Mol Cell
Title: A direct HDAC4-MAP kinase crosstalk activates muscle atrophy program.
Volume: 47
Issue: 1
Pages: 122-32
Publication
First Author: Lutter M
Year: 2017
Journal: Biol Psychiatry
Title: The Eating-Disorder Associated HDAC4A778T Mutation Alters Feeding Behaviors in Female Mice.
Volume: 81
Issue: 9
Pages: 770-777
Publication
First Author: Cernotta N
Year: 2011
Journal: Mol Biol Cell
Title: Ubiquitin-dependent degradation of HDAC4, a new regulator of random cell motility.
Volume: 22
Issue: 2
Pages: 278-89
Publication
First Author: Huang YH
Year: 2015
Journal: PLoS One
Title: Activation of Mir-29a in Activated Hepatic Stellate Cells Modulates Its Profibrogenic Phenotype through Inhibition of Histone Deacetylases 4.
Volume: 10
Issue: 8
Pages: e0136453
Publication
First Author: Saha P
Year: 2019
Journal: J Neurotrauma
Title: Histone Deacetylase 4 Downregulation Elicits Post-Traumatic Psychiatric Disorders through Impairment of Neurogenesis.
Volume: 36
Issue: 23
Pages: 3284-3296
Publication
First Author: Wu Q
Year: 2017
Journal: Mol Neurobiol
Title: Nuclear Accumulation of Histone Deacetylase 4 (HDAC4) Exerts Neurotoxicity in Models of Parkinson's Disease.
Volume: 54
Issue: 9
Pages: 6970-6983
Publication
First Author: Di Giorgio E
Year: 2013
Journal: Mol Cell Biol
Title: MEF2 is a converging hub for histone deacetylase 4 and phosphatidylinositol 3-kinase/Akt-induced transformation.
Volume: 33
Issue: 22
Pages: 4473-91
Publication
First Author: Kim SJ
Year: 2022
Journal: Nature
Title: Kinase signalling in excitatory neurons regulates sleep quantity and depth.
Volume: 612
Issue: 7940
Pages: 512-518
Publication
First Author: Ago T
Year: 2008
Journal: Cell
Title: A redox-dependent pathway for regulating class II HDACs and cardiac hypertrophy.
Volume: 133
Issue: 6
Pages: 978-93
Publication
First Author: Asano F
Year: 2023
Journal: Proc Natl Acad Sci U S A
Title: SIK3-HDAC4 in the suprachiasmatic nucleus regulates the timing of arousal at the dark onset and circadian period in mice.
Volume: 120
Issue: 11
Pages: e2218209120
Publication  
First Author: Yuan H
Year: 2016
Journal: Neurobiol Dis
Title: Nuclear translocation of histone deacetylase 4 induces neuronal death in stroke.
Volume: 91
Pages: 182-93
Publication
First Author: Ling S
Year: 2012
Journal: Circulation
Title: CKIP-1 inhibits cardiac hypertrophy by regulating class II histone deacetylase phosphorylation through recruiting PP2A.
Volume: 126
Issue: 25
Pages: 3028-40
Publication
First Author: Lemercier C
Year: 2000
Journal: J Biol Chem
Title: mHDA1/HDAC5 histone deacetylase interacts with and represses MEF2A transcriptional activity.
Volume: 275
Issue: 20
Pages: 15594-9
Publication
First Author: Sailaja BS
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Stress-induced epigenetic transcriptional memory of acetylcholinesterase by HDAC4.
Volume: 109
Issue: 52
Pages: E3687-95
Publication
First Author: Chen Y
Year: 2014
Journal: J Neurosci
Title: Regulation of neuronal gene expression and survival by basal NMDA receptor activity: a role for histone deacetylase 4.
Volume: 34
Issue: 46
Pages: 15327-39
Publication
First Author: Litke C
Year: 2018
Journal: J Biol Chem
Title: Histone deacetylase 4 shapes neuronal morphology via a mechanism involving regulation of expression of vascular endothelial growth factor D.
Volume: 293
Issue: 21
Pages: 8196-8207
Publication  
First Author: Chen W
Year: 2016
Journal: Int J Mol Sci
Title: MicroRNA-381 Regulates Chondrocyte Hypertrophy by Inhibiting Histone Deacetylase 4 Expression.
Volume: 17
Issue: 9
Publication
First Author: Luan B
Year: 2014
Journal: Cell Metab
Title: Leptin-mediated increases in catecholamine signaling reduce adipose tissue inflammation via activation of macrophage HDAC4.
Volume: 19
Issue: 6
Pages: 1058-65
Publication
First Author: Zhang T
Year: 2007
Journal: J Biol Chem
Title: CaMKIIdelta isoforms differentially affect calcium handling but similarly regulate HDAC/MEF2 transcriptional responses.
Volume: 282
Issue: 48
Pages: 35078-87
Publication
First Author: Tang H
Year: 2009
Journal: Mol Biol Cell
Title: A histone deacetylase 4/myogenin positive feedback loop coordinates denervation-dependent gene induction and suppression.
Volume: 20
Issue: 4
Pages: 1120-31
Publication
First Author: Trazzi S
Year: 2016
Journal: Hum Mol Genet
Title: HDAC4: a key factor underlying brain developmental alterations in CDKL5 disorder.
Volume: 25
Issue: 18
Pages: 3887-3907
Publication
First Author: Abend A
Year: 2017
Journal: EMBO Rep
Title: Salt-inducible kinase induces cytoplasmic histone deacetylase 4 to promote vascular calcification.
Volume: 18
Issue: 7
Pages: 1166-1185
Publication
First Author: Bongers KS
Year: 2013
Journal: Am J Physiol Endocrinol Metab
Title: Skeletal muscle denervation causes skeletal muscle atrophy through a pathway that involves both Gadd45a and HDAC4.
Volume: 305
Issue: 7
Pages: E907-15
Publication
First Author: Jeong BC
Year: 2004
Journal: Mol Endocrinol
Title: Androgen receptor corepressor-19 kDa (ARR19), a leucine-rich protein that represses the transcriptional activity of androgen receptor through recruitment of histone deacetylase.
Volume: 18
Issue: 1
Pages: 13-25
Publication
First Author: Backs J
Year: 2008
Journal: Mol Cell Biol
Title: Histone deacetylase 5 acquires calcium/calmodulin-dependent kinase II responsiveness by oligomerization with histone deacetylase 4.
Volume: 28
Issue: 10
Pages: 3437-45
Publication
First Author: Yang Q
Year: 2015
Journal: Mol Cell Biol
Title: Cross talk between histone deacetylase 4 and STAT6 in the transcriptional regulation of arginase 1 during mouse dendritic cell differentiation.
Volume: 35
Issue: 1
Pages: 63-75
Publication
First Author: Kang H
Year: 2021
Journal: J Pathol
Title: The loss of histone deacetylase 4 in macrophages exacerbates hepatic and adipose tissue inflammation in male but not in female mice with diet-induced non-alcoholic steatohepatitis.
Volume: 255
Issue: 3
Pages: 319-329
Publication
First Author: Kang JS
Year: 2005
Journal: EMBO J
Title: Repression of Runx2 function by TGF-beta through recruitment of class II histone deacetylases by Smad3.
Volume: 24
Issue: 14
Pages: 2543-55
Publication
First Author: Moresi V
Year: 2010
Journal: Cell
Title: Myogenin and class II HDACs control neurogenic muscle atrophy by inducing E3 ubiquitin ligases.
Volume: 143
Issue: 1
Pages: 35-45
Publication
First Author: Niu Y
Year: 2017
Journal: Biochim Biophys Acta
Title: Exercise-induced GLUT4 transcription via inactivation of HDAC4/5 in mouse skeletal muscle in an AMPKα2-dependent manner.
Volume: 1863
Issue: 9
Pages: 2372-2381
Publication
First Author: Micheli L
Year: 2005
Journal: Mol Cell Biol
Title: PC4 coactivates MyoD by relieving the histone deacetylase 4-mediated inhibition of myocyte enhancer factor 2C.
Volume: 25
Issue: 6
Pages: 2242-59
Publication
First Author: McKinsey TA
Year: 2006
Journal: Mol Biol Cell
Title: Class II histone deacetylases confer signal responsiveness to the ankyrin-repeat proteins ANKRA2 and RFXANK.
Volume: 17
Issue: 1
Pages: 438-47
Publication
First Author: Kozhemyakina E
Year: 2009
Journal: Mol Cell Biol
Title: Parathyroid hormone-related peptide represses chondrocyte hypertrophy through a protein phosphatase 2A/histone deacetylase 4/MEF2 pathway.
Volume: 29
Issue: 21
Pages: 5751-62
Publication
First Author: Pan Z
Year: 2008
Journal: Dev Dyn
Title: Impaired placental trophoblast lineage differentiation in Alkbh1(-/-) mice.
Volume: 237
Issue: 2
Pages: 316-27
Publication
First Author: Arnold MA
Year: 2007
Journal: Dev Cell
Title: MEF2C transcription factor controls chondrocyte hypertrophy and bone development.
Volume: 12
Issue: 3
Pages: 377-89
Publication
First Author: Paulo E
Year: 2018
Journal: Sci Rep
Title: Sympathetic inputs regulate adaptive thermogenesis in brown adipose tissue through cAMP-Salt inducible kinase axis.
Volume: 8
Issue: 1
Pages: 11001
Publication  
First Author: Schneider S
Year: 2024
Journal: J Clin Invest
Title: BAP1 is required prenatally for differentiation and maintenance of postnatal murine enteric nervous system.
Volume: 134
Issue: 9
Publication
First Author: Lenoir O
Year: 2011
Journal: Diabetes
Title: Specific control of pancreatic endocrine β- and δ-cell mass by class IIa histone deacetylases HDAC4, HDAC5, and HDAC9.
Volume: 60
Issue: 11
Pages: 2861-71
Publication
First Author: Kang Y
Year: 2013
Journal: Circ Res
Title: Apelin-APJ signaling is a critical regulator of endothelial MEF2 activation in cardiovascular development.
Volume: 113
Issue: 1
Pages: 22-31
Publication
First Author: Sasagawa S
Year: 2012
Journal: Development
Title: SIK3 is essential for chondrocyte hypertrophy during skeletal development in mice.
Volume: 139
Issue: 6
Pages: 1153-63
Publication
First Author: Wang W
Year: 2016
Journal: PLoS Genet
Title: Smad2 and Smad3 Regulate Chondrocyte Proliferation and Differentiation in the Growth Plate.
Volume: 12
Issue: 10
Pages: e1006352
Publication
First Author: Potthoff MJ
Year: 2007
Journal: J Clin Invest
Title: Histone deacetylase degradation and MEF2 activation promote the formation of slow-twitch myofibers.
Volume: 117
Issue: 9
Pages: 2459-67
Publication
First Author: Nishimori S
Year: 2019
Journal: J Clin Invest
Title: Salt-inducible kinases dictate parathyroid hormone 1 receptor action in bone development and remodeling.
Volume: 129
Issue: 12
Pages: 5187-5203
Publication  
First Author: Ono W
Year: 2016
Journal: Nat Commun
Title: Parathyroid hormone receptor signalling in osterix-expressing mesenchymal progenitors is essential for tooth root formation.
Volume: 7
Pages: 11277
Publication
First Author: Richard AF
Year: 2011
Journal: Dev Biol
Title: Genesis of muscle fiber-type diversity during mouse embryogenesis relies on Six1 and Six4 gene expression.
Volume: 359
Issue: 2
Pages: 303-20
Publication
First Author: Kim HN
Year: 2011
Journal: J Bone Miner Res
Title: Histone deacetylase inhibitor MS-275 stimulates bone formation in part by enhancing Dhx36-mediated TNAP transcription.
Volume: 26
Issue: 9
Pages: 2161-73
Publication
First Author: Heverin M
Year: 2007
Journal: Arterioscler Thromb Vasc Biol
Title: Studies on the cholesterol-free mouse: strong activation of LXR-regulated hepatic genes when replacing cholesterol with desmosterol.
Volume: 27
Issue: 10
Pages: 2191-7
Publication
First Author: Wang Y
Year: 2017
Journal: Diabetes
Title: Adipocyte Liver Kinase b1 Suppresses Beige Adipocyte Renaissance Through Class IIa Histone Deacetylase 4.
Volume: 66
Issue: 12
Pages: 2952-2963
Publication
First Author: Weems JC
Year: 2012
Journal: Diabetes
Title: Class II histone deacetylases downregulate GLUT4 transcription in response to increased cAMP signaling in cultured adipocytes and fasting mice.
Volume: 61
Issue: 6
Pages: 1404-14
Publication
First Author: Zhu Y
Year: 2019
Journal: Nat Commun
Title: Class IIa HDACs regulate learning and memory through dynamic experience-dependent repression of transcription.
Volume: 10
Issue: 1
Pages: 3469