This entry includes chromatin assembly factor 1 subunit CHAF1B (also known as p60 subunit) from animals, and its homologues such as Cac2 from yeasts and FAS from Arabidopsis. They are a component of the chromatin assembly factor complex (CAF-1), an evolutionarily conserved heterotrimeric chaperone comprised of p150, p60 and p48 subunits, mediates DNA synthesis-coupled chromatin assembly in S-phase. It is also involved in chromatin assembly following DNA repair [, ]. In plants, the loss of activity of the CAF1 pathway causes delay and arrest of the cell cycle during pollen development []. The CAF1 complex is also required for stable maintenance of telomeres and 45S rDNA in Arabidopsis [].
