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Search results 101 to 130 out of 130 for Sae1

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Type Details Score
Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
34509475 | J:329804
First Author: Chen X
Year: 2021
Journal: J Biol Chem
Title: The SUMO-specific protease SENP2 plays an essential role in the regulation of Kv7.2 and Kv7.3 potassium channels.
Volume: 297
Issue: 4
Pages: 101183
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Protein Domain
IPR000011 | UBQ/SUMO-activ_enz_E1-like
Type: Family
Description: The post-translational attachment of ubiquitin () to proteins (ubiquitinylation) alters the function, location or trafficking of a protein, or targets it to the 26S proteasome for degradation [, , ]. Ubiquitinylation is an ATP-dependent process that involves the action of at least three enzymes: a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2, ), and a ubiquitin ligase (E3, , ), which work sequentially in a cascade []. The E1 enzyme is responsible for activating ubiquitin, the first step in ubiquitinylation. The E1 enzyme hydrolyses ATP and adenylates the C-terminal glycine residue of ubiquitin, and then links this residue to the active site cysteine of E1, yielding a ubiquitin-thioester and free AMP. To be fully active, E1 must non-covalently bind to and adenylate a second ubiquitin molecule. The E1 enzyme can then transfer the thioester-linked ubiquitin molecule to a cysteine residue on the ubiquitin-conjugating enzyme, E2, in an ATP-dependent reaction.This entry includes Ubiquitin-activating enzyme E1 (Uba1), SUMO-activating enzyme subunit 1 (Sae1) and similar proteins from eukaryotes. Sae1 is an heterodimer that acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4 and mediates ATP-dependent activation of SUMO proteins [, , ].
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Publication
20164921 | -
First Author: Olsen SK
Year: 2010
Journal: Nature
Title: Active site remodelling accompanies thioester bond formation in the SUMO E1.
Volume: 463
Issue: 7283
Pages: 906-12
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Publication
11451954 | -
First Author: Tatham MH
Year: 2001
Journal: J Biol Chem
Title: Polymeric chains of SUMO-2 and SUMO-3 are conjugated to protein substrates by SAE1/SAE2 and Ubc9.
Volume: 276
Issue: 38
Pages: 35368-74
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Protein
Q9R1T2
Organism: Mus musculus/domesticus
Length: 350  
Fragment?: false
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Protein
Q61341
Organism: Mus musculus/domesticus
Length: 179  
Fragment?: true
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Publication
15196553 | -
First Author: Sun L
Year: 2004
Journal: Curr Opin Cell Biol
Title: The novel functions of ubiquitination in signaling.
Volume: 16
Issue: 2
Pages: 119-26
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Publication
15660128 | -
First Author: Lois LM
Year: 2005
Journal: EMBO J
Title: Structures of the SUMO E1 provide mechanistic insights into SUMO activation and E2 recruitment to E1.
Volume: 24
Issue: 3
Pages: 439-51
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Protein
H3BJA7
Organism: Mus musculus/domesticus
Length: 410  
Fragment?: false
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Protein
Q9ET03
Organism: Mus musculus/domesticus
Length: 775  
Fragment?: true
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Protein
Q8BTN4
Organism: Mus musculus/domesticus
Length: 905  
Fragment?: false
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Publication
15556404 | -
First Author: Pickart CM
Year: 2004
Journal: Curr Opin Chem Biol
Title: Polyubiquitin chains: polymeric protein signals.
Volume: 8
Issue: 6
Pages: 610-6
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Protein
Q8C7R4
Organism: Mus musculus/domesticus
Length: 1053  
Fragment?: false
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Protein
P31254
Organism: Mus musculus/domesticus
Length: 1058  
Fragment?: false
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Protein
Q02053
Organism: Mus musculus/domesticus
Length: 1058  
Fragment?: false
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Protein
Q9DBK7
Organism: Mus musculus/domesticus
Length: 977  
Fragment?: false
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Protein
D3Z061
Organism: Mus musculus/domesticus
Length: 1022  
Fragment?: false
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Protein
B9EHN0
Organism: Mus musculus/domesticus
Length: 1058  
Fragment?: false
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Protein
A0A1S6GWH5
Organism: Mus musculus/domesticus
Length: 1118  
Fragment?: false
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Publication
15454246 | -
First Author: Burger AM
Year: 2004
Journal: Eur J Cancer
Title: The ubiquitin-mediated protein degradation pathway in cancer: therapeutic implications.
Volume: 40
Issue: 15
Pages: 2217-29
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Publication
14998368 | -
First Author: Passmore LA
Year: 2004
Journal: Biochem J
Title: Getting into position: the catalytic mechanisms of protein ubiquitylation.
Volume: 379
Issue: Pt 3
Pages: 513-25
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