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Search results 301 to 369 out of 369 for Dpy30

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Type Details Score
Publication
14992727 | J:88588
First Author: Hughes CM
Year: 2004
Journal: Mol Cell
Title: Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus.
Volume: 13
Issue: 4
Pages: 587-97
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Publication
19651892 | -
First Author: Xu Z
Year: 2009
Journal: J Cell Biol
Title: A role of histone H3 lysine 4 methyltransferase components in endosomal trafficking.
Volume: 186
Issue: 3
Pages: 343-53
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Protein Domain
IPR037856 | Sdc1/DPY30
Type: Family
Description: This entry includes Sdc1 from yeasts, and its homologues, Dpy-30, from animals. Protein dpy-30 homologue (DPY30) is a component of the MLL1/MLL complex which trimethylates histone H3 at 'Lys-4' as a specific tag for epigenetic transcriptional activation []. DPY30 is also a component in MLL2/3 and MLL4/WBP7 methyltransferase-containing complexes [, ]and the SET1 complex []. DPY30 is found in the nucleus and the trans-Golgi network where it interacts with ARFGEF1 implying a role in endosomal trafficking []. This entry also includes C. elegans dpy-30, which is an essential component of the C. elegans dosage compensation machinery that reduces X chromosome transcript levels in hermaphrodites (XX) [].The SET1 complex is a methyltransferase that that produces trimethylated histone H3 at Lys(4). It is composed of at least the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30 []. In yeast there is only one SET1 complex, but in mammals there are additional H3K4 methylases [].
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HT Experiment
GSE134181 | TrxG complex catalytic and non-catalytic activity play distinct roles in pancreas progenitor specification and differentiation (E18.5 Dpy30deltaP pancreas scRNA-seq)
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
36417862 | J:332237
First Author: Zhang X
Year: 2022
Journal: Cell Rep
Title: Differential requirements of IQUB for the assembly of radial spoke 1 and the motility of mouse cilia and flagella.
Volume: 41
Issue: 8
Pages: 111683
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HT Experiment
GSE134179 | TrxG complex catalytic and non-catalytic activity play distinct roles in pancreas progenitor specification and differentiation (E13.5 Dpy30deltaP pancreas scRNA-Seq)
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
35819198 | J:334136
First Author: Bochyńska A
Year: 2022
Journal: Nucleic Acids Res
Title: Induction of senescence upon loss of the Ash2l core subunit of H3K4 methyltransferase complexes.
Volume: 50
Issue: 14
Pages: 7889-7905
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Publication
34795238 | J:332364
First Author: Gu Y
Year: 2021
Journal: Nat Commun
Title: ABHD5 inhibits YAP-induced c-Met overexpression and colon cancer cell stemness via suppressing YAP methylation.
Volume: 12
Issue: 1
Pages: 6711
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Protein
Q99LT0
Organism: Mus musculus/domesticus
Length: 99  
Fragment?: false
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Publication
7588066 | -
First Author: Hsu DR
Year: 1995
Journal: Development
Title: DPY-30, a nuclear protein essential early in embryogenesis for Caenorhabditis elegans dosage compensation.
Volume: 121
Issue: 10
Pages: 3323-34
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Publication
19556245 | -
First Author: Patel A
Year: 2009
Journal: J Biol Chem
Title: On the mechanism of multiple lysine methylation by the human mixed lineage leukemia protein-1 (MLL1) core complex.
Volume: 284
Issue: 36
Pages: 24242-56
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Protein Domain
IPR037841 | SETD1A
Type: Family
Description: In animals, histone-lysine N-methyltransferase SETD1A () is a histone methyltransferase that produces mono-, di-, and trimethylated histone H3 at 'Lys-4. However, if 'Lys-9' residue is already methylated, 'Lys-4' will not be. The 'Lys-4' methylation is a tag for epigenetic transcriptional activation [, ]. The SET1 complex contains either SETD1A or SETD1B.The SET1 complex is a methyltransferase that that produces trimethylated histone H3 at Lys(4). It is composed of at least the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30 []. In yeast there is only one SET1 complex, but in mammals there are additional H3K4 methylases [].
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Protein Domain
IPR037842 | SETD1B
Type: Family
Description: Histone-lysine N-methyltransferase SETD1B () is a histone methyltransferase that produces trimethylated histone H3 at 'Lys-4'. However, if 'Lys-9' residue is already methylated, 'Lys-4' will not be. The 'Lys-4' methylation is a tag for epigenetic transcriptional activation []. The SET1 complex contains either SETD1A or SETD1B.The SET1 complex is a methyltransferase that that produces trimethylated histone H3 at Lys(4). It is composed of at least the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30 []. In yeast there is only one SET1 complex, but in mammals there are additional H3K4 methylases [].
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Publication
16990798 | -
First Author: Allen MD
Year: 2006
Journal: EMBO J
Title: Solution structure of the nonmethyl-CpG-binding CXXC domain of the leukaemia-associated MLL histone methyltransferase.
Volume: 25
Issue: 19
Pages: 4503-12
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Publication
12453419 | -
First Author: Nakamura T
Year: 2002
Journal: Mol Cell
Title: ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation.
Volume: 10
Issue: 5
Pages: 1119-28
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Publication
26886794 | -
First Author: Li Y
Year: 2016
Journal: Nature
Title: Structural basis for activity regulation of MLL family methyltransferases.
Volume: 530
Issue: 7591
Pages: 447-52
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Protein Domain
IPR041958 | KMT2A_ePHD
Type: Domain
Description: The extended plant homeodomain (ePHD) zinc finger is characterized as Cys2HisCys5HisCys2His. This entry represents the ePHD finger of Histone-lysine N-methyltransferase 2A (KMT2A), which is a histone methyltransferase that belongs to the MLL subfamily of H3K4-specific histone lysine methyltransferases (KMT2). It regulates chromatin-mediated transcription through the catalysis of methylation of histone 3 lysine 4 (H3K4), and is frequently rearranged in acute leukemia []. KMT2A functions as the catalytic subunit in the MLL1 complex, which also contains WDR5, RbBP5, ASH2L and DPY30 as integral core subunits required for the efficient methylation activity of the complex [, ]. The MLL1 complex is highly active and specific for H3K4 methylation. KMT2A contains a CxxC (x for any residue) zinc finger domain, three PHD fingers, a Bromodomain domain, this extended PHD finger, two FY (phenylalanine tyrosine)-rich domains, and a SET (Suppressor of variegation, Enhancer of zeste, Trithorax) domain [].
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Protein
D3YXL2
Organism: Mus musculus/domesticus
Length: 70  
Fragment?: true
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Publication
16253997 | -
First Author: Lee JH
Year: 2005
Journal: J Biol Chem
Title: CpG-binding protein (CXXC finger protein 1) is a component of the mammalian Set1 histone H3-Lys4 methyltransferase complex, the analogue of the yeast Set1/COMPASS complex.
Volume: 280
Issue: 50
Pages: 41725-31
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Publication
17355966 | -
First Author: Lee JH
Year: 2007
Journal: J Biol Chem
Title: Identification and characterization of the human Set1B histone H3-Lys4 methyltransferase complex.
Volume: 282
Issue: 18
Pages: 13419-28
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Publication
18838538 | -
First Author: Wu M
Year: 2008
Journal: Mol Cell Biol
Title: Molecular regulation of H3K4 trimethylation by Wdr82, a component of human Set1/COMPASS.
Volume: 28
Issue: 24
Pages: 7337-44
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Publication
10637508 | -
First Author: Huntsman DG
Year: 1999
Journal: Oncogene
Title: MLL2, the second human homolog of the Drosophila trithorax gene, maps to 19q13.1 and is amplified in solid tumor cell lines.
Volume: 18
Issue: 56
Pages: 7975-84
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Publication
23426673 | J:194254
First Author: Kerimoglu C
Year: 2013
Journal: J Neurosci
Title: Histone-methyltransferase MLL2 (KMT2B) is required for memory formation in mice.
Volume: 33
Issue: 8
Pages: 3452-64
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Publication
23358417 | J:203327
First Author: Ladopoulos V
Year: 2013
Journal: Mol Cell Biol
Title: The histone methyltransferase KMT2B is required for RNA polymerase II association and protection from DNA methylation at the MagohB CpG island promoter.
Volume: 33
Issue: 7
Pages: 1383-93
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Publication
10409430 | -
First Author: FitzGerald KT
Year: 1999
Journal: Genomics
Title: MLL2: A new mammalian member of the trx/MLL family of genes.
Volume: 59
Issue: 2
Pages: 187-92
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Publication
29323282 | J:308602
First Author: Hanna CW
Year: 2018
Journal: Nat Struct Mol Biol
Title: MLL2 conveys transcription-independent H3K4 trimethylation in oocytes.
Volume: 25
Issue: 1
Pages: 73-82
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Publication
16540515 | J:107403
First Author: Glaser S
Year: 2006
Journal: Development
Title: Multiple epigenetic maintenance factors implicated by the loss of Mll2 in mouse development.
Volume: 133
Issue: 8
Pages: 1423-32
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Publication
19726574 | -
First Author: Berr A
Year: 2009
Journal: Plant Physiol
Title: SET DOMAIN GROUP25 encodes a histone methyltransferase and is involved in FLOWERING LOCUS C activation and repression of flowering.
Volume: 151
Issue: 3
Pages: 1476-85
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Protein Domain
IPR041959 | KMT2B_ePHD
Type: Domain
Description: The extended plant homeodomain (ePHD) zinc finger is characterized as Cys2HisCys5HisCys2His. This entry represents the ePHD finger of Histone-lysine N-methyltransferase 2B (KMT2B), also known as MLL2. KMT2B is a second human homologue of Drosophila trithorax, located on chromosome 19 [, ]. It belongs to the MLL subfamily of H3K4-specific histone lysine methyltransferases (KMT2) and is vital for normal mammalian embryonic development []. KMT2B functions as the catalytic subunit in the MLL2 complex, which contains WDR5, RbBP5, ASH2L and DPY30 as integral core subunits required for the efficient methylation activity of the complex. The MLL2 complex is highly active and specific for histone 3 lysine 4 (H3K4) methylation, which stimulates chromatin transcription in a SAM- and H3K4-dependent manner []. Moreover, KMT2B plays a critical role in memory formation by mediating hippocampal H3K4 di- and trimethylation []. It is also required for RNA polymerase II association and protection from DNA methylation at the MagohB CpG island promoter []. KMT2B contains a CxxC (x for any residue) zinc finger domain, three PHD fingers, this ePHD finger, two FY (phenylalanine tyrosine)-rich domains, and a SET (Suppressor of variegation, Enhancer of zeste, Trithorax) domain.
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Protein Domain
IPR044570 | Set1-like
Type: Family
Description: The COMPASS complex (complex proteins associated with Set1) is conserved in yeasts and in other eukaryotes up to humans. This entry represents Set1 and its homologues. Set1 is a methyltransferase and the catalytic component of the COMPASS that produces trimethylated histone H3 at Lys(4). The yeast COMPASS (Set1C) complex specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation [, , ]. In yeasts, the Set1C complex consists of Set1(2), Bre2(2), Spp1(2), Sdc1(1), Shg1(1), Swd1(1), Swd2(1), and Swd3(1) [, , , ].In animals, SETD1A/B are histone methyltransferases that produce mono-, di-, and trimethylated histone H3 at 'Lys-4. However, if 'Lys-9' residue is already methylated, 'Lys-4' will not be. The 'Lys-4' methylation is a tag for epigenetic transcriptional activation [, ]. The animal COMPASS complex is composed of at least the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30 []. ATXR7, the Arabidopsis homologue to Set1, is required for the expression of the flowering repressors FLC and MADS-box genes of the MAF family [, ]. ATXR7 is also involved in the control of seed dormancy and germination [].
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Publication
18849979 | -
First Author: Vitaliano-Prunier A
Year: 2008
Journal: Nat Cell Biol
Title: Ubiquitylation of the COMPASS component Swd2 links H2B ubiquitylation to H3K4 trimethylation.
Volume: 10
Issue: 11
Pages: 1365-71
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Publication
18083099 | -
First Author: Lee JS
Year: 2007
Journal: Cell
Title: Histone crosstalk between H2B monoubiquitination and H3 methylation mediated by COMPASS.
Volume: 131
Issue: 6
Pages: 1084-96
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Publication
12488447 | -
First Author: Roguev A
Year: 2003
Journal: J Biol Chem
Title: High conservation of the Set1/Rad6 axis of histone 3 lysine 4 methylation in budding and fission yeasts.
Volume: 278
Issue: 10
Pages: 8487-93
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Publication
9988274 | -
First Author: Corda Y
Year: 1999
Journal: Nat Genet
Title: Interaction between Set1p and checkpoint protein Mec3p in DNA repair and telomere functions.
Volume: 21
Issue: 2
Pages: 204-8
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Publication
14617822 | -
First Author: Roguev A
Year: 2004
Journal: Mol Cell Proteomics
Title: A comparative analysis of an orthologous proteomic environment in the yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe.
Volume: 3
Issue: 2
Pages: 125-32
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Publication
27914912 | J:240319
First Author: Stauber M
Year: 2017
Journal: Dev Biol
Title: Identification of FOXJ1 effectors during ciliogenesis in the foetal respiratory epithelium and embryonic left-right organiser of the mouse.
Volume: 423
Issue: 2
Pages: 170-188
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Protein
Q3URP1
Organism: Mus musculus/domesticus
Length: 737  
Fragment?: true
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Protein
D3YUD4
Organism: Mus musculus/domesticus
Length: 247  
Fragment?: true
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Protein
D3YX07
Organism: Mus musculus/domesticus
Length: 196  
Fragment?: true
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Publication
21799800 | -
First Author: Liu Y
Year: 2011
Journal: PLoS One
Title: Identification of the Arabidopsis REDUCED DORMANCY 2 gene uncovers a role for the polymerase associated factor 1 complex in seed dormancy.
Volume: 6
Issue: 7
Pages: e22241
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Publication
11687631 | -
First Author: Miller T
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: COMPASS: a complex of proteins associated with a trithorax-related SET domain protein.
Volume: 98
Issue: 23
Pages: 12902-7
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Publication
19855050 | -
First Author: Tamada Y
Year: 2009
Journal: Plant Cell
Title: ARABIDOPSIS TRITHORAX-RELATED7 is required for methylation of lysine 4 of histone H3 and for transcriptional activation of FLOWERING LOCUS C.
Volume: 21
Issue: 10
Pages: 3257-69
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Protein
Q80V17
Organism: Mus musculus/domesticus
Length: 849  
Fragment?: false
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Protein
Q80V59
Organism: Mus musculus/domesticus
Length: 458  
Fragment?: true
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Protein
Q91Z33
Organism: Mus musculus/domesticus
Length: 316  
Fragment?: true
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Protein
A0A0U1RNP2
Organism: Mus musculus/domesticus
Length: 1173  
Fragment?: true
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Protein
G3UZ56
Organism: Mus musculus/domesticus
Length: 87  
Fragment?: true
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Protein
A0A0U1RPA4
Organism: Mus musculus/domesticus
Length: 29  
Fragment?: true
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Protein
E9PYH6
Organism: Mus musculus/domesticus
Length: 1716  
Fragment?: false
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Protein
Q8CFT2
Organism: Mus musculus/domesticus
Length: 1985  
Fragment?: false
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Publication
- | J:188991
     
First Author: The Jackson Laboratory
Year: 2012
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by The Jackson Laboratory
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Protein
Q8CHH1
Organism: Mus musculus/domesticus
Length: 1744  
Fragment?: true
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Protein
P55200
Organism: Mus musculus/domesticus
Length: 3966  
Fragment?: false
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Protein
O08550
Organism: Mus musculus/domesticus
Length: 2713  
Fragment?: false
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Protein
F8WJ40
Organism: Mus musculus/domesticus
Length: 2721  
Fragment?: false
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Protein
Q6PHU4
Organism: Mus musculus/domesticus
Length: 2013  
Fragment?: true
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Protein
F6W623
Organism: Mus musculus/domesticus
Length: 2014  
Fragment?: true
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
- | J:84900
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Journal: Database Download
Title: Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database
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Publication
- | J:346132
       
First Author: The Gene Ontology Consortium
Year: 2016
Title: Automatic assignment of GO terms using logical inference, based on on inter-ontology links
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Publication
11042159 | J:68323
First Author: Carninci P
Year: 2000
Journal: Genome Res
Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Volume: 10
Issue: 10
Pages: 1617-30
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Publication
10349636 | J:80645
 
First Author: Carninci P
Year: 1999
Journal: Methods Enzymol
Title: High-efficiency full-length cDNA cloning.
Volume: 303
Pages: 19-44
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Publication
11076861 | J:68324
First Author: Shibata K
Year: 2000
Journal: Genome Res
Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Volume: 10
Issue: 11
Pages: 1757-71
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Publication
16141073 | -
First Author: Katayama S
Year: 2005
Journal: Science
Title: Antisense transcription in the mammalian transcriptome.
Volume: 309
Issue: 5740
Pages: 1564-6
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
19468303 | -
First Author: Church DM
Year: 2009
Journal: PLoS Biol
Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume: 7
Issue: 5
Pages: e1000112
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom