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Search results 501 to 573 out of 573 for Pdk1

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Type Details Score
Publication
16517406 | J:129656
First Author: Papandreou I
Year: 2006
Journal: Cell Metab
Title: HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption.
Volume: 3
Issue: 3
Pages: 187-97
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Publication
24912186 | J:211709
First Author: Regan JN
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Up-regulation of glycolytic metabolism is required for HIF1α-driven bone formation.
Volume: 111
Issue: 23
Pages: 8673-8
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Publication
21694754 | J:274061
First Author: Cao Y
Year: 2011
Journal: PLoS One
Title: PDK1-Foxo1 in agouti-related peptide neurons regulates energy homeostasis by modulating food intake and energy expenditure.
Volume: 6
Issue: 4
Pages: e18324
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Publication
28137614 | J:249259
 
First Author: Lan ZJ
Year: 2017
Journal: Mol Cell Endocrinol
Title: Selective deletion of Pten in theca-interstitial cells leads to androgen excess and ovarian dysfunction in mice.
Volume: 444
Pages: 26-37
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Publication
17267763 | J:122117
First Author: Okamoto Y
Year: 2007
Journal: Diabetes
Title: Restoration of glucokinase expression in the liver normalizes postprandial glucose disposal in mice with hepatic deficiency of PDK1.
Volume: 56
Issue: 4
Pages: 1000-9
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Publication
31011187 | J:282639
First Author: Luo W
Year: 2019
Journal: Nat Immunol
Title: The AKT kinase signaling network is rewired by PTEN to control proximal BCR signaling in germinal center B cells.
Volume: 20
Issue: 6
Pages: 736-746
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Publication
37216099 | J:338922
First Author: Reilly L
Year: 2023
Journal: iScience
Title: Loss of PI3k activity of inositol polyphosphate multikinase impairs PDK1-mediated AKT activation, cell migration, and intestinal homeostasis.
Volume: 26
Issue: 5
Pages: 106623
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Publication
17525368 | J:137808
First Author: Santini MP
Year: 2007
Journal: Circ Res
Title: Enhancing repair of the mammalian heart.
Volume: 100
Issue: 12
Pages: 1732-40
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Publication
21145457 | J:168103
First Author: Chakraborty A
Year: 2010
Journal: Cell
Title: Inositol pyrophosphates inhibit Akt signaling, thereby regulating insulin sensitivity and weight gain.
Volume: 143
Issue: 6
Pages: 897-910
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Publication
17434141 | J:122347
First Author: Dey D
Year: 2007
Journal: Biochem Biophys Res Commun
Title: Fatty acid represses insulin receptor gene expression by impairing HMGA1 through protein kinase Cepsilon.
Volume: 357
Issue: 2
Pages: 474-9
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Publication
17617409 | J:123728
First Author: Wood CD
Year: 2007
Journal: FEBS Lett
Title: Phosphoinositide-dependent protein kinase-1 (PDK1)-independent activation of the protein kinase C substrate, protein kinase D.
Volume: 581
Issue: 18
Pages: 3494-8
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Publication
18285454 | J:135677
First Author: Hao Y
Year: 2008
Journal: Mol Cell Biol
Title: RalGDS couples growth factor signaling to Akt activation.
Volume: 28
Issue: 9
Pages: 2851-9
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Publication
21329883 | J:170850
First Author: Ou YH
Year: 2011
Journal: Mol Cell
Title: TBK1 directly engages Akt/PKB survival signaling to support oncogenic transformation.
Volume: 41
Issue: 4
Pages: 458-70
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Publication
26338797 | J:226500
First Author: Wheeler DB
Year: 2015
Journal: Science
Title: Identification of an oncogenic RAB protein.
Volume: 350
Issue: 6257
Pages: 211-7
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Publication
26553931 | J:230746
First Author: Park H
Year: 2015
Journal: J Cell Biol
Title: AMIGO2, a novel membrane anchor of PDK1, controls cell survival and angiogenesis via Akt activation.
Volume: 211
Issue: 3
Pages: 619-37
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Publication
25742010 | J:248141
First Author: Bär S
Year: 2015
Journal: PLoS Pathog
Title: PKCη/Rdx-driven phosphorylation of PDK1: a novel mechanism promoting cancer cell survival and permissiveness for parvovirus-induced lysis.
Volume: 11
Issue: 3
Pages: e1004703
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Publication
26846144 | J:258528
First Author: Gómez-Suárez M
Year: 2016
Journal: Cell Death Differ
Title: 14-3-3 Proteins regulate Akt Thr308 phosphorylation in intestinal epithelial cells.
Volume: 23
Issue: 6
Pages: 1060-72
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Publication
35294873 | J:324905
First Author: Hu SH
Year: 2022
Journal: Cell Rep
Title: Methylene-bridge tryptophan fatty acylation regulates PI3K-AKT signaling and glucose uptake.
Volume: 38
Issue: 11
Pages: 110509
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Publication
36173858 | J:330274
First Author: Bou Sleiman M
Year: 2022
Journal: Science
Title: Sex- and age-dependent genetics of longevity in a heterogeneous mouse population.
Volume: 377
Issue: 6614
Pages: eabo3191
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Publication
21119626 | -
 
First Author: Gallego O
Year: 2010
Journal: Mol Syst Biol
Title: A systematic screen for protein-lipid interactions in Saccharomyces cerevisiae.
Volume: 6
Pages: 430
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Genotype
Genotype
Symbol: Pdpk1/Pdpk1 Rag2/Rag2 Tnfrsf4/Tnfrsf4<+> Gt(ROSA)26Sor/Gt(ROSA)26Sor<+>
Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Publication
17669420 | J:166353
First Author: Degenhardt T
Year: 2007
Journal: J Mol Biol
Title: Three members of the human pyruvate dehydrogenase kinase gene family are direct targets of the peroxisome proliferator-activated receptor beta/delta.
Volume: 372
Issue: 2
Pages: 341-55
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Publication
21865597 | J:183019
First Author: He P
Year: 2011
Journal: Mol Biol Cell
Title: Serum- and glucocorticoid-induced kinase 3 in recycling endosomes mediates acute activation of Na+/H+ exchanger NHE3 by glucocorticoids.
Volume: 22
Issue: 20
Pages: 3812-25
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Publication
21540297 | J:182940
First Author: Bekhite MM
Year: 2011
Journal: J Cell Sci
Title: VEGF-mediated PI3K class IA and PKC signaling in cardiomyogenesis and vasculogenesis of mouse embryonic stem cells.
Volume: 124
Issue: Pt 11
Pages: 1819-30
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Publication
16527821 | J:113737
First Author: Frey RS
Year: 2006
Journal: J Biol Chem
Title: Phosphatidylinositol 3-kinase gamma signaling through protein kinase Czeta induces NADPH oxidase-mediated oxidant generation and NF-kappaB activation in endothelial cells.
Volume: 281
Issue: 23
Pages: 16128-38
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Publication
19887597 | J:169947
First Author: Sajan MP
Year: 2010
Journal: Am J Physiol Endocrinol Metab
Title: AICAR and metformin, but not exercise, increase muscle glucose transport through AMPK-, ERK-, and PDK1-dependent activation of atypical PKC.
Volume: 298
Issue: 2
Pages: E179-92
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Publication
27644329 | J:243001
     
First Author: Cordón-Barris L
Year: 2016
Journal: Mol Cell Biol
Title: Mutation of the 3-phosphoinositide-dependent protein kinase-1 (PDK1) substrate-docking site in the developing brain causes microcephaly with abnormal brain morphogenesis independently of Akt, leading to impaired cognition and disruptive behaviors.
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Publication
38091840 | J:344742
 
First Author: Imamori M
Year: 2024
Journal: Biochem Biophys Res Commun
Title: Thrombospondin-1 promotes liver fibrosis by enhancing TGF-β action in hepatic stellate cells.
Volume: 693
Pages: 149369
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Publication
28878342 | J:255538
First Author: Saurus P
Year: 2017
Journal: Sci Rep
Title: Inhibition of SHIP2 in CD2AP-deficient podocytes ameliorates reactive oxygen species generation but aggravates apoptosis.
Volume: 7
Issue: 1
Pages: 10731
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Publication
19703999 | J:153995
First Author: Waugh C
Year: 2009
Journal: Mol Cell Biol
Title: Phosphoinositide (3,4,5)-triphosphate binding to phosphoinositide-dependent kinase 1 regulates a protein kinase B/Akt signaling threshold that dictates T-cell migration, not proliferation.
Volume: 29
Issue: 21
Pages: 5952-62
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Publication
27119228 | J:311917
First Author: Qiu X
Year: 2016
Journal: Oncotarget
Title: NEDL2 regulates enteric nervous system and kidney development in its Nedd8 ligase activity-dependent manner.
Volume: 7
Issue: 21
Pages: 31440-53
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Publication
19443706 | J:148919
First Author: Rodriguez OC
Year: 2009
Journal: Am J Pathol
Title: A reduction in Pten tumor suppressor activity promotes ErbB-2-induced mouse prostate adenocarcinoma formation through the activation of signaling cascades downstream of PDK1.
Volume: 174
Issue: 6
Pages: 2051-60
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Publication
28462077 | J:271913
First Author: Sasanuma H
Year: 2017
Journal: Mol Metab
Title: PDK1-FoxO1 pathway in AgRP neurons of arcuate nucleus promotes bone formation via GHRH-GH-IGF1 axis.
Volume: 6
Issue: 5
Pages: 428-439
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Publication
20103739 | J:162892
First Author: Iskandar K
Year: 2010
Journal: Am J Physiol Endocrinol Metab
Title: PDK-1/FoxO1 pathway in POMC neurons regulates Pomc expression and food intake.
Volume: 298
Issue: 4
Pages: E787-98
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Publication
22108800 | J:283469
First Author: Tawaramoto K
Year: 2012
Journal: Mol Endocrinol
Title: Ablation of 3-phosphoinositide-dependent protein kinase 1 (PDK1) in vascular endothelial cells enhances insulin sensitivity by reducing visceral fat and suppressing angiogenesis.
Volume: 26
Issue: 1
Pages: 95-109
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Publication
22586579 | J:208461
First Author: Kawano Y
Year: 2012
Journal: Diabetes
Title: Loss of Pdk1-Foxo1 signaling in myeloid cells predisposes to adipose tissue inflammation and insulin resistance.
Volume: 61
Issue: 8
Pages: 1935-48
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Publication
25084011 | J:218993
First Author: Zhang Y
Year: 2014
Journal: PLoS One
Title: Rictor is required for early B cell development in bone marrow.
Volume: 9
Issue: 8
Pages: e103970
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Publication
24224061 | J:209318
First Author: Qin Z
Year: 2013
Journal: PLoS One
Title: Isoaspartate accumulation in mouse brain is associated with altered patterns of protein phosphorylation and acetylation, some of which are highly sex-dependent.
Volume: 8
Issue: 11
Pages: e80758
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Publication
23071621 | J:192091
First Author: MacKay KB
Year: 2012
Journal: PLoS One
Title: Wortmannin reduces insulin signaling and death in seizure-prone Pcmt1-/- mice.
Volume: 7
Issue: 10
Pages: e46719
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Publication
12663261 | J:134746
First Author: Hopkins TA
Year: 2003
Journal: Am J Physiol Heart Circ Physiol
Title: Control of cardiac pyruvate dehydrogenase activity in peroxisome proliferator-activated receptor-alpha transgenic mice.
Volume: 285
Issue: 1
Pages: H270-6
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Publication
27795296 | J:242994
 
First Author: Guentsch A
Year: 2017
Journal: Mol Cell Biol
Title: PHD2 Is a Regulator for Glycolytic Reprogramming in Macrophages.
Volume: 37
Issue: 1
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Publication
22041125 | J:344713
 
First Author: Xifró X
Year: 2011
Journal: Mol Neurodegener
Title: Increased 90-kDa ribosomal S6 kinase (Rsk) activity is protective against mutant huntingtin toxicity.
Volume: 6
Pages: 74
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Publication
32857910 | J:296937
First Author: Rao CV
Year: 2020
Journal: Aging Cell
Title: GSK3-ARC/Arg3.1 and GSK3-Wnt signaling axes trigger amyloid-β accumulation and neuroinflammation in middle-aged Shugoshin 1 mice.
Volume: 19
Issue: 10
Pages: e13221
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Publication
19703998 | J:153996
First Author: El-Naggar S
Year: 2009
Journal: Mol Cell Biol
Title: Mutation of the Rb1 pathway leads to overexpression of mTor, constitutive phosphorylation of Akt on serine 473, resistance to anoikis, and a block in c-Raf activation.
Volume: 29
Issue: 21
Pages: 5710-7
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Publication
26795955 | J:250192
 
First Author: Qin Z
Year: 2016
Journal: Sci Rep
Title: Tsc1 deficiency impairs mammary development in mice by suppression of AKT, nuclear ERα, and cell-cycle-driving proteins.
Volume: 6
Pages: 19587
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Publication
15187024 | J:93757
First Author: Yamazaki T
Year: 2004
Journal: Blood
Title: Puromycin-insensitive leucyl-specific aminopeptidase (PILSAP) binds and catalyzes PDK1, allowing VEGF-stimulated activation of S6K for endothelial cell proliferation and angiogenesis.
Volume: 104
Issue: 8
Pages: 2345-52
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Publication
15867396 | J:98331
First Author: Yin Y
Year: 2005
Journal: Cancer Res
Title: Peroxisome proliferator-activated receptor delta and gamma agonists differentially alter tumor differentiation and progression during mammary carcinogenesis.
Volume: 65
Issue: 9
Pages: 3950-7
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Publication
16785309 | J:124408
First Author: Nirula A
Year: 2006
Journal: J Exp Med
Title: Phosphoinositide-dependent kinase 1 targets protein kinase A in a pathway that regulates interleukin 4.
Volume: 203
Issue: 7
Pages: 1733-44
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Publication
17562488 | J:134717
First Author: Sargeant AM
Year: 2007
Journal: Toxicol Pathol
Title: Chemopreventive and bioenergetic signaling effects of PDK1/Akt pathway inhibition in a transgenic mouse model of prostate cancer.
Volume: 35
Issue: 4
Pages: 549-61
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Publication
18426911 | J:137298
First Author: Hagan GN
Year: 2008
Journal: Mol Cell Biol
Title: A Rictor-Myo1c complex participates in dynamic cortical actin events in 3T3-L1 adipocytes.
Volume: 28
Issue: 13
Pages: 4215-26
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Publication
18514190 | J:138007
First Author: Tamgüney T
Year: 2008
Journal: Exp Cell Res
Title: Analysis of 3-phosphoinositide-dependent kinase-1 signaling and function in ES cells.
Volume: 314
Issue: 11-12
Pages: 2299-312
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Publication
25645675 | J:229644
First Author: Sturm EM
Year: 2015
Journal: Eur J Immunol
Title: Phosphoinositide-dependent protein kinase 1 (PDK1) mediates potent inhibitory effects on eosinophils.
Volume: 45
Issue: 5
Pages: 1548-59
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Publication
28596235 | J:255642
First Author: Hsu JY
Year: 2017
Journal: FASEB J
Title: Epidermal growth factor-induced pyruvate dehydrogenase kinase 1 expression enhances head and neck squamous cell carcinoma metastasis via up-regulation of fibronectin.
Volume: 31
Issue: 10
Pages: 4265-4276
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Publication
30092282 | J:275772
 
First Author: Pan H
Year: 2019
Journal: Matrix Biol
Title: RNA binding protein HuR regulates extracellular matrix gene expression and pH homeostasis independent of controlling HIF-1α signaling in nucleus pulposus cells.
Volume: 77
Pages: 23-40
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Publication
34535769 | J:312446
First Author: Heltemes-Harris LM
Year: 2021
Journal: Oncogene
Title: Identification of mutations that cooperate with defects in B cell transcription factors to initiate leukemia.
Volume: 40
Issue: 43
Pages: 6166-6179
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Publication
25670795 | J:238888
First Author: Luo W
Year: 2015
Journal: Development
Title: Akt1 signaling coordinates BMP signaling and β-catenin activity to regulate second heart field progenitor development.
Volume: 142
Issue: 4
Pages: 732-42
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Protein
F2Z3Z9
Organism: Mus musculus/domesticus
Length: 432  
Fragment?: false
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Publication
17456009 | J:139422
First Author: Ford-Hutchinson AF
Year: 2007
Journal: J Bone Miner Res
Title: Inactivation of Pten in osteo-chondroprogenitor cells leads to epiphyseal growth plate abnormalities and skeletal overgrowth.
Volume: 22
Issue: 8
Pages: 1245-59
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Publication
15201286 | J:92558
First Author: Kondo T
Year: 2004
Journal: J Biol Chem
Title: Altered insulin signaling in retinal tissue in diabetic states.
Volume: 279
Issue: 36
Pages: 37997-8006
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Publication
34913989 | J:322738
First Author: Yang S
Year: 2022
Journal: Diabetologia
Title: MicroRNA-193b impairs muscle growth in mouse models of type 2 diabetes by targeting the PDK1/Akt signalling pathway.
Volume: 65
Issue: 3
Pages: 563-581
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Publication
29652518 | J:278995
First Author: Jia S
Year: 2018
Journal: Am J Respir Cell Mol Biol
Title: Discoidin Domain Receptor 2 Signaling Regulates Fibroblast Apoptosis through PDK1/Akt.
Volume: 59
Issue: 3
Pages: 295-305
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Publication
18591395 | J:141895
First Author: El Ouaamari A
Year: 2008
Journal: Diabetes
Title: miR-375 targets 3'-phosphoinositide-dependent protein kinase-1 and regulates glucose-induced biological responses in pancreatic beta-cells.
Volume: 57
Issue: 10
Pages: 2708-17
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Publication
32913213 | J:305622
First Author: Sun X
Year: 2020
Journal: Cell Death Dis
Title: miR-378-3p maintains the size of mouse primordial follicle pool by regulating cell autophagy and apoptosis.
Volume: 11
Issue: 9
Pages: 737
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Publication
34628272 | J:312367
 
First Author: Yuko AE
Year: 2021
Journal: Redox Biol
Title: LIN28a induced metabolic and redox regulation promotes cardiac cell survival in the heart after ischemic injury.
Volume: 47
Pages: 102162
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Publication
21865646 | J:178240
First Author: Goertz MJ
Year: 2011
Journal: J Clin Invest
Title: Foxo1 is required in mouse spermatogonial stem cells for their maintenance and the initiation of spermatogenesis.
Volume: 121
Issue: 9
Pages: 3456-66
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Publication
21295499 | J:168979
First Author: Macintyre AN
Year: 2011
Journal: Immunity
Title: Protein kinase B controls transcriptional programs that direct cytotoxic T cell fate but is dispensable for T cell metabolism.
Volume: 34
Issue: 2
Pages: 224-36
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Publication
23453634 | J:194830
First Author: Schweighoffer E
Year: 2013
Journal: Immunity
Title: The BAFF receptor transduces survival signals by co-opting the B cell receptor signaling pathway.
Volume: 38
Issue: 3
Pages: 475-88
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Publication
37781225 | J:341375
 
First Author: Kalra J
Year: 2023
Journal: Front Physiol
Title: p90RSK2, a new MLCK mediates contractility in myosin light chain kinase null smooth muscle.
Volume: 14
Pages: 1228488
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Publication
29045568 | J:258572
First Author: Francois AA
Year: 2018
Journal: Cardiovasc Res
Title: Loss of Protein Kinase Novel 1 (PKN1) is associated with mild systolic and diastolic contractile dysfunction, increased phospholamban Thr17 phosphorylation, and exacerbated ischaemia-reperfusion injury.
Volume: 114
Issue: 1
Pages: 138-157
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Publication
18925875 | J:144578
First Author: García-Martínez JM
Year: 2008
Journal: Biochem J
Title: mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1).
Volume: 416
Issue: 3
Pages: 375-85
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Publication
23453624 | J:197054
First Author: Eser S
Year: 2013
Journal: Cancer Cell
Title: Selective requirement of PI3K/PDK1 signaling for Kras oncogene-driven pancreatic cell plasticity and cancer.
Volume: 23
Issue: 3
Pages: 406-20
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Publication
25326799 | J:218155
First Author: Schönhuber N
Year: 2014
Journal: Nat Med
Title: A next-generation dual-recombinase system for time- and host-specific targeting of pancreatic cancer.
Volume: 20
Issue: 11
Pages: 1340-1347
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Publication
14594214 | -
 
First Author: Cozier GE
Year: 2004
Journal: Curr Top Microbiol Immunol
Title: Membrane targeting by pleckstrin homology domains.
Volume: 282
Pages: 49-88
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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