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Search results 601 to 613 out of 613 for Epha2

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Type

Details

Score

Protein Domain

IPR034263 | EphA2_rcpt_lig-bd

Type:

Domain

Description:

This entry represents the ligand-binding domain found in ephrin type-A receptor 2 (EphA2). EphA2 negatively regulates cell differentiation and has been shown to be overexpressed in tumor cells and tumor blood vessels in a variety of cancers including breast, prostate, lung, and colon. As a result, it is an attractive target for drug design since its inhibition could affect several aspects of tumor progression [, , ]. Class EphA receptors bind GPI-anchored ephrin-A ligands. There are ten vertebrate EphA receptors (EphA1-10), which display promiscuous interactions with six ephrin-A ligands [, ]. Ephrin receptors (EphRs) comprise the largest subfamily of receptor tyrosine kinases (RTKs). EphRs contain a ligand binding domain and two fibronectin repeats extracellularly, a transmembrane segment, and a cytoplasmic tyrosine kinase domain. Binding of the ephrin ligand to EphR requires cell-cell contact since both are anchored to the plasma membrane. The resulting downstream signals occur bidirectionally in both EphR-expressing cells (forward signaling) and ephrin-expressing cells (reverse signaling) [].

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Protein Domain

IPR035797 | ARHGEF16/ARHGEF26_SH3

Type:

Domain

Description:

ARHGEF16, also called ephexin-4, acts as a guanine nucleotide exchange factor (GEF) for RhoG, activating it by exchanging bound GDP for free GTP. RhoG is a small GTPase that is a crucial regulator of Rac in migrating cells. ARHGEF16 interacts directly with the ephrin receptor EphA2 and mediates cell migration and invasion in breast cancer cells by activating RhoG [, ]. ARHGEF26, also called SGEF (SH3 domain-containing GEF), also activates RhoG. It is highly expressed in liver and may play a role in regulating membrane dynamics []. ARHGEF16 and ARHGEF26 contain RhoGEF (also called Dbl-homologous or DH), Pleckstrin Homology(PH), and SH3 domains. The SH3 domains of ARHGEFs play an autoinhibitory role through intramolecular interactions with a proline-rich region N-terminal to the DH domain. The SH3 domain of ARHGEF16 also binds to Elmo, and this interaction may relieve the self-inhibitory state ofARHGEF16 [].This entry represents the SH3 domains of ARHGEF16 and ARHGEF26.

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Publication

27619642 | J:242097

First Author:	Lee H
Year:	2016
Journal:	Nat Commun
Title:	Anks1a regulates COPII-mediated anterograde transport of receptor tyrosine kinases critical for tumorigenesis.
Volume:	7

Pages:	12799

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Publication

20154726 | J:168266

First Author:	Zhang W
Year:	2010
Journal:	Oncogene
Title:	A potential tumor suppressor role for Hic1 in breast cancer through transcriptional repression of ephrin-A1.
Volume:	29
Issue:	17
Pages:	2467-76

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Publication

- | J:239145

First Author:	Gagnon LH
Year:	2017
Journal:	MGI Direct Data Submission
Title:	The pinwheel mutation

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Publication

26833123 | J:231631

First Author:	Youngblood VM
Year:	2016
Journal:	Cancer Res
Title:	The Ephrin-A1/EPHA2 Signaling Axis Regulates Glutamine Metabolism in HER2-Positive Breast Cancer.
Volume:	76
Issue:	7
Pages:	1825-36

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Publication

12370823 | J:79653

First Author:	Brantley DM
Year:	2002
Journal:	Oncogene
Title:	Soluble Eph A receptors inhibit tumor angiogenesis and progression in vivo.
Volume:	21
Issue:	46
Pages:	7011-26

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Publication

12134157 | J:108902

First Author:	Carter N
Year:	2002
Journal:	Nat Cell Biol
Title:	EphrinA1-induced cytoskeletal re-organization requires FAK and p130(cas).
Volume:	4
Issue:	8
Pages:	565-73

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Publication

18413883 | -

First Author:	Lackmann M
Year:	2008
Journal:	Sci Signal
Title:	Eph, a protein family coming of age: more confusion, insight, or complexity?
Volume:	1
Issue:	15
Pages:	re2

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Protein

Q3U5C8

Organism:	Mus musculus/domesticus
Length:	713
Fragment?:	false

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Protein

D3YYY8

Organism:	Mus musculus/domesticus
Length:	869
Fragment?:	false

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Publication

12495863 | -

First Author:	Himanen JP
Year:	2003
Journal:	Trends Neurosci
Title:	Eph signaling: a structural view.
Volume:	26
Issue:	1
Pages:	46-51

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Protein

Q03145

Organism:	Mus musculus/domesticus
Length:	977
Fragment?:	false

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