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Search results 101 to 200 out of 329 for Srsf1

0.056s
Type Details Score
GXD Expression
Probe: MGI:4886316
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4945323
Age: embryonic day 15.5
Image: g00818 E15.5
Note: Expression was region specific and scattered.
Specimen Label: g00818 E15.5
Detected: true
Specimen Num: 2
GXD Expression
Probe: MGI:4886316
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3284528
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4945323
Age: postnatal day 7
Image: g00818 P7
Note: Expression was region specific and scattered.
Specimen Label: g00818 P7
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:4886316
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689619
Pattern: Widespread
Stage: TS19
Assay Id: MGI:4945323
Age: embryonic day 11.5
Image: g00818 E11.5
Specimen Label: g00818 E11.5
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:6197083
Assay Type: Immunohistochemistry
Annotation Date: 2018-09-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Pattern: Spotted
Stage: TS28
Assay Id: MGI:6197098
Age: postnatal adult
Note: Authors report speckled expression.
Specimen Label: 4C Liver WT
Detected: true
Specimen Num: 7
GXD Expression  
Probe: MGI:6197083
Assay Type: Immunohistochemistry
Annotation Date: 2018-09-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Pattern: Spotted
Stage: TS28
Assay Id: MGI:6197098
Age: postnatal adult
Note: Authors report speckled expression.
Specimen Label: 4C Liver KO
Detected: true
Specimen Num: 8
GXD Expression  
Probe: MGI:4886316
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3267328
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945323
Age: postnatal day 7
Image: g00818 P7
Specimen Label: g00818 P7
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:4886316
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3274128
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4945323
Age: postnatal day 7
Image: g00818 P7
Specimen Label: g00818 P7
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:3615410
Assay Type: RNA in situ
Annotation Date: 2006-03-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876827
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3617604
Age: postnatal day 0
Image: P0
Specimen Label: P0
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4886316
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1609219
Pattern: Widespread
Stage: TS19
Assay Id: MGI:4945323
Age: embryonic day 11.5
Image: g00818 E11.5
Specimen Label: g00818 E11.5
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:4886316
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3266028
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4945323
Age: postnatal day 7
Image: g00818 P7
Specimen Label: g00818 P7
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:3615410
Assay Type: RNA in situ
Annotation Date: 2006-03-24
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:1679727
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3617604
Age: postnatal day 0
Image: P0
Note: Authors indicate that there was either ubiquitous or background expression.
Specimen Label: P0
Specimen Num: 2
GXD Expression  
Probe: MGI:3615410
Assay Type: RNA in situ
Annotation Date: 2006-03-24
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:1754027
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3617604
Age: postnatal day 0
Image: P0
Note: Authors indicate that there was either ubiquitous or background expression.
Specimen Label: P0
Specimen Num: 2
GXD Expression  
Probe: MGI:4886316
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754028
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945323
Age: postnatal day 7
Image: g00818 P7
Specimen Label: g00818 P7
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:3615410
Assay Type: RNA in situ
Annotation Date: 2006-03-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3280927
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3617604
Age: postnatal day 0
Image: P0
Specimen Label: P0
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4886316
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3280923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4945323
Age: embryonic day 15.5
Image: g00818 E15.5
Specimen Label: g00818 E15.5
Detected: true
Specimen Num: 2
GXD Expression
Probe: MGI:4886316
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3280928
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:4945323
Age: postnatal day 7
Image: g00818 P7
Note: Expression was region specific and scattered.
Specimen Label: g00818 P7
Detected: true
Specimen Num: 3
GXD Expression
Probe: MGI:4886316
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3266523
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4945323
Age: embryonic day 15.5
Image: g00818 E15.5
Note: Expression was region specific and scattered.
Specimen Label: g00818 E15.5
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:6197083
Assay Type: Immunohistochemistry
Annotation Date: 2018-09-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1702128
Pattern: Spotted
Stage: TS28
Assay Id: MGI:6197098
Age: postnatal adult
Note: Authors report speckled expression.
Specimen Label: 4C Stomach WT
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:6197083
Assay Type: Immunohistochemistry
Annotation Date: 2018-09-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1702128
Pattern: Spotted
Stage: TS28
Assay Id: MGI:6197098
Age: postnatal adult
Note: Authors report speckled expression.
Specimen Label: 4C Stomach KO
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:3615410
Assay Type: RNA in situ
Annotation Date: 2006-03-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3267921
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:3617604
Age: embryonic day 13.5
Image: E13.5
Specimen Label: E13.5
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3615410
Assay Type: RNA in situ
Annotation Date: 2006-03-24
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:1757721
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:3617604
Age: embryonic day 13.5
Image: E13.5
Note: Authors indicate that there was either ubiquitous or background expression.
Specimen Label: E13.5
Specimen Num: 1
GXD Expression    
Probe: MGI:3615410
Assay Type: RNA in situ
Annotation Date: 2006-03-24
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1757727
Stage: TS27
Assay Id: MGI:3617604
Age: postnatal day 0
Image: P0
Specimen Label: P0
Detected: false
Specimen Num: 2
GXD Expression
Probe: MGI:4886316
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4945323
Age: embryonic day 15.5
Image: g00818 E15.5
Note: Expression was region specific and scattered.
Specimen Label: g00818 E15.5
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4886316
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757728
Pattern: Widespread
Stage: TS28
Assay Id: MGI:4945323
Age: postnatal day 7
Image: g00818 P7
Specimen Label: g00818 P7
Detected: true
Specimen Num: 3
Publication
First Author: Houlard M
Year: 2011
Journal: Cell Cycle
Title: DNA-RNA hybrids contribute to the replication dependent genomic instability induced by Omcg1 deficiency.
Volume: 10
Issue: 1
Pages: 108-17
Publication
First Author: Delestienne N
Year: 2010
Journal: FEBS J
Title: The splicing factor ASF/SF2 is associated with TIA-1-related/TIA-1-containing ribonucleoproteic complexes and contributes to post-transcriptional repression of gene expression.
Volume: 277
Issue: 11
Pages: 2496-514
Publication
First Author: Lin S
Year: 2005
Journal: Mol Cell
Title: Dephosphorylation-dependent sorting of SR splicing factors during mRNP maturation.
Volume: 20
Issue: 3
Pages: 413-25
Publication
First Author: Huang SC
Year: 2009
Journal: Blood
Title: Coupled transcription-splicing regulation of mutually exclusive splicing events at the 5' exons of protein 4.1R gene.
Volume: 114
Issue: 19
Pages: 4233-42
Publication
First Author: Zerbe LK
Year: 2004
Journal: Mol Carcinog
Title: Relative amounts of antagonistic splicing factors, hnRNP A1 and ASF/SF2, change during neoplastic lung growth: implications for pre-mRNA processing.
Volume: 41
Issue: 4
Pages: 187-96
Publication
First Author: Vecerová J
Year: 2004
Journal: Mol Biol Cell
Title: Formation of nuclear splicing factor compartments is independent of lamins A/C.
Volume: 15
Issue: 11
Pages: 4904-10
Publication
First Author: Nakagawa S
Year: 2012
Journal: RNA
Title: Malat1 is not an essential component of nuclear speckles in mice.
Volume: 18
Issue: 8
Pages: 1487-99
Publication
First Author: Liu Y
Year: 2017
Journal: Sci Rep
Title: Angulin proteins ILDR1 and ILDR2 regulate alternative pre-mRNA splicing through binding to splicing factors TRA2A, TRA2B, or SRSF1.
Volume: 7
Issue: 1
Pages: 7466
Publication
First Author: Ayane M
Year: 1991
Journal: Nucleic Acids Res
Title: A differentially expressed murine RNA encoding a protein with similarities to two types of nucleic acid binding motifs.
Volume: 19
Issue: 6
Pages: 1273-8
Publication
First Author: Xu X
Year: 2005
Journal: Cell
Title: ASF/SF2-regulated CaMKIIdelta alternative splicing temporally reprograms excitation-contraction coupling in cardiac muscle.
Volume: 120
Issue: 1
Pages: 59-72
Publication
First Author: Zhong B
Year: 2012
Journal: Nat Immunol
Title: Negative regulation of IL-17-mediated signaling and inflammation by the ubiquitin-specific protease USP25.
Volume: 13
Issue: 11
Pages: 1110-7
Publication
First Author: Ji X
Year: 2013
Journal: Cell
Title: SR proteins collaborate with 7SK and promoter-associated nascent RNA to release paused polymerase.
Volume: 153
Issue: 4
Pages: 855-68
Publication
First Author: Wang J
Year: 2016
Journal: EMBO Rep
Title: A novel long intergenic noncoding RNA indispensable for the cleavage of mouse two-cell embryos.
Volume: 17
Issue: 10
Pages: 1452-1470
Publication
First Author: Pedrotti S
Year: 2012
Journal: Nucleic Acids Res
Title: The RNA recognition motif protein RBM11 is a novel tissue-specific splicing regulator.
Volume: 40
Issue: 3
Pages: 1021-32
Publication
First Author: Cazalla D
Year: 2005
Journal: Mol Cell Biol
Title: A novel SR-related protein is required for the second step of Pre-mRNA splicing.
Volume: 25
Issue: 8
Pages: 2969-80
Publication
First Author: Herjan T
Year: 2018
Journal: Nat Immunol
Title: IL-17-receptor-associated adaptor Act1 directly stabilizes mRNAs to mediate IL-17 inflammatory signaling.
Volume: 19
Issue: 4
Pages: 354-365
Publication
First Author: Sun D
Year: 2011
Journal: Nat Immunol
Title: Treatment with IL-17 prolongs the half-life of chemokine CXCL1 mRNA via the adaptor TRAF5 and the splicing-regulatory factor SF2 (ASF).
Volume: 12
Issue: 9
Pages: 853-60
Publication
First Author: Irwin S
Year: 2005
Journal: J Cell Sci
Title: RNA association and nucleocytoplasmic shuttling by ataxin-1.
Volume: 118
Issue: Pt 1
Pages: 233-42
Publication
First Author: Bermingham JR Jr
Year: 1995
Journal: Genomics
Title: Chromosomal localization of mouse and human genes encoding the splicing factors ASF/SF2 (SFRS1) and SC-35 (SFRS2).
Volume: 29
Issue: 1
Pages: 70-9
Publication
First Author: Manley JL
Year: 2010
Journal: Genes Dev
Title: A rational nomenclature for serine/arginine-rich protein splicing factors (SR proteins).
Volume: 24
Issue: 11
Pages: 1073-4
Publication    
First Author: Meinke S
Year: 2020
Journal: Elife
Title: Srsf10 and the minor spliceosome control tissue-specific and dynamic SR protein expression.
Volume: 9
Publication
First Author: Kanadia RN
Year: 2008
Journal: Development
Title: Temporal requirement of the alternative-splicing factor Sfrs1 for the survival of retinal neurons.
Volume: 135
Issue: 23
Pages: 3923-33
Publication
First Author: Kaput J
Year: 2004
Journal: Physiol Genomics
Title: Identification of genes contributing to the obese yellow Avy phenotype: caloric restriction, genotype, diet x genotype interactions.
Volume: 18
Issue: 3
Pages: 316-24
Publication
First Author: Zhou J
Year: 2017
Journal: Biochim Biophys Acta
Title: Conserved expression of ultra-conserved noncoding RNA in mammalian nervous system.
Volume: 1860
Issue: 12
Pages: 1159-1168
Publication
First Author: Bulfone A
Year: 2005
Journal: J Neurosci
Title: Telencephalic embryonic subtractive sequences: a unique collection of neurodevelopmental genes.
Volume: 25
Issue: 33
Pages: 7586-600
Publication  
First Author: McKee AE
Year: 2005
Journal: BMC Dev Biol
Title: A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain.
Volume: 5
Pages: 14
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: FANTOM2 Data Curation in Mouse Genome Informatics
Publication      
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
Publication        
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
Publication
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
Publication        
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
Publication        
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
Publication        
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
Publication        
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication        
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
Publication        
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: rat
Publication  
First Author: Wagner KD
Year: 2019
Journal: Cells
Title: Altered VEGF Splicing Isoform Balance in Tumor Endothelium Involves Activation of Splicing Factors Srpk1 and Srsf1 by the Wilms' Tumor Suppressor Wt1.
Volume: 8
Issue: 1
DO Term
Publication  
First Author: Gonçalves V
Year: 2015
Journal: Biomed Res Int
Title: Posttranscriptional Regulation of Splicing Factor SRSF1 and Its Role in Cancer Cell Biology.
Volume: 2015
Pages: 287048
Protein Domain
Type: Domain
Description: This entry represents the RNA recognition motif 1 (RRM1) of SRSF1 (also knwon as ASF/SF2). SRSF1 is a member of the SR (serine/arginine) protein family of splicing regulators. Besides mRNA splicing, it is also involved in regulating mRNA transcription, stability and nuclear export, NMD, and translation, as well as protein sumoylation. It has been identified as a proto-oncogene. SRSF1 contains two RRMs, which are required for efficient RNA binding and splicing []. The SR protein family is a group of mRNA metabolism regulators. Its members have a modular domain with one or two RNA-recognition motifs (RRMs) and a C-terminal RS domain comprising multiple Arg-Ser dipeptide repeats. There are 12 human SR proteins [].
Publication
First Author: Das S
Year: 2014
Journal: Mol Cancer Res
Title: Emerging functions of SRSF1, splicing factor and oncoprotein, in RNA metabolism and cancer.
Volume: 12
Issue: 9
Pages: 1195-204
Publication
First Author: Pradeepa MM
Year: 2012
Journal: PLoS Genet
Title: Psip1/Ledgf p52 binds methylated histone H3K36 and splicing factors and contributes to the regulation of alternative splicing.
Volume: 8
Issue: 5
Pages: e1002717
Protein Domain
Type: Family
Description: Nuclear speckles are subnuclear storage sites containing pre-mRNA splicing machinery. Nuclear speckle splicing regulatory protein 1 (Nsrp1), also known as NSRP70, is a nuclear speckle-related protein that mediates alternative splice site selection, targeting several pre-mRNAs []. It contains an N-terminal coiled-coil domain that is critical not only for self-oligomerization but also for splicing activity. It interacts physically with two SR (serine/arginine) proteins, SRSF1 and SRSF2, and reverses their splicing activity in terms of CD44 exon v5 as exon exclusion [].
Publication
First Author: Howard JM
Year: 2015
Journal: Wiley Interdiscip Rev RNA
Title: The RNAissance family: SR proteins as multifaceted regulators of gene expression.
Volume: 6
Issue: 1
Pages: 93-110
Protein
Organism: Mus musculus/domesticus
Length: 119  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 85  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 78  
Fragment?: true
Publication    
First Author: Zhou H
Year: 2017
Journal: Elife
Title: IRAK2 directs stimulus-dependent nuclear export of inflammatory mRNAs.
Volume: 6
Publication
First Author: Hall AE
Year: 2022
Journal: Nat Commun
Title: RNA splicing is a key mediator of tumour cell plasticity and a therapeutic vulnerability in colorectal cancer.
Volume: 13
Issue: 1
Pages: 2791
Publication
First Author: Farshadyeganeh P
Year: 2023
Journal: iScience
Title: Splicing regulation of GFPT1 muscle-specific isoform and its roles in glucose metabolisms and neuromuscular junction.
Volume: 26
Issue: 10
Pages: 107746