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Search results 1 to 1 out of 1 for Sema3e

Category restricted to ProteinDomain (x)

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Category: ProteinDomain
Type Details Score
Protein Domain
Type: Domain
Description: Plexin D1 belongs to the plexin family, whose members cell surface receptors for extracellular signals of the semaphorin family []. Plexin D1 is the receptor of Sema3E that regulates axon guidance, angiogenesis, tumour growth, and tumour metastasis []. In endothelial cells, Sema3E-PlexinD1 inhibit cell-substrate adhesion and exert an anti-angiogenic function, while in cancer cells they have been shown to have a pro-tumorigenic role []. The Sema domain is located at the N terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.