|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 1 to 100 out of 239 for Fhit

<< First    < Previous  |  Next >    Last >>
0.023s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Protein Domain
Type: Family
Description: FHIT (fragile histidine) proteins are related to the HIT family members that carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid) []. On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into three branches: the Hint branch, which consists of adenosine 5' -monophosphoramide hydrolases, the FHIT branch, that consists of diadenosine polyphosphate hydrolases, and the GalT branch consisting of specific nucloside monophosphate transferases [, , ]. FHIT plays a very important role in the development of tumours. In fact, FHIT deletions are among the earliest and most frequent genetic alterations in the development of tumours [, ].
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: chimpanzee
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Pekarsky Y
Year: 2002
Journal: Cancer Biol Ther
Title: FHIT as tumor suppressor: mechanisms and therapeutic opportunities.
Volume: 1
Issue: 3
Pages: 232-6
Protein
Organism: Mus musculus/domesticus
Length: 150  
Fragment?: false
Publication
First Author: Pace HC
Year: 1998
Journal: Proc Natl Acad Sci U S A
Title: Genetic, biochemical, and crystallographic characterization of Fhit-substrate complexes as the active signaling form of Fhit.
Volume: 95
Issue: 10
Pages: 5484-9
Protein
Organism: Mus musculus/domesticus
Length: 100  
Fragment?: true
Publication
First Author: Lima CD
Year: 1997
Journal: Science
Title: Structure-based analysis of catalysis and substrate definition in the HIT protein family.
Volume: 278
Issue: 5336
Pages: 286-90
Publication
First Author: Pekarsky Y
Year: 2002
Journal: Lancet Oncol
Title: FHIT: from gene discovery to cancer treatment and prevention.
Volume: 3
Issue: 12
Pages: 748-54
Publication
First Author: Séraphin B
Year: 1992
Journal: DNA Seq
Title: The HIT protein family: a new family of proteins present in prokaryotes, yeast and mammals.
Volume: 3
Issue: 3
Pages: 177-9
Protein
Organism: Mus musculus/domesticus
Length: 213  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 124  
Fragment?: true
Publication
First Author: Ishii H
Year: 2006
Journal: Cancer Res
Title: Fhit modulates the DNA damage checkpoint response.
Volume: 66
Issue: 23
Pages: 11287-92
Publication
First Author: Sun J
Year: 2009
Journal: J Cell Biochem
Title: Nit1 and Fhit tumor suppressor activities are additive.
Volume: 107
Issue: 6
Pages: 1097-106
Publication
First Author: McCorkell KA
Year: 2007
Journal: Cytogenet Genome Res
Title: Influence of a nonfragile FHIT transgene on murine tumor susceptibility.
Volume: 118
Issue: 2-4
Pages: 196-203
Publication
First Author: Hu B
Year: 2005
Journal: Cancer Res
Title: Fhit and CHK1 have opposing effects on homologous recombination repair.
Volume: 65
Issue: 19
Pages: 8613-6
Publication
First Author: Dumon KR
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: FHIT gene therapy prevents tumor development in Fhit-deficient mice.
Volume: 98
Issue: 6
Pages: 3346-51
Publication
First Author: Brenner C
Year: 2002
Journal: Biochemistry
Title: Hint, Fhit, and GalT: function, structure, evolution, and mechanism of three branches of the histidine triad superfamily of nucleotide hydrolases and transferases.
Volume: 41
Issue: 29
Pages: 9003-14
Publication
First Author: Fujishita T
Year: 2004
Journal: Br J Cancer
Title: Development of spontaneous tumours and intestinal lesions in Fhit gene knockout mice.
Volume: 91
Issue: 8
Pages: 1571-4
Publication
First Author: Saldivar JC
Year: 2012
Journal: PLoS Genet
Title: Initiation of genome instability and preneoplastic processes through loss of Fhit expression.
Volume: 8
Issue: 11
Pages: e1003077
Publication
First Author: Balansky R
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Influence of FHIT on benzo[a]pyrene-induced tumors and alopecia in mice: chemoprevention by budesonide and N-acetylcysteine.
Volume: 103
Issue: 20
Pages: 7823-8
Publication
First Author: Ohta M
Year: 1996
Journal: Cell
Title: The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers.
Volume: 84
Issue: 4
Pages: 587-97
Publication
First Author: Pekarsky Y
Year: 1998
Journal: Cancer Res
Title: The murine Fhit locus: isolation, characterization, and expression in normal and tumor cells.
Volume: 58
Issue: 15
Pages: 3401-8
Publication
First Author: Pekarsky Y
Year: 1998
Journal: Proc Natl Acad Sci U S A
Title: Nitrilase and Fhit homologs are encoded as fusion proteins in Drosophila melanogaster and Caenorhabditis elegans.
Volume: 95
Issue: 15
Pages: 8744-9
Publication
First Author: Romero I
Year: 2012
Journal: J Pathol
Title: The tumour suppressor Fhit positively regulates MHC class I expression on cancer cells.
Volume: 227
Issue: 3
Pages: 367-79
Publication
First Author: Glover TW
Year: 1998
Journal: Cancer Res
Title: The murine Fhit gene is highly similar to its human orthologue and maps to a common fragile site region.
Volume: 58
Issue: 15
Pages: 3409-14
Publication
First Author: Fong LY
Year: 2000
Journal: Proc Natl Acad Sci U S A
Title: Muir-Torre-like syndrome in Fhit-deficient mice.
Volume: 97
Issue: 9
Pages: 4742-7
Publication
First Author: Barnes LD
Year: 1996
Journal: Biochemistry
Title: Fhit, a putative tumor suppressor in humans, is a dinucleoside 5',5"'-P1,P3-triphosphate hydrolase.
Volume: 35
Issue: 36
Pages: 11529-35
Publication
First Author: Semba S
Year: 2006
Journal: J Biol Chem
Title: Biological functions of mammalian Nit1, the counterpart of the invertebrate NitFhit Rosetta stone protein, a possible tumor suppressor.
Volume: 281
Issue: 38
Pages: 28244-53
Publication
First Author: Zanesi N
Year: 2005
Journal: Mutat Res
Title: A mouse model of the fragile gene FHIT: From carcinogenesis to gene therapy and cancer prevention.
Volume: 591
Issue: 1-2
Pages: 103-9
Publication
First Author: Ishii H
Year: 2008
Journal: Cancer Res
Title: Fhit-deficient hematopoietic stem cells survive hydroquinone exposure carrying precancerous changes.
Volume: 68
Issue: 10
Pages: 3662-70
Publication
First Author: Zanesi N
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: The tumor spectrum in FHIT-deficient mice.
Volume: 98
Issue: 18
Pages: 10250-5
Publication
First Author: Shiraishi T
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: Sequence conservation at human and mouse orthologous common fragile regions, FRA3B/FHIT and Fra14A2/Fhit.
Volume: 98
Issue: 10
Pages: 5722-7
Publication
First Author: De Flora S
Year: 2007
Journal: Cancer Res
Title: Molecular and cytogenetical alterations induced by environmental cigarette smoke in mice heterozygous for Fhit.
Volume: 67
Issue: 3
Pages: 1001-6
Publication
First Author: Zanesi N
Year: 2005
Journal: Cancer Res
Title: Lung cancer susceptibility in Fhit-deficient mice is increased by Vhl haploinsufficiency.
Volume: 65
Issue: 15
Pages: 6576-82
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
GXD Expression    
Probe: MGI:3846563
Assay Type: Western blot
Annotation Date: 2009-06-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:3846567
Age: postnatal adult
Image: 1
Specimen Label: Spleen
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:3846563
Assay Type: Western blot
Annotation Date: 2009-06-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:3846567
Age: postnatal adult
Image: 1
Specimen Label: Kidney
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:3846563
Assay Type: Western blot
Annotation Date: 2009-06-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1775928
Stage: TS28
Assay Id: MGI:3846567
Age: postnatal adult
Image: 1
Specimen Label: Breast
Detected: true
Specimen Num: 8
GXD Expression    
Probe: MGI:3846563
Assay Type: Western blot
Annotation Date: 2009-06-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:3846567
Age: postnatal adult
Image: 1
Specimen Label: Lung
Detected: false
Specimen Num: 3
GXD Expression    
Probe: MGI:3846563
Assay Type: Western blot
Annotation Date: 2009-06-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3846567
Age: postnatal adult
Image: 1
Specimen Label: Heart
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:3846563
Assay Type: Western blot
Annotation Date: 2009-06-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:3846567
Age: postnatal adult
Image: 1
Specimen Label: Liver
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:3846563
Assay Type: Western blot
Annotation Date: 2009-06-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1893928
Stage: TS28
Assay Id: MGI:3846567
Age: postnatal adult
Image: 1
Specimen Label: Colon
Detected: false
Specimen Num: 4
GXD Expression    
Probe: MGI:3846563
Assay Type: Western blot
Annotation Date: 2009-06-03
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:3846567
Age: postnatal adult
Image: 1
Specimen Label: Testis
Detected: true
Specimen Num: 10
GXD Expression    
Probe: MGI:3846563
Assay Type: Western blot
Annotation Date: 2009-06-03
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3557728
Stage: TS28
Assay Id: MGI:3846567
Age: postnatal adult
Image: 1
Specimen Label: Muscle
Detected: false
Specimen Num: 11
GXD Expression    
Probe: MGI:3846563
Assay Type: Western blot
Annotation Date: 2009-06-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:3846567
Age: postnatal adult
Image: 1
Specimen Label: Brain
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:3846563
Assay Type: Western blot
Annotation Date: 2009-06-03
Strength: Absent
Sex: Female
Emaps: EMAPS:1796228
Stage: TS28
Assay Id: MGI:3846567
Age: postnatal adult
Image: 1
Specimen Label: Ovary
Detected: false
Specimen Num: 9
GXD Expression      
Probe: MGI:5309974
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3516422
Stage: TS22
Assay Id: MGI:5423300
Age: embryonic day 14.5
Specimen Label: EG706; Specimen G0312
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5309974
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1716122
Stage: TS22
Assay Id: MGI:5423300
Age: embryonic day 14.5
Specimen Label: EG706; Specimen G0312
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5309974
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1691622
Stage: TS22
Assay Id: MGI:5423300
Age: embryonic day 14.5
Specimen Label: EG706; Specimen G0312
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5309974
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1760622
Stage: TS22
Assay Id: MGI:5423300
Age: embryonic day 14.5
Specimen Label: EG706; Specimen G0312
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5309974
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1737322
Stage: TS22
Assay Id: MGI:5423300
Age: embryonic day 14.5
Specimen Label: EG706; Specimen G0312
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5309974
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3284222
Stage: TS22
Assay Id: MGI:5423300
Age: embryonic day 14.5
Specimen Label: EG706; Specimen G0312
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5309974
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1666522
Stage: TS22
Assay Id: MGI:5423300
Age: embryonic day 14.5
Specimen Label: EG706; Specimen G0312
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5309974
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1619822
Stage: TS22
Assay Id: MGI:5423300
Age: embryonic day 14.5
Specimen Label: EG706; Specimen G0312
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5309974
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1754922
Stage: TS22
Assay Id: MGI:5423300
Age: embryonic day 14.5
Note: Expression was not detected in the corpus striatum (lateral ganglionic eminence).
Specimen Label: EG706; Specimen G0312
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5309974
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1697422
Stage: TS22
Assay Id: MGI:5423300
Age: embryonic day 14.5
Specimen Label: EG706; Specimen G0312
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5309974
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3276322
Stage: TS22
Assay Id: MGI:5423300
Age: embryonic day 14.5
Note: Expression was not detected in the face/soft tissues.
Specimen Label: EG706; Specimen G0312
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5309974
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1783822
Stage: TS22
Assay Id: MGI:5423300
Age: embryonic day 14.5
Specimen Label: EG706; Specimen G0312
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5309974
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1665922
Stage: TS22
Assay Id: MGI:5423300
Age: embryonic day 14.5
Specimen Label: EG706; Specimen G0312
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5309974
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1706822
Stage: TS22
Assay Id: MGI:5423300
Age: embryonic day 14.5
Specimen Label: EG706; Specimen G0312
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5309974
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1674822
Stage: TS22
Assay Id: MGI:5423300
Age: embryonic day 14.5
Specimen Label: EG706; Specimen G0312
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5309974
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1670622
Stage: TS22
Assay Id: MGI:5423300
Age: embryonic day 14.5
Specimen Label: EG706; Specimen G0312
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5309974
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1738222
Stage: TS22
Assay Id: MGI:5423300
Age: embryonic day 14.5
Specimen Label: EG706; Specimen G0312
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5309974
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1654222
Stage: TS22
Assay Id: MGI:5423300
Age: embryonic day 14.5
Specimen Label: EG706; Specimen G0312
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5309974
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1777922
Stage: TS22
Assay Id: MGI:5423300
Age: embryonic day 14.5
Specimen Label: EG706; Specimen G0312
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5309974
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1684922
Stage: TS22
Assay Id: MGI:5423300
Age: embryonic day 14.5
Specimen Label: EG706; Specimen G0312
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5309974
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1716822
Stage: TS22
Assay Id: MGI:5423300
Age: embryonic day 14.5
Specimen Label: EG706; Specimen G0312
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5309974
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1619322
Stage: TS22
Assay Id: MGI:5423300
Age: embryonic day 14.5
Specimen Label: EG706; Specimen G0312
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5309974
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1755022
Stage: TS22
Assay Id: MGI:5423300
Age: embryonic day 14.5
Specimen Label: EG706; Specimen G0312
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5309974
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1733122
Stage: TS22
Assay Id: MGI:5423300
Age: embryonic day 14.5
Specimen Label: EG706; Specimen G0312
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5309974
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1736622
Stage: TS22
Assay Id: MGI:5423300
Age: embryonic day 14.5
Note: Expression was not detected in the genito-urinary system.
Specimen Label: EG706; Specimen G0312
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5309974
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1610422
Stage: TS22
Assay Id: MGI:5423300
Age: embryonic day 14.5
Specimen Label: EG706; Specimen G0312
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5309974
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1876922
Stage: TS22
Assay Id: MGI:5423300
Age: embryonic day 14.5
Specimen Label: EG706; Specimen G0312
Detected: false
Specimen Num: 1