Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
zebrafish |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
DCC (deleted in colorectal cancer) is a receptor for netrin required for axon guidance [, ]. It also binds a second axon guidance protein, Draxin []. The interactions between these guidance cues and DCC play a key role in the development of the nervous system.DCC belongs to the immunoglobulin superfamily. The protein consists of four N-terminal Ig-like domains []followed by six fibronectin type III domains (FN), a transmembrane segment and the cytosolic portion []. The deletion of DCC has been linked to the propensity of cancerous cells to metastasise [, ]. DCC indeed functions as a tumour suppressor through its ability to trigger tumour cell apoptosis []. |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Castets M |
Year: |
2011 |
Journal: |
Nature |
Title: |
DCC constrains tumour progression via its dependence receptor activity. |
Volume: |
482 |
Issue: |
7386 |
Pages: |
534-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ahmed G |
Year: |
2011 |
Journal: |
J Neurosci |
Title: |
Draxin inhibits axonal outgrowth through the netrin receptor DCC. |
Volume: |
31 |
Issue: |
39 |
Pages: |
14018-23 |
|
•
•
•
•
•
|
Publication |
First Author: |
Krimpenfort P |
Year: |
2012 |
Journal: |
Nature |
Title: |
Deleted in colorectal carcinoma suppresses metastasis in p53-deficient mammary tumours. |
Volume: |
482 |
Issue: |
7386 |
Pages: |
538-41 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1447
![FASTA](model/images/fasta.gif) |
Fragment?: |
false |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2670856 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2023-05-16 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271222 |
Pattern: |
Regionally restricted |
Stage: |
TS22 |
Assay Id: |
MGI:7481908 |
Age: |
embryonic day 14.5 |
Image: |
2B DCC |
Note: |
Expression overlapping with CTIP2 (Bcl11b) expression. |
Specimen Label: |
2B DCC |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2670856 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2023-05-16 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3271122 |
Pattern: |
Regionally restricted |
Stage: |
TS22 |
Assay Id: |
MGI:7481908 |
Age: |
embryonic day 14.5 |
Image: |
2B DCC |
Note: |
Expression overlapping with CTIP2 (Bcl11b) expression. |
Specimen Label: |
2B DCC |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
Publication |
First Author: |
Stein E |
Year: |
2001 |
Journal: |
Science |
Title: |
Binding of DCC by netrin-1 to mediate axon guidance independent of adenosine A2B receptor activation. |
Volume: |
291 |
Issue: |
5510 |
Pages: |
1976-82 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen Q |
Year: |
2013 |
Journal: |
J Cell Sci |
Title: |
N-terminal horseshoe conformation of DCC is functionally required for axon guidance and might be shared by other neural receptors. |
Volume: |
126 |
Issue: |
Pt 1 |
Pages: |
186-95 |
|
•
•
•
•
•
|
Publication |
First Author: |
Miyake S |
Year: |
1994 |
Journal: |
Cancer Res |
Title: |
Point mutations and allelic deletion of tumor suppressor gene DCC in human esophageal squamous cell carcinomas and their relation to metastasis. |
Volume: |
54 |
Issue: |
11 |
Pages: |
3007-10 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3821385 |
Assay Type: |
RNA in situ |
Annotation Date: |
2009-01-15 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1750322 |
|
Stage: |
TS22 |
Assay Id: |
MGI:3825941 |
Age: |
embryonic day 14.5 |
Image: |
Additional file 4 Dcc |
|
Specimen Label: |
Additional file 4 Dcc |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6170971 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-05-30 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689419 |
Pattern: |
Regionally restricted |
Stage: |
TS19 |
Assay Id: |
MGI:6158893 |
Age: |
embryonic day 11.5 |
Image: |
Dcc - E11.5 |
Note: |
There is particularly highly expression at early stages in developing neurons of the cortical plate and brainstem nuclei; expression subsequently tapers off with age. |
Specimen Label: |
Dcc - E11.5 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6170971 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-05-30 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689421 |
Pattern: |
Regionally restricted |
Stage: |
TS21 |
Assay Id: |
MGI:6158893 |
Age: |
embryonic day 13.5 |
Image: |
Dcc - E13.5 |
Note: |
There is particularly highly expression at early stages in developing neurons of the cortical plate and brainstem nuclei; expression subsequently tapers off with age. |
Specimen Label: |
Dcc - E13.5 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6170971 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-05-30 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689423 |
Pattern: |
Regionally restricted |
Stage: |
TS23 |
Assay Id: |
MGI:6158893 |
Age: |
embryonic day 15.5 |
Image: |
Dcc - E15.5 |
Note: |
There is particularly highly expression at early stages in developing neurons of the cortical plate and brainstem nuclei; expression subsequently tapers off with age. |
Specimen Label: |
Dcc - E15.5 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6170971 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-05-30 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689426 |
Pattern: |
Regionally restricted |
Stage: |
TS26 |
Assay Id: |
MGI:6158893 |
Age: |
embryonic day 18.5 |
Image: |
Dcc - E18.5 |
Note: |
There is particularly highly expression at early stages in developing neurons of the cortical plate and brainstem nuclei; expression subsequently tapers off with age. |
Specimen Label: |
Dcc - E18.5 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Keino-Masu K |
Year: |
1996 |
Journal: |
Cell |
Title: |
Deleted in Colorectal Cancer (DCC) encodes a netrin receptor. |
Volume: |
87 |
Issue: |
2 |
Pages: |
175-85 |
|
•
•
•
•
•
|
Publication |
First Author: |
Reynolds LM |
Year: |
2016 |
Journal: |
Behav Brain Res |
Title: |
dcc Haploinsufficiency results in blunted sensitivity to cocaine enhancement of reward seeking. |
Volume: |
298 |
Issue: |
Pt A |
Pages: |
27-31 |
|
•
•
•
•
•
|
Publication |
First Author: |
Manitt C |
Year: |
2011 |
Journal: |
J Neurosci |
Title: |
The netrin receptor DCC is required in the pubertal organization of mesocortical dopamine circuitry. |
Volume: |
31 |
Issue: |
23 |
Pages: |
8381-94 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jamuar SS |
Year: |
2017 |
Journal: |
Nat Genet |
Title: |
Biallelic mutations in human DCC cause developmental split-brain syndrome. |
Volume: |
49 |
Issue: |
4 |
Pages: |
606-612 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pokinko M |
Year: |
2017 |
Journal: |
Neuroscience |
Title: |
Dcc haploinsufficiency regulates dopamine receptor expression across postnatal lifespan. |
Volume: |
346 |
|
Pages: |
182-189 |
|
•
•
•
•
•
|
Publication |
First Author: |
Horn KE |
Year: |
2013 |
Journal: |
Cell Rep |
Title: |
DCC expression by neurons regulates synaptic plasticity in the adult brain. |
Volume: |
3 |
Issue: |
1 |
Pages: |
173-85 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liang DY |
Year: |
2014 |
Journal: |
BMC Genomics |
Title: |
The Netrin-1 receptor DCC is a regulator of maladaptive responses to chronic morphine administration. |
Volume: |
15 |
|
Pages: |
345 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ly A |
Year: |
2008 |
Journal: |
Cell |
Title: |
DSCAM is a netrin receptor that collaborates with DCC in mediating turning responses to netrin-1. |
Volume: |
133 |
Issue: |
7 |
Pages: |
1241-54 |
|
•
•
•
•
•
|
Publication |
First Author: |
Reynolds LM |
Year: |
2018 |
Journal: |
Biol Psychiatry |
Title: |
DCC Receptors Drive Prefrontal Cortex Maturation by Determining Dopamine Axon Targeting in Adolescence. |
Volume: |
83 |
Issue: |
2 |
Pages: |
181-192 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kim YJ |
Year: |
2016 |
Journal: |
Sci Rep |
Title: |
Dcc Mediates Functional Assembly of Peripheral Auditory Circuits. |
Volume: |
6 |
|
Pages: |
23799 |
|
•
•
•
•
•
|
Publication |
First Author: |
Glasgow SD |
Year: |
2020 |
Journal: |
Mol Brain |
Title: |
Pre- and post-synaptic roles for DCC in memory consolidation in the adult mouse hippocampus. |
Volume: |
13 |
Issue: |
1 |
Pages: |
56 |
|
•
•
•
•
•
|
Publication |
First Author: |
Manitt C |
Year: |
2013 |
Journal: |
Transl Psychiatry |
Title: |
dcc orchestrates the development of the prefrontal cortex during adolescence and is altered in psychiatric patients. |
Volume: |
3 |
|
Pages: |
e338 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bull SJ |
Year: |
2014 |
Journal: |
J Neurosci |
Title: |
Progressive disorganization of paranodal junctions and compact myelin due to loss of DCC expression by oligodendrocytes. |
Volume: |
34 |
Issue: |
29 |
Pages: |
9768-78 |
|
•
•
•
•
•
|
Publication |
First Author: |
Grant A |
Year: |
2009 |
Journal: |
Eur J Neurosci |
Title: |
Post-pubertal emergence of a dopamine phenotype in netrin-1 receptor-deficient mice. |
Volume: |
30 |
Issue: |
7 |
Pages: |
1318-28 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yetnikoff L |
Year: |
2010 |
Journal: |
Eur J Neurosci |
Title: |
Netrin-1 receptor in the ventral tegmental area is required for sensitization to amphetamine. |
Volume: |
31 |
Issue: |
7 |
Pages: |
1292-302 |
|
•
•
•
•
•
|
Publication |
First Author: |
Castillo-Paterna M |
Year: |
2015 |
Journal: |
EMBO Rep |
Title: |
DCC functions as an accelerator of thalamocortical axonal growth downstream of spontaneous thalamic activity. |
Volume: |
16 |
Issue: |
7 |
Pages: |
851-62 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rabe Bernhardt N |
Year: |
2012 |
Journal: |
Dev Biol |
Title: |
DCC mediated axon guidance of spinal interneurons is essential for normal locomotor central pattern generator function. |
Volume: |
366 |
Issue: |
2 |
Pages: |
279-89 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1140
![FASTA](model/images/fasta.gif) |
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Boussouar A |
Year: |
2020 |
Journal: |
Cancer Res |
Title: |
Netrin-1 and Its Receptor DCC Are Causally Implicated in Melanoma Progression. |
Volume: |
80 |
Issue: |
4 |
Pages: |
747-756 |
|
•
•
•
•
•
|
Publication |
First Author: |
Thiry L |
Year: |
2022 |
Journal: |
eNeuro |
Title: |
Heterozygous Dcc Mutant Mice Have a Subtle Locomotor Phenotype. |
Volume: |
9 |
Issue: |
2 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Finger JH |
Year: |
2002 |
Journal: |
J Neurosci |
Title: |
The netrin 1 receptors Unc5h3 and Dcc are necessary at multiple choice points for the guidance of corticospinal tract axons. |
Volume: |
22 |
Issue: |
23 |
Pages: |
10346-56 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shi M |
Year: |
2010 |
Journal: |
Dev Biol |
Title: |
DCC is specifically required for the survival of retinal ganglion and displaced amacrine cells in the developing mouse retina. |
Volume: |
348 |
Issue: |
1 |
Pages: |
87-96 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang JH |
Year: |
2018 |
Journal: |
Cell Rep |
Title: |
DCC-Mediated Dab1 Phosphorylation Participates in the Multipolar-to-Bipolar Transition of Migrating Neurons. |
Volume: |
22 |
Issue: |
13 |
Pages: |
3598-3611 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jiang Y |
Year: |
2003 |
Journal: |
Dev Biol |
Title: |
Netrins and DCC in the guidance of migrating neural crest-derived cells in the developing bowel and pancreas. |
Volume: |
258 |
Issue: |
2 |
Pages: |
364-84 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shi M |
Year: |
2008 |
Journal: |
Mol Cell Neurosci |
Title: |
DCC is required for the tangential migration of noradrenergic neurons in locus coeruleus of mouse brain. |
Volume: |
39 |
Issue: |
4 |
Pages: |
529-38 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vosberg DE |
Year: |
2018 |
Journal: |
J Neurosci |
Title: |
Mesocorticolimbic Connectivity and Volumetric Alterations in DCC Mutation Carriers. |
Volume: |
38 |
Issue: |
20 |
Pages: |
4655-4665 |
|
•
•
•
•
•
|
Publication |
First Author: |
Welniarz Q |
Year: |
2017 |
Journal: |
Sci Rep |
Title: |
Non cell-autonomous role of DCC in the guidance of the corticospinal tract at the midline. |
Volume: |
7 |
Issue: |
1 |
Pages: |
410 |
|
•
•
•
•
•
|
Publication |
First Author: |
Morcom L |
Year: |
2021 |
Journal: |
Elife |
Title: |
DCC regulates astroglial development essential for telencephalic morphogenesis and corpus callosum formation. |
Volume: |
10 |
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Marcos S |
Year: |
2009 |
Journal: |
Mol Cell Neurosci |
Title: |
Differential roles of Netrin-1 and its receptor DCC in inferior olivary neuron migration. |
Volume: |
41 |
Issue: |
4 |
Pages: |
429-39 |
|
•
•
•
•
•
|
Publication |
First Author: |
Deiner MS |
Year: |
1997 |
Journal: |
Neuron |
Title: |
Netrin-1 and DCC mediate axon guidance locally at the optic disc: loss of function leads to optic nerve hypoplasia. |
Volume: |
19 |
Issue: |
3 |
Pages: |
575-89 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rajasekharan S |
Year: |
2009 |
Journal: |
Development |
Title: |
Netrin 1 and Dcc regulate oligodendrocyte process branching and membrane extension via Fyn and RhoA. |
Volume: |
136 |
Issue: |
3 |
Pages: |
415-26 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jarjour AA |
Year: |
2008 |
Journal: |
J Neurosci |
Title: |
Maintenance of axo-oligodendroglial paranodal junctions requires DCC and netrin-1. |
Volume: |
28 |
Issue: |
43 |
Pages: |
11003-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vigouroux RJ |
Year: |
2020 |
Journal: |
Elife |
Title: |
Revisiting the role of Dcc in visual system development with a novel eye clearing method. |
Volume: |
9 |
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Auger ML |
Year: |
2013 |
Journal: |
Eur J Neurosci |
Title: |
unc5c haploinsufficient phenotype: striking similarities with the dcc haploinsufficiency model. |
Volume: |
38 |
Issue: |
6 |
Pages: |
2853-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bouchard JF |
Year: |
2008 |
Journal: |
J Neurochem |
Title: |
Depolarization recruits DCC to the plasma membrane of embryonic cortical neurons and enhances axon extension in response to netrin-1. |
Volume: |
107 |
Issue: |
2 |
Pages: |
398-417 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6170971 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689421 |
Pattern: |
Not Specified |
Stage: |
TS21 |
Assay Id: |
MGI:6190099 |
Age: |
embryonic day 13.5 |
|
|
Specimen Label: |
Table S2 - E13.5 - Dcc |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6170971 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689424 |
Pattern: |
Not Specified |
Stage: |
TS24 |
Assay Id: |
MGI:6190099 |
Age: |
embryonic day 15.5 |
|
|
Specimen Label: |
Table S2 - E15.5 - Dcc |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6170971 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6190099 |
Age: |
postnatal day 4 |
|
|
Specimen Label: |
Table S2 - P4 - Dcc |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6170971 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6190099 |
Age: |
postnatal day 14 |
|
|
Specimen Label: |
Table S2 - P14 - Dcc |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6170971 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689419 |
Pattern: |
Not Specified |
Stage: |
TS19 |
Assay Id: |
MGI:6190099 |
Age: |
embryonic day 11.5 |
|
|
Specimen Label: |
Table S2 - E11.5 - Dcc |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6170971 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689426 |
Pattern: |
Not Specified |
Stage: |
TS26 |
Assay Id: |
MGI:6190099 |
Age: |
embryonic day 18.5 |
|
|
Specimen Label: |
Table S2 - E18.5 - Dcc |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6170971 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6190099 |
Age: |
postnatal day 28 |
|
|
Specimen Label: |
Table S2 - P28 - Dcc |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Peng J |
Year: |
2018 |
Journal: |
Dev Dyn |
Title: |
Loss of Dcc in the spinal cord is sufficient to cause a deficit in lateralized motor control and the switch to a hopping gait. |
Volume: |
247 |
Issue: |
4 |
Pages: |
620-629 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lo PS |
Year: |
2022 |
Journal: |
J Neurochem |
Title: |
The netrin-1 receptor DCC promotes the survival of a subpopulation of midbrain dopaminergic neurons: Relevance for ageing and Parkinson's disease. |
Volume: |
161 |
Issue: |
3 |
Pages: |
254-265 |
|
•
•
•
•
•
|
Publication |
First Author: |
Plooster M |
Year: |
2017 |
Journal: |
Mol Biol Cell |
Title: |
TRIM9-dependent ubiquitination of DCC constrains kinase signaling, exocytosis, and axon branching. |
Volume: |
28 |
Issue: |
18 |
Pages: |
2374-2385 |
|
•
•
•
•
•
|
Publication |
First Author: |
da Silva RV |
Year: |
2018 |
Journal: |
Cell Rep |
Title: |
DCC Is Required for the Development of Nociceptive Topognosis in Mice and Humans. |
Volume: |
22 |
Issue: |
5 |
Pages: |
1105-1114 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ding YQ |
Year: |
2005 |
Journal: |
Development |
Title: |
Ventral migration of early-born neurons requires Dcc and is essential for the projections of primary afferents in the spinal cord. |
Volume: |
132 |
Issue: |
9 |
Pages: |
2047-56 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cooper HM |
Year: |
1995 |
Journal: |
Oncogene |
Title: |
Cloning of the mouse homologue of the deleted in colorectal cancer gene (mDCC) and its expression in the developing mouse embryo. |
Volume: |
11 |
Issue: |
11 |
Pages: |
2243-54 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu Y |
Year: |
2012 |
Journal: |
J Cell Sci |
Title: |
Differential regulation of myosin X movements by its cargos, DCC and neogenin. |
Volume: |
125 |
Issue: |
Pt 3 |
Pages: |
751-62 |
|
•
•
•
•
•
|
Publication |
First Author: |
Laumonnerie C |
Year: |
2014 |
Journal: |
Development |
Title: |
Netrin 1 and Dcc signalling are required for confinement of central axons within the central nervous system. |
Volume: |
141 |
Issue: |
3 |
Pages: |
594-603 |
|
•
•
•
•
•
|
Publication |
First Author: |
Leggere JC |
Year: |
2016 |
Journal: |
Elife |
Title: |
NOVA regulates Dcc alternative splicing during neuronal migration and axon guidance in the spinal cord. |
Volume: |
5 |
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bourojeni FB |
Year: |
2021 |
Journal: |
Pain |
Title: |
Netrin-1 receptor DCC is required for the contralateral topography of lamina I anterolateral system neurons. |
Volume: |
162 |
Issue: |
1 |
Pages: |
161-175 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dalvin S |
Year: |
2003 |
Journal: |
Gene Expr Patterns |
Title: |
Expression of Netrin-1 and its two receptors DCC and UNC5H2 in the developing mouse lung. |
Volume: |
3 |
Issue: |
3 |
Pages: |
279-83 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tcherkezian J |
Year: |
2010 |
Journal: |
Cell |
Title: |
Transmembrane receptor DCC associates with protein synthesis machinery and regulates translation. |
Volume: |
141 |
Issue: |
4 |
Pages: |
632-44 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gad JM |
Year: |
2000 |
Journal: |
Exp Eye Res |
Title: |
The spatial and temporal expression patterns of netrin receptors, DCC and neogenin, in the developing mouse retina. |
Volume: |
70 |
Issue: |
6 |
Pages: |
711-22 |
|
•
•
•
•
•
|
Publication |
First Author: |
Flores C |
Year: |
2005 |
Journal: |
Mol Psychiatry |
Title: |
Netrin receptor deficient mice exhibit functional reorganization of dopaminergic systems and do not sensitize to amphetamine. |
Volume: |
10 |
Issue: |
6 |
Pages: |
606-12 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kim JH |
Year: |
2013 |
Journal: |
Psychopharmacology (Berl) |
Title: |
Netrin-1 receptor-deficient mice show age-specific impairment in drug-induced locomotor hyperactivity but still self-administer methamphetamine. |
Volume: |
230 |
Issue: |
4 |
Pages: |
607-16 |
|
•
•
•
•
•
|
Publication |
First Author: |
Grant A |
Year: |
2007 |
Journal: |
Eur J Neurosci |
Title: |
Netrin-1 receptor-deficient mice show enhanced mesocortical dopamine transmission and blunted behavioural responses to amphetamine. |
Volume: |
26 |
Issue: |
11 |
Pages: |
3215-28 |
|
•
•
•
•
•
|
Publication |
First Author: |
Xie Y |
Year: |
2005 |
Journal: |
Nat Cell Biol |
Title: |
Phosphatidylinositol transfer protein-alpha in netrin-1-induced PLC signalling and neurite outgrowth. |
Volume: |
7 |
Issue: |
11 |
Pages: |
1124-32 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dailey-Krempel B |
Year: |
2023 |
Journal: |
Cell Rep |
Title: |
A tug of war between DCC and ROBO1 signaling during commissural axon guidance. |
Volume: |
42 |
Issue: |
5 |
Pages: |
112455 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gad JM |
Year: |
1997 |
Journal: |
Dev Biol |
Title: |
The expression patterns of guidance receptors, DCC and Neogenin, are spatially and temporally distinct throughout mouse embryogenesis. |
Volume: |
192 |
Issue: |
2 |
Pages: |
258-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
Srivatsa S |
Year: |
2014 |
Journal: |
Nat Commun |
Title: |
Unc5C and DCC act downstream of Ctip2 and Satb2 and contribute to corpus callosum formation. |
Volume: |
5 |
|
Pages: |
3708 |
|
•
•
•
•
•
|
Publication |
First Author: |
Salehi P |
Year: |
2016 |
Journal: |
J Assoc Res Otolaryngol |
Title: |
Genome-Wide Association Analysis Identifies Dcc as an Essential Factor in the Innervation of the Peripheral Vestibular System in Inbred Mice. |
Volume: |
17 |
Issue: |
5 |
Pages: |
417-31 |
|
•
•
•
•
•
|
Publication |
First Author: |
Howell DM |
Year: |
2007 |
Journal: |
J Comp Neurol |
Title: |
Molecular guidance cues necessary for axon pathfinding from the ventral cochlear nucleus. |
Volume: |
504 |
Issue: |
5 |
Pages: |
533-49 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bouhidel JO |
Year: |
2015 |
Journal: |
Biochim Biophys Acta |
Title: |
Netrin-1 improves post-injury cardiac function in vivo via DCC/NO-dependent preservation of mitochondrial integrity, while attenuating autophagy. |
Volume: |
1852 |
Issue: |
2 |
Pages: |
277-89 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shide K |
Year: |
2008 |
Journal: |
Leukemia |
Title: |
Development of ET, primary myelofibrosis and PV in mice expressing JAK2 V617F. |
Volume: |
22 |
Issue: |
1 |
Pages: |
87-95 |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Publication |
First Author: |
Furne C |
Year: |
2008 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Netrin-1 is a survival factor during commissural neuron navigation. |
Volume: |
105 |
Issue: |
38 |
Pages: |
14465-70 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu L |
Year: |
2021 |
Journal: |
Int J Mol Sci |
Title: |
A Novel Netrin-1-Derived Peptide Enhances Protection against Neuronal Death and Mitigates of Intracerebral Hemorrhage in Mice. |
Volume: |
22 |
Issue: |
9 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Ren XR |
Year: |
2004 |
Journal: |
Nat Neurosci |
Title: |
Focal adhesion kinase in netrin-1 signaling. |
Volume: |
7 |
Issue: |
11 |
Pages: |
1204-12 |
|
•
•
•
•
•
|
Publication |
First Author: |
Schwarting GA |
Year: |
2001 |
Journal: |
J Neurosci |
Title: |
Deleted in colorectal cancer (DCC) regulates the migration of luteinizing hormone-releasing hormone neurons to the basal forebrain. |
Volume: |
21 |
Issue: |
3 |
Pages: |
911-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ren T |
Year: |
2007 |
Journal: |
J Neurosci |
Title: |
Diffusion tensor magnetic resonance imaging and tract-tracing analysis of Probst bundle structure in Netrin1- and DCC-deficient mice. |
Volume: |
27 |
Issue: |
39 |
Pages: |
10345-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Xu B |
Year: |
2010 |
Journal: |
Neuroscience |
Title: |
Critical roles for the netrin receptor deleted in colorectal cancer in dopaminergic neuronal precursor migration, axon guidance, and axon arborization. |
Volume: |
169 |
Issue: |
2 |
Pages: |
932-49 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kameda T |
Year: |
2015 |
Journal: |
Blood |
Title: |
Loss of TET2 has dual roles in murine myeloproliferative neoplasms: disease sustainer and disease accelerator. |
Volume: |
125 |
Issue: |
2 |
Pages: |
304-15 |
|
•
•
•
•
•
|