Synaptonemal complex protein 1 (SYCP1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase [].
The synaptonemal complex (SC) is a tripartite structure that physically links homologous chromosomes during prophase I. The SC has a zipper-like structure composed of two lateral elements (LEs) and a central element (CE). Transverse filaments, composed of SYCP1 molecules, bridge the gap between one LE and the CE.Syce2/CESC1 localises to the CE and interacts with the transverse filament protein SYCP1. Its localization to the CE is dependent on recruitment by SYCP1 []. Syce2/ CESC1 is required for synaptonemal complex assembly and also for double strand break repair and homologous recombination [].
