This entry represents a group of probable tubulin-tyrosine ligases from fungi, including Pby1 from budding yeast []. Tubulin--tyrosine ligase catalyses the post-translational addition of a tyrosine to the C-terminal end of detyrosinated alpha-tubulin [].
This entry includes CCDC84 from animals and TITAN-like protein (TTL; At4g24900) from Arabidopsis. TTL is a key regulator for endosperm and embryo nuclear divisions []. CCDC84 has been shown to constrain centriole number by modulating APC/CCdh1-mediated HsSAS-6 degradation [].
