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Search results 201 to 300 out of 304 for Ogdh

0.038s
Type Details Score
GXD Expression  
Probe: MGI:3724942
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1738222
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421593
Age: embryonic day 14.5
Image: MH1551; Specimen C1750
Specimen Label: MH1551; Specimen C1750
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3724942
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1738322
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421593
Age: embryonic day 14.5
Image: MH1551; Specimen C1750
Specimen Label: MH1551; Specimen C1750
Detected: true
Specimen Num: 1
GXD Expression
Probe: MGI:3724942
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1842522
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421593
Age: embryonic day 14.5
Image: MH1551; Specimen C1750
Note: Expression was detected in the endocrine system.
Specimen Label: MH1551; Specimen C1750
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3724942
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1706822
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421593
Age: embryonic day 14.5
Image: MH1551; Specimen C1750
Specimen Label: MH1551; Specimen C1750
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3724942
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:3599822
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421593
Age: embryonic day 14.5
Image: MH1551; Specimen C1750
Specimen Label: MH1551; Specimen C1750
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3724942
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1750322
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421593
Age: embryonic day 14.5
Image: MH1551; Specimen C1750
Specimen Label: MH1551; Specimen C1750
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3724942
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1842622
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421593
Age: embryonic day 14.5
Image: MH1551; Specimen C1750
Specimen Label: MH1551; Specimen C1750
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3724942
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1610422
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421593
Age: embryonic day 14.5
Image: MH1551; Specimen C1750
Specimen Label: MH1551; Specimen C1750
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3724942
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1610522
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421593
Age: embryonic day 14.5
Image: MH1551; Specimen C1750
Specimen Label: MH1551; Specimen C1750
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3724942
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1668822
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421593
Age: embryonic day 14.5
Image: MH1551; Specimen C1750
Specimen Label: MH1551; Specimen C1750
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3724942
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1733122
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421593
Age: embryonic day 14.5
Image: MH1551; Specimen C1750
Specimen Label: MH1551; Specimen C1750
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3724942
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:3274322
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421593
Age: embryonic day 14.5
Image: MH1551; Specimen C1750
Specimen Label: MH1551; Specimen C1750
Detected: true
Specimen Num: 1
GXD Expression
Probe: MGI:3724942
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1876522
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421593
Age: embryonic day 14.5
Image: MH1551; Specimen C1750
Note: Expression was detected in the immune system.
Specimen Label: MH1551; Specimen C1750
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3724942
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1853522
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421593
Age: embryonic day 14.5
Image: MH1551; Specimen C1750
Specimen Label: MH1551; Specimen C1750
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3724942
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1752322
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421593
Age: embryonic day 14.5
Image: MH1551; Specimen C1750
Specimen Label: MH1551; Specimen C1750
Detected: true
Specimen Num: 1
GXD Expression
Probe: MGI:3724942
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:3272922
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421593
Age: embryonic day 14.5
Image: MH1551; Specimen C1750
Note: Expression was detected in the skeleton (limbs, shoulder, hip).
Specimen Label: MH1551; Specimen C1750
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3724942
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:3557722
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421593
Age: embryonic day 14.5
Image: MH1551; Specimen C1750
Specimen Label: MH1551; Specimen C1750
Detected: true
Specimen Num: 1
GXD Expression
Probe: MGI:3724942
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:3276322
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421593
Age: embryonic day 14.5
Image: MH1551; Specimen C1750
Note: Expression was detected in the face/soft tissues.
Specimen Label: MH1551; Specimen C1750
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3724942
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1802422
Stage: TS22
Assay Id: MGI:5421593
Age: embryonic day 14.5
Specimen Label: MH1551; Specimen C1750
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:3724942
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1768022
Stage: TS22
Assay Id: MGI:5421593
Age: embryonic day 14.5
Note: Expression was not detected in the skull (base and vault).
Specimen Label: MH1551; Specimen C1750
Detected: false
Specimen Num: 1
GXD Expression  
Probe: MGI:3724942
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1721422
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421593
Age: embryonic day 14.5
Image: MH1551; Specimen C1750
Specimen Label: MH1551; Specimen C1750
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3724942
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1674822
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421593
Age: embryonic day 14.5
Image: MH1551; Specimen C1750
Specimen Label: MH1551; Specimen C1750
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3724942
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1741222
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421593
Age: embryonic day 14.5
Image: MH1551; Specimen C1750
Specimen Label: MH1551; Specimen C1750
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3724942
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1745822
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421593
Age: embryonic day 14.5
Image: MH1551; Specimen C1750
Specimen Label: MH1551; Specimen C1750
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3724942
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1752422
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421593
Age: embryonic day 14.5
Image: MH1551; Specimen C1750
Specimen Label: MH1551; Specimen C1750
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3724942
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1752522
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421593
Age: embryonic day 14.5
Image: MH1551; Specimen C1750
Specimen Label: MH1551; Specimen C1750
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3724942
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1876922
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421593
Age: embryonic day 14.5
Image: MH1551; Specimen C1750
Specimen Label: MH1551; Specimen C1750
Detected: true
Specimen Num: 1
GXD Expression
Probe: MGI:3724942
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:2672022
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421593
Age: embryonic day 14.5
Image: MH1551; Specimen C1750
Note: Expression was detected in whisker follicle.
Specimen Label: MH1551; Specimen C1750
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:3691103
Assay Type: RNA in situ
Annotation Date: 2006-12-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3816028
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3691289
Age: postnatal day 21
Note: Expression is present in the rostral migratory stream.
Specimen Label: 2 P21
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:3691103
Assay Type: RNA in situ
Annotation Date: 2006-12-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3816028
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3691289
Age: postnatal day 7
Specimen Label: 2 P7
Detected: true
Specimen Num: 1
Publication
First Author: Andrade J
Year: 2021
Journal: Nat Cell Biol
Title: Control of endothelial quiescence by FOXO-regulated metabolites.
Volume: 23
Issue: 4
Pages: 413-423
Publication
First Author: Starkov AA
Year: 2004
Journal: J Neurosci
Title: Mitochondrial alpha-ketoglutarate dehydrogenase complex generates reactive oxygen species.
Volume: 24
Issue: 36
Pages: 7779-88
Publication
First Author: Gibson GE
Year: 2012
Journal: Neurobiol Aging
Title: Deficits in the mitochondrial enzyme α-ketoglutarate dehydrogenase lead to Alzheimer's disease-like calcium dysregulation.
Volume: 33
Issue: 6
Pages: 1121.e13-24
Publication
First Author: Wagner M
Year: 2020
Journal: Basic Res Cardiol
Title: Selective NADH communication from α-ketoglutarate dehydrogenase to mitochondrial transhydrogenase prevents reactive oxygen species formation under reducing conditions in the heart.
Volume: 115
Issue: 5
Pages: 53
Publication
First Author: Karlstaedt A
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: Oncometabolite d-2-hydroxyglutarate impairs α-ketoglutarate dehydrogenase and contractile function in rodent heart.
Volume: 113
Issue: 37
Pages: 10436-41
Publication
First Author: Oktay Y
Year: 2007
Journal: J Biol Chem
Title: Hypoxia-inducible factor 2alpha regulates expression of the mitochondrial aconitase chaperone protein frataxin.
Volume: 282
Issue: 16
Pages: 11750-6
Publication
First Author: Schatton D
Year: 2017
Journal: J Cell Biol
Title: CLUH regulates mitochondrial metabolism by controlling translation and decay of target mRNAs.
Volume: 216
Issue: 3
Pages: 675-693
Publication
First Author: Mayeuf-Louchart A
Year: 2019
Journal: Cell Rep
Title: Glycogen Dynamics Drives Lipid Droplet Biogenesis during Brown Adipocyte Differentiation.
Volume: 29
Issue: 6
Pages: 1410-1418.e6
Publication  
First Author: Zhao K
Year: 2022
Journal: Development
Title: LONP1-mediated mitochondrial quality control safeguards metabolic shifts in heart development.
Volume: 149
Issue: 6
Publication  
First Author: Cankaya M
Year: 2007
Journal: BMC Genomics
Title: An analysis of expression patterns of genes encoding proteins with catalytic activities.
Volume: 8
Pages: 232
Publication      
First Author: Mouse Genome Informatics and the Consortium: Deciphering the Mechanisms of Developmental Disorders (DMDD)
Year: 2017
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from Deciphering the Mechanisms of Developmental Disorders (DMDD)
Publication
First Author: Bowman CE
Year: 2016
Journal: Mol Cell Biol
Title: Requirement for the Mitochondrial Pyruvate Carrier in Mammalian Development Revealed by a Hypomorphic Allelic Series.
Volume: 36
Issue: 15
Pages: 2089-104
Publication
First Author: Bulusu V
Year: 2017
Journal: Dev Cell
Title: Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to Mouse Embryo Mesoderm Development.
Volume: 40
Issue: 4
Pages: 331-341.e4
Publication
First Author: Nakano Y
Year: 2019
Journal: Cell Rep
Title: Overlapping Activities of Two Neuronal Splicing Factors Switch the GABA Effect from Excitatory to Inhibitory by Regulating REST.
Volume: 27
Issue: 3
Pages: 860-871.e8
Publication
First Author: Sansom SN
Year: 2009
Journal: PLoS Genet
Title: The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis.
Volume: 5
Issue: 6
Pages: e1000511
Publication
First Author: Mootha VK
Year: 2003
Journal: Cell
Title: Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria.
Volume: 115
Issue: 5
Pages: 629-40
Publication
First Author: Pagliarini DJ
Year: 2008
Journal: Cell
Title: A mitochondrial protein compendium elucidates complex I disease biology.
Volume: 134
Issue: 1
Pages: 112-23
Publication
First Author: Ingham NJ
Year: 2019
Journal: PLoS Biol
Title: Mouse screen reveals multiple new genes underlying mouse and human hearing loss.
Volume: 17
Issue: 4
Pages: e3000194
Publication
First Author: Ko MS
Year: 2000
Journal: Development
Title: Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.
Volume: 127
Issue: 8
Pages: 1737-49
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Mouse Synonym Curation
Publication
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
Publication
First Author: Visel A
Year: 2004
Journal: Nucleic Acids Res
Title: GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
Volume: 32
Issue: Database issue
Pages: D552-6
Publication
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
Publication      
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
Publication      
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
Publication        
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
Publication
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
Publication      
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Rat to Mouse ISO GO annotation transfer
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
Publication        
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication
First Author: Gaudet P
Year: 2011
Journal: Brief Bioinform
Title: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Volume: 12
Issue: 5
Pages: 449-62
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication
First Author: Leandro J
Year: 2020
Journal: Hum Mol Genet
Title: DHTKD1 and OGDH display substrate overlap in cultured cells and form a hybrid 2-oxo acid dehydrogenase complex in vivo.
Volume: 29
Issue: 7
Pages: 1168-1179
Publication
First Author: Gao Y
Year: 2023
Journal: Cell Rep
Title: ALKBH5 modulates hematopoietic stem and progenitor cell energy metabolism through m(6)A modification-mediated RNA stability control.
Volume: 42
Issue: 10
Pages: 113163
Publication  
First Author: Chalker J
Year: 2018
Journal: Redox Biol
Title: Characterization of the impact of glutaredoxin-2 (GRX2) deficiency on superoxide/hydrogen peroxide release from cardiac and liver mitochondria.
Volume: 15
Pages: 216-227
Publication
First Author: Denton RM
Year: 2016
Journal: Biochem J
Title: Calcium-insensitive splice variants of mammalian E1 subunit of 2-oxoglutarate dehydrogenase complex with tissue-specific patterns of expression.
Volume: 473
Issue: 9
Pages: 1165-78
Publication
First Author: Wongkittichote P
Year: 2019
Journal: Mol Genet Metab
Title: Tricarboxylic acid cycle enzyme activities in a mouse model of methylmalonic aciduria.
Volume: 128
Issue: 4
Pages: 444-451
Protein
Organism: Mus musculus/domesticus
Length: 27  
Fragment?: true
Publication
First Author: Robien MA
Year: 1992
Journal: Biochemistry
Title: Three-dimensional solution structure of the E3-binding domain of the dihydrolipoamide succinyltransferase core from the 2-oxoglutarate dehydrogenase multienzyme complex of Escherichia coli.
Volume: 31
Issue: 13
Pages: 3463-71
Publication
First Author: Brautigam CA
Year: 2006
Journal: Structure
Title: Structural insight into interactions between dihydrolipoamide dehydrogenase (E3) and E3 binding protein of human pyruvate dehydrogenase complex.
Volume: 14
Issue: 3
Pages: 611-21
Publication
First Author: Kumaran S
Year: 2013
Journal: Molecules
Title: Nuclear magnetic resonance approaches in the study of 2-oxo acid dehydrogenase multienzyme complexes--a literature review.
Volume: 18
Issue: 10
Pages: 11873-903
Protein Domain
Type: Domain
Description: The ubiquitous 2-oxoacid dehydrogenases are a family of very large multienzymecomplexes consisting of multiple copies of at least three enzymes whichcatalyze the oxidative decarboxylation of several different 2-oxoacids,resulting in acyl-CoA products. Members of this family include pyruvatedehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxoacid dehydrogenase (BCDH). The three enzymes assembling to form thesecomplexes are the decarboxylase E1 (called E1p, E1o and E1b in PDH, OGDH andBCDH, respectively), dihydrolipoamide acetyl, succinyl and branched-chaintransferase E2 (E2p, E2o and E2b, respectively) and dihydrolipoamidedehydrogenase E3. The E3 component is identical in all three complexes (PDH,OGDH and BCDH) and catalyzes the same reaction. The structural core of all 2-oxoacid dehydrogenase complexes (ODHc) is formed of multiple copies of E2subunits, with the E1 and E3 subunits bound on the periphery. The E2 componentof the ODHc's of both bacteria and eukaryotes serves as the structural core ofthese multienzyme complexes and is comprised of three types of domains.Starting with the N terminus, there are 1-3 tandem repeated lipoyl domains(LD), followed by a peripheral subunit-binding domain (PSBD)responsible for binding E1/E3 chains. The third domain is the C-terminalcatalytic domain (CD). The individual domains are separated by long, flexiblelinker regions allowing large movements of the lipoyl domain(s) to enableactive site coupling. The PSBD domain binds E1 or E3, but not bothsimultaneously. The flexible linker allows the PSBD domain (associated witheither E1 or E3) to move quite freely with respect to the core formed E2catalytic domains [, , , , ].The ~35-residue PSBD domain has a compact structure consisting of two short,parallel α-helices (H1 and H2) separated by a loop (L1), a single helicalturn, and a further, less well-ordered loop (L2) (see PDB:1BAL). The compactstructure of the PSBD domain is stabilized mainly by hydrophobic interactions.The interactions between the PSBD domain and E3 are all mediated by chargedside chains, forming an 'electrostatic zipper'. The residues of the PSBDdomain involved in the interactions are all provided by helix H1 of thisdomain. Helix H2 of PSBD does not interact with E3, but may be involved inbinding E1 [, , ].
Publication
First Author: Mande SS
Year: 1996
Journal: Structure
Title: Protein-protein interactions in the pyruvate dehydrogenase multienzyme complex: dihydrolipoamide dehydrogenase complexed with the binding domain of dihydrolipoamide acetyltransferase.
Volume: 4
Issue: 3
Pages: 277-86
Publication  
First Author: Perham RN
Year: 2000
Journal: Annu Rev Biochem
Title: Swinging arms and swinging domains in multifunctional enzymes: catalytic machines for multistep reactions.
Volume: 69
Pages: 961-1004
Protein
Organism: Mus musculus/domesticus
Length: 482  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 220  
Fragment?: false