Type |
Details |
Score |
GXD Expression |
Probe: |
MGI:3724942 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1738222 |
Pattern: |
Regionally restricted |
Stage: |
TS22 |
Assay Id: |
MGI:5421593 |
Age: |
embryonic day 14.5 |
Image: |
MH1551; Specimen C1750 |
|
Specimen Label: |
MH1551; Specimen C1750 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3724942 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1738322 |
Pattern: |
Regionally restricted |
Stage: |
TS22 |
Assay Id: |
MGI:5421593 |
Age: |
embryonic day 14.5 |
Image: |
MH1551; Specimen C1750 |
|
Specimen Label: |
MH1551; Specimen C1750 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3724942 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1842522 |
Pattern: |
Regionally restricted |
Stage: |
TS22 |
Assay Id: |
MGI:5421593 |
Age: |
embryonic day 14.5 |
Image: |
MH1551; Specimen C1750 |
Note: |
Expression was detected in the endocrine system. |
Specimen Label: |
MH1551; Specimen C1750 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3724942 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1706822 |
Pattern: |
Regionally restricted |
Stage: |
TS22 |
Assay Id: |
MGI:5421593 |
Age: |
embryonic day 14.5 |
Image: |
MH1551; Specimen C1750 |
|
Specimen Label: |
MH1551; Specimen C1750 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3724942 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:3599822 |
Pattern: |
Regionally restricted |
Stage: |
TS22 |
Assay Id: |
MGI:5421593 |
Age: |
embryonic day 14.5 |
Image: |
MH1551; Specimen C1750 |
|
Specimen Label: |
MH1551; Specimen C1750 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3724942 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1750322 |
Pattern: |
Regionally restricted |
Stage: |
TS22 |
Assay Id: |
MGI:5421593 |
Age: |
embryonic day 14.5 |
Image: |
MH1551; Specimen C1750 |
|
Specimen Label: |
MH1551; Specimen C1750 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3724942 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1842622 |
Pattern: |
Regionally restricted |
Stage: |
TS22 |
Assay Id: |
MGI:5421593 |
Age: |
embryonic day 14.5 |
Image: |
MH1551; Specimen C1750 |
|
Specimen Label: |
MH1551; Specimen C1750 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3724942 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1610422 |
Pattern: |
Regionally restricted |
Stage: |
TS22 |
Assay Id: |
MGI:5421593 |
Age: |
embryonic day 14.5 |
Image: |
MH1551; Specimen C1750 |
|
Specimen Label: |
MH1551; Specimen C1750 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3724942 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1610522 |
Pattern: |
Regionally restricted |
Stage: |
TS22 |
Assay Id: |
MGI:5421593 |
Age: |
embryonic day 14.5 |
Image: |
MH1551; Specimen C1750 |
|
Specimen Label: |
MH1551; Specimen C1750 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3724942 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1668822 |
Pattern: |
Regionally restricted |
Stage: |
TS22 |
Assay Id: |
MGI:5421593 |
Age: |
embryonic day 14.5 |
Image: |
MH1551; Specimen C1750 |
|
Specimen Label: |
MH1551; Specimen C1750 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3724942 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1733122 |
Pattern: |
Regionally restricted |
Stage: |
TS22 |
Assay Id: |
MGI:5421593 |
Age: |
embryonic day 14.5 |
Image: |
MH1551; Specimen C1750 |
|
Specimen Label: |
MH1551; Specimen C1750 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3724942 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:3274322 |
Pattern: |
Regionally restricted |
Stage: |
TS22 |
Assay Id: |
MGI:5421593 |
Age: |
embryonic day 14.5 |
Image: |
MH1551; Specimen C1750 |
|
Specimen Label: |
MH1551; Specimen C1750 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3724942 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1876522 |
Pattern: |
Regionally restricted |
Stage: |
TS22 |
Assay Id: |
MGI:5421593 |
Age: |
embryonic day 14.5 |
Image: |
MH1551; Specimen C1750 |
Note: |
Expression was detected in the immune system. |
Specimen Label: |
MH1551; Specimen C1750 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3724942 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1853522 |
Pattern: |
Regionally restricted |
Stage: |
TS22 |
Assay Id: |
MGI:5421593 |
Age: |
embryonic day 14.5 |
Image: |
MH1551; Specimen C1750 |
|
Specimen Label: |
MH1551; Specimen C1750 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3724942 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1752322 |
Pattern: |
Regionally restricted |
Stage: |
TS22 |
Assay Id: |
MGI:5421593 |
Age: |
embryonic day 14.5 |
Image: |
MH1551; Specimen C1750 |
|
Specimen Label: |
MH1551; Specimen C1750 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3724942 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:3272922 |
Pattern: |
Regionally restricted |
Stage: |
TS22 |
Assay Id: |
MGI:5421593 |
Age: |
embryonic day 14.5 |
Image: |
MH1551; Specimen C1750 |
Note: |
Expression was detected in the skeleton (limbs, shoulder, hip). |
Specimen Label: |
MH1551; Specimen C1750 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3724942 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:3557722 |
Pattern: |
Regionally restricted |
Stage: |
TS22 |
Assay Id: |
MGI:5421593 |
Age: |
embryonic day 14.5 |
Image: |
MH1551; Specimen C1750 |
|
Specimen Label: |
MH1551; Specimen C1750 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3724942 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:3276322 |
Pattern: |
Regionally restricted |
Stage: |
TS22 |
Assay Id: |
MGI:5421593 |
Age: |
embryonic day 14.5 |
Image: |
MH1551; Specimen C1750 |
Note: |
Expression was detected in the face/soft tissues. |
Specimen Label: |
MH1551; Specimen C1750 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3724942 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1802422 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5421593 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
MH1551; Specimen C1750 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3724942 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1768022 |
|
Stage: |
TS22 |
Assay Id: |
MGI:5421593 |
Age: |
embryonic day 14.5 |
|
Note: |
Expression was not detected in the skull (base and vault). |
Specimen Label: |
MH1551; Specimen C1750 |
Detected: |
false |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3724942 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1721422 |
Pattern: |
Regionally restricted |
Stage: |
TS22 |
Assay Id: |
MGI:5421593 |
Age: |
embryonic day 14.5 |
Image: |
MH1551; Specimen C1750 |
|
Specimen Label: |
MH1551; Specimen C1750 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3724942 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1674822 |
Pattern: |
Regionally restricted |
Stage: |
TS22 |
Assay Id: |
MGI:5421593 |
Age: |
embryonic day 14.5 |
Image: |
MH1551; Specimen C1750 |
|
Specimen Label: |
MH1551; Specimen C1750 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3724942 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1741222 |
Pattern: |
Regionally restricted |
Stage: |
TS22 |
Assay Id: |
MGI:5421593 |
Age: |
embryonic day 14.5 |
Image: |
MH1551; Specimen C1750 |
|
Specimen Label: |
MH1551; Specimen C1750 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3724942 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1745822 |
Pattern: |
Regionally restricted |
Stage: |
TS22 |
Assay Id: |
MGI:5421593 |
Age: |
embryonic day 14.5 |
Image: |
MH1551; Specimen C1750 |
|
Specimen Label: |
MH1551; Specimen C1750 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3724942 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1752422 |
Pattern: |
Regionally restricted |
Stage: |
TS22 |
Assay Id: |
MGI:5421593 |
Age: |
embryonic day 14.5 |
Image: |
MH1551; Specimen C1750 |
|
Specimen Label: |
MH1551; Specimen C1750 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3724942 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Strong |
Sex: |
Not Specified |
Emaps: |
EMAPS:1752522 |
Pattern: |
Regionally restricted |
Stage: |
TS22 |
Assay Id: |
MGI:5421593 |
Age: |
embryonic day 14.5 |
Image: |
MH1551; Specimen C1750 |
|
Specimen Label: |
MH1551; Specimen C1750 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3724942 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:1876922 |
Pattern: |
Regionally restricted |
Stage: |
TS22 |
Assay Id: |
MGI:5421593 |
Age: |
embryonic day 14.5 |
Image: |
MH1551; Specimen C1750 |
|
Specimen Label: |
MH1551; Specimen C1750 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3724942 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:2672022 |
Pattern: |
Regionally restricted |
Stage: |
TS22 |
Assay Id: |
MGI:5421593 |
Age: |
embryonic day 14.5 |
Image: |
MH1551; Specimen C1750 |
Note: |
Expression was detected in whisker follicle. |
Specimen Label: |
MH1551; Specimen C1750 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3691103 |
Assay Type: |
RNA in situ |
Annotation Date: |
2006-12-19 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3816028 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:3691289 |
Age: |
postnatal day 21 |
|
Note: |
Expression is present in the rostral migratory stream. |
Specimen Label: |
2 P21 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3691103 |
Assay Type: |
RNA in situ |
Annotation Date: |
2006-12-19 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3816028 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:3691289 |
Age: |
postnatal day 7 |
|
|
Specimen Label: |
2 P7 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
Publication |
First Author: |
Andrade J |
Year: |
2021 |
Journal: |
Nat Cell Biol |
Title: |
Control of endothelial quiescence by FOXO-regulated metabolites. |
Volume: |
23 |
Issue: |
4 |
Pages: |
413-423 |
|
•
•
•
•
•
|
Publication |
First Author: |
Starkov AA |
Year: |
2004 |
Journal: |
J Neurosci |
Title: |
Mitochondrial alpha-ketoglutarate dehydrogenase complex generates reactive oxygen species. |
Volume: |
24 |
Issue: |
36 |
Pages: |
7779-88 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gibson GE |
Year: |
2012 |
Journal: |
Neurobiol Aging |
Title: |
Deficits in the mitochondrial enzyme α-ketoglutarate dehydrogenase lead to Alzheimer's disease-like calcium dysregulation. |
Volume: |
33 |
Issue: |
6 |
Pages: |
1121.e13-24 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wagner M |
Year: |
2020 |
Journal: |
Basic Res Cardiol |
Title: |
Selective NADH communication from α-ketoglutarate dehydrogenase to mitochondrial transhydrogenase prevents reactive oxygen species formation under reducing conditions in the heart. |
Volume: |
115 |
Issue: |
5 |
Pages: |
53 |
|
•
•
•
•
•
|
Publication |
First Author: |
Karlstaedt A |
Year: |
2016 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Oncometabolite d-2-hydroxyglutarate impairs α-ketoglutarate dehydrogenase and contractile function in rodent heart. |
Volume: |
113 |
Issue: |
37 |
Pages: |
10436-41 |
|
•
•
•
•
•
|
Publication |
First Author: |
Oktay Y |
Year: |
2007 |
Journal: |
J Biol Chem |
Title: |
Hypoxia-inducible factor 2alpha regulates expression of the mitochondrial aconitase chaperone protein frataxin. |
Volume: |
282 |
Issue: |
16 |
Pages: |
11750-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Schatton D |
Year: |
2017 |
Journal: |
J Cell Biol |
Title: |
CLUH regulates mitochondrial metabolism by controlling translation and decay of target mRNAs. |
Volume: |
216 |
Issue: |
3 |
Pages: |
675-693 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mayeuf-Louchart A |
Year: |
2019 |
Journal: |
Cell Rep |
Title: |
Glycogen Dynamics Drives Lipid Droplet Biogenesis during Brown Adipocyte Differentiation. |
Volume: |
29 |
Issue: |
6 |
Pages: |
1410-1418.e6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhao K |
Year: |
2022 |
Journal: |
Development |
Title: |
LONP1-mediated mitochondrial quality control safeguards metabolic shifts in heart development. |
Volume: |
149 |
Issue: |
6 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Cankaya M |
Year: |
2007 |
Journal: |
BMC Genomics |
Title: |
An analysis of expression patterns of genes encoding proteins with catalytic activities. |
Volume: |
8 |
|
Pages: |
232 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics and the Consortium: Deciphering the Mechanisms of Developmental Disorders (DMDD) |
Year: |
2017 |
Journal: |
Database Release |
Title: |
Obtaining and Loading Phenotype Annotations from Deciphering the Mechanisms of Developmental Disorders (DMDD) |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bowman CE |
Year: |
2016 |
Journal: |
Mol Cell Biol |
Title: |
Requirement for the Mitochondrial Pyruvate Carrier in Mammalian Development Revealed by a Hypomorphic Allelic Series. |
Volume: |
36 |
Issue: |
15 |
Pages: |
2089-104 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bulusu V |
Year: |
2017 |
Journal: |
Dev Cell |
Title: |
Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to Mouse Embryo Mesoderm Development. |
Volume: |
40 |
Issue: |
4 |
Pages: |
331-341.e4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nakano Y |
Year: |
2019 |
Journal: |
Cell Rep |
Title: |
Overlapping Activities of Two Neuronal Splicing Factors Switch the GABA Effect from Excitatory to Inhibitory by Regulating REST. |
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27 |
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3 |
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860-871.e8 |
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PLoS Genet |
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Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. |
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Cell |
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A mitochondrial protein compendium elucidates complex I disease biology. |
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PLoS Biol |
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Nucleic Acids Res |
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Lennon G |
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International Mouse Strain Resource |
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Database Download |
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MGI download of germline transmission data for alleles from IMSR strain data |
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First Author: |
Wellcome Trust Sanger Institute |
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MGI Direct Data Submission |
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Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute |
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First Author: |
Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC) |
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Database Release |
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Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
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Title: |
Rat to Mouse ISO GO annotation transfer |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2003 |
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Title: |
MGI Sequence Curation Reference |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
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Title: |
Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database |
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Carninci P |
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Science |
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The transcriptional landscape of the mammalian genome. |
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309 |
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Kawai J |
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Nature |
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Functional annotation of a full-length mouse cDNA collection. |
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Zambrowicz BP |
Year: |
2003 |
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Proc Natl Acad Sci U S A |
Title: |
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. |
Volume: |
100 |
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24 |
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14109-14 |
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
Year: |
2008 |
Journal: |
Database Download |
Title: |
Mouse Gene Trap Data Load from dbGSS |
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First Author: |
Skarnes WC |
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2011 |
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Nature |
Title: |
A conditional knockout resource for the genome-wide study of mouse gene function. |
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474 |
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337-42 |
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GemPharmatech |
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2020 |
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Title: |
GemPharmatech Website. |
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Mouse Genome Informatics Scientific Curators |
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2001 |
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Title: |
Gene Ontology Annotation by the MGI Curatorial Staff |
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Publication |
First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
Year: |
2004 |
Journal: |
Database Release |
Title: |
Mouse T31 Radiation Hybrid Data Load |
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Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
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420 |
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6915 |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2000 |
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Title: |
Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
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Title: |
Human to Mouse ISO GO annotation transfer |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
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Database Download |
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Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
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Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
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Publication |
First Author: |
Gaudet P |
Year: |
2011 |
Journal: |
Brief Bioinform |
Title: |
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. |
Volume: |
12 |
Issue: |
5 |
Pages: |
449-62 |
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Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
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First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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First Author: |
Bairoch A |
Year: |
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Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
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Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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Publication |
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Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
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Publication |
First Author: |
Leandro J |
Year: |
2020 |
Journal: |
Hum Mol Genet |
Title: |
DHTKD1 and OGDH display substrate overlap in cultured cells and form a hybrid 2-oxo acid dehydrogenase complex in vivo. |
Volume: |
29 |
Issue: |
7 |
Pages: |
1168-1179 |
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Publication |
First Author: |
Gao Y |
Year: |
2023 |
Journal: |
Cell Rep |
Title: |
ALKBH5 modulates hematopoietic stem and progenitor cell energy metabolism through m(6)A modification-mediated RNA stability control. |
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42 |
Issue: |
10 |
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113163 |
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Publication |
First Author: |
Chalker J |
Year: |
2018 |
Journal: |
Redox Biol |
Title: |
Characterization of the impact of glutaredoxin-2 (GRX2) deficiency on superoxide/hydrogen peroxide release from cardiac and liver mitochondria. |
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15 |
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Pages: |
216-227 |
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Publication |
First Author: |
Denton RM |
Year: |
2016 |
Journal: |
Biochem J |
Title: |
Calcium-insensitive splice variants of mammalian E1 subunit of 2-oxoglutarate dehydrogenase complex with tissue-specific patterns of expression. |
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473 |
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Publication |
First Author: |
Wongkittichote P |
Year: |
2019 |
Journal: |
Mol Genet Metab |
Title: |
Tricarboxylic acid cycle enzyme activities in a mouse model of methylmalonic aciduria. |
Volume: |
128 |
Issue: |
4 |
Pages: |
444-451 |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
27
|
Fragment?: |
true |
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•
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Publication |
First Author: |
Robien MA |
Year: |
1992 |
Journal: |
Biochemistry |
Title: |
Three-dimensional solution structure of the E3-binding domain of the dihydrolipoamide succinyltransferase core from the 2-oxoglutarate dehydrogenase multienzyme complex of Escherichia coli. |
Volume: |
31 |
Issue: |
13 |
Pages: |
3463-71 |
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•
•
•
•
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Publication |
First Author: |
Brautigam CA |
Year: |
2006 |
Journal: |
Structure |
Title: |
Structural insight into interactions between dihydrolipoamide dehydrogenase (E3) and E3 binding protein of human pyruvate dehydrogenase complex. |
Volume: |
14 |
Issue: |
3 |
Pages: |
611-21 |
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•
•
•
•
•
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Publication |
First Author: |
Kumaran S |
Year: |
2013 |
Journal: |
Molecules |
Title: |
Nuclear magnetic resonance approaches in the study of 2-oxo acid dehydrogenase multienzyme complexes--a literature review. |
Volume: |
18 |
Issue: |
10 |
Pages: |
11873-903 |
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•
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Protein Domain |
Type: |
Domain |
Description: |
The ubiquitous 2-oxoacid dehydrogenases are a family of very large multienzymecomplexes consisting of multiple copies of at least three enzymes whichcatalyze the oxidative decarboxylation of several different 2-oxoacids,resulting in acyl-CoA products. Members of this family include pyruvatedehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxoacid dehydrogenase (BCDH). The three enzymes assembling to form thesecomplexes are the decarboxylase E1 (called E1p, E1o and E1b in PDH, OGDH andBCDH, respectively), dihydrolipoamide acetyl, succinyl and branched-chaintransferase E2 (E2p, E2o and E2b, respectively) and dihydrolipoamidedehydrogenase E3. The E3 component is identical in all three complexes (PDH,OGDH and BCDH) and catalyzes the same reaction. The structural core of all 2-oxoacid dehydrogenase complexes (ODHc) is formed of multiple copies of E2subunits, with the E1 and E3 subunits bound on the periphery. The E2 componentof the ODHc's of both bacteria and eukaryotes serves as the structural core ofthese multienzyme complexes and is comprised of three types of domains.Starting with the N terminus, there are 1-3 tandem repeated lipoyl domains(LD), followed by a peripheral subunit-binding domain (PSBD)responsible for binding E1/E3 chains. The third domain is the C-terminalcatalytic domain (CD). The individual domains are separated by long, flexiblelinker regions allowing large movements of the lipoyl domain(s) to enableactive site coupling. The PSBD domain binds E1 or E3, but not bothsimultaneously. The flexible linker allows the PSBD domain (associated witheither E1 or E3) to move quite freely with respect to the core formed E2catalytic domains [, , , , ].The ~35-residue PSBD domain has a compact structure consisting of two short,parallel α-helices (H1 and H2) separated by a loop (L1), a single helicalturn, and a further, less well-ordered loop (L2) (see PDB:1BAL). The compactstructure of the PSBD domain is stabilized mainly by hydrophobic interactions.The interactions between the PSBD domain and E3 are all mediated by chargedside chains, forming an 'electrostatic zipper'. The residues of the PSBDdomain involved in the interactions are all provided by helix H1 of thisdomain. Helix H2 of PSBD does not interact with E3, but may be involved inbinding E1 [, , ]. |
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Publication |
First Author: |
Mande SS |
Year: |
1996 |
Journal: |
Structure |
Title: |
Protein-protein interactions in the pyruvate dehydrogenase multienzyme complex: dihydrolipoamide dehydrogenase complexed with the binding domain of dihydrolipoamide acetyltransferase. |
Volume: |
4 |
Issue: |
3 |
Pages: |
277-86 |
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•
•
•
•
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Publication |
First Author: |
Perham RN |
Year: |
2000 |
Journal: |
Annu Rev Biochem |
Title: |
Swinging arms and swinging domains in multifunctional enzymes: catalytic machines for multistep reactions. |
Volume: |
69 |
|
Pages: |
961-1004 |
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•
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
482
|
Fragment?: |
false |
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•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
220
|
Fragment?: |
false |
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•
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