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Search results 101 to 166 out of 166 for Chd3

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Type Details Score
Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
21642969 | -
First Author: Goodarzi AA
Year: 2011
Journal: Nat Struct Mol Biol
Title: KAP-1 phosphorylation regulates CHD3 nucleosome remodeling during the DNA double-strand break response.
Volume: 18
Issue: 7
Pages: 831-9
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Protein
Q3UFM8
Organism: Mus musculus/domesticus
Length: 240  
Fragment?: false
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Protein
A0A5F8MQ82
Organism: Mus musculus/domesticus
Length: 385  
Fragment?: true
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Protein
Q3ULG0
Organism: Mus musculus/domesticus
Length: 342  
Fragment?: true
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Protein Domain
IPR012958 | CHD_N
Type: Domain
Description: This entry represents the N-terminal domain of CHD (Chromodomain, Helicase, DNA-binding) proteins. CHD3 and CHD4 belong to the class II subfamily of CHD ATPases, and each is present as a core catalytic subunit in separate NuRD complexes, which regulate chromatin organisation and gene transcription []. CHD5 forms a NuRD-type chromatin remodeling complex and acts as a tumour suppressor []. There are nine members of the Chromodomain, Helicase, DNA-binding (CHD) family. They are characterised by two chromodomains arranged in tandem, N-terminal to the ATPase/helicase domain. Chromodomains are comprised of a β-sheet folded against an α-helix that collectively mediates binding to methyl-lysine residues [].
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Protein Domain
IPR012957 | CHD_C2
Type: Domain
Description: This entry represents the C-terminal domain of CHD (Chromodomain, Helicase, DNA-binding) proteins. CHD3 and CHD4 belong to the class II subfamily of CHD ATPases, and each is present as a core catalytic subunit in separate NuRD complexes, which regulate chromatin organisation and gene transcription []. CHD5 forms a NuRD-type chromatin remodeling complex and acts as a tumour suppressor []. There are nine members of the Chromodomain, Helicase, DNA-binding (CHD) family. They are characterised by two chromodomains arranged in tandem, N-terminal to the ATPase/helicase domain. Chromodomains are comprised of a β-sheet folded against an α-helix that collectively mediates binding to methyl-lysine residues [].
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Publication
23340908 | -
First Author: Allen HF
Year: 2013
Journal: Cell Mol Life Sci
Title: The NuRD architecture.
Volume: 70
Issue: 19
Pages: 3513-24
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Publication
24419087 | -
First Author: Kolla V
Year: 2014
Journal: Cancer Res
Title: Role of CHD5 in human cancers: 10 years later.
Volume: 74
Issue: 3
Pages: 652-8
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Publication
21931736 | J:207814
First Author: Potts RC
Year: 2011
Journal: PLoS One
Title: CHD5, a brain-specific paralog of Mi2 chromatin remodeling enzymes, regulates expression of neuronal genes.
Volume: 6
Issue: 9
Pages: e24515
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Publication
9804427 | J:175129
First Author: Tong JK
Year: 1998
Journal: Nature
Title: Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex.
Volume: 395
Issue: 6705
Pages: 917-21
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Publication
24849318 | J:216320
First Author: Bergs JW
Year: 2014
Journal: PLoS One
Title: Differential expression and sex chromosome association of CHD3/4 and CHD5 during spermatogenesis.
Volume: 9
Issue: 5
Pages: e98203
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Publication
23954449 | -
First Author: Stanley FK
Year: 2013
Journal: Mutat Res
Title: CHD chromatin remodelling enzymes and the DNA damage response.
Volume: 750
Issue: 1-2
Pages: 31-44
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Protein
Q4QQN1
Organism: Mus musculus/domesticus
Length: 368  
Fragment?: false
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Protein Domain
IPR042713 | TIF1beta_RING-HC
Type: Domain
Description: TIF1-beta, also known as Kruppel-associated Box (KRAB)-associated protein 1 (KAP-1), belongs to the C-VI subclass of TRIM (tripartite motif) family of proteins that are defined by their N-terminal RBCC (RING, Bbox, and coiled coil) domains, including three consecutive zinc-binding domains, a C3HC4-type RING-HC finger, Bbox1 and Bbox2, and a coiled coil region, as well as a plant homeodomain (PHD), and a bromodomain (Bromo) positioned C-terminal to the RBCC domain. It acts as a nuclear co-repressor that plays a role in transcription and in the DNA damage response [, , ]. Upon DNA damage, the phosphorylation of KAP-1 on serine 824 by the ataxia telangiectasia-mutated (ATM) kinase enhances cell survival and facilitates chromatin relaxation and heterochromatic DNA repair []. It also regulates CHD3 nucleosome remodelling during the DNA double-strand break (DSB) response []. Meanwhile, KAP-1 can be dephosphorylated by protein phosphatase PP4C in the DNA damage response []. Moreover, KAP-1 is a co-activator of the orphan nuclear receptor NGFI-B (or Nur77) and is involved in NGFI-B-dependent transcription []. It is also a coiled-coil binding partner, substrate and activator of the c-Fes protein tyrosine kinase []. The N-terminal RBCC domains of TIF1-beta are responsible for the interaction with KRAB zinc finger proteins (KRAB-ZFPs), MDM2, MM1, C/EBPbeta, and the regulation of homo- and heterodimerization []. The C-terminal PHD/Bromo domains are involved in interacting with SETDB1, Mi-2alpha and other proteins to form complexes with histone deacetylase or methyltransferase activity [, ].This entry represents the RING-HC finger found in TIF1-beta.
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Protein Domain
IPR037373 | KAP1
Type: Family
Description: TIF1-beta, also known as Kruppel-associated Box (KRAB)-associated protein 1 (KAP-1), belongs to the C-VI subclass of TRIM (tripartite motif) family of proteins that are defined by their N-terminal RBCC (RING, Bbox, and coiled coil) domains, including three consecutive zinc-binding domains, a C3HC4-type RING-HC finger, Bbox1 and Bbox2, and a coiled coil region, as well as a plant homeodomain (PHD), and a bromodomain (Bromo) positioned C-terminal to the RBCC domain. It acts as a nuclear co-repressor that plays a role in transcription and in the DNA damage response [, , ]. Upon DNA damage, the phosphorylation of KAP-1 on serine 824 by the ataxia telangiectasia-mutated (ATM) kinase enhances cell survival and facilitates chromatin relaxation and heterochromatic DNA repair []. It also regulates CHD3 nucleosome remodelling during the DNA double-strand break (DSB) response []. Meanwhile, KAP-1 can be dephosphorylated by protein phosphatase PP4C in the DNA damage response []. Moreover, KAP-1 is a co-activator of the orphan nuclear receptor NGFI-B (or Nur77) and is involved in NGFI-B-dependent transcription []. It is also a coiled-coil binding partner, substrate and activator of the c-Fes protein tyrosine kinase []. The N-terminal RBCC domains of TIF1-beta are responsible for the interaction with KRAB zinc finger proteins (KRAB-ZFPs), MDM2, MM1, C/EBPbeta, and the regulation of homo- and heterodimerization []. The C-terminal PHD/Bromo domains are involved in interacting with SETDB1, Mi-2alpha and other proteins to form complexes with histone deacetylase or methyltransferase activity [, ].
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Publication
19321449 | J:222151
First Author: Rambaud J
Year: 2009
Journal: J Biol Chem
Title: TIF1beta/KAP-1 is a coactivator of the orphan nuclear receptor NGFI-B/Nur77.
Volume: 284
Issue: 21
Pages: 14147-56
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Publication
8769649 | -
First Author: Friedman JR
Year: 1996
Journal: Genes Dev
Title: KAP-1, a novel corepressor for the highly conserved KRAB repression domain.
Volume: 10
Issue: 16
Pages: 2067-78
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Publication
11226167 | -
First Author: Capili AD
Year: 2001
Journal: EMBO J
Title: Solution structure of the PHD domain from the KAP-1 corepressor: structural determinants for PHD, RING and LIM zinc-binding domains.
Volume: 20
Issue: 1-2
Pages: 165-77
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Publication
9016654 | -
First Author: Moosmann P
Year: 1996
Journal: Nucleic Acids Res
Title: Transcriptional repression by RING finger protein TIF1 beta that interacts with the KRAB repressor domain of KOX1.
Volume: 24
Issue: 24
Pages: 4859-67
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Publication
16792528 | -
First Author: Delfino FJ
Year: 2006
Journal: Biochem J
Title: The KRAB-associated co-repressor KAP-1 is a coiled-coil binding partner, substrate and activator of the c-Fes protein tyrosine kinase.
Volume: 399
Issue: 1
Pages: 141-50
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Publication
1610787 | -
First Author: Simon E
Year: 1992
Journal: Physiol Res
Title: Osmoreception in the duck's brain identified by neurophysiological methods and phylogenetic structural cues.
Volume: 41
Issue: 1
Pages: 93-4
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Publication
16862143 | -
First Author: Ziv Y
Year: 2006
Journal: Nat Cell Biol
Title: Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathway.
Volume: 8
Issue: 8
Pages: 870-6
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Publication
11959841 | -
First Author: Schultz DC
Year: 2002
Journal: Genes Dev
Title: SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins.
Volume: 16
Issue: 8
Pages: 919-32
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Publication
11230151 | -
First Author: Schultz DC
Year: 2001
Journal: Genes Dev
Title: Targeting histone deacetylase complexes via KRAB-zinc finger proteins: the PHD and bromodomains of KAP-1 form a cooperative unit that recruits a novel isoform of the Mi-2alpha subunit of NuRD.
Volume: 15
Issue: 4
Pages: 428-43
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Publication
22491012 | -
First Author: Lee DH
Year: 2012
Journal: EMBO J
Title: Phosphoproteomic analysis reveals that PP4 dephosphorylates KAP-1 impacting the DNA damage response.
Volume: 31
Issue: 10
Pages: 2403-15
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Protein
Q9CUI4
Organism: Mus musculus/domesticus
Length: 256  
Fragment?: true
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Protein
Q99JM0
Organism: Mus musculus/domesticus
Length: 829  
Fragment?: true
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Protein
Q62318
Organism: Mus musculus/domesticus
Length: 834  
Fragment?: false
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Protein
Q5EBP9
Organism: Mus musculus/domesticus
Length: 834  
Fragment?: false
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Protein
Q3UDN8
Organism: Mus musculus/domesticus
Length: 631  
Fragment?: true
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Protein
A2A8L1
Organism: Mus musculus/domesticus
Length: 1946  
Fragment?: false
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Protein
Q6PDQ2
Organism: Mus musculus/domesticus
Length: 1915  
Fragment?: false
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Protein
Q5DTP7
Organism: Mus musculus/domesticus
Length: 1945  
Fragment?: true
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Protein
E9Q614
Organism: Mus musculus/domesticus
Length: 2021  
Fragment?: false
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Protein
F7C528
Organism: Mus musculus/domesticus
Length: 1886  
Fragment?: true
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Protein
E9PYU4
Organism: Mus musculus/domesticus
Length: 1915  
Fragment?: false
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Protein
E9PYL1
Organism: Mus musculus/domesticus
Length: 1952  
Fragment?: false
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Protein
B1AR17
Organism: Mus musculus/domesticus
Length: 2055  
Fragment?: false
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Protein
E9QAS4
Organism: Mus musculus/domesticus
Length: 1902  
Fragment?: false
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Protein
E9QAS5
Organism: Mus musculus/domesticus
Length: 1922  
Fragment?: false
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Protein
Q8BR71
Organism: Mus musculus/domesticus
Length: 708  
Fragment?: true
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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