This domain can be found in budding yeast Fsh1/2/3, fission yeast Dfr1 and the human OVCA2 protein. Fsh1/2/3 are putative serine hydrolases []. Dfr1 is a dihydrofolate reductase (DHFR) []. OVCA2 is a putative serine-hydrolase that has been linked to cancers []. Proteins containing this domain also includes Aspergillus terreus esterase LovG, which catalyzes the release of covalently bound dihydromonacolin L from LovB during lovastatin biosynthesis [].
