Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
zebrafish |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Lee PS |
Year: |
1999 |
Journal: |
EMBO J |
Title: |
The Cbl protooncoprotein stimulates CSF-1 receptor multiubiquitination and endocytosis, and attenuates macrophage proliferation. |
Volume: |
18 |
Issue: |
13 |
Pages: |
3616-28 |
|
•
•
•
•
•
|
Publication |
First Author: |
Miyake S |
Year: |
1998 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
The tyrosine kinase regulator Cbl enhances the ubiquitination and degradation of the platelet-derived growth factor receptor alpha. |
Volume: |
95 |
Issue: |
14 |
Pages: |
7927-32 |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Publication |
First Author: |
Langdon WY |
Year: |
1995 |
Journal: |
Aust N Z J Med |
Title: |
The cbl oncogene: a novel substrate of protein tyrosine kinases. |
Volume: |
25 |
Issue: |
6 |
Pages: |
859-64 |
|
•
•
•
•
•
|
Publication |
First Author: |
Schmid FM |
Year: |
2018 |
Journal: |
J Cell Biol |
Title: |
IFT20 modulates ciliary PDGFRα signaling by regulating the stability of Cbl E3 ubiquitin ligases. |
Volume: |
217 |
Issue: |
1 |
Pages: |
151-161 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chiang YJ |
Year: |
2009 |
Journal: |
J Biol Chem |
Title: |
Cbl enforces an SLP76-dependent signaling pathway for T cell differentiation. |
Volume: |
284 |
Issue: |
7 |
Pages: |
4429-38 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bulut GB |
Year: |
2013 |
Journal: |
Blood |
Title: |
Cbl ubiquitination of p85 is essential for Epo-induced EpoR endocytosis. |
Volume: |
122 |
Issue: |
24 |
Pages: |
3964-72 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shao Y |
Year: |
2003 |
Journal: |
EMBO Rep |
Title: |
Negative regulation of Rap1 activation by the Cbl E3 ubiquitin ligase. |
Volume: |
4 |
Issue: |
4 |
Pages: |
425-31 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chiang J |
Year: |
2011 |
Journal: |
PLoS One |
Title: |
Cbl enforces Vav1 dependence and a restricted pathway of T cell development. |
Volume: |
6 |
Issue: |
4 |
Pages: |
e18542 |
|
•
•
•
•
•
|
Publication |
First Author: |
Blake TJ |
Year: |
1991 |
Journal: |
Oncogene |
Title: |
The sequences of the human and mouse c-cbl proto-oncogenes show v-cbl was generated by a large truncation encompassing a proline-rich domain and a leucine zipper-like motif. |
Volume: |
6 |
Issue: |
4 |
Pages: |
653-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kitaura Y |
Year: |
2007 |
Journal: |
Immunity |
Title: |
Control of the B cell-intrinsic tolerance programs by ubiquitin ligases Cbl and Cbl-b. |
Volume: |
26 |
Issue: |
5 |
Pages: |
567-78 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li X |
Year: |
2018 |
Journal: |
Immunity |
Title: |
Cbl Ubiquitin Ligases Control B Cell Exit from the Germinal-Center Reaction. |
Volume: |
48 |
Issue: |
3 |
Pages: |
530-541.e6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gupte A |
Year: |
2006 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Activation of the Cbl insulin signaling pathway in cardiac muscle; dysregulation in obesity and diabetes. |
Volume: |
342 |
Issue: |
3 |
Pages: |
751-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li X |
Year: |
2020 |
Journal: |
J Exp Med |
Title: |
Cbl and Cbl-b control the germinal center reaction by facilitating naive B cell antigen processing. |
Volume: |
217 |
Issue: |
9 |
|
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2667164 |
Assay Type: |
RNase protection |
Annotation Date: |
2003-07-23 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1778728 |
|
Stage: |
TS28 |
Assay Id: |
MGI:2667202 |
Age: |
postnatal adult |
Image: |
2 |
|
Specimen Label: |
cbl |
Detected: |
true |
Specimen Num: |
16 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:3772057 |
Assay Type: |
RT-PCR |
Annotation Date: |
2008-02-26 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1778728 |
|
Stage: |
TS28 |
Assay Id: |
MGI:3772063 |
Age: |
postnatal month 2 |
|
|
Specimen Label: |
Cbl |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5473546 |
Assay Type: |
Western blot |
Annotation Date: |
2013-04-09 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1778727 |
|
Stage: |
TS27 |
Assay Id: |
MGI:5473557 |
Age: |
postnatal day 0 |
Image: |
2 |
|
Specimen Label: |
cbl |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5473546 |
Assay Type: |
Western blot |
Annotation Date: |
2013-04-09 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1778728 |
|
Stage: |
TS28 |
Assay Id: |
MGI:5473558 |
Age: |
postnatal adult |
Image: |
2 |
|
Specimen Label: |
cbl |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6864066 |
Assay Type: |
Western blot |
Annotation Date: |
2022-02-03 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1778728 |
|
Stage: |
TS28 |
Assay Id: |
MGI:6864079 |
Age: |
postnatal adult |
Image: |
2 |
|
Specimen Label: |
cbl |
Detected: |
true |
Specimen Num: |
10 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7520263 |
Assay Type: |
Northern blot |
Annotation Date: |
2023-08-24 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1778728 |
|
Stage: |
TS28 |
Assay Id: |
MGI:7520334 |
Age: |
postnatal adult |
Image: |
3 |
|
Specimen Label: |
CBL |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7571378 |
Assay Type: |
RT-PCR |
Annotation Date: |
2024-01-04 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1778728 |
|
Stage: |
TS28 |
Assay Id: |
MGI:7571385 |
Age: |
postnatal adult |
Image: |
3 |
|
Specimen Label: |
Cbl |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7571379 |
Assay Type: |
RT-PCR |
Annotation Date: |
2024-01-04 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1778728 |
|
Stage: |
TS28 |
Assay Id: |
MGI:7571386 |
Age: |
postnatal adult |
Image: |
3 |
|
Specimen Label: |
Cbl |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mohapatra B |
Year: |
2017 |
Journal: |
Development |
Title: |
An essential role of CBL and CBL-B ubiquitin ligases in mammary stem cell maintenance. |
Volume: |
144 |
Issue: |
6 |
Pages: |
1072-1086 |
|
•
•
•
•
•
|
Publication |
First Author: |
Caveggion E |
Year: |
2003 |
Journal: |
J Cell Physiol |
Title: |
Expression and tyrosine phosphorylation of Cbl regulates macrophage chemokinetic and chemotactic movement. |
Volume: |
195 |
Issue: |
2 |
Pages: |
276-89 |
|
•
•
•
•
•
|
Publication |
First Author: |
Latour S |
Year: |
1996 |
Journal: |
J Biol Chem |
Title: |
Differential intrinsic enzymatic activity of Syk and Zap-70 protein-tyrosine kinases. |
Volume: |
271 |
Issue: |
37 |
Pages: |
22782-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fournel M |
Year: |
1996 |
Journal: |
J Exp Med |
Title: |
Association of tyrosine protein kinase Zap-70 with the protooncogene product p120c-cbl in T lymphocytes. |
Volume: |
183 |
Issue: |
1 |
Pages: |
301-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tong H |
Year: |
2021 |
Journal: |
Front Immunol |
Title: |
Ubiquitin Ligases CBL and CBL-B Maintain the Homeostasis and Immune Quiescence of Dendritic Cells. |
Volume: |
12 |
|
Pages: |
757231 |
|
•
•
•
•
•
|
Publication |
First Author: |
An W |
Year: |
2016 |
Journal: |
Oncotarget |
Title: |
VAV1-Cre mediated hematopoietic deletion of CBL and CBL-B leads to JMML-like aggressive early-neonatal myeloproliferative disease. |
Volume: |
7 |
Issue: |
37 |
Pages: |
59006-59016 |
|
•
•
•
•
•
|
Publication |
First Author: |
Henry CM |
Year: |
2023 |
Journal: |
Cell Rep |
Title: |
SYK ubiquitination by CBL E3 ligases restrains cross-presentation of dead cell-associated antigens by type 1 dendritic cells. |
Volume: |
42 |
Issue: |
12 |
Pages: |
113506 |
|
•
•
•
•
•
|
Publication |
First Author: |
An W |
Year: |
2015 |
Journal: |
Oncotarget |
Title: |
Loss of Cbl and Cbl-b ubiquitin ligases abrogates hematopoietic stem cell quiescence and sensitizes leukemic disease to chemotherapy. |
Volume: |
6 |
Issue: |
12 |
Pages: |
10498-509 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hunter S |
Year: |
1999 |
Journal: |
J Biol Chem |
Title: |
Fyn associates with Cbl and phosphorylates tyrosine 731 in Cbl, a binding site for phosphatidylinositol 3-kinase. |
Volume: |
274 |
Issue: |
4 |
Pages: |
2097-106 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
83
|
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Huang F |
Year: |
2006 |
Journal: |
Immunity |
Title: |
Establishment of the major compatibility complex-dependent development of CD4+ and CD8+ T cells by the Cbl family proteins. |
Volume: |
25 |
Issue: |
4 |
Pages: |
571-81 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lv K |
Year: |
2017 |
Journal: |
Genes Dev |
Title: |
CBL family E3 ubiquitin ligases control JAK2 ubiquitination and stability in hematopoietic stem cells and myeloid malignancies. |
Volume: |
31 |
Issue: |
10 |
Pages: |
1007-1023 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang L |
Year: |
2013 |
Journal: |
PLoS One |
Title: |
Berberine inhibits proliferation and down-regulates epidermal growth factor receptor through activation of Cbl in colon tumor cells. |
Volume: |
8 |
Issue: |
2 |
Pages: |
e56666 |
|
•
•
•
•
•
|
Publication |
First Author: |
Meng F |
Year: |
1998 |
Journal: |
EMBO J |
Title: |
A beta 1 integrin signaling pathway involving Src-family kinases, Cbl and PI-3 kinase is required for macrophage spreading and migration. |
Volume: |
17 |
Issue: |
15 |
Pages: |
4391-403 |
|
•
•
•
•
•
|
Publication |
First Author: |
Schnyder T |
Year: |
2011 |
Journal: |
Immunity |
Title: |
B cell receptor-mediated antigen gathering requires ubiquitin ligase Cbl and adaptors Grb2 and Dok-3 to recruit dynein to the signaling microcluster. |
Volume: |
34 |
Issue: |
6 |
Pages: |
905-18 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dale BM |
Year: |
2009 |
Journal: |
J Immunol |
Title: |
Phagocytosis in macrophages lacking Cbl reveals an unsuspected role for Fc gamma receptor signaling and actin assembly in target binding. |
Volume: |
182 |
Issue: |
9 |
Pages: |
5654-62 |
|
•
•
•
•
•
|
Publication |
First Author: |
Voisinne G |
Year: |
2016 |
Journal: |
Mol Syst Biol |
Title: |
Co-recruitment analysis of the CBL and CBLB signalosomes in primary T cells identifies CD5 as a key regulator of TCR-induced ubiquitylation. |
Volume: |
12 |
Issue: |
7 |
Pages: |
876 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li X |
Year: |
2024 |
Journal: |
Immunity |
Title: |
Deficiency of CBL and CBLB ubiquitin ligases leads to hyper T follicular helper cell responses and lupus by reducing BCL6 degradation. |
Volume: |
57 |
Issue: |
7 |
Pages: |
1603-1617.e7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tezuka T |
Year: |
1996 |
Journal: |
J Exp Med |
Title: |
Physical and functional association of the cbl protooncogen product with an src-family protein tyrosine kinase, p53/56lyn, in the B cell antigen receptor-mediated signaling. |
Volume: |
183 |
Issue: |
2 |
Pages: |
675-80 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
913
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Fasen K |
Year: |
2008 |
Journal: |
Traffic |
Title: |
Ligand binding induces Cbl-dependent EphB1 receptor degradation through the lysosomal pathway. |
Volume: |
9 |
Issue: |
2 |
Pages: |
251-66 |
|
•
•
•
•
•
|
Publication |
First Author: |
Loreto MP |
Year: |
2002 |
Journal: |
Mol Cell Biol |
Title: |
Functional cooperation between c-Cbl and Src-like adaptor protein 2 in the negative regulation of T-cell receptor signaling. |
Volume: |
22 |
Issue: |
12 |
Pages: |
4241-55 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ollendorff V |
Year: |
1998 |
Journal: |
Int J Oncol |
Title: |
A third human CBL gene is on chromosome 19. |
Volume: |
13 |
Issue: |
6 |
Pages: |
1159-61 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
79
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
78
|
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Scanlon V |
Year: |
2015 |
Journal: |
PLoS One |
Title: |
Role of Cbl-PI3K Interaction during Skeletal Remodeling in a Murine Model of Bone Repair. |
Volume: |
10 |
Issue: |
9 |
Pages: |
e0138194 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yu J |
Year: |
2019 |
Journal: |
Bone |
Title: |
Cbl-PI3K interaction regulates Cathepsin K secretion in osteoclasts. |
Volume: |
127 |
|
Pages: |
376-385 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nakata Y |
Year: |
2017 |
Journal: |
Blood |
Title: |
Acquired expression of CblQ367P in mice induces dysplastic myelopoiesis mimicking chronic myelomonocytic leukemia. |
Volume: |
129 |
Issue: |
15 |
Pages: |
2148-2160 |
|
•
•
•
•
•
|
Publication |
First Author: |
Adapala NS |
Year: |
2010 |
Journal: |
J Biol Chem |
Title: |
The loss of Cbl-phosphatidylinositol 3-kinase interaction perturbs RANKL-mediated signaling, inhibiting bone resorption and promoting osteoclast survival. |
Volume: |
285 |
Issue: |
47 |
Pages: |
36745-58 |
|
•
•
•
•
•
|
Publication |
First Author: |
Doherty L |
Year: |
2019 |
Journal: |
PLoS One |
Title: |
A PDGFRβ-PI3K signaling axis mediates periosteal cell activation during fracture healing. |
Volume: |
14 |
Issue: |
10 |
Pages: |
e0223846 |
|
•
•
•
•
•
|
Publication |
First Author: |
Adapala NS |
Year: |
2014 |
Journal: |
Bone |
Title: |
Loss of Cbl-PI3K interaction in mice prevents significant bone loss following ovariectomy. |
Volume: |
67 |
|
Pages: |
1-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Feng L |
Year: |
2011 |
Journal: |
Cell Biochem Funct |
Title: |
SH3KBP1-binding protein 1 prevents epidermal growth factor receptor degradation by the interruption of c-Cbl-CIN85 complex. |
Volume: |
29 |
Issue: |
7 |
Pages: |
589-96 |
|
•
•
•
•
•
|
Publication |
First Author: |
Scanlon V |
Year: |
2017 |
Journal: |
Bone |
Title: |
Loss of Cbl-PI3K interaction modulates the periosteal response to fracture by enhancing osteogenic commitment and differentiation. |
Volume: |
95 |
|
Pages: |
124-135 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
51
|
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Ribon V |
Year: |
1998 |
Journal: |
Mol Cell Biol |
Title: |
A novel, multifuntional c-Cbl binding protein in insulin receptor signaling in 3T3-L1 adipocytes. |
Volume: |
18 |
Issue: |
2 |
Pages: |
872-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Adapala NS |
Year: |
2014 |
Journal: |
J Cell Biochem |
Title: |
Loss of Cbl-PI3K interaction enhances osteoclast survival due to p21-Ras mediated PI3K activation independent of Cbl-b. |
Volume: |
115 |
Issue: |
7 |
Pages: |
1277-89 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen W |
Year: |
2013 |
Journal: |
Cell |
Title: |
Induction of Siglec-G by RNA viruses inhibits the innate immune response by promoting RIG-I degradation. |
Volume: |
152 |
Issue: |
3 |
Pages: |
467-78 |
|
•
•
•
•
•
|
Publication |
First Author: |
Märklin M |
Year: |
2020 |
Journal: |
J Cell Mol Med |
Title: |
C-Cbl regulates c-MPL receptor trafficking and its internalization. |
Volume: |
24 |
Issue: |
21 |
Pages: |
12491-12503 |
|
•
•
•
•
•
|
Publication |
First Author: |
Molero JC |
Year: |
2006 |
Journal: |
Diabetes |
Title: |
Genetic ablation of the c-Cbl ubiquitin ligase domain results in increased energy expenditure and improved insulin action. |
Volume: |
55 |
Issue: |
12 |
Pages: |
3411-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Buitrago L |
Year: |
2011 |
Journal: |
Blood |
Title: |
Tyrosine phosphorylated c-Cbl regulates platelet functional responses mediated by outside-in signaling. |
Volume: |
118 |
Issue: |
20 |
Pages: |
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