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Search results 1 to 100 out of 1086 for Ntrk2

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Type Details Score
Gene
4915 | NTRK2
Type: gene
Organism: human
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Gene
735394 | NTRK2
Type: gene
Organism: chimpanzee
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Gene
484147 | NTRK2
Type: gene
Organism: dog, domestic
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Gene
505824 | NTRK2
Type: gene
Organism: cattle
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Gene
396157 | NTRK2
Type: gene
Organism: chicken
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Gene
709757 | NTRK2
Type: gene
Organism: macaque, rhesus
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Gene
780110 | ntrk2
Type: gene
Organism: frog, western clawed
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Gene
25054 | Ntrk2
Type: gene
Organism: rat
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Protein Domain
IPR020455 | NTRK2
Type: Family
Description: Neurotrophins are a family of secreted proteins that regulate development, maintenance and function of vertebrate nervous systems. They act via two different classes of receptor: p75NTR (a member of the TNF receptor superfamily), and neurotrophic tyrosine kinase receptors (NTRKs) - also known as tropomyosin-related kinases (Trks) []. NTRKs are multi-domain, transmembrane proteins - in addition to their cytoplasmic kinase domains, members of the family possess a number of extracellular leucine-rich repeat (LRR) and Ig-like C2-type regions. Ligand binding induces them to dimerise, resulting in activation of their cytoplasmic tyrosine kinase domains. The activated receptors couple to a variety of intracellular signalling cascades, including the Ras, phosphatidylinositol-3-kinase (PI-3 kinase), mitogen-activated protein (MAP) kinase, and phospholipase C (PLC)-gamma pathways []. This entry represents NTRK2 (also termed TrkB) is a high-affinity receptor for brain-derived neurotrophic factor (BDNF) and neurotrophin (NT-4). It is broadly expressed in the nervous system, and is also found in some non neural tissues []. The receptor is involved in synaptogenesis and neuronal development []. It plays a crucial role in learning and memory [].
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Protein Coding Gene
MGI:97384 | Ntrk2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
B5BQV3
Organism: Mus musculus/domesticus
Length: 478  
Fragment?: false
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Protein
B5BQV4
Organism: Mus musculus/domesticus
Length: 455  
Fragment?: false
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Publication
11836532 | J:74960
First Author: Rico B
Year: 2002
Journal: Nat Neurosci
Title: TrkB receptor signaling is required for establishment of GABAergic synapses in the cerebellum.
Volume: 5
Issue: 3
Pages: 225-33
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Publication
12719654 | -
First Author: Yamada K
Year: 2003
Journal: J Pharmacol Sci
Title: Brain-derived neurotrophic factor/TrkB signaling in memory processes.
Volume: 91
Issue: 4
Pages: 267-70
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GXD Expression
GXD Expression
   
Probe: MGI:4354366
Assay Type: RNA in situ
Annotation Date: 2009-08-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3270422
Stage: TS22
Assay Id: MGI:4354838
Age: embryonic day 14.5
Image: 3C & Table S5 - Ntrk2
Specimen Label: 3C & Table S5 - Ntrk2
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:4354366
Assay Type: RNA in situ
Annotation Date: 2009-08-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754722
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:4354838
Age: embryonic day 14.5
Image: 3C & Table S5 - Ntrk2
Specimen Label: 3C & Table S5 - Ntrk2
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:4354366
Assay Type: RNA in situ
Annotation Date: 2009-08-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271122
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:4354838
Age: embryonic day 14.5
Image: 3C & Table S5 - Ntrk2
Note: Expression is present in the upper, but not the lower, cortical plate.
Specimen Label: 3C & Table S5 - Ntrk2
Detected: true
Specimen Num: 1
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Publication
17192812 | -
First Author: Lei L
Year: 2007
Journal: Cell Mol Life Sci
Title: Transcriptional regulation of Trk family neurotrophin receptors.
Volume: 64
Issue: 5
Pages: 522-32
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Protein
P15209
Organism: Mus musculus/domesticus
Length: 821  
Fragment?: false
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Publication
7605062 | -
 
First Author: Bothwell M
Year: 1995
Journal: Annu Rev Neurosci
Title: Functional interactions of neurotrophins and neurotrophin receptors.
Volume: 18
Pages: 223-53
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Publication
11520916 | -
 
First Author: Huang EJ
Year: 2001
Journal: Annu Rev Neurosci
Title: Neurotrophins: roles in neuronal development and function.
Volume: 24
Pages: 677-736
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Protein
A0A286YDA0
Organism: Mus musculus/domesticus
Length: 466  
Fragment?: false
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Protein
A0A286YCV8
Organism: Mus musculus/domesticus
Length: 489  
Fragment?: false
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Protein
Q3UHE3
Organism: Mus musculus/domesticus
Length: 476  
Fragment?: false
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Protein
A0A286YDA3
Organism: Mus musculus/domesticus
Length: 492  
Fragment?: false
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Publication
25710496 | J:246217
First Author: Dalton JE
Year: 2015
Journal: PLoS Pathog
Title: The neurotrophic receptor Ntrk2 directs lymphoid tissue neovascularization during Leishmania donovani infection.
Volume: 11
Issue: 2
Pages: e1004681
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Publication
32532995 | J:292338
First Author: Pattwell SS
Year: 2020
Journal: Nat Commun
Title: A kinase-deficient NTRK2 splice variant predominates in glioma and amplifies several oncogenic signaling pathways.
Volume: 11
Issue: 1
Pages: 2977
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Publication
19357131 | J:152505
First Author: Kerr B
Year: 2009
Journal: Reproduction
Title: NTRK1 and NTRK2 receptors facilitate follicle assembly and early follicular development in the mouse ovary.
Volume: 138
Issue: 1
Pages: 131-40
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Publication
18760367 | J:142444
First Author: Kumanogoh H
Year: 2008
Journal: Mol Cell Neurosci
Title: Balanced expression of various TrkB receptor isoforms from the Ntrk2 gene locus in the mouse nervous system.
Volume: 39
Issue: 3
Pages: 465-77
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GXD Expression
GXD Expression
   
Probe: MGI:6179393
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6190979
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Ntrk2
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6179393
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6190979
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Ntrk2
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:6179393
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6190979
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Ntrk2
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:6179393
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6190979
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Ntrk2
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:6179393
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190979
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Ntrk2
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:6179393
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190979
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Ntrk2
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:6179393
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6190979
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Ntrk2
Detected: true
Specimen Num: 7
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Publication
36206341 | J:330529
First Author: Pattwell SS
Year: 2022
Journal: Sci Adv
Title: Oncogenic role of a developmentally regulated NTRK2 splice variant.
Volume: 8
Issue: 40
Pages: eabo6789
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Publication
16115204 | J:100991
First Author: Irintchev A
Year: 2005
Journal: Eur J Neurosci
Title: Impacts of lesion severity and tyrosine kinase receptor B deficiency on functional outcome of femoral nerve injury assessed by a novel single-frame motion analysis in mice.
Volume: 22
Issue: 4
Pages: 802-8
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UniProt Feature
UniProt Feature
Begin: 829
Description: Phosphotyrosine; by NTRK2
Type: modified residue
End: 829
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Publication
32265438 | J:287168
First Author: An JJ
Year: 2020
Journal: Nat Commun
Title: TrkB-expressing paraventricular hypothalamic neurons suppress appetite through multiple neurocircuits.
Volume: 11
Issue: 1
Pages: 1729
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Publication
33606976 | J:303948
First Author: Casarotto PC
Year: 2021
Journal: Cell
Title: Antidepressant drugs act by directly binding to TRKB neurotrophin receptors.
Volume: 184
Issue: 5
Pages: 1299-1313.e19
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Publication
16418274 | J:105706
First Author: Chakravarthy S
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Postsynaptic TrkB signaling has distinct roles in spine maintenance in adult visual cortex and hippocampus.
Volume: 103
Issue: 4
Pages: 1071-6
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Publication
25316336 | J:225477
First Author: Saiepour MH
Year: 2015
Journal: Cereb Cortex
Title: Competition and Homeostasis of Excitatory and Inhibitory Connectivity in the Adult Mouse Visual Cortex.
Volume: 25
Issue: 10
Pages: 3713-22
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Publication
21192928 | J:170724
First Author: Baydyuk M
Year: 2011
Journal: Exp Neurol
Title: Chronic deprivation of TrkB signaling leads to selective late-onset nigrostriatal dopaminergic degeneration.
Volume: 228
Issue: 1
Pages: 118-25
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Publication
25127683 | J:217073
 
First Author: Lucas EK
Year: 2014
Journal: Behav Brain Res
Title: Mice lacking TrkB in parvalbumin-positive cells exhibit sexually dimorphic behavioral phenotypes.
Volume: 274
Pages: 219-25
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Publication
30718415 | J:272924
First Author: Liao GY
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: TrkB-expressing neurons in the dorsomedial hypothalamus are necessary and sufficient to suppress homeostatic feeding.
Volume: 116
Issue: 8
Pages: 3256-3261
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Publication
11745667 | J:116954
First Author: Boyd JG
Year: 2001
Journal: J Neurobiol
Title: The neurotrophin receptors, trkB and p75, differentially regulate motor axonal regeneration.
Volume: 49
Issue: 4
Pages: 314-25
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Publication
31429825 | J:279113
   
First Author: Tomassoni-Ardori F
Year: 2019
Journal: Elife
Title: Rbfox1 up-regulation impairs BDNF-dependent hippocampal LTP by dysregulating TrkB isoform expression levels.
Volume: 8
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Publication
23041929 | J:189225
First Author: Southwell DG
Year: 2012
Journal: Nature
Title: Intrinsically determined cell death of developing cortical interneurons.
Volume: 491
Issue: 7422
Pages: 109-13
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Publication
32277855 | J:336346
First Author: Dragunas G
Year: 2020
Journal: FASEB J
Title: Cholinergic neuroplasticity in asthma driven by TrkB signaling.
Volume: 34
Issue: 6
Pages: 7703-7717
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Publication
10995833 | J:69123
First Author: Xu B
Year: 2000
Journal: J Neurosci
Title: The role of brain-derived neurotrophic factor receptors in the mature hippocampus: modulation of long-term potentiation through a presynaptic mechanism involving TrkB.
Volume: 20
Issue: 18
Pages: 6888-97
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Publication
10798407 | J:77452
First Author: Xu B
Year: 2000
Journal: Neuron
Title: Cortical degeneration in the absence of neurotrophin signaling: dendritic retraction and neuronal loss after removal of the receptor TrkB.
Volume: 26
Issue: 1
Pages: 233-45
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Publication
21949401 | J:177465
First Author: Zheng K
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: TrkB signaling in parvalbumin-positive interneurons is critical for gamma-band network synchronization in hippocampus.
Volume: 108
Issue: 41
Pages: 17201-6
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Publication
24877631 | J:214372
First Author: Dorfman MD
Year: 2014
Journal: Endocrinology
Title: Loss of Ntrk2/Kiss1r signaling in oocytes causes premature ovarian failure.
Volume: 155
Issue: 8
Pages: 3098-111
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Publication
16264195 | J:102417
First Author: Wagner N
Year: 2005
Journal: Genes Dev
Title: Coronary vessel development requires activation of the TrkB neurotrophin receptor by the Wilms' tumor transcription factor Wt1.
Volume: 19
Issue: 21
Pages: 2631-42
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Publication
20460112 | J:162252
First Author: Horiguchi S
Year: 2010
Journal: Biochem Biophys Res Commun
Title: Downregulation of msh-like 2 (msx2) and neurotrophic tyrosine kinase receptor type 2 (ntrk2) in the developmental gut of KIT mutant mice.
Volume: 396
Issue: 3
Pages: 774-9
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Publication
17584746 | J:124770
First Author: Inoue K
Year: 2007
Journal: J Biol Chem
Title: The transcription factor Runx3 represses the neurotrophin receptor TrkB during lineage commitment of dorsal root ganglion neurons.
Volume: 282
Issue: 33
Pages: 24175-84
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Publication
12796784 | J:84073
First Author: Xu B
Year: 2003
Journal: Nat Neurosci
Title: Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor.
Volume: 6
Issue: 7
Pages: 736-42
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Publication
35831953 | J:327901
 
First Author: Ye Q
Year: 2022
Journal: Development
Title: Understanding the development of oral epithelial organs through single cell transcriptomic analysis.
Volume: 149
Issue: 16
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Publication
26073495 | J:299579
First Author: An JJ
Year: 2015
Journal: Cell Metab
Title: Discrete BDNF Neurons in the Paraventricular Hypothalamus Control Feeding and Energy Expenditure.
Volume: 22
Issue: 1
Pages: 175-88
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Protein Coding Gene
MGP_CAROLIEiJ_G0018602 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0020636 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0020590 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0020568 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0020586 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0020385 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_97384 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0021020 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0019899 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0020345 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0020468 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0020447 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0020544 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0020476 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0021063 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0019655 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0019961 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0019666 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0019482 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
2160854 | J:41358
First Author: Klein R
Year: 1990
Journal: Cell
Title: The trkB tyrosine protein kinase gene codes for a second neurogenic receptor that lacks the catalytic kinase domain.
Volume: 61
Issue: 4
Pages: 647-56
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Publication
9148911 | J:40431
First Author: Ninkina N
Year: 1997
Journal: J Biol Chem
Title: TrkB variants with deletions in the leucine-rich motifs of the extracellular domain.
Volume: 272
Issue: 20
Pages: 13019-25
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Publication
8402890 | J:56847
First Author: Klein R
Year: 1993
Journal: Cell
Title: Targeted disruption of the trkB neurotrophin receptor gene results in nervous system lesions and neonatal death.
Volume: 75
Issue: 1
Pages: 113-22
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Publication
10571233 | J:58229
First Author: Minichiello L
Year: 1999
Journal: Neuron
Title: Essential role for TrkB receptors in hippocampus-mediated learning.
Volume: 24
Issue: 2
Pages: 401-14
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Publication
14581459 | J:86332
First Author: Du J
Year: 2003
Journal: J Cell Biol
Title: Regulation of TrkB receptor tyrosine kinase and its internalization by neuronal activity and Ca2+ influx.
Volume: 163
Issue: 2
Pages: 385-95
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Publication
14603320 | J:180482
First Author: Rose CR
Year: 2003
Journal: Nature
Title: Truncated TrkB-T1 mediates neurotrophin-evoked calcium signalling in glia cells.
Volume: 426
Issue: 6962
Pages: 74-8
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Publication
15329723 | J:180478
First Author: Douma S
Year: 2004
Journal: Nature
Title: Suppression of anoikis and induction of metastasis by the neurotrophic receptor TrkB.
Volume: 430
Issue: 7003
Pages: 1034-9
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Publication
11918285 | J:113305
First Author: Vyssotski AL
Year: 2002
Journal: Hippocampus
Title: Long-term monitoring of hippocampus-dependent behavior in naturalistic settings: mutant mice lacking neurotrophin receptor TrkB in the forebrain show spatial learning but impaired behavioral flexibility.
Volume: 12
Issue: 1
Pages: 27-38
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Publication
23512795 | J:210126
First Author: Mason BL
Year: 2013
Journal: Obesity (Silver Spring)
Title: Trk B signaling in dopamine 1 receptor neurons regulates food intake and body weight.
Volume: 21
Issue: 11
Pages: 2372-6
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Publication
20947769 | J:164868
First Author: Lobo MK
Year: 2010
Journal: Science
Title: Cell type-specific loss of BDNF signaling mimics optogenetic control of cocaine reward.
Volume: 330
Issue: 6002
Pages: 385-90
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Publication
24070857 | J:202462
 
First Author: Bollen E
Year: 2013
Journal: Behav Brain Res
Title: 7,8-Dihydroxyflavone improves memory consolidation processes in rats and mice.
Volume: 257
Pages: 8-12
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Publication
15829629 | J:98613
First Author: Luikart BW
Year: 2005
Journal: J Neurosci
Title: TrkB has a cell-autonomous role in the establishment of hippocampal Schaffer collateral synapses.
Volume: 25
Issue: 15
Pages: 3774-86
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Publication
24619096 | J:210229
 
First Author: Geibel M
Year: 2014
Journal: Nat Commun
Title: Ablation of TrkB signalling in CCK neurons results in hypercortisolism and obesity.
Volume: 5
Pages: 3427
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Publication
12070090 | J:111369
First Author: Polleux F
Year: 2002
Journal: Development
Title: Control of cortical interneuron migration by neurotrophins and PI3-kinase signaling.
Volume: 129
Issue: 13
Pages: 3147-60
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Publication
26629410 | J:273976
First Author: Ozek C
Year: 2015
Journal: Mol Metab
Title: Ablation of intact hypothalamic and/or hindbrain TrkB signaling leads to perturbations in energy balance.
Volume: 4
Issue: 11
Pages: 867-80
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Publication
33875572 | J:325525
First Author: Huang T
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