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Search results 201 to 300 out of 405 for Ulk1

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Type Details Score
Publication
32876528 | J:310981
First Author: González-Rodríguez P
Year: 2021
Journal: Autophagy
Title: The DNA methyltransferase DNMT3A contributes to autophagy long-term memory.
Volume: 17
Issue: 5
Pages: 1259-1277
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Publication
29056340 | J:249176
First Author: Moretti J
Year: 2017
Journal: Cell
Title: STING Senses Microbial Viability to Orchestrate Stress-Mediated Autophagy of the Endoplasmic Reticulum.
Volume: 171
Issue: 4
Pages: 809-823.e13
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Publication
30245008 | J:267290
First Author: Cunha LD
Year: 2018
Journal: Cell
Title: LC3-Associated Phagocytosis in Myeloid Cells Promotes Tumor Immune Tolerance.
Volume: 175
Issue: 2
Pages: 429-441.e16
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Publication
34242585 | J:308686
First Author: Tiu GC
Year: 2021
Journal: Dev Cell
Title: A p53-dependent translational program directs tissue-selective phenotypes in a model of ribosomopathies.
Volume: 56
Issue: 14
Pages: 2089-2102.e11
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Publication
28474670 | J:250342
 
First Author: Wang F
Year: 2017
Journal: Nat Commun
Title: Protein kinase C-alpha suppresses autophagy and induces neural tube defects via miR-129-2 in diabetic pregnancy.
Volume: 8
Pages: 15182
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Publication
36198274 | J:329967
First Author: Li H
Year: 2022
Journal: Cell Rep
Title: Destabilization of TP53 by USP10 is essential for neonatal autophagy and survival.
Volume: 41
Issue: 1
Pages: 111435
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Publication
22904094 | J:212629
First Author: Papanicolaou KN
Year: 2012
Journal: Circ Res
Title: Mitofusins 1 and 2 are essential for postnatal metabolic remodeling in heart.
Volume: 111
Issue: 8
Pages: 1012-26
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Publication
11423996 | J:70201
First Author: Kannan K
Year: 2001
Journal: Oncogene
Title: DNA microarray analysis of genes involved in p53 mediated apoptosis: activation of Apaf-1.
Volume: 20
Issue: 26
Pages: 3449-55
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Publication
27166947 | J:235368
First Author: Gómez-Del Arco P
Year: 2016
Journal: Cell Metab
Title: The Chromatin Remodeling Complex Chd4/NuRD Controls Striated Muscle Identity and Metabolic Homeostasis.
Volume: 23
Issue: 5
Pages: 881-92
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
12693553 | J:83413
First Author: Okazaki N
Year: 2003
Journal: DNA Res
Title: Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.
Volume: 10
Issue: 1
Pages: 35-48
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Publication
- | J:165964
     
First Author: Mammalian Functional Genomics Centre
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the NorCOMM project by the Mammalian Functional Genomics Centre (Mfgc), University of Manitoba
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Publication
- | J:94338
     
First Author: NIH Mouse Knockout Inventory
Year: 2004
Journal: MGI Direct Data Submission
Title: Information obtained from the NIH Mouse Knockout Inventory
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Publication
- | J:342607
       
First Author: Birgit Meldal and Sandra Orchard (1). (1) European Bioinformatics Institute (EBI), Hinxton, Cambridgeshire, United Kingdom
Year: 2023
Title: Manual transfer of experimentally-verified manual GO annotation data to homologous complexes by curator judgment of sequence, composition and function similarity
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Publication
15226823 | J:93300
First Author: Blackshaw S
Year: 2004
Journal: PLoS Biol
Title: Genomic analysis of mouse retinal development.
Volume: 2
Issue: 9
Pages: E247
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Publication
- | J:342608
       
First Author: GO Central curators, GOA curators, Rhea curators
Year: 2020
Title: Automatic Gene Ontology annotation based on Rhea mapping
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Publication
10725249 | J:60984
First Author: Ko MS
Year: 2000
Journal: Development
Title: Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.
Volume: 127
Issue: 8
Pages: 1737-49
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Publication
- | J:73065
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
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Publication
12904583 | J:85162
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
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Publication
17967808 | J:152068
First Author: Friedel RH
Year: 2007
Journal: Brief Funct Genomic Proteomic
Title: EUCOMM--the European conditional mouse mutagenesis program.
Volume: 6
Issue: 3
Pages: 180-5
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Publication
34321999 | J:313619
 
First Author: Bedogni F
Year: 2021
Journal: Front Mol Neurosci
Title: Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.
Volume: 14
Pages: 686034
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Publication
- | J:80155
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:155856
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Rat to Mouse ISO GO annotation transfer
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:60000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Protein
A0A0G2JFU2
Organism: Mus musculus/domesticus
Length: 86  
Fragment?: true
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Protein
A0A0G2JG09
Organism: Mus musculus/domesticus
Length: 84  
Fragment?: true
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Protein
O70405
Organism: Mus musculus/domesticus
Length: 1051  
Fragment?: false
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Publication
28924239 | J:254767
First Author: Dite TA
Year: 2017
Journal: Nat Commun
Title: The autophagy initiator ULK1 sensitizes AMPK to allosteric drugs.
Volume: 8
Issue: 1
Pages: 571
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UniProt Feature
UniProt Feature
Begin: 68
Description: Phosphoserine; by ULK1
Type: modified residue
End: 68
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UniProt Feature
UniProt Feature
Begin: 38
Description: Phosphoserine; by ULK1
Type: modified residue
End: 38
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UniProt Feature
UniProt Feature
Begin: 39
Description: Phosphothreonine; by ULK1
Type: modified residue
End: 39
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UniProt Feature
UniProt Feature
Begin: 260
Description: Phosphoserine; by ULK1
Type: modified residue
End: 260
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UniProt Feature
UniProt Feature
Begin: 269
Description: Phosphoserine; by ULK1
Type: modified residue
End: 269
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UniProt Feature
UniProt Feature
Begin: 262
Description: Phosphothreonine; by ULK1
Type: modified residue
End: 262
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UniProt Feature
UniProt Feature
Begin: 354
Description: Phosphoserine; by ULK1
Type: modified residue
End: 354
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UniProt Feature
UniProt Feature
Begin: 488
Description: Phosphothreonine; by ULK1
Type: modified residue
End: 488
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UniProt Feature
UniProt Feature
Begin: 368
Description: Phosphothreonine; by ULK1
Type: modified residue
End: 368
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UniProt Feature
UniProt Feature
Begin: 397
Description: Phosphoserine; by ULK1
Type: modified residue
End: 397
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UniProt Feature
UniProt Feature
Begin: 360
Description: Phosphoserine; by ULK1
Type: modified residue
End: 360
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UniProt Feature
UniProt Feature
Begin: 572
Description: Phosphoserine; by ULK1
Type: modified residue
End: 572
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UniProt Feature
UniProt Feature
Begin: 554
Description: Phosphoserine; by ULK1
Type: modified residue
End: 554
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UniProt Feature
UniProt Feature
Begin: 1
Description: Serine/threonine-protein kinase ULK1
Type: chain
End: 1051
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Publication
23078367 | J:194025
First Author: Pike LR
Year: 2013
Journal: Biochem J
Title: Transcriptional up-regulation of ULK1 by ATF4 contributes to cancer cell survival.
Volume: 449
Issue: 2
Pages: 389-400
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Publication
32275117 | J:316350
First Author: Shen Y
Year: 2020
Journal: FASEB J
Title: TRAF3 promotes ROS production and pyroptosis by targeting ULK1 ubiquitination in macrophages.
Volume: 34
Issue: 5
Pages: 7144-7159
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Publication
23262492 | J:245290
First Author: Gammoh N
Year: 2013
Journal: Nat Struct Mol Biol
Title: Interaction between FIP200 and ATG16L1 distinguishes ULK1 complex-dependent and -independent autophagy.
Volume: 20
Issue: 2
Pages: 144-9
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Publication
34233158 | J:313749
First Author: Nguyen TTP
Year: 2021
Journal: Mol Cell
Title: SREBP-1c impairs ULK1 sulfhydration-mediated autophagic flux to promote hepatic steatosis in high-fat-diet-fed mice.
Volume: 81
Issue: 18
Pages: 3820-3832.e7
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Publication
23524951 | J:197628
First Author: Nazio F
Year: 2013
Journal: Nat Cell Biol
Title: mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6.
Volume: 15
Issue: 4
Pages: 406-16
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Publication
36068299 | J:329282
First Author: Zhang H
Year: 2022
Journal: Commun Biol
Title: NAT10 regulates neutrophil pyroptosis in sepsis via acetylating ULK1 RNA and activating STING pathway.
Volume: 5
Issue: 1
Pages: 916
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UniProt Feature
UniProt Feature
Begin: 405
Description: Phosphoserine; by ULK1 and TBK1
Type: modified residue
End: 405
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Allele
Ulk1<em1Smoc> | MGI:7293071
Name: unc-51 like kinase 1; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Interaction Experiment
Lim J (2015)
Description: Proteotoxic stress induces phosphorylation of p62/SQSTM1 by ULK1 to regulate selective autophagic clearance of protein aggregates.
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Interaction Experiment
Di Rienzo M (2019)
Description: Autophagy induction in atrophic muscle cells requires ULK1 activation by TRIM32 through unanchored K63-linked polyubiquitin chains.
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Publication
21072212 | -
First Author: Lee JW
Year: 2010
Journal: PLoS One
Title: The association of AMPK with ULK1 regulates autophagy.
Volume: 5
Issue: 11
Pages: e15394
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Publication
19287211 | -
First Author: Mercer CA
Year: 2009
Journal: Autophagy
Title: A novel, human Atg13 binding protein, Atg101, interacts with ULK1 and is essential for macroautophagy.
Volume: 5
Issue: 5
Pages: 649-62
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Publication
28195531 | -
   
First Author: Jung J
Year: 2017
Journal: Elife
Title: Multiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulator.
Volume: 6
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GO Term
GO:1990316 | Atg1/ULK1 kinase complex
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Publication
22275429 | -
First Author: Itakura E
Year: 2012
Journal: J Cell Sci
Title: Structures containing Atg9A and the ULK1 complex independently target depolarized mitochondria at initial stages of Parkin-mediated mitophagy.
Volume: 125
Issue: Pt 6
Pages: 1488-99
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GO Term
GO:1904745 | Atg1/ULK1 kinase complex assembly
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Publication
24879146 | -
First Author: Alers S
Year: 2014
Journal: Autophagy
Title: ATG13: just a companion, or an executor of the autophagic program?
Volume: 10
Issue: 6
Pages: 944-56
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Publication
21460634 | -
First Author: Löffler AS
Year: 2011
Journal: Autophagy
Title: Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop.
Volume: 7
Issue: 7
Pages: 696-706
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Protein Domain
IPR018731 | Atg13_N
Type: Domain
Description: This entry represents the N-terminal domain of autophagy-related protein 13 (Atg13) from yeasts, animals and plants. They function in autophagy.Fission yeast autophagy initiation is controlled by the Atg1 kinase complex, which is composed of the Ser/Thr kinase Atg1, the adaptor protein Atg13, and the ternary complex of Atg17-Atg31-Atg29. Atg13 recruits Atg1 to the site of autophagosome formation and enhancing Atg1 kinase activity. Atg13 may have additional functions that are independent of a direct interaction or permanent colocalization with Atg1 []. In vertebrates, the orthologous ULK1 kinase complex contains the Ser/Thr kinase ULK1 and the accessory proteins ATG13, RB1CC1, and ATG101 []. Through its regulation of ULK1 activity, Atg13 plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation [].
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Protein Domain
IPR040182 | ATG13
Type: Family
Description: This entry represents autophagy-related protein 13 (Atg13) from yeasts, animals and plants, which functions in autophagy.Fission yeast autophagy initiation is controlled by the Atg1 kinase complex, which is composed of the Ser/Thr kinase Atg1, the adaptor protein Atg13, and the ternary complex of Atg17-Atg31-Atg29. Atg13 recruits Atg1 to the site of autophagosome formation and enhancing Atg1 kinase activity. Atg13 may have additional functions that are independent of a direct interaction or permanent colocalization with Atg1 []. In vertebrates, the orthologous ULK1 kinase complex contains the Ser/Thr kinase ULK1 and the accessory proteins ATG13, RB1CC1, and ATG101 []. Through its regulation of ULK1 activity, Atg13 plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation [].
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GO Term
GO:1905864 | regulation of Atg1/ULK1 kinase complex assembly
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Protein
Q78YZ6
Organism: Mus musculus/domesticus
Length: 125  
Fragment?: false
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Protein
A0A1D5RML7
Organism: Mus musculus/domesticus
Length: 47  
Fragment?: false
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Protein
A0A1D5RMF2
Organism: Mus musculus/domesticus
Length: 35  
Fragment?: true
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Publication
22354037 | -
First Author: McKnight NC
Year: 2012
Journal: EMBO J
Title: Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC.
Volume: 31
Issue: 8
Pages: 1931-46
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Protein Domain
IPR019357 | SCOC
Type: Family
Description: This entry represents short coiled-coil protein (SCOC). In human, SCOC is required for autophagosome formation during amino acid starvation. It forms a starvation-sensitive trimeric complex with UVRAG (UV radiation resistance associated gene) and FEZ1 and may regulate ULK1 and Beclin 1 complex activities [].
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HT Experiment
GSE79508 | Cathepsin B modulates lysosomal biogenesis and host defense against Francisella novicida infection
Series Id: E-GEOD-79508
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: GEO
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Protein
Q91YI1
Organism: Mus musculus/domesticus
Length: 516  
Fragment?: false
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Protein Domain
IPR016237 | Ser/Thr_kin_STPK_Ulk-1/2
Type: Family
Description: Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. Phosphoprotein phosphatases catalyse the reverse process. Protein kinases fall into three broad classes, characterised with respect to substrate specificity []:Serine/threonine-protein kinasesTyrosine-protein kinasesDual specificity protein kinases (e.g. MEK - phosphorylates both Thr and Tyr on target proteins)Protein kinase function is evolutionarily conserved from Escherichia coli to human []. Protein kinases play a role in a multitude of cellular processes, including division, proliferation, apoptosis, and differentiation []. Phosphorylation usually results in a functional change of the target protein by changing enzyme activity, cellular location, or association with other proteins. The catalytic subunits of protein kinases are highly conserved, and several structures have been solved [], leading to large screens to develop kinase-specific inhibitors for the treatments of a number of diseases [].This represents serine/threonine-protein kinases (), such as Ulk1 and Ulk2 (Unc-51-Like Kinase). Ulk1 and Ulk2 regulate filopodia extension and branching of sensory axons. They are important for axon growth, playing an essential role in neurite extension of cerebellar granule cells [, ].
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