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Search results 201 to 287 out of 287 for Cntn5

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Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Strain
MGI:6850163 | B6.FVB(Cg)-Tg(TPO-cre)1Shk/J
Attribute String: congenic, mutant strain, transgenic
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Publication
19177518 | -
First Author: Toyoshima M
Year: 2009
Journal: J Comp Neurol
Title: Preferential localization of neural cell recognition molecule NB-2 in developing glutamatergic neurons in the rat auditory brainstem.
Volume: 513
Issue: 4
Pages: 349-62
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Protein Domain
IPR032989 | Contactin-5
Type: Family
Description: Contactin-5 (Cntn5) or neural recognition molecule NB-2 mediates cell surface interactions necessary for connectivity during nervous system development and synaptic maintenance during adulthood [, ]. Cntn5 contributes to the development of glutamatergic neurons in the rat auditory brainstem [, ].Contactins are cell adhesion molecules that belong to the immunoglobulin superfamily and are involved in neural development []. They usually consist of six N-terminal Ig domains, four fibronectin type III domains, and a C-terminal glycophosphatidylinositol (GPI)-anchor to the extracellular part of the cell membrane [].
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Genotype
Genotype
Symbol: Nkx2-1/Nkx2-1 Tg(TPO-cre)1Shk/?
Background: involves: 129X1/SvJ * FVB/NCr
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gnas/Gnas Tg(TPO-cre)1Shk/?
Background: involves: 129S6/SvEvTac * FVB/NCr
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Nf2/Nf2 Tg(TPO-cre)1Shk/?
Background: involves: 129P2/OlaHsd * FVB/NCr
Zygosity: cn
Has Mutant Allele: true
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Publication
19581346 | J:152193
First Author: Hoshi S
Year: 2009
Journal: Carcinogenesis
Title: Role of NKX2-1 in N-bis(2-hydroxypropyl)-nitrosamine-induced thyroid adenoma in mice.
Volume: 30
Issue: 9
Pages: 1614-9
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Strain
MGI:5897836 | 129.Cg-Tg(TPO-cre)1Shk Trp53<tm1Brn> Pten<tm2.1Ppp>
Attribute String: congenic, mutant strain, targeted mutation, transgenic
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Strain
MGI:4868761 | 129S1.Cg-Pten<tm2.1Ppp> Tg(TPO-cre)1Shk
Attribute String: transgenic, mutant strain, targeted mutation
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Strain
MGI:4868759 | 129S1.Cg-Cdkn1b<tm1Ako> Tg(TPO-cre)1Shk Pten<tm2.1Ppp>
Attribute String: congenic, targeted mutation, transgenic
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Publication
18199538 | J:131418
First Author: Yeager N
Year: 2008
Journal: Cancer Res
Title: Mammalian target of rapamycin is the key effector of phosphatidylinositol-3-OH-initiated proliferative signals in the thyroid follicular epithelium.
Volume: 68
Issue: 2
Pages: 444-9
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Publication
31331961 | J:278688
 
First Author: Jezek J
Year: 2019
Journal: J Cell Sci
Title: Synergistic repression of thyroid hyperplasia by cyclin C and Pten.
Volume: 132
Issue: 16
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Publication
17283127 | J:118219
First Author: Yeager N
Year: 2007
Journal: Cancer Res
Title: Pten loss in the mouse thyroid causes goiter and follicular adenomas: insights into thyroid function and Cowden disease pathogenesis.
Volume: 67
Issue: 3
Pages: 959-66
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Publication
22136853 | J:196861
First Author: Lin CI
Year: 2011
Journal: Surgery
Title: Thyroid-specific knockout of the tumor suppressor mitogen-inducible gene 6 activates epidermal growth factor receptor signaling pathways and suppresses nuclear factor-κB activity.
Volume: 150
Issue: 6
Pages: 1295-302
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Publication
21383698 | J:174636
First Author: Knauf JA
Year: 2011
Journal: Oncogene
Title: Progression of BRAF-induced thyroid cancer is associated with epithelial-mesenchymal transition requiring concomitant MAP kinase and TGFβ signaling.
Volume: 30
Issue: 28
Pages: 3153-62
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Publication
22514108 | J:241066
First Author: Pringle DR
Year: 2012
Journal: Endocr Relat Cancer
Title: Thyroid-specific ablation of the Carney complex gene, PRKAR1A, results in hyperthyroidism and follicular thyroid cancer.
Volume: 19
Issue: 3
Pages: 435-46
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Publication
23796563 | J:200610
First Author: Antico Arciuch VG
Year: 2013
Journal: Cancer Res
Title: Inhibition of AMPK and Krebs cycle gene expression drives metabolic remodeling of Pten-deficient preneoplastic thyroid cells.
Volume: 73
Issue: 17
Pages: 5459-72
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Publication
31314096 | J:279001
First Author: Kurashige T
Year: 2019
Journal: Endocrinology
Title: Basal Autophagy Deficiency Causes Thyroid Follicular Epithelial Cell Death in Mice.
Volume: 160
Issue: 9
Pages: 2085-2092
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Publication
20676139 | J:165293
First Author: Antico-Arciuch VG
Year: 2010
Journal: Oncogene
Title: Cross-talk between PI3K and estrogen in the mouse thyroid predisposes to the development of follicular carcinomas with a higher incidence in females.
Volume: 29
Issue: 42
Pages: 5678-86
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Publication
22190384 | J:211100
First Author: Antico Arciuch VG
Year: 2011
Journal: Oncotarget
Title: Thyrocyte-specific inactivation of p53 and Pten results in anaplastic thyroid carcinomas faithfully recapitulating human tumors.
Volume: 2
Issue: 12
Pages: 1109-26
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Genotype
Genotype
Symbol: Pten/Pten Tg(TPO-cre)1Shk/?
Background: 129S1.Cg-Pten Tg(TPO-cre)1Shk
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cdkn1b/Cdkn1b Pten/Pten Tg(TPO-cre)1Shk/?
Background: 129S1.Cg-Cdkn1b Tg(TPO-cre)1Shk Pten
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cdkn1b/Cdkn1b<+> Pten/Pten Tg(TPO-cre)1Shk/?
Background: 129S1.Cg-Cdkn1b Tg(TPO-cre)1Shk Pten
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(CAG-EGFP,-PAX8/PPARG)1Rkoe/? Tg(TPO-cre)1Shk/?
Background: involves: FVB/NCr * FVB/NJ
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Kras/Kras<+> Tg(TPO-cre)1Shk/?
Background: 129.Cg-Kras Tg(Tpo-cre)1Shk
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Pten/Pten Trp53/Trp53 Tg(TPO-cre)1Shk/?
Background: 129.Cg-Tg(TPO-cre)1Shk Trp53 Pten
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Prkar1a/Prkar1a Tg(TPO-cre)1Shk/?
Background: involves: 129S1/Sv * 129X1/SvJ * FVB/NCr
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Pten/Pten Tg(TPO-cre)1Shk/?
Background: involves: 129 * FVB/NCr
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Kras/Kras Tg(TPO-cre)1Shk/?
Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6N * FVB/NCr
Zygosity: cn
Has Mutant Allele: true
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Publication
16601074 | J:111027
First Author: Kusakabe T
Year: 2006
Journal: Mol Endocrinol
Title: Thyroid-specific enhancer-binding protein/NKX2.1 is required for the maintenance of ordered architecture and function of the differentiated thyroid.
Volume: 20
Issue: 8
Pages: 1796-809
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Publication
29289659 | J:273968
 
First Author: Russart KLG
Year: 2018
Journal: Horm Behav
Title: Elevated aggressive behavior in male mice with thyroid-specific Prkar1a and global Epac1 gene deletion.
Volume: 98
Pages: 121-129
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Strain
MGI:5897667 | 129.Cg-Kras<tm4Tyj> Tg(Tpo-cre)1Shk Pten<tm2.1Ppp>
Attribute String: congenic, mutant strain, targeted mutation, transgenic
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Publication
15282748 | J:92293
First Author: Kusakabe T
Year: 2004
Journal: Genesis
Title: Thyrocyte-specific expression of Cre recombinase in transgenic mice.
Volume: 39
Issue: 3
Pages: 212-6
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Publication
19351816 | J:147732
First Author: Miller KA
Year: 2009
Journal: Cancer Res
Title: Oncogenic Kras requires simultaneous PI3K signaling to induce ERK activation and transform thyroid epithelial cells in vivo.
Volume: 69
Issue: 8
Pages: 3689-94
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Publication
21908931 | J:234597
First Author: Ock S
Year: 2011
Journal: Endocr J
Title: Conditional deletion of insulin receptor in thyrocytes does not affect thyroid structure and function.
Volume: 58
Issue: 11
Pages: 1013-9
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Publication
19797117 | J:158236
First Author: Diallo-Krou E
Year: 2009
Journal: Endocrinology
Title: Paired box gene 8-peroxisome proliferator-activated receptor-gamma fusion protein and loss of phosphatase and tensin homolog synergistically cause thyroid hyperplasia in transgenic mice.
Volume: 150
Issue: 11
Pages: 5181-90
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Publication
24512487 | J:225245
First Author: Pringle DR
Year: 2014
Journal: J Clin Endocrinol Metab
Title: Follicular thyroid cancers demonstrate dual activation of PKA and mTOR as modeled by thyroid-specific deletion of Prkar1a and Pten in mice.
Volume: 99
Issue: 5
Pages: E804-12
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Publication
29990309 | J:266426
First Author: Knauf JA
Year: 2018
Journal: J Clin Invest
Title: Hgf/Met activation mediates resistance to BRAF inhibition in murine anaplastic thyroid cancers.
Volume: 128
Issue: 9
Pages: 4086-4097
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Publication
23751876 | J:202152
First Author: Sponziello M
Year: 2013
Journal: Endocrinology
Title: Molecular differences between human thyroid follicular adenoma and carcinoma revealed by analysis of a murine model of thyroid cancer.
Volume: 154
Issue: 9
Pages: 3043-53
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Publication
30086162 | J:264352
First Author: Shimamura M
Year: 2018
Journal: PLoS One
Title: Mouse models of sporadic thyroid cancer derived from BRAFV600E alone or in combination with PTEN haploinsufficiency under physiologic TSH levels.
Volume: 13
Issue: 8
Pages: e0201365
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Publication
31798532 | J:312029
 
First Author: Kari S
Year: 2019
Journal: Front Endocrinol (Lausanne)
Title: PKA Activates AMPK Through LKB1 Signaling in Follicular Thyroid Cancer.
Volume: 10
Pages: 769
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Genotype
Genotype
Symbol: Pten/Pten Tg(TPO-cre)1Shk/?
Background: involves: 129S4/SvJae * FVB/NCr
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Hras/? Tg(TPO-cre)1Shk/?
Background: involves: 129S6/SvEvTac * FVB/NCr
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/? Tg(TPO-cre)1Shk/?
Background: involves: 129P2/OlaHsd * FVB/NCr
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Hras/Hras Tg(TPO-cre)1Shk/?
Background: involves: 129S6/SvEvTac * FVB/NCr
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Kras/Kras<+> Pten/Pten Tg(TPO-cre)1Shk/?
Background: 129.Cg-Kras Tg(Tpo-cre)1Shk Pten
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Prkar1a/Prkar1a Pten/Pten Tg(TPO-cre)1Shk/?
Background: involves: 129S1/Sv * 129X1/SvJ * FVB/NCr
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Prkar1a/Prkar1a<+> Pten/Pten<+> Tg(TPO-cre)1Shk/?
Background: involves: 129S1/Sv * 129X1/SvJ * FVB/NCr
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(TPO-cre)1Shk/?
Background: involves: 129S4/SvJaeSor * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Publication
29420754 | J:267474
First Author: Yu J
Year: 2018
Journal: Endocrinology
Title: Thyroid-Specific PPARγ Deletion Is Benign in the Mouse.
Volume: 159
Issue: 3
Pages: 1463-1468
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Publication
30165401 | J:320950
First Author: Ashtekar A
Year: 2018
Journal: J Clin Endocrinol Metab
Title: Alterations in Sod2-Induced Oxidative Stress Affect Endocrine Cancer Progression.
Volume: 103
Issue: 11
Pages: 4135-4145
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Publication
29882482 | J:311903
First Author: Huk DJ
Year: 2018
Journal: Thyroid
Title: Deletion of Rap1b, but not Rap1a or Epac1, Reduces Protein Kinase A-Mediated Thyroid Cancer.
Volume: 28
Issue: 9
Pages: 1153-1161
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Publication
25076938 | J:311978
 
First Author: Ma R
Year: 2014
Journal: Front Endocrinol (Lausanne)
Title: Stemness is Derived from Thyroid Cancer Cells.
Volume: 5
Pages: 114
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Publication
29760048 | J:264284
First Author: Untch BR
Year: 2018
Journal: Cancer Res
Title: Tipifarnib Inhibits HRAS-Driven Dedifferentiated Thyroid Cancers.
Volume: 78
Issue: 16
Pages: 4642-4657
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Publication
28242615 | J:242074
First Author: Zou M
Year: 2017
Journal: Cancer Res
Title: Cyp24a1 Attenuation Limits Progression of BrafV600E -Induced Papillary Thyroid Cancer Cells and Sensitizes Them to BRAFV600E Inhibitor PLX4720.
Volume: 77
Issue: 8
Pages: 2161-2172
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Publication
19416908 | J:148393
First Author: Chen X
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Endogenous expression of Hras(G12V) induces developmental defects and neoplasms with copy number imbalances of the oncogene.
Volume: 106
Issue: 19
Pages: 7979-84
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Publication
26818109 | J:231632
First Author: Jolly LA
Year: 2016
Journal: Cancer Res
Title: Fibroblast-Mediated Collagen Remodeling Within the Tumor Microenvironment Facilitates Progression of Thyroid Cancers Driven by BrafV600E and Pten Loss.
Volume: 76
Issue: 7
Pages: 1804-13
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Publication
26477313 | J:312572
First Author: Zou M
Year: 2016
Journal: Oncogene
Title: TSH overcomes Braf(V600E)-induced senescence to promote tumor progression via downregulation of p53 expression in papillary thyroid cancer.
Volume: 35
Issue: 15
Pages: 1909-18
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Publication
21952241 | J:177181
First Author: Dobson ME
Year: 2011
Journal: Endocrinology
Title: Pioglitazone induces a proadipogenic antitumor response in mice with PAX8-PPARgamma fusion protein thyroid carcinoma.
Volume: 152
Issue: 11
Pages: 4455-65
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Publication
26359368 | J:231492
First Author: Garcia-Rendueles ME
Year: 2015
Journal: Cancer Discov
Title: NF2 Loss Promotes Oncogenic RAS-Induced Thyroid Cancers via YAP-Dependent Transactivation of RAS Proteins and Sensitizes Them to MEK Inhibition.
Volume: 5
Issue: 11
Pages: 1178-93
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Publication
26146959 | J:226338
First Author: Zou M
Year: 2015
Journal: Lab Invest
Title: KRAS(G12D)-mediated oncogenic transformation of thyroid follicular cells requires long-term TSH stimulation and is regulated by SPRY1.
Volume: 95
Issue: 11
Pages: 1269-77
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Publication
29055016 | J:252305
First Author: Orlacchio A
Year: 2017
Journal: Cancer Res
Title: SGK1 Is a Critical Component of an AKT-Independent Pathway Essential for PI3K-Mediated Tumor Development and Maintenance.
Volume: 77
Issue: 24
Pages: 6914-6926
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Publication
27669459 | J:239555
First Author: Nagarajah J
Year: 2016
Journal: J Clin Invest
Title: Sustained ERK inhibition maximizes responses of BrafV600E thyroid cancers to radioiodine.
Volume: 126
Issue: 11
Pages: 4119-4124
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Publication
21512141 | J:172205
First Author: Charles RP
Year: 2011
Journal: Cancer Res
Title: Mutationally activated BRAF(V600E) elicits papillary thyroid cancer in the adult mouse.
Volume: 71
Issue: 11
Pages: 3863-71
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Publication
25246276 | J:273044
First Author: Zhu X
Year: 2014
Journal: Neoplasia
Title: Synergistic signaling of KRAS and thyroid hormone receptor β mutants promotes undifferentiated thyroid cancer through MYC up-regulation.
Volume: 16
Issue: 9
Pages: 757-69
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Publication
23365119 | J:200123
First Author: Montero-Conde C
Year: 2013
Journal: Cancer Discov
Title: Relief of feedback inhibition of HER3 transcription by RAF and MEK inhibitors attenuates their antitumor effects in BRAF-mutant thyroid carcinomas.
Volume: 3
Issue: 5
Pages: 520-33
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Publication
31998431 | J:291446
 
First Author: Wang X
Year: 2020
Journal: Oxid Med Cell Longev
Title: Thyroid Stimulating Hormone Triggers Hepatic Mitochondrial Stress through Cyclophilin D Acetylation.
Volume: 2020
Pages: 1249630
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Publication
26501867 | J:227855
First Author: Parhar RS
Year: 2016
Journal: Lab Invest
Title: IL-12 immunotherapy of Braf(V600E)-induced papillary thyroid cancer in a mouse model.
Volume: 96
Issue: 1
Pages: 89-97
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Genotype
Genotype
Symbol: Pten/Pten Tg(CAG-EGFP,-PAX8/PPARG)1Rkoe/? Tg(TPO-cre)1Shk/?
Background: involves: 129S4/SvJae * FVB/NCr * FVB/NJ
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf Tg(TPO-cre)1Shk/?
Background: involves: 129P2/OlaHsd * FVB/NCr
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf Tshr/Tshr Tg(TPO-cre)1Shk/?
Background: involves: 129P2/OlaHsd * 129S1/Sv * FVB/NCr
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Braf/Braf Gnas/Gnas Tg(TPO-cre)1Shk/?
Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * FVB/NCr
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Hras/Hras Nf2/Nf2 Tg(TPO-cre)1Shk/?
Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * Black Swiss * C57BL/6 * FVB/NCr
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Hras/Hras Trp53/Trp53 Tg(TPO-cre)1Shk/?
Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * Black Swiss * C57BL/6 * FVB/NCr
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Hras/Hras Pten/Pten Tg(TPO-cre)1Shk/?
Background: involves: 129S1/Sv * 129S6/SvEvTac * FVB/NCr
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Kras/Kras Thrb/Thrb Tg(TPO-cre)1Shk/?
Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6N * FVB/NCr
Zygosity: cn
Has Mutant Allele: true
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Publication
21846565 | -
 
First Author: Zuko A
Year: 2011
Journal: Adv Protein Chem Struct Biol
Title: Contactins: structural aspects in relation to developmental functions in brain disease.
Volume: 84
Pages: 143-80
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Publication
37345654 | J:338857
 
First Author: Zhang X
Year: 2023
Journal: JCI Insight
Title: Perturbation of endoplasmic reticulum proteostasis triggers tissue injury in the thyroid gland.
Volume: 8
Issue: 12
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Publication
21220306 | J:168249
First Author: Franco AT
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Thyrotrophin receptor signaling dependence of Braf-induced thyroid tumor initiation in mice.
Volume: 108
Issue: 4
Pages: 1615-20
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Publication
28584132 | J:244142
First Author: Montero-Conde C
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Transposon mutagenesis identifies chromatin modifiers cooperating with Ras in thyroid tumorigenesis and detects ATXN7 as a cancer gene.
Volume: 114
Issue: 25
Pages: E4951-E4960
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Publication
25300137 | -
 
First Author: Mohebiany AN
Year: 2014
Journal: Adv Neurobiol
Title: New insights into the roles of the contactin cell adhesion molecules in neural development.
Volume: 8
Pages: 165-94
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Publication
33318036 | J:305677
First Author: Saqcena M
Year: 2021
Journal: Cancer Discov
Title: SWI/SNF Complex Mutations Promote Thyroid Tumor Progression and Insensitivity to Redifferentiation Therapies.
Volume: 11
Issue: 5
Pages: 1158-1175
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Publication
26123589 | J:236513
 
First Author: Kirschner LS
Year: 2016
Journal: Mol Cell Endocrinol
Title: Mouse models of thyroid cancer: A 2015 update.
Volume: 421
Pages: 18-27
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Protein
P68500
Organism: Mus musculus/domesticus
Length: 1098  
Fragment?: false
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Protein
Q3TRE5
Organism: Mus musculus/domesticus
Length: 893  
Fragment?: false
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Protein
Q3UUQ8
Organism: Mus musculus/domesticus
Length: 893  
Fragment?: false
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Protein
E9PYK7
Organism: Mus musculus/domesticus
Length: 893  
Fragment?: false
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