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Search results 901 to 1000 out of 1146 for E2f1

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Type Details Score
Publication
12724423 | J:83303
First Author: Scheijen B
Year: 2003
Journal: Mol Cell Biol
Title: Constitutive E2F1 overexpression delays endochondral bone formation by inhibiting chondrocyte differentiation.
Volume: 23
Issue: 10
Pages: 3656-68
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Publication
12080472 | J:77720
First Author: Wunderlich M
Year: 2002
Journal: Oncogene
Title: Mdm2 inhibition of p53 induces E2F1 transactivation via p21.
Volume: 21
Issue: 28
Pages: 4414-21
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Publication
29235459 | J:257672
First Author: Gnanasundram SV
Year: 2017
Journal: Nat Commun
Title: PI3Kδ activates E2F1 synthesis in response to mRNA translation stress.
Volume: 8
Issue: 1
Pages: 2103
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Publication
20805247 | J:173817
First Author: Taura M
Year: 2011
Journal: Nucleic Acids Res
Title: MEF/ELF4 transactivation by E2F1 is inhibited by p53.
Volume: 39
Issue: 1
Pages: 76-88
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Publication
9546428 | J:46535
First Author: Pierce AM
Year: 1998
Journal: Oncogene
Title: Deregulated expression of E2F1 induces hyperplasia and cooperates with ras in skin tumor development.
Volume: 16
Issue: 10
Pages: 1267-76
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Publication
8336704 | J:279973
First Author: Zacksenhaus E
Year: 1993
Journal: Mol Cell Biol
Title: A bipartite nuclear localization signal in the retinoblastoma gene product and its importance for biological activity.
Volume: 13
Issue: 8
Pages: 4588-99
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Publication
16892051 | J:178276
First Author: Wang C
Year: 2006
Journal: Nat Cell Biol
Title: Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage.
Volume: 8
Issue: 9
Pages: 1025-31
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Publication
16914062 | J:114896
 
First Author: Fedele M
Year: 2006
Journal: Cell Div
Title: E2F1 activation is responsible for pituitary adenomas induced by HMGA2 gene overexpression.
Volume: 1
Pages: 17
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Publication
19837943 | J:154681
First Author: Zhou C
Year: 2009
Journal: Mol Endocrinol
Title: E2F1 induces pituitary tumor transforming gene (PTTG1) expression in human pituitary tumors.
Volume: 23
Issue: 12
Pages: 2000-12
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Publication
33947907 | J:306067
First Author: Swiatnicki MR
Year: 2021
Journal: Sci Rep
Title: Metastasis is altered through multiple processes regulated by the E2F1 transcription factor.
Volume: 11
Issue: 1
Pages: 9502
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Publication
14739777 | -
First Author: Wunderlich M
Year: 2004
Journal: Cell Cycle
Title: MdmX represses E2F1 transactivation.
Volume: 3
Issue: 4
Pages: 472-8
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Publication
21625432 | J:172724
First Author: Palomer X
Year: 2011
Journal: PLoS One
Title: The interplay between NF-kappaB and E2F1 coordinately regulates inflammation and metabolism in human cardiac cells.
Volume: 6
Issue: 5
Pages: e19724
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Publication
17483310 | J:121307
First Author: Olson MV
Year: 2007
Journal: Cancer Res
Title: Transgenic E2F1 expression in the mouse brain induces a human-like bimodal pattern of tumors.
Volume: 67
Issue: 9
Pages: 4005-9
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Publication
12077144 | J:78775
First Author: Blais A
Year: 2002
Journal: J Biol Chem
Title: Regulation of the human cyclin-dependent kinase inhibitor p18INK4c by the transcription factors E2F1 and Sp1.
Volume: 277
Issue: 35
Pages: 31679-93
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Publication
16254079 | J:159155
First Author: Zhang Y
Year: 2005
Journal: Nucleic Acids Res
Title: The ErbB3 binding protein Ebp1 interacts with Sin3A to repress E2F1 and AR-mediated transcription.
Volume: 33
Issue: 18
Pages: 6024-33
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Transgene
MGI:2677032 | Tg(KRT5-E2F1)2Dgj
Type: transgene
Organism: mouse, laboratory
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Interaction Experiment
Fedele M (2006)
Description: HMGA2 induces pituitary tumorigenesis by enhancing E2F1 activity.
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Publication
24038073 | J:320512
First Author: Wang B
Year: 2014
Journal: Hepatology
Title: Reciprocal regulation of microRNA-122 and c-Myc in hepatocellular cancer: role of E2F1 and transcription factor dimerization partner 2.
Volume: 59
Issue: 2
Pages: 555-66
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Publication
15209999 | J:110247
First Author: Matsumoto N
Year: 2004
Journal: Oral Microbiol Immunol
Title: Role of gene E2f1 in susceptibility to bacterial adherence of oral streptococci to tooth surfaces in mice.
Volume: 19
Issue: 4
Pages: 270-6
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Publication
23744542 | J:200011
First Author: Mans DA
Year: 2013
Journal: J Pathol
Title: Regulation of E2F1 by the von Hippel-Lindau tumour suppressor protein predicts survival in renal cell cancer patients.
Volume: 231
Issue: 1
Pages: 117-29
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Publication
28702328 | J:256322
First Author: Haim Y
Year: 2017
Journal: Mol Metab
Title: ASK1 (MAP3K5) is transcriptionally upregulated by E2F1 in adipose tissue in obesity, molecularly defining a human dys-metabolic obese phenotype.
Volume: 6
Issue: 7
Pages: 725-736
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Publication
27470638 | J:251187
First Author: Gurha P
Year: 2016
Journal: Circ Res
Title: Knockdown of Plakophilin 2 Downregulates miR-184 Through CpG Hypermethylation and Suppression of the E2F1 Pathway and Leads to Enhanced Adipogenesis In Vitro.
Volume: 119
Issue: 6
Pages: 731-50
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Interaction Experiment
Zhou F (2008)
Description: The association of GSK3 beta with E2F1 facilitates nerve growth factor-induced neural cell differentiation.
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Interaction Experiment
Hong W (2011)
Description: Epigenetic involvement of Alien/ESET complex in thyroid hormone-mediated repression of E2F1 gene expression and cell proliferation.
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GXD Expression
GXD Expression
 
Probe: MGI:29437
Assay Type: RNA in situ
Annotation Date: 2020-05-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3578426
Pattern: Regionally restricted
Stage: TS26
Assay Id: MGI:6415734
Age: embryonic day 18.5
Note: Expressed in the core of the villus (lamina propria) and the adjacent epithelia, same as the E2f1 expression.
Specimen Label: 4 left
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:29437
Assay Type: RNA in situ
Annotation Date: 2020-05-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3578426
Pattern: Regionally restricted
Stage: TS26
Assay Id: MGI:6415734
Age: embryonic day 18.5
Note: Expressed in the core of the villus (lamina propria) and the adjacent epithelia, same as the E2f1 expression.
Specimen Label: 4 right
Detected: true
Specimen Num: 2
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Interaction Experiment
Swarnalatha M (2013)
Description: Promoter occupancy of MLL1 histone methyltransferase seems to specify the proliferative and apoptotic functions of E2F1 in a tumour microenvironment.
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Publication
20940255 | -
First Author: Pickard A
Year: 2010
Journal: J Cell Sci
Title: Acetylation of Rb by PCAF is required for nuclear localization and keratinocyte differentiation.
Volume: 123
Issue: Pt 21
Pages: 3718-26
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Publication
21653699 | -
First Author: Cartier J
Year: 2011
Journal: J Biol Chem
Title: Cellular inhibitor of apoptosis protein-1 (cIAP1) can regulate E2F1 transcription factor-mediated control of cyclin transcription.
Volume: 286
Issue: 30
Pages: 26406-17
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HT Experiment
E-GEOD-71380 | E2f regulation of gene expression in the liver [1 mo]
Series Id: GSE71380
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Allele
Tg(Alb-E2F1)8Sst | MGI:2429562
Name: transgene insertion 8, Snorri S Thorgeirsson
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Publication
10888886 | -
First Author: Robertson KD
Year: 2000
Journal: Nat Genet
Title: DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters.
Volume: 25
Issue: 3
Pages: 338-42
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Publication
9364211 | -
First Author: Johnson DG
Year: 1997
Journal: Mol Carcinog
Title: High-affinity binding of the cell cycle-regulated transcription factors E2F1 and E2F4 to benzo[a]pyrene diol epoxide-DNA adducts.
Volume: 20
Issue: 2
Pages: 216-23
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Publication
18367454 | -
First Author: Zhou F
Year: 2008
Journal: J Biol Chem
Title: The association of GSK3 beta with E2F1 facilitates nerve growth factor-induced neural cell differentiation.
Volume: 283
Issue: 21
Pages: 14506-15
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HT Experiment
E-GEOD-71381 | E2f regulation of gene expression in the liver [12 mo]
Series Id: GSE71381
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Allele
Tg(Pim1-E2F1)5Rebr | MGI:3527138
Name: transgene insertion 5, Rene Bernards
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Genotype
Genotype
Symbol: Tg(Alb-E2F1)8Sst/?
Background: involves: C57BL/6J * CBA/J
Zygosity: ot
Has Mutant Allele: true
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Publication
11429786 | J:70633
First Author: Wang D
Year: 2001
Journal: Mol Carcinog
Title: Deregulated expression of DP1 induces epidermal proliferation and enhances skin carcinogenesis.
Volume: 31
Issue: 2
Pages: 90-100
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Allele
Tg(E2F1-luc)1Ech | MGI:5648123
Name: transgene insertion 1, Eric C Holland
Allele Type: Transgenic
Attribute String: Reporter
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Allele
Gt(ROSA)26Sor<tm1(Pim1-E2F1)Rebr> | MGI:4940857
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Rene Bernards
Allele Type: Targeted
Attribute String: Conditional ready, Humanized sequence, Inserted expressed sequence, Reporter
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Allele
Tg(KRT5-E2F1)1Dgj | MGI:2384615
Name: transgene insertion 1, David G Johnson
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Publication
17006931 | J:115787
First Author: Coulouarn C
Year: 2006
Journal: Hepatology
Title: Oncogene-specific gene expression signatures at preneoplastic stage in mice define distinct mechanisms of hepatocarcinogenesis.
Volume: 44
Issue: 4
Pages: 1003-11
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Strain
MGI:5882804 | FVB/N-Tg(E2F1-luc)1Ech/Kctt
Attribute String: coisogenic, mutant strain, transgenic
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Publication
15502845 | J:93965
First Author: Uhrbom L
Year: 2004
Journal: Nat Med
Title: Dissecting tumor maintenance requirements using bioluminescence imaging of cell proliferation in a mouse glioma model.
Volume: 10
Issue: 11
Pages: 1257-60
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Allele
E2f3<tm5(E2f1)Gle> | MGI:3806823
Name: E2F transcription factor 3; targeted mutation 5, Gustavo Leone
Allele Type: Targeted
Attribute String: Inserted expressed sequence, Null/knockout
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Genotype
Genotype
Symbol: Tg(KRT5-E2F1)2Dgj/?
Background: involves: C57BL/6 * SJL/J *SKH1
Zygosity: ot
Has Mutant Allele: true
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Publication
12934101 | J:85354
First Author: Berton TR
Year: 2003
Journal: Oncogene
Title: Tumor formation in mice with conditional inactivation of Brca1 in epithelial tissues.
Volume: 22
Issue: 35
Pages: 5415-26
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Publication
15220935 | J:91632
First Author: Calvisi DF
Year: 2004
Journal: Lab Invest
Title: Disregulation of E-cadherin in transgenic mouse models of liver cancer.
Volume: 84
Issue: 9
Pages: 1137-47
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Protein
Q3UFM7
Organism: Mus musculus/domesticus
Length: 76  
Fragment?: true
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Protein Domain
IPR015030 | RB_C
Type: Domain
Description: The RB C-terminal domain is required for high-affinity binding to E2F-DP complexes and for maximal repression of E2F-responsive promoters, thereby acting as a growth suppressor by blocking the G1-S transition of the cell cycle. This domain has a strand-loop-helix structure, which directly interacts with both E2F1 and DP1, followed by a tail segment that lacks regular secondary structure [].
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HT Experiment
GSE182721 | Lats1/2 control TGF-beta directed EMT in the dorsal cranial neuroepithelium through YAP regulation
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Genotype
Genotype
Symbol: Brca1/Brca1<+> Tg(KRT5-E2F1)2Dgj/?
Background: involves: 129S6/SvEvTac * C57BL/6 * SJL
Zygosity: cx
Has Mutant Allele: true
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Publication
15565109 | J:95489
First Author: Lee JS
Year: 2004
Journal: Nat Genet
Title: Application of comparative functional genomics to identify best-fit mouse models to study human cancer.
Volume: 36
Issue: 12
Pages: 1306-11
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Protein Domain
IPR033576 | CDCA7
Type: Family
Description: Cell division cycle-associated protein 7 (CDCA7/JPO1) is a transcription regulator whose expression is activated by c-Myc and by E2F1 []. CDCA7 can associate with Myc in a phosphorylation-dependent manner. CDCA7 phosphorylation by AKT leads to loss of its association with Myc []. This interaction affects Myc-dependent apoptosis and transformation [, , ]. CDCA7 has also been identified as a Notch target involved in hematopoietic stem cell emergence [].
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Publication
15885355 | J:101128
First Author: Calvisi DF
Year: 2005
Journal: J Hepatol
Title: Activation of the canonical Wnt/beta-catenin pathway confers growth advantages in c-Myc/E2F1 transgenic mouse model of liver cancer.
Volume: 42
Issue: 6
Pages: 842-9
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Genotype
Genotype
Symbol: Brca1/Brca1 Tg(KRT5-E2F1)2Dgj/?
Background: involves: 129S6/SvEvTac * C57BL/6 * SJL
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: E2f1/E2f1 E2f3/E2f3
Background: involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N * NIH Black Swiss
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tmem163/?
Background: involves: 129P2/OlaHsd * FVB * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gtf2ird1/Gtf2ird1<+> Tg(Alb-E2F1)8Sst/?
Background: involves: C57BL/6 * CBA
Zygosity: cx
Has Mutant Allele: true
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Publication
16580749 | -
First Author: Goto Y
Year: 2006
Journal: Biochim Biophys Acta
Title: JPO1/CDCA7, a novel transcription factor E2F1-induced protein, possesses intrinsic transcriptional regulator activity.
Volume: 1759
Issue: 1-2
Pages: 60-8
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Protein
A2AR39
Organism: Mus musculus/domesticus
Length: 192  
Fragment?: true
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Publication
23166294 | J:194226
First Author: Gill RM
Year: 2013
Journal: Mol Cell Biol
Title: The MYC-associated protein CDCA7 is phosphorylated by AKT to regulate MYC-dependent apoptosis and transformation.
Volume: 33
Issue: 3
Pages: 498-513
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Publication
11598121 | -
First Author: Prescott JE
Year: 2001
Journal: J Biol Chem
Title: A novel c-Myc-responsive gene, JPO1, participates in neoplastic transformation.
Volume: 276
Issue: 51
Pages: 48276-84
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Publication
25385755 | -
First Author: Guiu J
Year: 2014
Journal: J Exp Med
Title: Identification of Cdca7 as a novel Notch transcriptional target involved in hematopoietic stem cell emergence.
Volume: 211
Issue: 12
Pages: 2411-23
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HT Experiment
E-GEOD-79451 | Gene expression in mouse thyrotrope adenoma: transcription elongation factor stimulates proliferation
Series Id: GSE79451
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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HT Experiment
E-GEOD-13753 | Transcription profiling of mouse placentas from wild-type and Rb -/- knock-out mice and embryonic day 11.5 placentas from wild-type and Rb -/-;E2f4 -/- double knock-outs reveals E2F4 cooperates with pRB in the development of extra-embryonic, not embryonic, tissues
Series Id: GSE13753
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
14684733 | J:88864
First Author: Scheijen B
Year: 2004
Journal: J Biol Chem
Title: High incidence of thymic epithelial tumors in E2F2 transgenic mice.
Volume: 279
Issue: 11
Pages: 10476-83
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Publication
15131798 | J:90164
First Author: Calvisi DF
Year: 2004
Journal: Gastroenterology
Title: Disruption of beta-catenin pathway or genomic instability define two distinct categories of liver cancer in transgenic mice.
Volume: 126
Issue: 5
Pages: 1374-86
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Genotype
Genotype
Symbol: Brca1/Brca1 Tg(KRT5-cre)5132Jlj/? Tg(KRT5-E2F1)2Dgj/?
Background: involves: 129S6/SvEvTac * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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Publication
1835093 | -
First Author: Webster LC
Year: 1991
Journal: Proc Natl Acad Sci U S A
Title: Conversion of the E1A Cys4 zinc finger to a nonfunctional His2,Cys2 zinc finger by a single point mutation.
Volume: 88
Issue: 22
Pages: 9989-93
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Publication
1316611 | -
First Author: Chellappan S
Year: 1992
Journal: Proc Natl Acad Sci U S A
Title: Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product.
Volume: 89
Issue: 10
Pages: 4549-53
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Publication
22718244 | -
First Author: Bellacchio E
Year: 2013
Journal: J Cell Physiol
Title: Understanding the targeting of the RB family proteins by viral oncoproteins to defeat their oncogenic machinery.
Volume: 228
Issue: 2
Pages: 285-91
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Protein Domain
IPR014410 | Aden_E1A
Type: Family
Description: This group represents adenoviral early E1A proteins. The E1A protein is responsible for the transcriptional activation of the early genes with in the viral genome at the start of the infection process as well as some cellular genes [].E1A disrupts the function of host retinoblastoma protein RB1/pRb, which is a key regulator of the cell cycle []. It also induces the disassembly of the E2F1 transcription factors from RB1 by direct competition for the same binding site on RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes []. Inactivation of the ability of RB1 to arrest the cell cycle is critical for cellular transformation, uncontrolled cellular growth and proliferation induced by viral infection. The stimulation of the progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication.
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Publication
15994933 | J:99527
First Author: Huang A
Year: 2005
Journal: Cancer Res
Title: Identification of a novel c-Myc protein interactor, JPO2, with transforming activity in medulloblastoma cells.
Volume: 65
Issue: 13
Pages: 5607-19
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Protein
Q9D0M2
Organism: Mus musculus/domesticus
Length: 382  
Fragment?: false
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Publication
11230146 | J:67783
First Author: Ziebold U
Year: 2001
Journal: Genes Dev
Title: E2F3 contributes both to the inappropriate proliferation and to the apoptosis arising in Rb mutant embryos.
Volume: 15
Issue: 4
Pages: 386-91
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Publication
23796898 | J:199460
First Author: Ammirante M
Year: 2013
Journal: Genes Dev
Title: An IKKα-E2F1-BMI1 cascade activated by infiltrating B cells controls prostate regeneration and tumor recurrence.
Volume: 27
Issue: 13
Pages: 1435-40
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Publication
25117714 | J:214594
First Author: Ozawa T
Year: 2014
Journal: Cancer Cell
Title: Most human non-GCIMP glioblastoma subtypes evolve from a common proneural-like precursor glioma.
Volume: 26
Issue: 2
Pages: 288-300
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Publication
20850540 | J:170790
First Author: Iakova P
Year: 2011
Journal: Semin Cancer Biol
Title: Intracellular signaling and hepatocellular carcinoma.
Volume: 21
Issue: 1
Pages: 28-34
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Publication
22174740 | -
First Author: Rodriguez-Jato S
Year: 2011
Journal: PLoS One
Title: Drosophila melanogaster dHCF interacts with both PcG and TrxG epigenetic regulators.
Volume: 6
Issue: 12
Pages: e27479
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Publication
18414036 | J:182490
First Author: Dubrez-Daloz L
Year: 2008
Journal: Cell Cycle
Title: IAPs: more than just inhibitors of apoptosis proteins.
Volume: 7
Issue: 8
Pages: 1036-46
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Protein
F7BQL8
Organism: Mus musculus/domesticus
Length: 138  
Fragment?: true
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Publication
10629049 | -
First Author: Mahajan SS
Year: 2000
Journal: Mol Cell Biol
Title: Mutations in host cell factor 1 separate its role in cell proliferation from recruitment of VP16 and LZIP.
Volume: 20
Issue: 3
Pages: 919-28
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Publication
14532282 | J:87274
First Author: Luciano RL
Year: 2003
Journal: J Biol Chem
Title: HCF-1 functions as a coactivator for the zinc finger protein Krox20.
Volume: 278
Issue: 51
Pages: 51116-24
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Publication
10675337 | -
First Author: Vogel JL
Year: 2000
Journal: EMBO J
Title: The novel coactivator C1 (HCF) coordinates multiprotein enhancer formation and mediates transcription activation by GABP.
Volume: 19
Issue: 4
Pages: 683-90
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Publication
12244100 | -
First Author: Piluso D
Year: 2002
Journal: J Biol Chem
Title: Host cell factor-1 interacts with and antagonizes transactivation by the cell cycle regulatory factor Miz-1.
Volume: 277
Issue: 48
Pages: 46799-808
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Publication
10920196 | -
First Author: Vogel JL
Year: 2000
Journal: Proc Natl Acad Sci U S A
Title: Autocatalytic proteolysis of the transcription factor-coactivator C1 (HCF): a potential role for proteolytic regulation of coactivator function.
Volume: 97
Issue: 17
Pages: 9425-30
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Publication
16624878 | -
First Author: Vogel JL
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Site-specific proteolysis of the transcriptional coactivator HCF-1 can regulate its interaction with protein cofactors.
Volume: 103
Issue: 18
Pages: 6817-22
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Publication
31049581 | -
First Author: Gudkova D
Year: 2019
Journal: Nucleic Acids Res
Title: HCF-2 inhibits cell proliferation and activates differentiation-gene expression programs.
Volume: 47
Issue: 11
Pages: 5792-5808
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Publication
19153467 | -
First Author: Kulathila R
Year: 2009
Journal: Acta Crystallogr D Biol Crystallogr
Title: The structure of the BIR3 domain of cIAP1 in complex with the N-terminal peptides of SMAC and caspase-9.
Volume: 65
Issue: Pt 1
Pages: 58-66
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Publication
22021857 | -
First Author: Dueber EC
Year: 2011
Journal: Science
Title: Antagonists induce a conformational change in cIAP1 that promotes autoubiquitination.
Volume: 334
Issue: 6054
Pages: 376-80
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Publication
21447281 | -
First Author: Damgaard RB
Year: 2011
Journal: Discov Med
Title: Inhibitor of apoptosis (IAP) proteins in regulation of inflammation and innate immunity.
Volume: 11
Issue: 58
Pages: 221-31
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Publication
12609738 | -
First Author: Izeta A
Year: 2003
Journal: Gene
Title: Primary structure and compartmentalization of Drosophila melanogaster host cell factor.
Volume: 305
Issue: 2
Pages: 175-83
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Publication
2568582 | -
First Author: Sabina RL
Year: 1989
Journal: Mol Cell Biol
Title: Expression of three stage-specific transcripts of AMP deaminase during myogenesis.
Volume: 9
Issue: 5
Pages: 2244-6
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Protein Domain
IPR043536 | HCF1/2
Type: Family
Description: This entry includes Host cell factor 1 (HCF1) and Host cell factor 2 (HCF2) from humans. They contain an N-terminal kelch domain and a C-terminal FnIII domain. However, HCF2 is smaller than HCF-1, lacking the complete central region including the HCF1 specific repeats and as a result is not subject to proteolytic processing []. This entry also includes their Drosophila melanogaster homologue, dHCF, which is involved in both activation and repression of transcription during fly development []. Host cell factor homologue hcf-1 from C. elegans controls the cell cycle through mitotic histone phosphorylation modulation and negatively regulates responses to environmental stresses [].HCF1 is associated with the activation and repression of gene expression. It is brought to specific promoters by association with DNA-sequence-specific transcription factors such as Sp1, GABP, YY1, Ronin/THAP11, and E2F1 and E2F4 []. HCFC1 recruits and is a part of several different complexes, including the SET1 histone methyltransferase complex (transcription activation), the SIN3 histone deacetylase complex (transcription repression) [], the THAP1/THAP3-HCFC1-OGT complex (required for the regulation of the transcriptional activity of RRM1) [], and the NSL complex (acetylation of nucleosomal histone H4) [].HCF2 is involved in activation of differentiation and morphogenesis gene expression programs, and in parallel in inhibition of cellular growth and metabolism [].
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Protein Domain
IPR037854 | HCF1
Type: Family
Description: Host cell factor 1 (HCFC1) is associated with the activation and repression of gene expression. It is brought to specific promoters by association with DNA-sequence-specific transcription factors such as Sp1, GABP, YY1, Ronin/THAP11, and E2F1 and E2F4 []. HCFC1 recruits and is a part of several different complexes, including the SET1 histone methyltransferase complex (transcription activation), the SIN3 histone deacetylase complex (transcription repression) [], the THAP1/THAP3-HCFC1-OGT complex (required for the regulation of the transcriptional activity of RRM1) [], and the NSL complex (acetylation of nucleosomal histone H4) []. This entry includes mammalian HCFC1 and the Drosophila homologue, dHCF. They undergo a process of proteolytic maturation to produce a heterodimeric complex of HCF-N and HCF-C subunits, by different enzymes, O-GlcNAc transferase and taspase1, respectively [, ]. They share a Kelch domain, regions biased for basic (Basic) or acidic (Acidic) amino acids, fibronectin type 3 repeats, and a nuclear localization signal [].During human herpes simplex virus infection, HCFC1 forms a multiprotein-DNA complex enabling transcription of the virus's early genes []. It is also a co-activator of EGR2/Krox20 []and the GA-binding protein GABP2 [], and represses ZBTB17/Miz-1 [].
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Protein Domain
IPR041933 | BIRC2/BIRC3_UBA
Type: Domain
Description: The entry represents the UBA domain found in c-IAPs, including BIRC2 (also known as C-IAP1) and BIRC3 (also known as C-IAP2). c-IAPs function as ubiquitin E3 ligases that mediate the ubiquitination of the substrates involved in apoptosis, nuclear factor-kappaB (NF-kappaB) signaling, and oncogenesis [, ]. Unlike other apoptosis proteins such as XIAP, c-IAPs exhibit minimal binding to caspases and may not play an important role in the inhibition of these proteases. c-IAP1 is a potent regulator of the tumor necrosis factor (TNF) receptor family and NF-kappaB signaling pathways in the cytoplasm. It can also regulate E2F1 transcription factor-mediated control of cyclin transcription in the nucleus []. c-IAP2 also influences ubiquitin-dependent pathways that modulate innate immune signalling by activation of NF-kappaB []. c-IAPs contain three N-terminal baculoviral IAP repeat (BIR) domains that enable interactions with proteins, a ubiquitin-association (UBA) domain that is responsible for the binding of polyubiquitin (polyUb), a caspase activation and recruitment domain (CARD) that serves as a protein interaction surface, and a RING domain at the carboxyl terminus that is required for ubiquitin ligase activity [, ].
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Protein Domain
IPR040221 | CDCA7/CDA7L
Type: Family
Description: This entry includes CDCA7 and CDA7L.Cell division cycle-associated protein 7 (CDCA7/JPO1) is a transcription regulator whose expression is activated by c-Myc and by E2F1 []. CDCA7 can associate with Myc in a phosphorylation-dependent manner. CDCA7 phosphorylation by AKT leads to loss of its association with Myc []. This interaction affects Myc-dependent apoptosis and transformation [, , ]. CDCA7 has also been identified as a Notch target involved in hematopoietic stem cell emergence [].Cell division cycle-associated 7-like protein (CDCA7L/JPO2/R1) is closely related to CDCA7/JPO1; and like CDCA7, it plays a role in transcriptional regulation and interacts with c-Myc []. JPO2 overexpression induces metastasis in medulloblastoma []. JPO2 can interact directly and dynamically with chromatin, the dynamics of JPO2 chromatin binding being decelerated upon interaction with LEDGF/p75, which binds and tethers JPO2 to chromatin [, ].JPO2 inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter []. JPO2 and MAOA act upstream of cyclin D1 and E2F1, and are involved in apoptotic signalling pathways [].
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Publication
18194653 | J:131292
First Author: Li J
Year: 2008
Journal: Dev Cell
Title: Synergistic function of E2F7 and E2F8 is essential for cell survival and embryonic development.
Volume: 14
Issue: 1
Pages: 62-75
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Publication
11350120 | J:69581
First Author: Wang A
Year: 2001
Journal: Genomics
Title: Molecular cloning and characterization of a novel mouse epidermal differentiation gene and its promoter.
Volume: 73
Issue: 3
Pages: 284-90
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