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Search results 801 to 900 out of 929 for Igf1r

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Categories

Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Protein Coding Gene
MGI:95522 | Fgfr1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:108088 | Gab1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
O35565
Organism: Mus musculus/domesticus
Length: 209  
Fragment?: false
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Protein
P81122
Organism: Mus musculus/domesticus
Length: 1321  
Fragment?: false
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Protein
P16092
Organism: Mus musculus/domesticus
Length: 822  
Fragment?: false
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Protein
Q9ESS2
Organism: Mus musculus/domesticus
Length: 162  
Fragment?: false
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Protein
Q9QYY0
Organism: Mus musculus/domesticus
Length: 695  
Fragment?: false
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Protein
P05524
Organism: Mus musculus/domesticus
Length: 245  
Fragment?: false
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Publication
26654940 | J:302263
First Author: Franks SE
Year: 2016
Journal: Oncotarget
Title: Unique roles of Akt1 and Akt2 in IGF-IR mediated lung tumorigenesis.
Volume: 7
Issue: 3
Pages: 3297-316
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Publication
25655427 | J:314979
 
First Author: Watson KL
Year: 2015
Journal: BMC Cancer
Title: High levels of dietary soy decrease mammary tumor latency and increase incidence in MTB-IGFIR transgenic mice.
Volume: 15
Pages: 37
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Publication
22020329 | J:186127
First Author: Franks SE
Year: 2012
Journal: Oncogene
Title: Transgenic IGF-IR overexpression induces mammary tumors with basal-like characteristics, whereas IGF-IR-independent mammary tumors express a claudin-low gene signature.
Volume: 31
Issue: 27
Pages: 3298-309
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Publication
27282619 | J:317013
 
First Author: Saleh S
Year: 2016
Journal: BMC Cancer
Title: Osteopontin regulates proliferation, apoptosis, and migration of murine claudin-low mammary tumor cells.
Volume: 16
Pages: 359
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Publication
29217479 | J:260695
First Author: Tham YK
Year: 2018
Journal: Biochim Biophys Acta
Title: Distinct lipidomic profiles in models of physiological and pathological cardiac remodeling, and potential therapeutic strategies.
Volume: 1863
Issue: 3
Pages: 219-234
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Genotype
Genotype
Symbol: Tg(MMTV-rtTA)1Lach/? Tg(tetO-IGF1R)1Ramo/?
Background: involves: FVB
Zygosity: cx
Has Mutant Allele: true
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Publication
28380379 | J:253648
First Author: Aguayo-Mazzucato C
Year: 2017
Journal: Cell Metab
Title: β Cell Aging Markers Have Heterogeneous Distribution and Are Induced by Insulin Resistance.
Volume: 25
Issue: 4
Pages: 898-910.e5
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Publication
33373620 | J:307744
First Author: Nishimura T
Year: 2021
Journal: Cell Stem Cell
Title: Generation of Functional Organs Using a Cell-Competitive Niche in Intra- and Inter-species Rodent Chimeras.
Volume: 28
Issue: 1
Pages: 141-149.e3
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Publication
16524678 | J:111921
First Author: Masternak MM
Year: 2006
Journal: Exp Gerontol
Title: Caloric restriction and growth hormone receptor knockout: effects on expression of genes involved in insulin action in the heart.
Volume: 41
Issue: 4
Pages: 417-29
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Publication
25584893 | J:218894
First Author: Damsky W
Year: 2015
Journal: Cancer Cell
Title: mTORC1 activation blocks BrafV600E-induced growth arrest but is insufficient for melanoma formation.
Volume: 27
Issue: 1
Pages: 41-56
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Publication
25544636 | J:218824
First Author: Schwartz S
Year: 2015
Journal: Cancer Cell
Title: Feedback suppression of PI3Kα signaling in PTEN-mutated tumors is relieved by selective inhibition of PI3Kβ.
Volume: 27
Issue: 1
Pages: 109-22
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Publication
24506864 | J:210538
First Author: Go GW
Year: 2014
Journal: Cell Metab
Title: The combined hyperlipidemia caused by impaired Wnt-LRP6 signaling is reversed by Wnt3a rescue.
Volume: 19
Issue: 2
Pages: 209-20
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Publication
20692232 | J:164896
First Author: Ohshima-Hosoyama S
Year: 2010
Journal: Biochem Biophys Res Commun
Title: IGF-1 receptor inhibition by picropodophyllin in medulloblastoma.
Volume: 399
Issue: 4
Pages: 727-32
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Publication
23325891 | J:193404
First Author: Lu TX
Year: 2013
Journal: J Immunol
Title: MiR-223 deficiency increases eosinophil progenitor proliferation.
Volume: 190
Issue: 4
Pages: 1576-82
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Publication
31267557 | J:285987
First Author: Yang F
Year: 2019
Journal: EMBO J
Title: GSTZ1-1 Deficiency Activates NRF2/IGF1R Axis in HCC via Accumulation of Oncometabolite Succinylacetone.
Volume: 38
Issue: 15
Pages: e101964
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Publication
28345670 | J:244592
 
First Author: Cai W
Year: 2017
Journal: Nat Commun
Title: Domain-dependent effects of insulin and IGF-1 receptors on signalling and gene expression.
Volume: 8
Pages: 14892
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Publication
35647546 | J:327222
First Author: Turvey SJ
Year: 2022
Journal: RSC Med Chem
Title: Recent developments in the structural characterisation of the IR and IGF1R: implications for the design of IR-IGF1R hybrid receptor modulators.
Volume: 13
Issue: 4
Pages: 360-374
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Publication
22373578 | J:182694
First Author: Okamoto K
Year: 2012
Journal: EMBO J
Title: miR-493 induction during carcinogenesis blocks metastatic settlement of colon cancer cells in liver.
Volume: 31
Issue: 7
Pages: 1752-63
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Publication
24636986 | J:209596
First Author: Llobet-Navas D
Year: 2014
Journal: Genes Dev
Title: The miR-424(322)/503 cluster orchestrates remodeling of the epithelium in the involuting mammary gland.
Volume: 28
Issue: 7
Pages: 765-82
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Publication
31991123 | J:293831
 
First Author: Hu S
Year: 2020
Journal: Brain Res
Title: Knock down of lncRNA H19 promotes axon sprouting and functional recovery after cerebral ischemic stroke.
Volume: 1732
Pages: 146681
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Publication
26025657 | J:311070
First Author: Simon CM
Year: 2015
Journal: Acta Neuropathol
Title: Dysregulated IGFBP5 expression causes axon degeneration and motoneuron loss in diabetic neuropathy.
Volume: 130
Issue: 3
Pages: 373-87
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Publication
35784559 | J:326453
 
First Author: Bulatowicz JJ
Year: 2022
Journal: Front Endocrinol (Lausanne)
Title: Activation Versus Inhibition of IGF1R: A Dual Role in Breast Tumorigenesis.
Volume: 13
Pages: 911079
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Publication
36824269 | J:333759
First Author: Yu Y
Year: 2023
Journal: iScience
Title: PTEN phosphatase inhibits metastasis by negatively regulating the Entpd5/IGF1R pathway through ATF6.
Volume: 26
Issue: 2
Pages: 106070
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Protein Coding Gene
MGI:1100860 | Frs2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1277980 | Fgf18
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:104723 | Fgf9
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1202401 | Fgf17
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1338068 | Pdpk1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:95515 | Fgf1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:99604 | Fgf8
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:95516 | Fgf2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:95519 | Fgf5
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:95520 | Fgf6
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1891427 | Fgf23
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:95518 | Fgf4
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1891346 | Fgf20
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1922019 | Pik3cb
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1931627 | Fgf16
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q9Z2A0
Organism: Mus musculus/domesticus
Length: 559  
Fragment?: false
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Protein
Q9EPC2
Organism: Mus musculus/domesticus
Length: 251  
Fragment?: false
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Protein
O89101
Organism: Mus musculus/domesticus
Length: 207  
Fragment?: false
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Protein
P15656
Organism: Mus musculus/domesticus
Length: 264  
Fragment?: false
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Protein
P11403
Organism: Mus musculus/domesticus
Length: 202  
Fragment?: false
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Protein
P15655
Organism: Mus musculus/domesticus
Length: 154  
Fragment?: false
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Protein
P37237
Organism: Mus musculus/domesticus
Length: 268  
Fragment?: false
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Protein
Q9ESL9
Organism: Mus musculus/domesticus
Length: 211  
Fragment?: false
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Protein
P54130
Organism: Mus musculus/domesticus
Length: 208  
Fragment?: false
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Protein
P63075
Organism: Mus musculus/domesticus
Length: 216  
Fragment?: false
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Protein
Q8C180
Organism: Mus musculus/domesticus
Length: 508  
Fragment?: false
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Protein
Q9ESL8
Organism: Mus musculus/domesticus
Length: 207  
Fragment?: false
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Protein
P61148
Organism: Mus musculus/domesticus
Length: 155  
Fragment?: false
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Protein
P21658
Organism: Mus musculus/domesticus
Length: 208  
Fragment?: false
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Protein
P98083-3
Organism: Mus musculus/domesticus
Length: 424  
Fragment?: false
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Protein
Q8BTI9
Organism: Mus musculus/domesticus
Length: 1064  
Fragment?: false
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Publication
12138094 | -
First Author: Pandini G
Year: 2002
Journal: J Biol Chem
Title: Insulin/insulin-like growth factor I hybrid receptors have different biological characteristics depending on the insulin receptor isoform involved.
Volume: 277
Issue: 42
Pages: 39684-95
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Publication
16831875 | -
First Author: Slaaby R
Year: 2006
Journal: J Biol Chem
Title: Hybrid receptors formed by insulin receptor (IR) and insulin-like growth factor I receptor (IGF-IR) have low insulin and high IGF-1 affinity irrespective of the IR splice variant.
Volume: 281
Issue: 36
Pages: 25869-74
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Publication
8276809 | -
First Author: Van Horn DJ
Year: 1994
Journal: J Biol Chem
Title: Direct activation of the phosphatidylinositol 3'-kinase by the insulin receptor.
Volume: 269
Issue: 1
Pages: 29-32
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Protein Domain
IPR016246 | Tyr_kinase_insulin-like_rcpt
Type: Family
Description: Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. Phosphoprotein phosphatases catalyse the reverse process. Protein kinases fall into three broad classes, characterised with respect to substrate specificity []:Serine/threonine-protein kinasesTyrosine-protein kinasesDual specificity protein kinases (e.g. MEK - phosphorylates both Thr and Tyr on target proteins)Protein kinase function is evolutionarily conserved from Escherichia coli to human []. Protein kinases play a role in a multitude of cellular processes, including division, proliferation, apoptosis, and differentiation []. Phosphorylation usually results in a functional change of the target protein by changing enzyme activity, cellular location, or association with other proteins. The catalytic subunits of protein kinases are highly conserved, and several structures have been solved [], leading to large screens to develop kinase-specific inhibitors for the treatments of a number of diseases [].Tyrosine-protein kinases can transfer a phosphate group from ATP to a tyrosine residue in a protein. These enzymes can be divided into two main groups []:Receptor tyrosine kinases (RTK), which are transmembrane proteins involved in signal transduction; they play key roles in growth, differentiation, metabolism, adhesion, motility, death and oncogenesis []. RTKs are composed of 3 domains: an extracellular domain (binds ligand), a transmembrane (TM) domain, and an intracellular catalytic domain (phosphorylates substrate). The TM domain plays an important role in the dimerisation process necessary for signal transduction []. Cytoplasmic / non-receptor tyrosine kinases, which act as regulatory proteins, playing key roles in cell differentiation, motility, proliferation, and survival. For example, the Src-family of protein-tyrosine kinases [].This entry represents the insulin receptor, as well as related insulin-like receptors. The insulin receptor binds insulin and has a tyrosine-protein kinase activity, and mediates the metabolic functions of insulin. Binding to insulin stimulates the association of the receptor with downstream mediators, including IRS1 and phosphatidylinositol 3'-kinase (PI3K). The insulin receptor can activate PI3K either directly by binding to the p85 regulatory subunit, or indirectly via IRS1. When the insulin receptor is present in a hybrid receptor with IGF1R (insulin growth factor receptor), it binds IGF1 (insulin growth factor 1) [, , ].
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Publication
10232609 | J:54539
First Author: Kaplan PJ
Year: 1999
Journal: Cancer Res
Title: The insulin-like growth factor axis and prostate cancer: lessons from the transgenic adenocarcinoma of mouse prostate (TRAMP) model.
Volume: 59
Issue: 9
Pages: 2203-9
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Publication
16027059 | J:102544
First Author: Hishiya A
Year: 2005
Journal: Bone
Title: Ataxia telangiectasia mutated (Atm) knockout mice as a model of osteopenia due to impaired bone formation.
Volume: 37
Issue: 4
Pages: 497-503
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Publication
30419192 | J:269792
First Author: Scully T
Year: 2019
Journal: Exp Cell Res
Title: Contrasting effects of IGF binding protein-3 expression in mammary tumor cells and the tumor microenvironment.
Volume: 374
Issue: 1
Pages: 38-45
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Publication
19500727 | J:151425
First Author: Keisala T
Year: 2009
Journal: J Steroid Biochem Mol Biol
Title: Premature aging in vitamin D receptor mutant mice.
Volume: 115
Issue: 3-5
Pages: 91-7
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Publication
15194422 | J:92474
First Author: Armand AS
Year: 2004
Journal: Exp Cell Res
Title: IGF-II is up-regulated and myofibres are hypertrophied in regenerating soleus of mice lacking FGF6.
Volume: 297
Issue: 1
Pages: 27-38
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Publication
27927611 | J:239958
First Author: Kawano F
Year: 2017
Journal: Am J Physiol Cell Physiol
Title: Prenatal myonuclei play a crucial role in skeletal muscle hypertrophy in rodents.
Volume: 312
Issue: 3
Pages: C233-C243
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Publication
25658474 | J:229048
First Author: Sargent KM
Year: 2015
Journal: PLoS One
Title: Loss of vascular endothelial growth factor A (VEGFA) isoforms in granulosa cells using pDmrt-1-Cre or Amhr2-Cre reduces fertility by arresting follicular development and by reducing litter size in female mice.
Volume: 10
Issue: 2
Pages: e0116332
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Publication
27803039 | J:260786
First Author: Zangi L
Year: 2017
Journal: Circulation
Title: Insulin-Like Growth Factor 1 Receptor-Dependent Pathway Drives Epicardial Adipose Tissue Formation After Myocardial Injury.
Volume: 135
Issue: 1
Pages: 59-72
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Publication
33577435 | J:305039
First Author: Weeks KL
Year: 2021
Journal: Am J Physiol Heart Circ Physiol
Title: FoxO1 is required for physiological cardiac hypertrophy induced by exercise but not by constitutively active PI3K.
Volume: 320
Issue: 4
Pages: H1470-H1485
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Publication
30981207 | J:290289
First Author: Anisimov VN
Year: 2019
Journal: Aging (Albany NY)
Title: In mice transgenic for IGF1 under keratin-14 promoter, lifespan is decreased and the rates of aging and thymus involution are accelerated.
Volume: 11
Issue: 7
Pages: 2098-2110
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Publication
34527673 | J:310890
 
First Author: Cao C
Year: 2021
Journal: Front Cell Dev Biol
Title: Lack of miR-379/miR-544 Cluster Resists High-Fat Diet-Induced Obesity and Prevents Hepatic Triglyceride Accumulation in Mice.
Volume: 9
Pages: 720900
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Publication
29099871 | J:252628
First Author: Pope C
Year: 2017
Journal: PLoS One
Title: The role of H19, a long non-coding RNA, in mouse liver postnatal maturation.
Volume: 12
Issue: 11
Pages: e0187557
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Publication
26324892 | J:226920
First Author: Lovat F
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: miR-15b/16-2 deletion promotes B-cell malignancies.
Volume: 112
Issue: 37
Pages: 11636-41
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Publication
23454899 | J:200122
First Author: Molina-Arcas M
Year: 2013
Journal: Cancer Discov
Title: Coordinate direct input of both KRAS and IGF1 receptor to activation of PI3 kinase in KRAS-mutant lung cancer.
Volume: 3
Issue: 5
Pages: 548-63
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Publication
11777937 | J:73555
First Author: Jiang Z
Year: 2002
Journal: J Cell Biol
Title: Activation of retinoblastoma protein in mammary gland leads to ductal growth suppression, precocious differentiation, and adenocarcinoma.
Volume: 156
Issue: 1
Pages: 185-98
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Publication
9166590 | J:41150
First Author: Jones CT
Year: 1997
Journal: Mamm Genome
Title: Gene homologs on human chromosome 15q21-q26 and a chicken microchromosome identify a new conserved segment.
Volume: 8
Issue: 6
Pages: 436-40
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Publication
20971705 | J:182914
First Author: Beauvais DM
Year: 2010
Journal: J Cell Sci
Title: Syndecan-1 couples the insulin-like growth factor-1 receptor to inside-out integrin activation.
Volume: 123
Issue: Pt 21
Pages: 3796-807
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Publication
24801305 | J:222758
First Author: Cuffe JS
Year: 2014
Journal: J Physiol
Title: Mid- to late term hypoxia in the mouse alters placental morphology, glucocorticoid regulatory pathways and nutrient transporters in a sex-specific manner.
Volume: 592
Issue: 14
Pages: 3127-41
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Publication
25609710 | J:223842
First Author: Kang YJ
Year: 2015
Journal: J Cell Sci
Title: MiR-145 suppresses embryo-epithelial juxtacrine communication at implantation by modulating maternal IGF1R.
Volume: 128
Issue: 4
Pages: 804-14
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Publication
26200114 | J:238617
First Author: Gan J
Year: 2015
Journal: PLoS One
Title: Integrative Analysis of the Developing Postnatal Mouse Heart Transcriptome.
Volume: 10
Issue: 7
Pages: e0133288
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Publication
28945762 | J:249834
First Author: Solomon-Zemler R
Year: 2017
Journal: PLoS One
Title: Nuclear insulin-like growth factor-1 receptor (IGF1R) displays proliferative and regulatory activities in non-malignant cells.
Volume: 12
Issue: 9
Pages: e0185164
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Publication
30509997 | J:268948
First Author: Andersson KME
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Inflammation in the hippocampus affects IGF1 receptor signaling and contributes to neurological sequelae in rheumatoid arthritis.
Volume: 115
Issue: 51
Pages: E12063-E12072
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Publication
34220714 | J:309898
 
First Author: Achlaug L
Year: 2021
Journal: Front Endocrinol (Lausanne)
Title: ZYG11A Is Expressed in Epithelial Ovarian Cancer and Correlates With Low Grade Disease.
Volume: 12
Pages: 688104
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Publication
33749878 | J:339818
First Author: Sekulovski N
Year: 2021
Journal: FASEB J
Title: Insulin signaling is an essential regulator of endometrial proliferation and implantation in mice.
Volume: 35
Issue: 4
Pages: e21440
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Publication
27765041 | J:316548
First Author: Farabaugh SM
Year: 2016
Journal: Cell Commun Signal
Title: Lack of interaction between ErbB2 and insulin receptor substrate signaling in breast cancer.
Volume: 14
Issue: 1
Pages: 25
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Publication
22625652 | J:318935
 
First Author: Hu Q
Year: 2012
Journal: ASN Neuro
Title: Signalling through the type 1 insulin-like growth factor receptor (IGF1R) interacts with canonical Wnt signalling to promote neural proliferation in developing brain.
Volume: 4
Issue: 5
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Publication
23919516 | J:317850
 
First Author: Watson KL
Year: 2013
Journal: BMC Cancer
Title: Loss of Akt1 or Akt2 delays mammary tumor onset and suppresses tumor growth rate in MTB-IGFIR transgenic mice.
Volume: 13
Pages: 375
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Protein Coding Gene
MGI:1206581 | Pik3ca
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:99511 | Ptpn11
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:104874 | Akt2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1098772 | Pik3r2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q60823
Organism: Mus musculus/domesticus
Length: 481  
Fragment?: false
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Protein
O08908
Organism: Mus musculus/domesticus
Length: 722  
Fragment?: false
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Protein
P42337
Organism: Mus musculus/domesticus
Length: 1068  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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