Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
This entry describes M-phase phosphoprotein 6 (MPP6), which is involved in generation of the 3' end of the 5.8S rRNA precursor []. MPP6 is required for the integrity maintenance of the rRNA processing complex as it mediates the interaction between MTR4 (RNA helicase) and RRP6 (an 3'-5' exonuclease), and the recruitment of Nuclear VCP-like 2 (NVL2) to the nuclear exosome []. |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
553
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
311
|
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Schilders G |
Year: |
2005 |
Journal: |
Nucleic Acids Res |
Title: |
MPP6 is an exosome-associated RNA-binding protein involved in 5.8S rRNA maturation. |
Volume: |
33 |
Issue: |
21 |
Pages: |
6795-804 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
307
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
161
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Yoshikatsu Y |
Year: |
2015 |
Journal: |
Biochem Biophys Res Commun |
Title: |
NVL2, a nucleolar AAA-ATPase, is associated with the nuclear exosome and is involved in pre-rRNA processing. |
Volume: |
464 |
Issue: |
3 |
Pages: |
780-6 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
539
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
315
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
315
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
48
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
175
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
553
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
539
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Tseng TC |
Year: |
2001 |
Journal: |
Biochim Biophys Acta |
Title: |
VAM-1: a new member of the MAGUK family binds to human Veli-1 through a conserved domain. |
Volume: |
1518 |
Issue: |
3 |
Pages: |
249-59 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
This entry represents the SH3 domain of MPP6 (also known as VAM-1), which is a scaffolding protein that binds to Veli-1, a homologue of Caenorhabditis Lin-7 []. MPP6 belongs to the membrane-associated guanylate kinase (MAGUK) p55 subfamily.The membrane-associated guanylate kinase (MAGUK) p55 subfamily (also known as MPP subfamily) members include the Drosophila Stardust protein and its vertebrate homologues, MPP1-7. They contain the core of three domains characteristic of MAGUK (membrane-associated guanylate kinase) proteins: PDZ, SH3, and guanylate kinase (GuK). In addition, they also contain the Hook (Protein 4.1 Binding) motif in between the SH3 and GuK domains []. MPP2-7 have two additional L27 domains at their N terminus. The GuK domain in MAGUK proteins is enzymatically inactive; instead, the domain mediates protein-protein interactions and associates intramolecularly with the SH3 domain []. |
|
•
•
•
•
•
|
Publication |
First Author: |
Nair L |
Year: |
2021 |
Journal: |
Mol Cell |
Title: |
Mechanism of noncoding RNA-associated N6-methyladenosine recognition by an RNA processing complex during IgH DNA recombination. |
Volume: |
81 |
Issue: |
19 |
Pages: |
3949-3964.e7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Saitoh Y |
Year: |
2019 |
Journal: |
Histochem Cell Biol |
Title: |
The membrane palmitoylated protein, MPP6, is involved in myelin formation in the mouse peripheral nervous system. |
Volume: |
151 |
Issue: |
5 |
Pages: |
385-394 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kamijo A |
Year: |
2016 |
Journal: |
Histochem Cell Biol |
Title: |
Immunohistochemical study of the membrane skeletal protein, membrane protein palmitoylated 6 (MPP6), in the mouse small intestine. |
Volume: |
145 |
Issue: |
1 |
Pages: |
81-92 |
|
•
•
•
•
•
|
Publication |
First Author: |
Terada N |
Year: |
2012 |
Journal: |
Mol Cell Biol |
Title: |
Essential function of protein 4.1G in targeting of membrane protein palmitoylated 6 into Schmidt-Lanterman incisures in myelinated nerves. |
Volume: |
32 |
Issue: |
1 |
Pages: |
199-205 |
|
•
•
•
•
•
|
Publication |
First Author: |
Stöhr H |
Year: |
2001 |
Journal: |
Genomics |
Title: |
Cloning and characterization of the human retina-specific gene MPP4, a novel member of the p55 subfamily of MAGUK proteins. |
Volume: |
74 |
Issue: |
3 |
Pages: |
377-84 |
|
•
•
•
•
•
|
Publication |
First Author: |
te Velthuis AJ |
Year: |
2007 |
Journal: |
BMC Evol Biol |
Title: |
Molecular evolution of the MAGUK family in metazoan genomes. |
Volume: |
7 |
|
Pages: |
129 |
|
•
•
•
•
•
|
Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kawai J |
Year: |
2001 |
Journal: |
Nature |
Title: |
Functional annotation of a full-length mouse cDNA collection. |
Volume: |
409 |
Issue: |
6821 |
Pages: |
685-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
Carninci P |
Year: |
2000 |
Journal: |
Genome Res |
Title: |
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. |
Volume: |
10 |
Issue: |
10 |
Pages: |
1617-30 |
|
•
•
•
•
•
|
Publication |
First Author: |
Carninci P |
Year: |
1999 |
Journal: |
Methods Enzymol |
Title: |
High-efficiency full-length cDNA cloning. |
Volume: |
303 |
|
Pages: |
19-44 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shibata K |
Year: |
2000 |
Journal: |
Genome Res |
Title: |
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. |
Volume: |
10 |
Issue: |
11 |
Pages: |
1757-71 |
|
•
•
•
•
•
|
Publication |
First Author: |
Katayama S |
Year: |
2005 |
Journal: |
Science |
Title: |
Antisense transcription in the mammalian transcriptome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
1564-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gerhard DS |
Year: |
2004 |
Journal: |
Genome Res |
Title: |
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
Volume: |
14 |
Issue: |
10B |
Pages: |
2121-7 |
|
•
•
•
•
•
|