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Search results 901 to 1000 out of 1200 for Mdm2

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Type Details Score
Protein Domain
IPR029418 | MTBP_C
Type: Domain
Description: This entry represents the C-terminal domain of the MDM2-binding protein (MTBP). MDM2 is an E3 ubiquitin-protein ligase that mediates ubiquitination of p53, leading to its degradation by the proteasome []. MTBP inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability, and this promotes MDM2-mediated ubiquitination of p53 and its subsequent degradation []. Mouse MTBP also inhibits cancer cell migration by interacting with alpha-actinin-4 (ACTN4) [].
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Protein Domain
IPR039061 | MTBP
Type: Family
Description: This entry represents the MDM2-binding protein (MTBP). MDM2 is an E3 ubiquitin-protein ligase that mediates ubiquitination of p53, leading to its degradation by the proteasome []. MTBP inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability, and this promotes MDM2-mediated ubiquitination of p53 and its subsequent degradation []. Mouse MTBP also inhibits cancer cell migration by interacting with alpha-actinin-4 (ACTN4) [].
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Publication
14586409 | J:86658
First Author: Moore L
Year: 2003
Journal: Oncogene
Title: Cooperativity of p19ARF, Mdm2, and p53 in murine tumorigenesis.
Volume: 22
Issue: 49
Pages: 7831-7
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Publication
16965791 | -
First Author: Kostic M
Year: 2006
Journal: J Mol Biol
Title: Solution structure of the Hdm2 C2H2C4 RING, a domain critical for ubiquitination of p53.
Volume: 363
Issue: 2
Pages: 433-50
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Protein Domain
IPR044080 | MDM2_mRING-HC-C2H2C4
Type: Domain
Description: MDM2 is an E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome []. p53 acts as an important defense mechanism against cancer, and is negatively regulated by interaction with the oncoprotein MDM2 []. MDM2 overexpression correlates with metastasis and advanced forms of several cancers and may be used as a cancer drug target []. In addition, MDM2 has important roles in the cell independent of p53. It interacts with several proteins such as Rb/E2F-1 complex [], the DNA methyltransferase DNMT3A [], p107 [], MTBP []and the cyclin kinase inhibitor p21 []. MDM2 also affects cell apoptosis [, ].MDM2 contains an N-terminal p53-binding domain, and a C-terminal modified C2H2C4-type RING-HC finger conferring E3 ligase activity that is required for ubiquitination and nuclear export of p53. It is also responsible for the hetero-oligomerization of MDM2, which is crucial for the suppression of P53 activity during embryonic development, and the recruitment of E2 ubiquitin-conjugating enzymes []. MDM2 also harbours a RanBP2-type zinc finger (Znf-RanBP2) domain, as well as a nuclear localisation signal (NLS) and a nuclear export signal (NES), near the central acidic region. The Znf-RanBP2 domain plays an important role in mediating MDM2 binding to ribosomal proteins and thus is involved in MDM2-mediated p53 suppression.This entry represents the C-terminal modified C2H2C4-type RING-HC finger.
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Allele
Tg(BLG-Mdm2)1Caf | MGI:2386369
Name: transgene insertion 1, Cathy A Finlay
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Mdm2<1m1.1Dwg> | MGI:7485930
Name: transformed mouse 3T3 cell double minute 2; targeted mutation 1.1, David W Goodrich
Allele Type: Targeted
Attribute String: Humanized sequence
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Allele
Trp53<tm2Att> | MGI:3775090
 
Name: transformation related protein 53; targeted mutation 2, Laura D Attardi
Allele Type: Targeted
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Genotype
Genotype
Symbol: Trp53/Trp53
Background: either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * C57BL/6)
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Mdm2)1Snj/? Trp53/Trp53
Background: involves: 129S7/SvEvBrd * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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HT Experiment
GSE201067 | RNA-seq of non-tumorous liver tissues in LiK and LiKM mice after normal diet or ACR diet
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Protein Domain
IPR016495 | p53_neg-reg_MDM_2/4
Type: Family
Description: This group represents a p53 negative regulator Mdm2/Mdm4.MDM2 is an oncoprotein that acts as a cellular inhibitor of the p53 tumour suppressor by binding to the transactivation domain of p53 and suppressing its ability to activate transcription []. In addition, MDM2 acts as an E3 ubiquitin ligase responsible for the ubiquitination and subsequent degradation of p53 []. P53 acts in response to DNA damage, inducing cell cycle arrest and apoptosis. Inactivation of p53 is a common occurrence in neoplastic transformations. MDM2 is also known to have p53-independent functions.The core of MDM2 folds into an open bundle of four helices which is capped by two small 3-stranded β-sheets. It consists of a duplication of two structural repeats. MDM2 has a deep hydrophobic cleft on which the p53 α-helix binds; p53 residues involved in transactivation are buried deep within the cleft of MDM2, thereby concealing the p53 transactivation domain. In addition to its N-terminal p53 binding domain, MDM2 contains a central acidic domain, zinc finger domain and a C-terminal RING-finger domain.MDM4, also known as MDMX, is a MDM2-related protein that has also been shown to inhibit p53, although not as well as MDM2. Most studies have not been able to ascribe E3 ligase function to MDM4.
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Genotype
Genotype
Symbol: Tg(CMV-cre)1Cgn/? Trp53/Trp53<+>
Background: involves: 129S4/SvJae * BALB/cJ
Zygosity: cn
Has Mutant Allele: true
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Protein
Q64364
Organism: Mus musculus/domesticus
Length: 169  
Fragment?: false
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Publication
12660818 | -
First Author: Eymin B
Year: 2003
Journal: Oncogene
Title: p14ARF induces G2 arrest and apoptosis independently of p53 leading to regression of tumours established in nude mice.
Volume: 22
Issue: 12
Pages: 1822-35
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Publication
16600663 | -
First Author: Gallagher SJ
Year: 2006
Journal: Int J Biochem Cell Biol
Title: The ARF tumour suppressor.
Volume: 38
Issue: 10
Pages: 1637-41
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Publication
20082327 | -
First Author: Zhang HJ
Year: 2010
Journal: J Cell Biochem
Title: p14ARF interacts with E2F factors to form p14ARF-E2F/partner-DNA complexes repressing E2F-dependent transcription.
Volume: 109
Issue: 4
Pages: 693-701
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Publication
25723571 | -
First Author: Vivo M
Year: 2015
Journal: PLoS One
Title: MDM2-mediated degradation of p14ARF: a novel mechanism to control ARF levels in cancer cells.
Volume: 10
Issue: 2
Pages: e0117252
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Publication
24019527 | -
First Author: Liu S
Year: 2013
Journal: J Biol Chem
Title: NEDD8 ultimate buster-1 long (NUB1L) protein promotes transfer of NEDD8 to proteasome for degradation through the P97UFD1/NPL4 complex.
Volume: 288
Issue: 43
Pages: 31339-49
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Publication
28099510 | -
First Author: Bonacci T
Year: 2017
Journal: PLoS One
Title: Regulation of NUB1 Activity through Non-Proteolytic Mdm2-Mediated Ubiquitination.
Volume: 12
Issue: 1
Pages: e0169988
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Protein Domain
IPR010868 | Tumor_suppres_ARF
Type: Family
Description: ARF (also known as p14ARF in the human and p19ARF in the mouse) is an alternative transcript of the INK4a/ARF tumour-suppressor locus that encodes p16INK4a, an inhibitor of cyclin dependent kinases. ARFs are tumour suppressors participating in p53-dependent or independent pathways that restrain abnormal cell growth and maintain genomic stability [, , ]. ARF interacts with MDM2 and neutralizes MDM2's inhibition of p53 []. Mdm2 may also regulate ARF turnover by mediating its degradation through the proteasome []. p14ARF has also been shown to interact with E2F factors to form p14ARF-E2F/partner-DNA complexes repressing E2F-dependent transcription [].
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Protein Domain
IPR041207 | NUB1_ubiquitin-like_dom
Type: Domain
Description: This entry includes N-terminal ubiquitin-like domain from proteins such as NEDD8 ultimate buster 1.NUB1 is an adaptor protein which negatively regulates the ubiquitin-like protein Nedd8 as well as neddylated proteins levels through proteasomal degradation [, ]. It has been shown to be regulated by Mdm2 (E3 ubiquitin ligase) through ubiquitination on its lysine 159 [].
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Protein Domain
IPR039749 | NUB1
Type: Family
Description: NUB1 is an adaptor protein which negatively regulates the ubiquitin-like protein Nedd8 as well as neddylated proteins levels through proteasomal degradation [, ]. It has been shown to be regulated by Mdm2 (E3 ubiquitin ligase) through ubiquitination on its lysine 159 [].
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Allele
Tg(GFAP-Mdm2*b)19Snj | MGI:3524951
Name: transgene insertion 19, Stephen N Jones
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Strain
MGI:7620055 | B6(129S4)-Igs79<em1Aven> Igs80<em1Aven>/J
Attribute String: endonuclease-mediated mutation, mutant strain
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Publication
18216268 | J:131856
First Author: Johnson TM
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: Knockin mice expressing a chimeric p53 protein reveal mechanistic differences in how p53 triggers apoptosis and senescence.
Volume: 105
Issue: 4
Pages: 1215-20
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Allele
Tg(GFAP-Mdm2*b)31Snj | MGI:3524952
Name: transgene insertion 31, Stephen N Jones
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(GFAP-Mdm2*b)45Snj | MGI:3524953
Name: transgene insertion 45, Stephen N Jones
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Protein Domain
IPR028895 | CCNG2
Type: Family
Description: Cyclins are eukaryotic proteins that play an active role in controlling nuclear cell division cycles, and regulate cyclin dependent kinases (CDKs) [].Members of the cyclin-G subfamily of cyclins can associate with cdk5 and GAK. They also interact with the B' subclass of PP2A phosphatase and with Mdm2 and may regulate the p53-Mdm2 network []. In humans and other mammals, there are two cyclin-G subtypes - cyclin-G1 and cyclin-G2. Their expression is linked to cancer progression [, ]. This entry represents cyclin-G2 and cycling-G.
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Protein Domain
IPR028860 | CCNG1
Type: Family
Description: Cyclins are eukaryotic proteins that play an active role in controlling nuclear cell division cycles, and regulate cyclin dependent kinases (CDKs) [].Members of the cyclin-G subfamily of cyclins can associate with cdk5 and GAK. They also interact with the B' subclass of PP2A phosphatase and with Mdm2 and may regulate the p53-Mdm2 network []. In humans and other mammals, there are two cyclin-G subtypes - cyclin-G1 and cyclin-G2. Their expression is linked to cancer progression [, ]. This entry represents cyclin-G1.
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Protein
A0A087WQP2
Organism: Mus musculus/domesticus
Length: 110  
Fragment?: true
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Protein
A0A087WQ90
Organism: Mus musculus/domesticus
Length: 141  
Fragment?: false
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Protein
A0A087WQ20
Organism: Mus musculus/domesticus
Length: 128  
Fragment?: false
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Protein
A0A087WRX7
Organism: Mus musculus/domesticus
Length: 318  
Fragment?: false
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Protein Domain
IPR003121 | SWIB_MDM2_domain
Type: Domain
Description: The SWI/SNF family of complexes, which are conserved from yeast to humans, are ATP-dependent chromatin-remodelling proteins that facilitate transcription activation [, , ]. The mammalian complexes are made up of 9-12 proteins called BAFs (BRG1-associated factors). The BAF60 family have at least three members: BAF60a, which is ubiquitous, BAF60b and BAF60c, which are expressed in muscle and pancreatic tissues, respectively. BAF60b is present in alternative forms of the SWI/SNF complex, including complex B (SWIB), which lacks BAF60a. The SWIB domain is a conserved region found within the BAF60b proteins [], and can be found fused to the C terminus of DNA topoisomerase in Chlamydia. This domain is also found in the Saccharomyces cerevisiae SNF12 protein, the eukaryotic initiation factor 2 (eIF2) []and the Arabidopsis thaliana At1g31760 protein [].MDM2 is an oncoprotein that acts as a cellular inhibitor of the p53 tumour suppressor by binding to the transactivation domain of p53 and suppressing its ability to activate transcription []. p53 acts in response to DNA damage, inducing cell cycle arrest and apoptosis. Inactivation of p53 is a common occurrence in neoplastic transformations. The core of MDM2 folds into an open bundle of four helices, which is capped by two small 3-stranded β-sheets. It consists of a duplication of two structural repeats. MDM2 has a deep hydrophobic cleft on which the p53 α-helix binds; p53 residues involved in transactivation are buried deep within the cleft of MDM2, thereby concealing the p53 transactivation domain.The SWIB and MDM2 domains are homologous and share a common fold.
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Publication
8168847 | J:34707
First Author: Heighway J
Year: 1994
Journal: Hum Genet
Title: A transcribed polymorphism and sub-localisation of MDM2.
Volume: 93
Issue: 5
Pages: 611-2
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Publication
30815226 | J:298130
First Author: van Oosterwijk JG
Year: 2019
Journal: Oncotarget
Title: Sexually dimorphic tumor suppression by small mitochondrial Arf.
Volume: 10
Issue: 12
Pages: 1235-1237
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Publication
11147808 | -
First Author: Decristofaro MF
Year: 2001
Journal: J Cell Physiol
Title: Characterization of SWI/SNF protein expression in human breast cancer cell lines and other malignancies.
Volume: 186
Issue: 1
Pages: 136-45
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Publication
28736176 | -
First Author: Vaidya AT
Year: 2017
Journal: J Mol Biol
Title: Crystal Structure of the C-terminal Domain of Human eIF2D and Its Implications on Eukaryotic Translation Initiation.
Volume: 429
Issue: 18
Pages: 2765-2771
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Publication
26791088 | -
 
First Author: Vieira WA
Year: 2016
Journal: Malar J
Title: Localization and interactions of Plasmodium falciparum SWIB/MDM2 homologues.
Volume: 15
Pages: 32
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Publication
28420746 | -
First Author: Blomme J
Year: 2017
Journal: Plant Cell
Title: The Mitochondrial DNA-Associated Protein SWIB5 Influences mtDNA Architecture and Homologous Recombination.
Volume: 29
Issue: 5
Pages: 1137-1156
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Protein Domain
IPR036885 | SWIB_MDM2_dom_sf
Type: Homologous_superfamily
Description: The SWI/SNF family of complexes, which are conserved from yeast to humans, are ATP-dependent chromatin-remodelling proteins that facilitate transcription activation [, , ]. The mammalian complexes are made up of 9-12 proteins called BAFs (BRG1-associated factors). The BAF60 family have at least three members: BAF60a, which is ubiquitous, BAF60b and BAF60c, which are expressed in muscle and pancreatic tissues, respectively. BAF60b is present in alternative forms of the SWI/SNF complex, including complex B (SWIB), which lacks BAF60a. The SWIB domain is a conserved region found within the BAF60b proteins [], and can be found fused to the C terminus of DNA topoisomerase in Chlamydia. This domain is also found in the Saccharomyces cerevisiae SNF12 protein, the eukaryotic initiation factor 2 (eIF2) []and the Arabidopsis thaliana At1g31760 protein [].MDM2 is an oncoprotein that acts as a cellular inhibitor of the p53 tumour suppressor by binding to the transactivation domain of p53 and suppressing its ability to activate transcription []. p53 acts in response to DNA damage, inducing cell cycle arrest and apoptosis. Inactivation of p53 is a common occurrence in neoplastic transformations. The core of MDM2 folds into an open bundle of four helices, which is capped by two small 3-stranded β-sheets. It consists of a duplication of two structural repeats. MDM2 has a deep hydrophobic cleft on which the p53 α-helix binds; p53 residues involved in transactivation are buried deep within the cleft of MDM2, thereby concealing the p53 transactivation domain.The SWIB and MDM2 domains are homologous and share a common fold. The core of this domain is composed of four helices arranged in an open bundle, capped by two small 3-stranded β-sheets.
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Publication
15652475 | J:95926
First Author: Vousden KH
Year: 2005
Journal: Cell
Title: P53 and prognosis: new insights and further complexity.
Volume: 120
Issue: 1
Pages: 7-10
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Publication
12015958 | -
First Author: Chen X
Year: 2002
Journal: Dev Cell
Title: Cyclin G: a regulator of the p53-Mdm2 network.
Volume: 2
Issue: 5
Pages: 518-9
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Publication
24297335 | -
First Author: Chen JQ
Year: 2014
Journal: Tumour Biol
Title: Changes in the expression of cyclin G2 in esophageal cancer cell and its significance.
Volume: 35
Issue: 4
Pages: 3355-62
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Publication
9757829 | J:49292
First Author: Chin L
Year: 1998
Journal: Trends Biochem Sci
Title: The INK4a/ARF tumor suppressor: one gene--two products--two pathways.
Volume: 23
Issue: 8
Pages: 291-6
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Publication
17128209 | J:120252
First Author: Toledo F
Year: 2006
Journal: Nat Rev Cancer
Title: Regulating the p53 pathway: in vitro hypotheses, in vivo veritas.
Volume: 6
Issue: 12
Pages: 909-23
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Publication
19166854 | J:146144
First Author: Wood NT
Year: 2009
Journal: FEBS Lett
Title: 14-3-3 Binding to Pim-phosphorylated Ser166 and Ser186 of human Mdm2--Potential interplay with the PKB/Akt pathway and p14(ARF).
Volume: 583
Issue: 4
Pages: 615-20
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Publication
19450511 | J:148917
First Author: Kruse JP
Year: 2009
Journal: Cell
Title: Modes of p53 regulation.
Volume: 137
Issue: 4
Pages: 609-22
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Publication
23303139 | J:193502
First Author: Wade M
Year: 2013
Journal: Nat Rev Cancer
Title: MDM2, MDMX and p53 in oncogenesis and cancer therapy.
Volume: 13
Issue: 2
Pages: 83-96
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Publication
28406729 | J:345749
First Author: Kendig RD
Year: 2017
Journal: Cancer Invest
Title: Stabilization of the p53-DNA Complex by the Nuclear Protein Dmp1α.
Volume: 35
Issue: 5
Pages: 301-312
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Publication
- | J:346905
     
First Author: Pradella D
Year: 2023
Journal: bioRxiv
Title: Immortalization and transformation of primary cells mediated by engineered ecDNAs.
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Publication
22952240 | -
First Author: Euskirchen G
Year: 2012
Journal: J Biol Chem
Title: SWI/SNF chromatin-remodeling factors: multiscale analyses and diverse functions.
Volume: 287
Issue: 37
Pages: 30897-905
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Protein
Q61466
Organism: Mus musculus/domesticus
Length: 515  
Fragment?: false
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Protein
Q6P9Z1
Organism: Mus musculus/domesticus
Length: 483  
Fragment?: false
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Protein
Q99JR8
Organism: Mus musculus/domesticus
Length: 531  
Fragment?: false
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Protein
Q8C8I3
Organism: Mus musculus/domesticus
Length: 453  
Fragment?: false
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Protein
Q3TM59
Organism: Mus musculus/domesticus
Length: 255  
Fragment?: false
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Protein
G3UXC0
Organism: Mus musculus/domesticus
Length: 247  
Fragment?: true
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Protein
Q68FH8
Organism: Mus musculus/domesticus
Length: 476  
Fragment?: false
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Protein
A0A0G2JG60
Organism: Mus musculus/domesticus
Length: 454  
Fragment?: false
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Protein
A0A2R8VKP3
Organism: Mus musculus/domesticus
Length: 474  
Fragment?: false
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Protein
Q3TXH6
Organism: Mus musculus/domesticus
Length: 531  
Fragment?: false
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Protein
O35618
Organism: Mus musculus/domesticus
Length: 489  
Fragment?: false
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Protein
Q99L86
Organism: Mus musculus/domesticus
Length: 490  
Fragment?: false
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Protein
Q3UTC9
Organism: Mus musculus/domesticus
Length: 490  
Fragment?: false
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Protein
Q61211
Organism: Mus musculus/domesticus
Length: 570  
Fragment?: false
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Protein
A0A0R4J298
Organism: Mus musculus/domesticus
Length: 587  
Fragment?: false
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Protein
E9PUG7
Organism: Mus musculus/domesticus
Length: 552  
Fragment?: false
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Publication
12702766 | J:99823
First Author: Kondo S
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Characterization of cells and gene-targeted mice deficient for the p53-binding kinase homeodomain-interacting protein kinase 1 (HIPK1).
Volume: 100
Issue: 9
Pages: 5431-6
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Publication
29262616 | J:272648
First Author: Aryal NK
Year: 2017
Journal: Oncotarget
Title: Loss of digestive organ expansion factor (Diexf) reveals an essential role during murine embryonic development that is independent of p53.
Volume: 8
Issue: 61
Pages: 103996-104006
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Publication
12782311 | J:83672
First Author: Vega FM
Year: 2003
Journal: FEBS Lett
Title: Expression of the VRK (vaccinia-related kinase) gene family of p53 regulators in murine hematopoietic development.
Volume: 544
Issue: 1-3
Pages: 176-80
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Publication
11779495 | J:88792
First Author: Sharpless NE
Year: 2001
Journal: Mol Cell
Title: Impaired nonhomologous end-joining provokes soft tissue sarcomas harboring chromosomal translocations, amplifications, and deletions.
Volume: 8
Issue: 6
Pages: 1187-96
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Publication
25600590 | J:219719
 
First Author: Wang L
Year: 2015
Journal: Nat Commun
Title: Intracellular CD24 disrupts the ARF-NPM interaction and enables mutational and viral oncogene-mediated p53 inactivation.
Volume: 6
Pages: 5909
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Publication
27499244 | J:241266
 
First Author: Riascos-Bernal DF
Year: 2016
Journal: Nat Commun
Title: β-Catenin C-terminal signals suppress p53 and are essential for artery formation.
Volume: 7
Pages: 12389
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Publication
10344759 | J:55311
First Author: Kamijo T
Year: 1999
Journal: Cancer Res
Title: Loss of the ARF tumor suppressor reverses premature replicative arrest but not radiation hypersensitivity arising from disabled atm function.
Volume: 59
Issue: 10
Pages: 2464-9
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Publication
29153842 | J:252273
First Author: Todoric J
Year: 2017
Journal: Cancer Cell
Title: Stress-Activated NRF2-MDM2 Cascade Controls Neoplastic Progression in Pancreas.
Volume: 32
Issue: 6
Pages: 824-839.e8
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Publication
22331460 | J:184938
First Author: Frazier DP
Year: 2012
Journal: Cancer Res
Title: Dmp1 physically interacts with p53 and positively regulates p53's stability, nuclear localization, and function.
Volume: 72
Issue: 7
Pages: 1740-50
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Publication
29540569 | J:261078
First Author: Kuser-Abali G
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: An EZH2-mediated epigenetic mechanism behind p53-dependent tissue sensitivity to DNA damage.
Volume: 115
Issue: 13
Pages: 3452-3457
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Publication
37527040 | J:338904
First Author: Yu M
Year: 2023
Journal: Cell Rep
Title: FRMD8 targets both CDK4 activation and RB degradation to suppress colon cancer growth.
Volume: 42
Issue: 8
Pages: 112886
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Publication
30244867 | J:270442
First Author: Liu L
Year: 2018
Journal: Cell Stem Cell
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