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Search results 101 to 146 out of 146 for Itm2b

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Type Details Score
Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
25557390 | -
First Author: Baron BW
Year: 2015
Journal: Biochim Biophys Acta
Title: The ITM2B (BRI2) gene is a target of BCL6 repression: Implications for lymphomas and neurodegenerative diseases.
Volume: 1852
Issue: 5
Pages: 742-8
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Allele
Itm2b<em1Smoc> | MGI:7290622
Name: integral membrane protein 2B; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Publication
24831988 | J:217351
First Author: Tai TS
Year: 2014
Journal: PLoS One
Title: Itm2a, a target gene of GATA-3, plays a minimal role in regulating the development and function of T cells.
Volume: 9
Issue: 5
Pages: e96535
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DO Term
DOID:0070030 | ITM2B-related cerebral amyloid angiopathy 2
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Publication
17873332 | -
First Author: Rengaraj D
Year: 2007
Journal: Endocrine
Title: Expression and regulation of type II integral membrane protein family members in mouse male reproductive tissues.
Volume: 31
Issue: 2
Pages: 193-201
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Publication
19747390 | -
 
First Author: Hedlund J
Year: 2009
Journal: BMC Res Notes
Title: BRICHOS - a superfamily of multidomain proteins with diverse functions.
Volume: 2
Pages: 180
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Publication
24099305 | -
First Author: Knight SD
Year: 2013
Journal: Biochemistry
Title: The BRICHOS domain, amyloid fibril formation, and their relationship.
Volume: 52
Issue: 43
Pages: 7523-31
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Publication
16027166 | -
First Author: Fotinopoulou A
Year: 2005
Journal: J Biol Chem
Title: BRI2 interacts with amyloid precursor protein (APP) and regulates amyloid beta (Abeta) production.
Volume: 280
Issue: 35
Pages: 30768-72
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Publication
20036644 | -
First Author: Peng S
Year: 2010
Journal: Biochem Biophys Res Commun
Title: The extracellular domain of Bri2 (ITM2B) binds the ABri peptide (1-23) and amyloid beta-peptide (Abeta1-40): Implications for Bri2 effects on processing of amyloid precursor protein and Abeta aggregation.
Volume: 393
Issue: 3
Pages: 356-61
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Publication
19366692 | -
First Author: Matsuda S
Year: 2009
Journal: J Biol Chem
Title: BRI3 inhibits amyloid precursor protein processing in a mechanistically distinct manner from its homologue dementia gene BRI2.
Volume: 284
Issue: 23
Pages: 15815-25
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Protein Domain
IPR040145 | ITM2
Type: Family
Description: The family of type 2 integral membrane protein (ITM2) consists of three members, ITM2A, ITM2B and ITM2C []. Members of this family contain a BRICHOS domain, which possesses chaperone activity [,].ITM2A is a target gene of GATA-3, a T cell-specific transcription factor [].ITM2B is proteolytically cleaved at three locations; cleavage by furin in the C-terminal region generates a 23-residue peptide (ABri23), processing by ADAM10 results in release of the BRICHOS domain from the membrane-bound N-terminal part and intramembrane cleavage by SPPL2a/2b liberates the intracellular domain []. ITM2B (BRI2) is a target of BCL6 transcriptional repression and a short form of the ITM2B protein, similarly to other targets of BCL6, induces apoptosis in hematopoietic cell lines []. ITM2B interacts with amyloid precursor protein (APP) and regulates amyloid beta (Abeta) production [, ]. ITM2C (BRI3) also inhibits amyloid precursor protein processing, but through a different mechanism to ITM2B [].
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DO Term
DOID:0070029 | ITM2B-related cerebral amyloid angiopathy 1
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Allele
Tg(Camk2a-ITM2B)8.4Ldad | MGI:3810989
Name: transgene insertion 8.4, Luciano D'Adamio
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Protein
Q91VK4
Organism: Mus musculus/domesticus
Length: 269  
Fragment?: false
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Protein
Q61500
Organism: Mus musculus/domesticus
Length: 263  
Fragment?: false
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Protein
O89051
Organism: Mus musculus/domesticus
Length: 266  
Fragment?: false
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Protein
Q3TVJ0
Organism: Mus musculus/domesticus
Length: 266  
Fragment?: false
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Protein
Q9JME4
Organism: Mus musculus/domesticus
Length: 210  
Fragment?: false
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Protein
Q9D1Q3
Organism: Mus musculus/domesticus
Length: 266  
Fragment?: false
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Protein
A0A087WRM2
Organism: Mus musculus/domesticus
Length: 232  
Fragment?: false
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Protein
A0A2I3BPW7
Organism: Mus musculus/domesticus
Length: 144  
Fragment?: true
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Protein
Q3U0F3
Organism: Mus musculus/domesticus
Length: 269  
Fragment?: false
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Protein
Q3UCT9
Organism: Mus musculus/domesticus
Length: 266  
Fragment?: false
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Publication
17965014 | -
First Author: Martin L
Year: 2008
Journal: J Biol Chem
Title: Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b.
Volume: 283
Issue: 3
Pages: 1644-52
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Strain
MGI:4938268 | B6.Cg-Itm2b<tm2.1Ldad> Tg(Camk2a-ITM2B)8.4Ldad
Attribute String: congenic, mutant strain, targeted mutation, transgenic
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Genotype
Genotype
Symbol: Tg(Camk2a-ITM2B)8.4Ldad/? Tg(PRNP-APPSweInd)8Dwst/?
Background: involves: C3H/HeJ * C57BL/6J * FVB/N
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Itm2b/Itm2b<+> Tg(Camk2a-ITM2B)8.4Ldad/?
Background: B6.Cg-Itm2b Tg(Camk2a-ITM2B)8.4Ldad
Zygosity: cx
Has Mutant Allele: true
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